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Article ; Online: Clinical experience in the treatment of COVID-19 with monoclonal antibodies in solid organ transplant recipients.

Múñez-Rubio, E / Calderón-Parra, J / Gutiérrez-Villanueva, A / Fernández-Cruz, A / Ramos-Martínez, A

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2023 Volume 36 Suppl 1, Page(s) 25–28

Abstract: Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). SOT recipients mount lower immunological responses to vaccines than general population and are at high risk for breakthrough COVID-19 ... ...

Abstract	Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). SOT recipients mount lower immunological responses to vaccines than general population and are at high risk for breakthrough COVID-19 infections. Passive immunotherapy in the form of anti-Spike monoclonal antibodies (MoAbs) may be an alternative for the prophylaxis and treatment of COVID-19 in these patients. SARS-CoV-2 has evolved by accumulating resistance mutations that have escaped the neutralizing action of most MoAbs. However, MoAbs directed at more conserved epitopes and that maintain effector functions could maintain efficacy in the treatment of these patients. According to published data, SOT recipients with low anti-spike antibody responses to vaccination could benefit from the use of MoAbs in pre-exposure prophylaxis, in the treatment of COVID-19 mild to moderate and severe COVID-19 with less than 15 days of symptom duration and low oxygen requirements. Combination therapy could be more effective than monotherapy for the treatment of mild-to-moderate SARS-CoV-2 infection.
MeSH term(s)	Humans ; COVID-19 ; Antibodies, Monoclonal/therapeutic use ; SARS-CoV-2 ; Organ Transplantation/adverse effects
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2023-11-24
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/s01.07.2023
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Article ; Online: Strategies for prevention and treatment of SARS-COV-2 infection in patients with chronic kidney disease: Literature review.

Marques Vidas, María / Muñez Rubio, Elena / Quiroga, Borja / Montejano, Rocío / Morales, Enrique / Candel, Francisco Javier

Nefrologia

2024 Volume 44, Issue 2, Page(s) 150–158

Abstract: COVID-19 has proven to be particularly aggressive in patients with chronic kidney disease (CKD). The lower immune response rate and the greater susceptibility to progress to severe forms of the disease have contributed to this phenomenon, which has ... ...

Abstract	COVID-19 has proven to be particularly aggressive in patients with chronic kidney disease (CKD). The lower immune response rate and the greater susceptibility to progress to severe forms of the disease have contributed to this phenomenon, which has persisted in the post-vaccination era of the pandemic. Paradoxically, CKD has been excluded from most clinical trials of the main therapeutic tools developed against SARS-CoV-2. However, experience in the use of these drugs has been accumulating in different stages of CKD, supporting their use with guarantees of efficacy and safety. The objective of this review is to gather all treatment indications for COVID-19 in the different phases of the disease, tailored to CKD in its various stages, including renal replacement therapy.
MeSH term(s)	Humans ; COVID-19/complications ; COVID-19/prevention & control ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Antiviral Agents/therapeutic use ; COVID-19 Drug Treatment ; SARS-CoV-2 ; Renal Replacement Therapy ; COVID-19 Vaccines
Chemical Substances	Antiviral Agents ; COVID-19 Vaccines
Language	English
Publishing date	2024-04-04
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2024.03.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fosfomycin in antimicrobial stewardship programs.

Múñez Rubio, E / Ramos Martínez, A / Fernández Cruz, A

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2019 Volume 32 Suppl 1, Page(s) 62–66

Abstract: Due to the increase in antimicrobial resistance, strategies such as antimicrobial stewardship programs (ASP) have been developed to improve the clinical results, decrease the adverse effects and the development of resistances and ensure cost-effective ... ...

Abstract	Due to the increase in antimicrobial resistance, strategies such as antimicrobial stewardship programs (ASP) have been developed to improve the clinical results, decrease the adverse effects and the development of resistances and ensure cost-effective therapies. Fosfomycin has a unique mechanism of action against Gram-positive and Gram-negative bacteria. Cross-resistance is uncommon; however, fosfomycin should be used in combination in severe infections to avoid selecting resistant mutations. Fosfomycin's oral formulation facilitates sequential treatment, has low toxicity and high tissue penetration, even in the central nervous system and bone. Fosfomycin is active against resistant Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin- resistant enterococci and penicillin-resistant Streptococcus pneumoniae, as well as against resistant Gram-negative bacteria such as extended-spectrum beta-lactamase-producing and carbapenemase-producing enterobacteria. Fosfomycin is therefore useful for cases of persistent bacteremia, skin and soft tissue infections, as a glycopeptide-sparing and carbapenem-sparing drug for healthcare-associated infections and for polymicrobial infections. Published studies have demonstrated the synergy between fosfomycin and beta-lactams, daptomycin and glycopeptides against MSSA and MRSA; with linezolid in biofilm-associated infections and with aminoglycosides and colistin against Gram-negative bacteria, providing a nephroprotective effect.
MeSH term(s)	Animals ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Drug Resistance, Multiple, Bacterial ; Fosfomycin/therapeutic use ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology ; Humans
Chemical Substances	Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE)
Language	English
Publishing date	2019-05-27
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Infecciones en el paciente inmunocomprometido (II). Paciente trasplantado.

Ramos Martínez, A / Pintos Pascual, I / Múñez Rubio, E

Medicine

2018 Volume 12, Issue 55, Page(s) 3245–3252

Abstract: Recipients of the different types of transplantation are at high risk of infection. Nosocomial infections predominate in patients who have undergone haematopoietic stem cell transplantation during the early post-engraftment period (30-100 days after the ... ...

Title translation	Infections in immunocompromised patients (II). The transplanted patient.
Abstract	Recipients of the different types of transplantation are at high risk of infection. Nosocomial infections predominate in patients who have undergone haematopoietic stem cell transplantation during the early post-engraftment period (30-100 days after the infusion); the incidence of infection is higher in graft-versus-host disease. Nodular lesions can appear in the lungs due to invasive fungal infection. A diffuse pattern is usually secondary to viral infection or
Keywords	covid19
Language	Spanish
Publishing date	2018-05-08
Publishing country	Spain
Document type	English Abstract ; Journal Article
ISSN	0304-5412
ISSN	0304-5412
DOI	10.1016/j.med.2018.04.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Trends in epidemiology, surgical management, and prognosis of infective endocarditis during the XXI century in Spain: A population-based nationwide study.

Calderón-Parra, Jorge / Gutiérrez-Villanueva, Andrea / Yagüe-Diego, Itziar / Cobo, Marta / Domínguez, Fernando / Forteza, Alberto / Ana, Fernández-Cruz / Muñez-Rubio, Elena / Moreno-Torres, Victor / Ramos-Martínez, Antonio

Journal of infection and public health

2024 Volume 17, Issue 5, Page(s) 881–888

Abstract: Background: Few population-based studies have evaluated the epidemiology of infective endocarditis (IE). Changes in population demographics and guidelines on IE may have affected both the incidence and outcomes of IE. Therefore, the aim of our study is ... ...

Abstract	Background: Few population-based studies have evaluated the epidemiology of infective endocarditis (IE). Changes in population demographics and guidelines on IE may have affected both the incidence and outcomes of IE. Therefore, the aim of our study is to provide contemporary population-based epidemiological data of IE in Spain. Methods: Retrospective nationwide observational study using data from the Spanish National Health System Discharge Database. We included all patients hospitalized with IE from January 2000 to December 2019. Results: A total of 64,550 IE episodes were included. The incidence of IE rose from 5.25 cases/100,000 person-year in 2000 to 7.21 in 2019, with a 2% annual percentage change (95% CI 1.3-2.6). IE incidence was higher among those aged 85 or older (43.5 cases/100.000 person-years). Trends across the study period varied with sex and age. Patients with IE were progressively older (63.9 years in 2000-2004 to 70.0 in 2015-2019, p < 0.001) and had more frequent comorbidities and predispositions, including, previous valvular prosthesis (12.1% vs 20.9%, p < 0.001). After adjustment, a progressive reduction in mortality was noted including in 2015-2019 compared to 2010-2014 (adjusted odds ratio 0.93, 95% confident interval 0.88-0.99, p = 0.023)., which was associated with more frequent cardiac surgery in recent years (15.1% in 2010-2014 vs 19.9% in 2015-2019). Conclusions: In Spain, the incidence of IE has increased during the XXI century, with a more pronounced increase in elderly individuals. Adjusted-mortality decreased over the years, which could be related to a higher percentage of surgery. Our results highlight the changing epidemiology of IE.
MeSH term(s)	Aged ; Humans ; Spain/epidemiology ; Retrospective Studies ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/surgery ; Endocarditis/epidemiology ; Endocarditis/surgery ; Prognosis ; Incidence
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2024.03.011
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Article ; Online: Epidemiología y clínica de las infecciones y colonizaciones causadas por enterobacterias productoras de carbapenemasas en un hospital de tercer nivel.

Pintos-Pascual, I / Cantero-Caballero, M / Muñez Rubio, E / Sánchez-Romero, I / Asensio-Vegas, A / Ramos-Martínez, A

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2020 Volume 33, Issue 2, Page(s) 122–129

Abstract: Objective: To describe the epidemiology of Enterobacterales producing carbapenemases (EPC) in a tertiary hospital.: Methods: A retrospective observational study, all patients with a positive sample for EPC treated in hospitalization or in the ... ...

Title translation	Epidemiology and clinical of infections and colonizations caused by Enterobacterales producing carbapenemases in a tertiary hospital.
Abstract	Objective: To describe the epidemiology of Enterobacterales producing carbapenemases (EPC) in a tertiary hospital. Methods: A retrospective observational study, all patients with a positive sample for EPC treated in hospitalization or in the Emergency Department were included, between January 1, 2014 and December 31, 2016. Results: A total of 272 patients (316 samples) were included: 155 (57%) male. Mean age of 70.4 years (95% CI 68.2 -72.7). Mean Charlson index was 3.6 (95% CI 3.4-3.8). In 63.2% the acquisition was nosocomial, in 35.3% it was health-care associated (HA). 55.1% presented infection, the most frequent infection was urinary tract infection (UTI) (58.7%). The most frequent species were Klebsiella pneumoniae (62.7%) and Enterobacter cloacae (10.1%). The most frequent types of carbapenemase were OXA-48 (53.8%) and VIM (43%). The nosocomial acquisition was associated with the male gender, transplantation, immunosuppression, admission to the Intensive Care Unit (ICU) or surgical service, prior antibiotic treatment, Enterobacter, VIM, respiratory and intra-abdominal infections. The HA acquisition was associated with age and comorbidity, nursery home origin, bladder catheterization, greater number of outpatient procedures, previous hospital admission, K. pneumoniae and E. coli, OXA-48, coproduction of extended spectrum betalactamases, UTI and sepsis. Conclusions: Patients who acquire EPC in nursery homes frequently have an infection. Patients with nosocomial acqui-sition are colonized by EPC in the ICU, in relation to invasive procedures and transplantation. This population has a higher mortality due to developing respiratory infections by EPC.
MeSH term(s)	Aged ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Enterobacter cloacae/enzymology ; Enterobacter cloacae/isolation & purification ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Female ; Humans ; Klebsiella pneumoniae/enzymology ; Klebsiella pneumoniae/isolation & purification ; Male ; Middle Aged ; Retrospective Studies ; Sex Distribution ; Tertiary Care Centers ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/microbiology ; beta-Lactamases/metabolism
Chemical Substances	beta-Lactamases (EC 3.5.2.6)
Language	Spanish
Publishing date	2020-03-09
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/086.2019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of faecal microbiota transplantation on recurrent urinary tract infection in a patient with long-term suprapubic urinary catheter.

Ramos-Martínez, A / Martínez-Ruiz, R / Múñez-Rubio, E / Valencia-Alijo, A / Ferre-Aracil, C / Vera-Mendoza, M I

The Journal of hospital infection

2020 Volume 105, Issue 2, Page(s) 332–333

MeSH term(s)	Adult ; Fecal Microbiota Transplantation ; Humans ; Recurrence ; Treatment Outcome ; Urinary Catheters/adverse effects ; Urinary Catheters/microbiology ; Urinary Tract Infections/therapy
Language	English
Publishing date	2020-01-28
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2020.01.016
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Zs.A 1586: Show issues

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Article: Infecciones por virus de la gripe y virus respiratorios.

Pintos Pascual, I / Muñez Rubio, E / Alarcón Tomás, A / Ramos Martínez, A

Medicine

2018 Volume 12, Issue 56, Page(s) 3291–3297

Abstract: In general, respiratory infections are benign and self-limiting, but occasionally they can cause severe symptoms and become a major cause of mortality and morbidity, especially in the more vulnerable population groups. Flu epidemics occur annually, and ... ...

Title translation	Flu virus and respiratory virus infections.
Abstract	In general, respiratory infections are benign and self-limiting, but occasionally they can cause severe symptoms and become a major cause of mortality and morbidity, especially in the more vulnerable population groups. Flu epidemics occur annually, and there can be pandemics every few years, such as those caused by types H1N1 or H3N2. The main clinical manifestations are respiratory symptoms associated with fever, and complications such as pneumonia can arise. Nasopharyngeal swab and RT-PCR should be performed to confirm the diagnosis, which can yield results for other viruses as well. Treatment is generally symptomatic, reserving neuraminidase inhibitors for the more serious cases. The best preventive measure is annual vaccination of the population at risk. The coronavirus is also particularly relevant, due to its potential prognostic implications, and the respiratory syncytial virus and parainfluenza virus should be borne in mind in children.
Keywords	covid19
Language	Spanish
Publishing date	2018-05-09
Publishing country	Spain
Document type	English Abstract ; Journal Article
ISSN	0304-5412
ISSN	0304-5412
DOI	10.1016/j.med.2018.04.019
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Article ; Online: Eosinophilia and abdominal pain after severe pneumonia due to COVID 19.

Pintos-Pascual, Ilduara / López-Dosil, Marcos / Castillo-Núñez, Ciara / Múñez-Rubio, Elena

Enfermedades infecciosas y microbiologia clinica (English ed.)

2021 Volume 39, Issue 9, Page(s) 478–480

MeSH term(s)	Abdominal Pain/etiology ; COVID-19 ; Eosinophilia/diagnosis ; Humans ; Pneumonia ; SARS-CoV-2
Language	English
Publishing date	2021-08-24
Publishing country	Spain
Document type	Case Reports
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2021.08.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Eosinofilia y dolor abdominal tras una neumonía grave por COVID 19

Pintos Pascual, I. / López Dosil, M. / Castillo Núñez, C. / Múñez Rubio, E.

Enfermedades Infecciosas y Microbiología Clínica ; ISSN 0213-005X

2020

Keywords	Microbiology (medical) ; covid19
Language	Spanish
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.eimc.2020.10.014
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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