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  1. Article ; Online: Lessons learned from implementation of four HIV self-testing (HIVST) distribution models in Zambia: applying the Consolidated Framework for Implementation Research to understand impact of contextual factors on implementation.

    Simwinga, Musonda / Gwanu, Lwiindi / Hensen, Bernadette / Sigande, Lucheka / Mainga, Mwami / Phiri, Thokozile / Mwanza, Eliphas / Kabumbu, Mutale / Mulubwa, Chama / Mwenge, Lawrence / Bwalya, Chiti / Kumwenda, Moses / Mubanga, Ellen / Mee, Paul / Johnson, Cheryl C / Corbett, Elizabeth L / Hatzold, Karin / Neuman, Melissa / Ayles, Helen /
    Taegtmeyer, Miriam

    BMC infectious diseases

    2024  Volume 22, Issue Suppl 1, Page(s) 977

    Abstract: Background: Although Zambia has integrated HIV-self-testing (HIVST) into its Human Immunodeficiency Virus (HIV) regulatory frameworks, few best practices to optimize the use of HIV self-testing to increase testing coverage have been documented. We ... ...

    Abstract Background: Although Zambia has integrated HIV-self-testing (HIVST) into its Human Immunodeficiency Virus (HIV) regulatory frameworks, few best practices to optimize the use of HIV self-testing to increase testing coverage have been documented. We conducted a prospective case study to understand contextual factors guiding implementation of four HIVST distribution models to inform scale-up in Zambia.
    Methods: We used the qualitative case study method to explore user and provider experiences with four HIVST distribution models (two secondary distribution models in Antenatal Care (ANC) and Antiretroviral Therapy (ART) clinics, community-led, and workplace) to understand factors influencing HIVST distribution. Participants were purposefully selected based on their participation in HIVST and on their ability to provide rich contextual experience of the distribution models. Data were collected using observations (n = 31), group discussions (n = 10), and in-depth interviews (n = 77). Data were analyzed using the thematic approach and aligned to the four Consolidated Framework for Implementation Research (CFIR) domains.
    Results: Implementation of the four distribution models was influenced by an interplay of outer and inner setting factors. Inadequate compensation and incentives for distributors may have contributed to distributor attrition in the community-led and workplace HIVST models. Stockouts, experienced at the start of implementation in the secondary-distribution and community-led distribution models often disrupted distribution. The existence of policy and practices aided integration of HIVST in the workplace. External factors complimented internal factors for successful implementation. For instance, despite distributor attrition leading to excessive workload, distributors often multi-tasked to keep up with demand for kits, even though distribution points were geographically widespread in the workplace, and to a less extent in the community-led models. Use of existing communication platforms such as lunchtime and safety meetings to promote and distribute kits, peers to support distributors, reduction in trips by distributors to replenish stocks, increase in monetary incentives and reorganisation of stakeholder roles proved to be good adaptations.
    Conclusion: HIVST distribution was influenced by a combination of contextual factors in variable ways. Understanding how the factors interacted in real world settings informed adaptations to implementation devised to minimize disruptions to distribution.
    MeSH term(s) Pregnancy ; Female ; Humans ; HIV ; Zambia ; Self-Testing ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Testing
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09168-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Initial implementation of PrEP in Zambia: health policy development and service delivery scale-up.

    Claassen, Cassidy W / Mumba, Daliso / Njelesani, Mwansa / Nyimbili, Derrick / Mwango, Linah K / Mwitumwa, Mundia / Mubanga, Ellen / Mulenga, Lloyd B / Chisenga, Tina / Nichols, Brooke E / Hendrickson, Cheryl / Chitembo, Lastone / Okuku, Jackson / O'Bra, Heidi

    BMJ open

    2021  Volume 11, Issue 7, Page(s) e047017

    Abstract: Introduction: Daily pre-exposure prophylaxis (PrEP) for HIV prevention is highly effective, but not yet widely deployed in sub-Saharan Africa. We describe how Zambia developed PrEP health policy and then successfully implemented national PrEP service ... ...

    Abstract Introduction: Daily pre-exposure prophylaxis (PrEP) for HIV prevention is highly effective, but not yet widely deployed in sub-Saharan Africa. We describe how Zambia developed PrEP health policy and then successfully implemented national PrEP service delivery.
    Policy development: Zambia introduced PrEP as a key strategy for HIV prevention in 2016, and established a National PrEP Task Force to lead policy advocacy and development. The Task Force was composed of government representatives, regulatory agencies, international donors, implementation partners and civil society organisations. Following an implementation pilot, PrEP was rolled out nationally using risk-based criteria alongside a national HIV prevention campaign.
    National scale-up: In the first year of implementation, ending September 2018, 3626 persons initiated PrEP. By September 2019, the number of people starting PrEP increased by over sixfold to 23 327 persons at 728 sites across all ten Zambian provinces. In the first 2 years, 26 953 clients initiated PrEP in Zambia, of whom 31% were from key and priority populations. Continuation remains low at 25% and 11% at 6 and 12 months, respectively.
    Lessons learnt: Risk-based criteria for PrEP ensures access to those most in need of HIV prevention. Healthcare worker training in PrEP service delivery and health needs of key and priority populations is crucial. PrEP expansion into primary healthcare clinics and community education is required to reach full potential. Additional work is needed to understand and address low PrEP continuation. Finally, a task force of key stakeholders can rapidly develop and implement health policy, which may serve as a model for countries seeking to implement PrEP.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Health Policy ; Humans ; Policy Making ; Pre-Exposure Prophylaxis ; Zambia
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2021-07-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-047017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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