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  1. Article ; Online: Extensive and deep granulomatous ulcers as an atypical manifestation of cartilage-hair hypoplasia syndrome: A diagnostic and therapeutic challenge.

    Rozas-Muñoz, Eduardo / Blamey-Diaz, Rodrigo / Gallardo-Olivos, Ana Maria / Jerez, Javiera / Madariaga, Juan-Andres

    The Australasian journal of dermatology

    2024  

    Abstract: Cartilage hypoplasia syndrome is a primary immunodeficiency disease characterized by short stature, hypoplastic hair and a variable degree of immunodeficiency. Noninfectious cutaneous granulomas represent an uncommon yet well-recognized manifestation ... ...

    Abstract Cartilage hypoplasia syndrome is a primary immunodeficiency disease characterized by short stature, hypoplastic hair and a variable degree of immunodeficiency. Noninfectious cutaneous granulomas represent an uncommon yet well-recognized manifestation within the spectrum of primary immunodeficiency diseases. However, cutaneous granulomas as a manifestation of cartilage-hair hypoplasia syndrome, are extremely rare. We present a case of a middle-aged man with cartilage hypoplasia syndrome featuring cutaneous granulomas, manifesting as chronic, extensive and deep cutaneous ulcers. The patient was treated with anti-TNF-alpha adalimumab with partial improvement. Our case underscores the broad spectrum of clinical manifestations associated with cartilage hypoplasia syndrome and adds new evidence to the potential therapeutic efficacy of anti-TNF-alpha drugs in its treatment.
    Language English
    Publishing date 2024-03-27
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.14258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 236: Show issues Location:
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  2. Article: The Cannabigerol Derivative VCE-003.2 Exerts Therapeutic Effects in 6-Hydroxydopamine-Lesioned Mice: Comparison with The Classic Dopaminergic Replacement Therapy.

    Rodríguez-Carreiro, Santiago / Navarro, Elisa / Muñoz, Eduardo / Fernández-Ruiz, Javier

    Brain sciences

    2023  Volume 13, Issue 9

    Abstract: 1) Background: A cannabigerol aminoquinone derivative, so-called VCE-003.2, has been found to behave as a neuroprotective agent (administered both i.p. and orally) in different experimental models of Parkinson's disease (PD) in mice. These effects were ... ...

    Abstract (1) Background: A cannabigerol aminoquinone derivative, so-called VCE-003.2, has been found to behave as a neuroprotective agent (administered both i.p. and orally) in different experimental models of Parkinson's disease (PD) in mice. These effects were exerted through mechanisms that involved the activation of a regulatory site within the peroxisome proliferator-activated receptor-γ (PPAR-γ). (2) Methods: We are now interested in comparing such neuroprotective potential of VCE-003.2, orally administered, with the effect of the classic dopaminergic replacement therapy with L-DOPA/benserazide in similar conditions, using 6-hydroxydopamine-lesioned mice. (3) Results: The oral administration of VCE-003.2 during 14 days at the dose of 20 mg/kg improved, as expected, the neurological status (measured in motor tests) in these mice. This correlated with a preservation of TH-labelled neurons in the substantia nigra. By contrast, the treatment with L-DOPA/benserazide (during 7 days at 2 mg/kg) was significantly less active in these experimental conditions, in concordance with their profile as a mere symptom-alleviating agent. (4) Conclusions: Our results confirmed again the therapeutic profile of VCE-003.2 in experimental PD and revealed a different and more relevant effect, as a disease modifier, compared to the classic symptom-alleviating L-DOPA treatment. This reinforces the interest in VCE-003.2 for a future clinical development in this disease.
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13091272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Erythrokeratodermia.

    Rozas-Muñoz, Eduardo / Ramos-Arancibia, Nelson / Madariaga, Juan-Andres

    JAMA dermatology

    2023  Volume 159, Issue 8, Page(s) 875–876

    MeSH term(s) Humans ; Keratosis
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2023.0117
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  4. Article ; Online: Generalized Micropapular Eruption in a Teenager.

    Rozas-Muñoz, Eduardo / Terrasa-Sagrista, Fernando / Mir-Bonafé, Juan-Francisco

    JAMA dermatology

    2022  Volume 158, Issue 4, Page(s) 449–450

    MeSH term(s) Adolescent ; Exanthema ; Humans ; Skin
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2022.0066
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  5. Article ; Online: Multiple Yellowish Plaques in a Cobblestone Pattern on the Tongue.

    Rozas-Muñoz, Eduardo / Venegas-Rebolledo, Oscar / Madariaga, Juan-Andres

    JAMA dermatology

    2022  

    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2022.4751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A comparative electromyographic study of scapular stabilizing muscles during five main rehabilitation exercises.

    Mendez-Rebolledo, Guillermo / Araya-Quintanilla, Felipe / Guzmán-Muñoz, Eduardo / Salazar-Mendez, Joaquín / Cruz-Montecinos, Carlos / Berckmans, Kelly R / Calatayud, Joaquín

    American journal of physical medicine & rehabilitation

    2024  

    Abstract: Objective: To compare the surface electromyographic (sEMG) amplitude, activation ratio, and onset latency of the main scapular stabilizing muscles between five typical rehabilitative exercises.: Design: Twenty-seven healthy participants performed ... ...

    Abstract Objective: To compare the surface electromyographic (sEMG) amplitude, activation ratio, and onset latency of the main scapular stabilizing muscles between five typical rehabilitative exercises.
    Design: Twenty-seven healthy participants performed five scapular exercises [wall-slide (WS), wall push-up plus, prone horizontal abduction with external rotation (PHABER), external rotation in side-lying (ERSL), and low row] while simultaneously recording sEMG of serratus anterior (SA), middle trapezius (MT), lower trapezius (LT), and upper trapezius (UT). sEMG amplitudes, onset latencies, and activation ratios were calculated.
    Results: PHABER showed an excellent UT/MT (0.43) and UT/LT (0.30) muscle balance with high (> 50% MVIC) MT and LT amplitudes, a low (< 20% MVIC) UT amplitude, and an early activation of the scapular stabilizing muscles (-474.7 to 89.9 ms) relative to UT. ERSL showed excellent UT/SA (0.26), UT/MT (0.32), and UT/LT (0.21) activation ratios; and along with LR and WS, showed early activation of the scapular stabilizing muscles (-378.1 to -26.6 ms).
    Conclusions: PHABER presented optimal scapular neuromuscular control. Although ERSL, low row, and WS did not meet all the criteria associated with optimal scapular neuromuscular control, these exercises could be used in early stages of shoulder rehabilitation because they favor early activation of the scapular stabilizing muscles.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Follicular Papules in a Linear Distribution on a Child's Face.

    Carvajal-Zuñiga, Carolina / Jerez, Javiera / Rozas-Muñoz, Eduardo

    JAMA dermatology

    2021  Volume 157, Issue 3, Page(s) 340–341

    MeSH term(s) Biopsy ; Facial Dermatoses/diagnosis ; Facial Dermatoses/pathology ; Female ; Humans ; Infant ; Mucinosis, Follicular/diagnosis ; Mucinosis, Follicular/pathology
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2020.5588
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  8. Article ; Online: Severe and recalcitrant periungual warts in a child successfully treated with cimetidine.

    Ramos-Arancibia, Nelson / Varas, Carmen / Rozas-Muñoz, Eduardo

    Dermatologic therapy

    2021  Volume 34, Issue 6, Page(s) e15154

    MeSH term(s) Child ; Cimetidine/therapeutic use ; Family ; Humans ; Nail Diseases/diagnosis ; Nail Diseases/drug therapy ; Warts/diagnosis ; Warts/drug therapy
    Chemical Substances Cimetidine (80061L1WGD)
    Language English
    Publishing date 2021-10-15
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: AMPK Activation by

    Günther, Madeline / Schnierle, Peter / Rose, Thorsten / Schlegel, Jonathan / Boonen, Georg / Drewe, Jürgen / Muñoz, Eduardo / Fiebich, Bernd L / Culmsee, Carsten

    Pharmaceutics

    2024  Volume 16, Issue 3

    Abstract: Cimicifuga ... ...

    Abstract Cimicifuga racemosa
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16030393
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  10. Article ; Online: Relationship between appendicular muscular mass index and physical function in older people.

    Alarcón-Rivera, Miguel / Cornejo-Mella, Carolina / Cáceres-Aravena, Camila / Concha-Cisternas, Yeny / Fernández-Valero, Paz / Guzmán-Muñoz, Eduardo

    AIMS public health

    2024  Volume 11, Issue 1, Page(s) 130–140

    Abstract: This study aimed to establish the relationship between the appendicular muscle mass index (AMMI), assessed from anthropometric variables, and the physical function of older people. Seventy-six older people participated in this study (72.03 ± 7.03 years). ...

    Abstract This study aimed to establish the relationship between the appendicular muscle mass index (AMMI), assessed from anthropometric variables, and the physical function of older people. Seventy-six older people participated in this study (72.03 ± 7.03 years). The participants underwent evaluations to determine their AMMI using anthropometry (weight, calf circumference, hip circumference, and knee height) and manual grip strength. Additionally, their physical function was evaluated using the 5-chair stand test, the 3-meter walk test, and the timed up and go test (TUG) to determine the strength of the lower limbs, the gait speed, and the dynamic balance, respectively. The results show that the AMMI did not present a significant relationship with the 5-chair stand test in both women (
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2777115-5
    ISSN 2327-8994 ; 2327-8994
    ISSN (online) 2327-8994
    ISSN 2327-8994
    DOI 10.3934/publichealth.2024006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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