Article ; Online: Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity.
American journal of respiratory cell and molecular biology
2022 Volume 67, Issue 6, Page(s) 632–640
Abstract: Chronic beryllium disease (CBD) is a Th1 granulomatous lung disease preceded by sensitization to beryllium (BeS). We profiled the methylome, transcriptome, and selected proteins in the lung to identify molecular signatures and networks associated with ... ...
Abstract | Chronic beryllium disease (CBD) is a Th1 granulomatous lung disease preceded by sensitization to beryllium (BeS). We profiled the methylome, transcriptome, and selected proteins in the lung to identify molecular signatures and networks associated with BeS and CBD. BAL cell DNA and RNA were profiled using microarrays from CBD ( |
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MeSH term(s) | Humans ; Berylliosis/genetics ; T-Lymphocytes ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid ; Immunity, Innate/genetics ; RNA ; Chronic Disease |
Chemical Substances | BES (10191-18-1) ; RNA (63231-63-0) |
Language | English |
Publishing date | 2022-08-16 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1025960-0 |
ISSN | 1535-4989 ; 1044-1549 |
ISSN (online) | 1535-4989 |
ISSN | 1044-1549 |
DOI | 10.1165/rcmb.2022-0077OC |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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