Article ; Online: Extended use of bemiparin as thromboprophylaxis during bariatric surgery: results of anti-factor Xa activity measurements.
2017 Volume 14, Issue 3, Page(s) 354–360
Abstract: Background: The incidence of venous thromboembolism (VTE) in morbidly obese patients after obesity surgery is between .2% and 3.5%. Because there are a lack of prospective studies on the type of drug, the correct dosage, and the optimal duration, there ... ...
Abstract | Background: The incidence of venous thromboembolism (VTE) in morbidly obese patients after obesity surgery is between .2% and 3.5%. Because there are a lack of prospective studies on the type of drug, the correct dosage, and the optimal duration, there are no specific recommendations found in the guidelines on thrombophylaxis. Objectives: To compare the incidence of VTE and hemorrhagic events in bariatric surgical patients receiving bemiparin thromboprophylaxis who have prophylactic and nonprophylactic Anti-factor Xa (AFXa) levels. Setting: University General Hospital of Ciudad Real, Spain, public practice. Methods: A cohort study of 122 morbidly obese patients who underwent bariatric surgery. The thromboprophylactic regimen consisted of bemiparin 5000 IU/24 hr for 30 days. AFXa levels were measured on the second and third day postoperation (prophylactic range: .3-.5 IU/mL). Body mass index, co-morbidities, prothrombotic risk factors, and thrombotic and hemorrhagic events were noted. Results: The mean body mass index was 48.4 kg/m Conclusion: A regimen of 5000 IU/24 hr of bemiparin for 30 days after obesity surgery appears to prevent VTE without increasing the risk of a major hemorrhage. The level of AFXa is not associated with postoperative thrombotic or hemorrhagic events occurring after bariatric surgery. |
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MeSH term(s) | Adult ; Anticoagulants/administration & dosage ; Bariatric Surgery/adverse effects ; Bariatric Surgery/methods ; Body Mass Index ; Drug Administration Schedule ; Factor Xa/metabolism ; Heparin, Low-Molecular-Weight/administration & dosage ; Humans ; Middle Aged ; Obesity, Morbid/surgery ; Operative Time ; Postoperative Complications/prevention & control ; Postoperative Hemorrhage/etiology ; Prospective Studies ; Risk Factors ; Treatment Outcome ; Venous Thromboembolism/prevention & control ; Young Adult |
Chemical Substances | Anticoagulants ; Heparin, Low-Molecular-Weight ; Factor Xa (EC 3.4.21.6) ; bemiparin (PUE0TO3XDR) |
Language | English |
Publishing date | 2017-12-14 |
Publishing country | United States |
Document type | Clinical Trial ; Comparative Study ; Journal Article |
ZDB-ID | 2274243-8 |
ISSN | 1878-7533 ; 1550-7289 |
ISSN (online) | 1878-7533 |
ISSN | 1550-7289 |
DOI | 10.1016/j.soard.2017.12.004 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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