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Article ; Online: Preventing tobacco use from the start: Short- and medium-term impacts on the youth.

Beneito, Pilar / Muñoz, Marina

2022 Volume 126, Issue 8, Page(s) 831–836

Abstract: Adolescent substance use is a persistent global problem and a challenge for society and the public health authorities. In this paper we investigate the impact of a prevention-oriented policy implemented in Icelandic secondary schools from 1997 to 2002 ( ... ...

Abstract	Adolescent substance use is a persistent global problem and a challenge for society and the public health authorities. In this paper we investigate the impact of a prevention-oriented policy implemented in Icelandic secondary schools from 1997 to 2002 (the "Drug-free Iceland" programme) on country-level smoking rates on the youth. Using a panel data source spanning from 1985 to 2010 and composed both by Iceland and a set of countries where such a type of policy was absent, we apply the Synthetic Control Method to construct the counterfactual of Iceland. Comparing Iceland with this counterfactual, we estimate the effect of the intervention on those aged 15 to 19 -who were the main target of the policy-, during the years of implementation of the programme, and follow their smoking prevalence rates overtime until 2010, when they became adults (25 to 29-years old). Our results show that the intervention reduced youth smoking prevalence on the targeted groups that lasted at least until they became adults. We also find evidence of externalities in the age groups adjacent to those directly targeted by the policy. The results differ by gender, with the impact on females being more marked.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Prevalence ; Smoking/epidemiology ; Smoking Prevention ; Substance-Related Disorders ; Tobacco Use/epidemiology ; Tobacco Use/prevention & control
Language	English
Publishing date	2022-05-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605805-x
ISSN	1872-6054 ; 0168-8510
ISSN (online)	1872-6054
ISSN	0168-8510
DOI	10.1016/j.healthpol.2022.05.017
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Article ; Online: Transgenerational plasticity to drought: contrasting patterns of non-genetic inheritance in two semiarid Mediterranean shrubs.

Ramos-Muñoz, Marina / Blanco-Sánchez, Mario / Pías, Beatriz / Escudero, Adrián / Matesanz, Silvia

Annals of botany

2024

Abstract: Background and aims: Intra- and transgenerational plasticity may provide substantial phenotypic variation to cope with environmental change. Since assessing the unique contribution of the maternal environment to the offspring phenotype is challenging in ...

Abstract	Background and aims: Intra- and transgenerational plasticity may provide substantial phenotypic variation to cope with environmental change. Since assessing the unique contribution of the maternal environment to the offspring phenotype is challenging in perennial, outcrossing plants, little is known about the evolutionary and ecological implications of transgenerational plasticity and its persistence over the life cycle in these species. We evaluated how intra- and transgenerational plasticity interplay to shape the adaptive responses to drought in two perennial Mediterranean shrubs. Methods: We used a novel common garden approach that reduced within-family genetic variation in both the maternal and offspring generations by growing the same maternal individual in two contrasting watering environments, well-watered and drought, in consecutive years. We then assessed phenotypic differences at the reproductive stage between offspring reciprocally-grown in the same environments. Key results: Maternal drought had an effect on offspring performance only in Helianthemum squamatum. Offspring of drought-stressed plants showed more inflorescences, less sclerophyllous leaves and higher growth rates in both watering conditions, and heavier seeds under drought, than offspring of well-watered maternal plants. Maternal drought also induced similar plasticity patterns across maternal families, showing a general increase in seed mass in response to offspring drought, a pattern not observed in the offspring of well-watered plants. In contrast, both species expressed immediate adaptive plasticity, and the magnitude of intragenerational plasticity was larger than the transgenerational plastic responses. Conclusions: Our results highlight that adaptive effects associated with maternal drought can persist beyond the seedling stage and provide evidence of species-level variation in the expression of transgenerational plasticity. Such differences between co-occurring Mediterranean species in the prevalence of this form of non-genetic inheritance may result in differential vulnerability to climate change.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1461328-1
ISSN	1095-8290 ; 0305-7364
ISSN (online)	1095-8290
ISSN	0305-7364
DOI	10.1093/aob/mcae039
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Article: The cumulative niche approach: A framework to assess the performance of ecological niche model projections.

Arlé, Eduardo / Knight, Tiffany Marie / Jiménez-Muñoz, Marina / Biancolini, Dino / Belmaker, Jonathan / Meyer, Carsten

Ecology and evolution

2024 Volume 14, Issue 2, Page(s) e11060

Abstract: Ecological Niche Models (ENMs) are often used to project species distributions within alien ranges and in future climatic scenarios. However, ENMs depend on species-environment equilibrium, which may be absent for actively expanding species. We present a ...

Abstract	Ecological Niche Models (ENMs) are often used to project species distributions within alien ranges and in future climatic scenarios. However, ENMs depend on species-environment equilibrium, which may be absent for actively expanding species. We present a novel framework to estimate whether species have reached environmental equilibrium in their native and alien ranges. The method is based on the estimation of niche breadth with the accumulation of species occurrences. An asymptote will indicate exhaustive knowledge of the realised niches. We demonstrate the CNA framework for 26 species of mammals, amphibians, and birds. Possible outcomes of the framework include: (1) There is enough data to quantify the native and alien realised niches, allowing us to calculate niche expansion between the native and alien ranges, also indicating that ENMs can be reliably projected to new environmental conditions. (2) The data in the native range is not adequate but an asymptote is reached in the alien realised niche, indicating low confidence in our ability to evaluate niche expansion in the alien range but high confidence in model projections to new environmental conditions within the alien range. (3) There is enough data to quantify the native realised niche, but not enough knowledge about the alien realised niche, hindering the reliability of projections beyond sampled conditions. (4) Both the native and alien ranges do not reach an asymptote, and thus few robust conclusions about the species' niche or future projections can be made. Our framework can be used to detect species' environmental equilibrium in both the native and alien ranges, to quantify changes in the realised niche during the invasion processes, and to estimate the likely accuracy of model projections to new environmental conditions.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.11060
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Article ; Online: Unveiling the pathogenic mechanisms of

Camargo, Anny / Ramírez, Juan David / Kiu, Raymond / Hall, Lindsay J / Muñoz, Marina

Emerging microbes & infections

2024 Volume 13, Issue 1, Page(s) 2341968

Abstract: Clostridium ... ...

Abstract	Clostridium perfringens
MeSH term(s)	Bacterial Toxins/metabolism ; Bacterial Toxins/genetics ; Bacterial Toxins/toxicity ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Humans ; Animals ; Clostridium perfringens/genetics ; Clostridium perfringens/pathogenicity ; Clostridium perfringens/metabolism ; Clostridium Infections/microbiology
Chemical Substances	Bacterial Toxins ; Virulence Factors
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2341968
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Article: Sexualized Drug Use and Chemsex among Men Who Have Sex with Men in Europe: A Systematic Review and Meta-Analysis.

Coronado-Muñoz, Marina / García-Cabrera, Emilio / Quintero-Flórez, Angélica / Román, Encarnación / Vilches-Arenas, Ángel

Journal of clinical medicine

2024 Volume 13, Issue 6

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061812
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Article ; Online: Do we need to change our perspective about gut biomarkers? A public data mining approach to identify differentially abundant bacteria in intestinal inflammatory diseases.

Vega, Laura / Bohórquez, Laura / Ramírez, Juan David / Muñoz, Marina

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 918237

Abstract: Introduction: The gut microbiome is involved in multiple processes that influence host physiology, and therefore, disruptions in microbiome homeostasis have been linked to diseases or secondary infections. Given the importance of the microbiome and the ... ...

Abstract	Introduction: The gut microbiome is involved in multiple processes that influence host physiology, and therefore, disruptions in microbiome homeostasis have been linked to diseases or secondary infections. Given the importance of the microbiome and the communities of microorganisms that compose it (microbiota), the term biomarkers were coined, which are bacteria correlated with disease states, diets, and the lifestyle of the host. However, a large field in the study of intestinal biomarkers remains unexplored because the bacterial communities associated with a given disease state have not been exactly defined yet. Methods: Here, we analyzed public data of studies focused on describing the intestinal microbiota of patients with some intestinal inflammatory diseases together with their respective controls. With these analyses, we aimed to identify differentially abundant bacteria between the subjects with the disease and their controls. Results: We found that frequently reported bacteria such as Fusobacterium, Streptococcus, and Escherichia/Shigella were differentially abundant between the groups, with a higher abundance mostly in patients with the disease in contrast with their controls. On the other hand, we also identified potentially beneficial bacteria such as Faecalibacterium and Phascolarctobacterium, with a higher abundance in control patients. Discussion: Our results of the differentially abundant bacteria contrast with what was already reported in previous studies on certain inflammatory diseases, but we highlight the importance of considering more comprehensive approaches to redefine or expand the definition of biomarkers. For instance, the intra-taxa diversity within a bacterial community must be considered, as well as environmental and genetic factors of the host, and even consider a functional validation of these biomarkers through in vivo and in vitro approaches. With the above, these key bacterial communities in the intestinal microbiota may have potential as next-generation probiotics or may be functional for the design of specific therapies in certain intestinal diseases.
MeSH term(s)	Humans ; Bacteria/genetics ; Intestinal Diseases ; Data Mining
Language	English
Publishing date	2022-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.918237
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Article: Pseudomonas taetrolens

Ghoreshizadeh, Seyedehtannaz / Calvo-Peña, Carla / Ruiz-Muñoz, Marina / Otero-Suárez, Rebeca / Coque, Juan José R / Cobos, Rebeca

Plants (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: Most of the phosphorus incorporated into agricultural soils through the use of fertilizers precipitates in the form of insoluble salts that are incapable of being used by plants. This insoluble phosphorus present in large quantities in soil forms the ... ...

Abstract	Most of the phosphorus incorporated into agricultural soils through the use of fertilizers precipitates in the form of insoluble salts that are incapable of being used by plants. This insoluble phosphorus present in large quantities in soil forms the well-known "phosphorus legacy". The solubilization of this "phosphorus legacy" has become a goal of great agronomic importance, and the use of phosphate-solubilizing bacteria would be a useful tool for this purpose. In this work, we have isolated and characterized phosphate-solubilizing bacteria from the rhizosphere of hop plants. Two particular strains,
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13030402
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Article ; Online: Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission?

Gómez, Marcela / Martinez, David / Muñoz, Marina / Ramírez, Juan David

Parasites & vectors

2022 Volume 15, Issue 1, Page(s) 287

Abstract: Aedes aegypti and Aedes albopictus are the main vectors of highly pathogenic viruses for humans, such as dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which cause febrile, hemorrhagic, and neurological diseases and remain a major threat to global ... ...

Abstract	Aedes aegypti and Aedes albopictus are the main vectors of highly pathogenic viruses for humans, such as dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which cause febrile, hemorrhagic, and neurological diseases and remain a major threat to global public health. The high ecological plasticity, opportunistic feeding patterns, and versatility in the use of urban and natural breeding sites of these vectors have favored their dispersal and adaptation in tropical, subtropical, and even temperate zones. Due to the lack of available treatments and vaccines, mosquito population control is the most effective way to prevent arboviral diseases. Resident microorganisms play a crucial role in host fitness by preventing or enhancing its vectorial ability to transmit viral pathogens. High-throughput sequencing and metagenomic analyses have advanced our understanding of the composition and functionality of the microbiota of Aedes spp. Interestingly, shotgun metagenomics studies have established that mosquito vectors harbor a highly conserved virome composed of insect-specific viruses (ISV). Although ISVs are not infectious to vertebrates, they can alter different phases of the arboviral cycle, interfering with transmission to the human host. Therefore, this review focuses on the description of Ae. aegypti and Ae. albopictus as vectors susceptible to infection by viral pathogens, highlighting the role of the microbiota-virome in vectorial competence and its potential in control strategies for new emerging and re-emerging arboviruses.
MeSH term(s)	Aedes ; Animals ; Arboviruses/genetics ; Humans ; Mosquito Vectors ; Virome ; Zika Virus/genetics ; Zika Virus Infection
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-022-05401-9
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Article ; Online: Prokaryotic and eukaryotic skin microbiota modifications triggered by Leishmania infection in localized Cutaneous Leishmaniasis.

Jaimes, Jesús / Patiño, Luz Helena / Herrera, Giovanny / Cruz, Claudia / Pérez, Julie / Correa-Cárdenas, Camilo A / Muñoz, Marina / Ramírez, Juan David

PLoS neglected tropical diseases

2024 Volume 18, Issue 3, Page(s) e0012029

Abstract: Cutaneous Leishmaniasis (CL) is a tropical disease characterized by cutaneous ulcers, sometimes with satellite lesions and nodular lymphangitis. Leishmania parasites, transmitted by sandfly vectors, cause this widespread public health challenge affecting ...

Abstract	Cutaneous Leishmaniasis (CL) is a tropical disease characterized by cutaneous ulcers, sometimes with satellite lesions and nodular lymphangitis. Leishmania parasites, transmitted by sandfly vectors, cause this widespread public health challenge affecting millions worldwide. CL's complexity stems from diverse Leishmania species and intricate host interactions. Therefore, this study aims to shed light on the spatial-temporal distribution of Leishmania species and exploring the influence of skin microbiota on disease progression. We analyzed 40 samples from CL patients at three military bases across Colombia. Using Oxford Nanopore's Heat Shock Protein 70 sequencing, we identified Leishmania species and profiled microbiota in CL lesions and corresponding healthy limbs. Illumina sequencing of 16S-rRNA and 18S-rRNA genes helped analyze prokaryotic and eukaryotic communities. Our research uncovered a spatial-temporal overlap between regions of high CL incidence and our sampling locations, indicating the coexistence of various Leishmania species. L. naiffi emerged as a noteworthy discovery. In addition, our study delved into the changes in skin microbiota associated with CL lesions sampled by scraping compared with healthy skin sampled by brushing of upper and lower limbs. We observed alterations in microbial diversity, both in prokaryotic and eukaryotic communities, within the lesioned areas, signifying the potential role of microbiota in CL pathogenesis. The significant increase in specific bacterial families, such as Staphylococcaceae and Streptococcaceae, within CL lesions indicates their contribution to local inflammation. In essence, our study contributes to the ongoing research into CL, highlighting the need for a multifaceted approach to decipher the intricate interactions between Leishmaniasis and the skin microbiota.
MeSH term(s)	Animals ; Humans ; Leishmaniasis, Cutaneous/epidemiology ; Leishmania/genetics ; Skin/pathology ; Psychodidae/parasitology ; Skin Ulcer
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0012029
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Article ; Online: A matter of wrapper: Defects in the nuclear envelope of lagging and bridging chromatin threatens genome integrity.

Rodriguez-Muñoz, Marina / Anglada, Teresa / Genescà, Anna

Seminars in cell & developmental biology

2021 Volume 123, Page(s) 124–130

Abstract: The nuclear envelope surrounds the eukaryotic genome and, through the nuclear pore complexes, regulates transport in and out of the nucleus. Correct nucleo-cytoplasm compartmentations are essential for nuclear functions such as DNA replication or repair. ...

Abstract	The nuclear envelope surrounds the eukaryotic genome and, through the nuclear pore complexes, regulates transport in and out of the nucleus. Correct nucleo-cytoplasm compartmentations are essential for nuclear functions such as DNA replication or repair. During metazoan mitosis, the nuclear envelope disintegrates to allow the segregation of the two copies of DNA between daughter cells. At the end of mitosis, it reforms on each group of chromosomes in the daughter cells. However, nuclear envelope reformation is delayed on lagging chromosomes and DNA bridges. Defects in the coordination between nuclear envelope reformation and chromosome segregation impair the nuclear functions. Mechanical stress to which micronuclei and DNA bridges are subjected to combined with their particular architecture and the altered nuclear functions result in DNA damage. While micronuclei and DNA bridges were considered for more than 100 years as mere indicators of chromosomal instability, rapid technological advances are helping to better understand the biological consequences of these aberrant nuclear morphologies. Recent studies provide interesting evidence that micronuclei and chromatin bridges act as a key platforms for a catastrophic mutational process observed in cancers called chromothripsis and a trigger for the innate immune response. Therefore, they could affect cellular functions by both genetic and non-genetic means.
MeSH term(s)	Animals ; Cell Nucleus/genetics ; Chromatin/genetics ; Chromosomes ; Chromothripsis ; Mitosis ; Nuclear Envelope/genetics
Chemical Substances	Chromatin
Language	English
Publishing date	2021-03-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2021.03.004
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