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Article: An In-Orbit Measurement Method for Elevation Antenna Pattern of MEO Synthetic Aperture Radar Based on Nano Calibration Satellite

Qiu, Tian / Wang, Yu / Hong, Jun / Xing, Kaichu / Du, Shaoyan / Mu, Jingwen

Remote Sensing. 2022 Feb. 05, v. 14, no. 3

2022

Abstract: The medium-Earth-orbit synthetic aperture radar (MEO-SAR) is deployed at orbit altitude above low-Earth-orbit synthetic aperture radar (LEO-SAR, around 2000 km) and below the geosynchronous orbit SAR (GEO-SAR, near 35786 km) to cover a wide swath, which ... ...

Abstract	The medium-Earth-orbit synthetic aperture radar (MEO-SAR) is deployed at orbit altitude above low-Earth-orbit synthetic aperture radar (LEO-SAR, around 2000 km) and below the geosynchronous orbit SAR (GEO-SAR, near 35786 km) to cover a wide swath, which is four to five times larger than LEO-SAR. Therefore, the measurement method for the LEO-SAR elevation antenna pattern using the SAR data acquired over the Amazon tropical rainforest (ground-based method), where the typical width of rainforest area is approximately 150 km, can hardly meet the requirement of a wide swath to determine the MEO-SAR antenna elevation pattern. Moreover, several new MEO-SAR systems are now proposed that will use low frequency, and the low frequency penetration characteristics may affect the elevation antenna pattern determination using homogenous distributed targets such as the Amazon rainforest. This paper proposes a novel space-based method for the in-orbit measurement of the elevation antenna pattern of MEO-SAR based on one nano calibration satellite mounted with a receiver. Through appropriate orbit design, the nano calibration satellite can fly across the entire MEO-SAR swath along the range direction, and the elevation antenna pattern envelope can be extracted from the data recorded by the receiver. Simulation work is performed to verify the feasibility of the proposed space-based method, and the measurement accuracy of this method is analyzed.
Keywords	altitude ; calibration ; satellites ; synthetic aperture radar ; tropical rain forests ; Amazonia
Language	English
Dates of publication	2022-0205
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs14030741
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Semaphorin 4A restricts tumor progression by inhibiting angiogenesis of oral squamous cell carcinoma cells.

Liu, Xiao-Qin / Yao, Yao / Mu, Jing-Wen / Yang, Feng-Ying

Tissue & cell

2021 Volume 69, Page(s) 101485

Abstract: Objective: To investigate the effects of Semaphorin 4A (Sema4A) on the angiogenesis, migration and invasion of oral squamous cell carcinoma (OSCC) cells.: Methods: Sema4A expression in OSCC patients was detected by Immunohistochemistry, and its ... ...

Abstract	Objective: To investigate the effects of Semaphorin 4A (Sema4A) on the angiogenesis, migration and invasion of oral squamous cell carcinoma (OSCC) cells. Methods: Sema4A expression in OSCC patients was detected by Immunohistochemistry, and its relationship with clinicopathological features and prognosis of patients was analyzed. The mRNA and protein expression of Sema4A in primary human oral keratinocytes (HOKs) and OSCC cells (SCC-25, HSC-3, CAL-27) were determined by Western blotting and qRT-PCR. After HOKs, HSC-3 cells and SCC-25 cells transfected with Control/Sema4A CRISPR activation plasmid, the migration and invasion abilities were detected by Wound healing and Transwell invasion. Tube formation assay was also performed on endothelial cells and the contents of VEGF and bFGF were quantified using qRT-PCR and ELISA. Results: Cytoplasmic Sema4A expression was related to T classification, clinical stage and nodal metastasis of OSCC patients. Patients with low cytoplasmic Sema4A expression showed the higher microvessel density (MVD) and the poorer prognosis in OSCC. Compared with HOK, OSCC cells (SCC-25, HSC-3, CAL-27) declined apparently in Sema4A expression, which was much more significant in metastatic HSC-3 and SCC-25 cells. After HOKs, HSC-3 cells and SCC-25 cells transfected with Sema4A over-expression plasmid, the invasion and migration abilities were decreased. Besides, overexpression of Sema4A could significantly inhibit the tube formation of HUVEC induced by OSCC cells with reductions of angiogenic factors (VEGF and bFGF). Conclusion: Over-expression of Sema4A could restrict tumor progression through inhibiting the angiogenesis, invasion and migration of OSCC cells.
MeSH term(s)	Aged ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Carcinoma, Squamous Cell/blood supply ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Male ; Middle Aged ; Mouth Neoplasms/blood supply ; Mouth Neoplasms/pathology ; Neoplasm Invasiveness ; Neovascularization, Pathologic/drug therapy ; Prognosis ; Semaphorins/genetics ; Semaphorins/metabolism
Chemical Substances	Angiogenesis Inhibitors ; SEMA4A protein, human ; Semaphorins
Language	English
Publishing date	2021-01-06
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2021.101485
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Zs.A 1016: Show issues

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Article ; Online: MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.

Yao, Yao / Liu, Xiao-Qin / Yang, Feng-Ying / Mu, Jing-Wen

Oral diseases

2021 Volume 28, Issue 6, Page(s) 1509–1518

Abstract: Objective: To explore the effect of miR-873-5p on proliferation, apoptosis, migration, and invasion of tongue squamous cell carcinoma (TSCC) by targeting SEC11A.: Methods: Tongue squamous cell carcinoma tissues were collected and performed by qRT-PCR ...

Abstract	Objective: To explore the effect of miR-873-5p on proliferation, apoptosis, migration, and invasion of tongue squamous cell carcinoma (TSCC) by targeting SEC11A. Methods: Tongue squamous cell carcinoma tissues were collected and performed by qRT-PCR and Western blotting to determine the expression of miR-873-5p and SPC18. SCC9 and CAL-27 cells were transfected and divided into Mock, mimic NC, miR-873-5p mimic, SEC11A, and miR-873-5p mimic + SEC11A groups. Then, a series of experiments including cell count kit 8 (CCK-8), wound healing, Transwell, and flow cytometry were conducted. Besides, Western blotting was used to detect the expression of SPC18 and EGFR pathway-related proteins. Results: MiR-873-5p was downregulated while SPC18 was upregulated in TSCC, and miR-873-5p was negatively correlated with SPC18. Dual luciferase reporter gene assay confirmed SEC11A to be a target of miR-873-5p. Cell proliferation, migration, and invasion of SCC9 and CAL-27 cells in miR-873-5p mimic group were decreased with increased cell apoptosis, presenting with downregulations of SPC18 and EGFR pathway-related proteins, while cells in SEC11A group manifested totally different changes. Moreover, the inhibitory effect of miR-873-5p mimic on TSCC cell growth was abolished by SEC11A overexpression. Conclusion: Overexpression of miR-873-5p may suppress cell proliferation, migration, and invasion, but facilitate apoptosis in TSCC via targeting SEC11A.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Peptide Hydrolases/metabolism ; Tongue ; Tongue Neoplasms/pathology
Chemical Substances	MIRN873 microRNA, human ; MicroRNAs ; ErbB Receptors (EC 2.7.10.1) ; Peptide Hydrolases (EC 3.4.-) ; SEC11A protein, human (EC 3.4.21.89)
Language	English
Publishing date	2021-03-19
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.13830
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4427: Show issues

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Article: Long non-coding RNA CRNDE regulates cell proliferation, migration, invasion, epithelial-mesenchymal transition and apoptosis in oral squamous cell carcinoma.

Dai, Jing / Mu, Jing-Wen / Mu, Hong

Oncology letters

2019 Volume 17, Issue 3, Page(s) 3330–3340

Abstract: The present study aimed to investigate whether the long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) can promote the migration and invasion of human oral squamous cell carcinoma (OSCC) cells via the regulation of ... ...

Abstract	The present study aimed to investigate whether the long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) can promote the migration and invasion of human oral squamous cell carcinoma (OSCC) cells via the regulation of epithelial-mesenchymal transition (EMT). CAL-27 and SCC-15 cells were classified into a control group, a small interfering negative control (si-NC) group (cells transfected with control siRNA) and an si-CRNDE group (cells transfected with CRNDE siRNA). The expression of CRNDE in OSCC tissues and cell lines was detected by
Language	English
Publishing date	2019-01-28
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2019.9978
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Corrigendum to "Fei-Yan-Qing-Hua decoction decreases hyperinflammation by inhibiting HMGB1/RAGE signaling and promotes bacterial phagocytosis in the treatment of sepsis" [J. Ethnopharmacol. (2024 Mar 1) 321:117553].

Zhang, Huan / Xu, Guihua / Wu, Xiao / Xu, Yanwu / Xu, Lirong / Zou, Yingxiang / Yang, Xiaodong / Pan, Lingyun / Lei, Biao / Mu, Jingwen / Huang, Qilin / Ma, Yuhe / Duan, Naifan / Zhang, Wei / Zheng, Yuejuan

Journal of ethnopharmacology

2024 Volume 326, Page(s) 117978

Language	English
Publishing date	2024-03-05
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117978
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Zs.A 1494: Show issues

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Article ; Online: Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages.

Zou, Ying-Xiang / Xiang, Tian-Nan / Xu, Li-Rong / Zhang, Huan / Ma, Yu-He / Zhang, Lu / Zhou, Chun-Xian / Wu, Xiao / Huang, Qi-Lin / Lei, Biao / Mu, Jing-Wen / Qin, Xiang-Yang / Jiang, Xin / Zheng, Yue-Juan

International immunopharmacology

2024 Volume 132, Page(s) 111889

Abstract: Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified ... ...

Abstract	Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistant Klebsiella pneumoniae (CRKP) infection mouse model was used for testing in vivo. RAW264.7 cells, mouse primary macrophages, and DCs were used for in vitro experiments. Dexamethasone (DXM) was used as a positive control agent. DHZD ameliorated tissue damage (lung, kidney, and liver) and excessive inflammatory response induced by LPS or CRKP infection in mice. Also, DHZD improved the hypothermic symptoms of acute peritonitis induced by CRKP, inhibited heat-killed CRKP (HK-CRKP)-induced inflammatory response in macrophages, and upregulated the proportions of phagocytic cell types in lungs. In vitro data suggested that DHZD decreases LPS-stimulated expression of IL-6, TNF-α and MCP-1 via PI3K/Akt/p70S6K signaling pathway in macrophages. Interestingly, the combined treatment group of DXM and DHZD had a higher survival rate and lower level of IL-6 than those of the DXM-treated group; the combination of DHZD and DXM played a synergistic role in decreasing IL-6 secretion in sera. Moreover, the phagocytic receptor CD36 was increased by DHZD in macrophages, which was accompanied by increased bacterial phagocytosis in a clathrin- and actin-dependent manner. This data suggests that DHZD may be a potential drug candidate for treating bacterial infections.
MeSH term(s)	Animals ; Mice ; Phagocytosis/drug effects ; Klebsiella Infections/drug therapy ; Klebsiella Infections/immunology ; Klebsiella pneumoniae/drug effects ; Macrophages/drug effects ; Macrophages/immunology ; RAW 264.7 Cells ; Sepsis/drug therapy ; Sepsis/immunology ; Male ; Lipopolysaccharides ; Disease Models, Animal ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Cytokines/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	Lipopolysaccharides ; Cytokines ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111889
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5408: Show issues

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Article ; Online: Gerhardtite as a Precursor to an Efficient CO-to-Acetate Electroreduction Catalyst.

Wu, Zhi-Zheng / Zhang, Xiao-Long / Yang, Peng-Peng / Niu, Zhuang-Zhuang / Gao, Fei-Yue / Zhang, Yu-Cai / Chi, Li-Ping / Sun, Shu-Ping / DuanMu, Jing-Wen / Lu, Pu-Gan / Li, Ye-Cheng / Gao, Min-Rui

Journal of the American Chemical Society

2023 Volume 145, Issue 44, Page(s) 24338–24348

Abstract: Carbon-carbon coupling electrochemistry on a conventional copper (Cu) catalyst still undergoes low selectivity among many different multicarbon ( ... ...

Abstract	Carbon-carbon coupling electrochemistry on a conventional copper (Cu) catalyst still undergoes low selectivity among many different multicarbon (C
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c09255
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Article ; Online: Fei-Yan-Qing-Hua decoction decreases hyperinflammation by inhibiting HMGB1/RAGE signaling and promotes bacterial phagocytosis in the treatment of sepsis.

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117553

Abstract: Ethnopharmacological relevance: Fei-Yan-Qing-Hua decoction (FYQHD), derived from the renowned formula Ma Xing Shi Gan tang documented in Zhang Zhong Jing's "Treatise on Exogenous Febrile Disease" during the Han Dynasty, has demonstrated notable efficacy ...

Abstract	Ethnopharmacological relevance: Fei-Yan-Qing-Hua decoction (FYQHD), derived from the renowned formula Ma Xing Shi Gan tang documented in Zhang Zhong Jing's "Treatise on Exogenous Febrile Disease" during the Han Dynasty, has demonstrated notable efficacy in the clinical treatment of pneumonia resulting from bacterial infection. However, its molecular mechanisms underlying the therapeutic effects remains elusive. Aim of the study: This study aimed to investigate the protective effects of FYQHD against lipopolysaccharide (LPS) and carbapenem-resistant Klebsiella pneumoniae (CRKP)-induced sepsis in mice and to elucidate its specific mechanism of action. Materials and methods: Sepsis models were established in mice through intraperitoneal injection of LPS or CRKP. FYQHD was administered via gavage at low and high doses. Serum cytokines, bacterial load, and pathological damage were assessed using enzyme-linked immunosorbent assay (ELISA), minimal inhibitory concentration (MIC) detection, and hematoxylin and eosin staining (H&E), respectively. In vitro, the immunoregulatory effects of FYQHD on macrophages were investigated through ELISA, MIC, quantitative real-time PCR (Q-PCR), immunofluorescence, Western blot, and a network pharmacological approach. Results: The application of FYQHD in the treatment of LPS or CRKP-induced septic mouse models revealed significant outcomes. FYQHD increased the survival rate of mice exposed to a lethal dose of LPS to 33.3%, prevented hypothermia (with a rise of 3.58 °C), reduced pro-inflammatory variables (including TNF-α, IL-6, and MCP-1), and mitigated tissue damage in LPS or CRKP-induced septic mice. Additionally, FYQHD decreased bacterial load in CRKP-infected mice. In vitro, FYQHD suppressed the expression of inflammatory cytokines in macrophages activated by LPS or HK-CRKP. Mechanistically, FYQHD inhibited the PI3K/AKT/mTOR/4E-BP1 signaling pathway, thereby suppressing the translational level of inflammatory cytokines. Furthermore, it reduced the expression of HMGB1/RAGE, a positive feedback loop in the inflammatory response. Moreover, FYQHD was found to enhance the phagocytic activity of macrophages by upregulating the expression of phagocytic receptors such as CD169 and SR-A1. Conclusion: FYQHD provides protection against bacterial sepsis by concurrently inhibiting the inflammatory response and augmenting the phagocytic ability of immune cells.
MeSH term(s)	Mice ; Animals ; Lipopolysaccharides/pharmacology ; HMGB1 Protein/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Cytokines/metabolism ; Phagocytosis ; Sepsis/drug therapy
Chemical Substances	Lipopolysaccharides ; HMGB1 Protein ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Cytokines
Language	English
Publishing date	2023-12-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117553
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Book ; Online: Evaluating approaches to identifying research supporting the United Nations Sustainable Development Goals

Kashnitsky, Yury / Roberge, Guillaume / Mu, Jingwen / Kang, Kevin / Wang, Weiwei / Vanderfeesten, Maurice / Rivest, Maxim / Chamezopoulos, Savvas / Jaworek, Robert / Vignes, Maéva / Jayabalasingham, Bamini / Boonen, Finne / James, Chris / Doornenbal, Marius / Labrosse, Isabelle

2022

Abstract: The United Nations (UN) Sustainable Development Goals (SDGs) challenge the global community to build a world where no one is left behind. Recognizing that research plays a fundamental part in supporting these goals, attempts have been made to classify ... ...

Abstract	The United Nations (UN) Sustainable Development Goals (SDGs) challenge the global community to build a world where no one is left behind. Recognizing that research plays a fundamental part in supporting these goals, attempts have been made to classify research publications according to their relevance in supporting each of the UN's SDGs. In this paper, we outline the methodology that we followed when mapping research articles to SDGs and which is adopted by Times Higher Education in their Social Impact rankings. We compare our solution with other existing queries and models mapping research papers to SDGs. We also discuss various aspects in which the methodology can be improved and generalized to other types of content apart from research articles. The results presented in this paper are the outcome of the SDG Research Mapping Initiative that was established as a partnership between the University of Southern Denmark, the Aurora European Universities Alliance (represented by Vrije Universiteit Amsterdam), the University of Auckland, and Elsevier to bring together broad expertise and share best practices on identifying research contributions to UN's Sustainable Development Goals. Comment: 16 pages, 2 figures, 12 tables, 24 references
Keywords	Computer Science - Digital Libraries
Subject code	001 ; 306
Publishing date	2022-09-15
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Matrix metalloproteinase 2 overexpression and prognosis in colorectal cancer: a meta-analysis.

Shi, Mumu / Yu, Bo / Gao, Hongguo / Mu, Jingwen / Ji, Changwei

Molecular biology reports

2012 Volume 40, Issue 1, Page(s) 617–623

Abstract: Many studies investigated the relationship between matrix metalloproteinase 2 (MMP-2) overexpression and survival in patients with colorectal cancer (CRC), but yielded inconsistent results. To derive a more precise estimate of the prognostic significance ...

Abstract	Many studies investigated the relationship between matrix metalloproteinase 2 (MMP-2) overexpression and survival in patients with colorectal cancer (CRC), but yielded inconsistent results. To derive a more precise estimate of the prognostic significance of MMP-2 overexpression, we reviewed published studies and carried out a meta-analysis. Eligible articles were identified for the period up to March 2012 in electronic databases. To evaluate the correlation between MMP-2 overexpression and the prognosis in CRC, pooled hazard ratio (HR) and its 95 % confidence interval (95 % CI) for poorer overall and progression-free survival were appropriately derived from fixed-effects or random-effects models using standard meta-analysis techniques. Thirteen studies with a total of 1,919 CRC patients stratifying overall survival (OS) and/or progression-free survival in CRC patients by MMP-2 expression status were eligible for analysis. Ten studies investigated the OS in a total of 1,612 cases with CRC, and five studies investigated the progression-free survival in a total of 508 patients CRC. The combined HR estimate for OS and progression-free survival was 1.74 (95 % CI, 1.34-2.26) and 1.35 (95 % CI, 1.07-1.80), respectively. Both subgroup analyses and sensitivity analysis further identified the prognostic role of MMP-2 overexpression in patients with CRC. There was no evidence for publication bias. In conclusion, MMP-2 overexpression is associated with poorer overall and progression-free survival in patients with CRC.
MeSH term(s)	Colorectal Neoplasms/genetics ; Colorectal Neoplasms/mortality ; Female ; Gene Expression ; Humans ; Male ; Matrix Metalloproteinase 2/genetics ; Odds Ratio ; Prognosis ; Publication Bias
Chemical Substances	Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2012-11-27
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-012-2100-3
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