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  1. Book ; Thesis: Histologische und molekularbiologische Veränderungen der Kaumuskulatur bei jungen und alten dystrophen Mäusen

    Müller, Anne-Katrin

    2015  

    Author's details von Anne-Katrin Müller
    Language German
    Size VI, 119 Blätter, Illustrationen
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, 2016
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT019067397
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 E 1354 order for loan Magazin

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  2. Book ; Thesis: Erfassung des Spektrums und Beurteilung der Spezifität kutaner Manifestationen bei Rheumatoider Arthritis (RA): eine klinisch-histopathologische Untersuchung

    Müller, Anne-Katrin

    2013  

    Author's details von Anne-Katrin Müller
    Language German
    Size 114 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2013
    HBZ-ID HT018227206
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2014 E 477 order for loan Magazin

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  3. Book ; Thesis: Beitrag zur systematischen Klassifizierung und röntgenologischen Morphologie des congenitalen Tibiadefektes

    Müller, Annekatrin

    1987  

    Size 120 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1988
    HBZ-ID HT003204711
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Pharmakotherapie und intensivmedizinische Aspekte des Status epilepticus: Update 2020/2021.

    Saitov, Gabrielė / Müller, Annekatrin / Bastian, Börge / Michalski, Dominik

    Der Anaesthesist

    2021  Volume 70, Issue 10, Page(s) 874–887

    Abstract: Focused treatment of epileptic emergencies, and in particular status epilepticus (SE), require a reliable differentiation of epileptic syndromes. In these cases, and especially in cases with predominant non-motor symptoms, clinical and ... ...

    Title translation Pharmacotherapy and intensive care aspects of status epilepticus: update 2020/2021.
    Abstract Focused treatment of epileptic emergencies, and in particular status epilepticus (SE), require a reliable differentiation of epileptic syndromes. In these cases, and especially in cases with predominant non-motor symptoms, clinical and electroencephalographic expertise is necessary. In 2020 the German guidelines for the management of SE were updated, which adhere to a strict stage-based treatment algorithm. The staged approach includes the administration of benzodiazepines, antiepileptic drugs and anesthetic agents. So far, efforts failed to determine the most effective and safest antiepileptic drug without interaction potential. Therefore, for the differentiated treatment of SE, individual pre-existing medical conditions and concomitant circumstances must be considered, added by the experience of the medical team. Therapeutic interventions especially for refractory forms of SE have been shown to be complex with relevant implications concerning intensive care aspects. Consequently, the modern treatment strategy of SE is characterized by an interdisciplinary approach. Future research is needed to define the optimal treatment of non-convulsive SE, in particular regarding the time point and degree of treatment escalation with associated ethical considerations.
    MeSH term(s) Anticonvulsants/therapeutic use ; Benzodiazepines/therapeutic use ; Critical Care ; Epilepsy/drug therapy ; Humans ; Status Epilepticus/drug therapy
    Chemical Substances Anticonvulsants ; Benzodiazepines (12794-10-4)
    Language German
    Publishing date 2021-07-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 260-4
    ISSN 1432-055X ; 0003-2417
    ISSN (online) 1432-055X
    ISSN 0003-2417
    DOI 10.1007/s00101-021-01000-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Does diabetes mellitus affect the safety profile of valproic acid for the treatment of status epilepticus? A retrospective cohort study.

    Müller, Annekatrin / von Hofen-Hohloch, Judith / Awissus, Carolin / Przybilla, Jens / Mrestani, Achmed / Classen, Joseph

    Neurological research and practice

    2022  Volume 4, Issue 1, Page(s) 52

    Abstract: Background: In the treatment of status epilepticus less is known about the influence of comorbidities on the safety profile of anticonvulsive drugs. Especially patients with diabetes mellitus may be predisposed to certain adverse events that have been ... ...

    Abstract Background: In the treatment of status epilepticus less is known about the influence of comorbidities on the safety profile of anticonvulsive drugs. Especially patients with diabetes mellitus may be predisposed to certain adverse events that have been related to therapy with valproic acid. In this single-center retrospective cohort study we examined if the complications of the intravenous treatment with valproic acid is different in patients with or without diabetes.
    Methods: Patients who were treated for status epilepticus with intravenous valproic acid between 2008 and 2020 were identified. Primary endpoint was the discontinuation of therapy with valproic acid due to adverse events. Relevant secondary endpoints were the functional status at the time of discharge from hospital in comparison to the premorbid state and the in-hospital mortality. Both groups (patients with or without diabetes) were compared by Mann-Whitney U-Test or Pearson´s Chi
    Results: During the study period 408 patients and 482 episodes of status epilepticus were treated with intravenous valproic acid. Group comparisons did not reveal a significant difference in the rates of discontinuation of therapy. A difference was found in the rate of thrombocytopenia (p = 0.015), which occurred more often in patients with diabetes. In total, 36 hypoglycemic episodes could be identified, two occurred spontaneously under intravenous valproic acid. After correction for potential confounders, continuous therapy with valproic acid could not be confirmed as an independent risk factor for in-hospital mortality (p = 0.079). In patients with diabetes, the proportion of patients with a good functional state, indicated by the modified Rankin Scale, was significantly lower in both times (premorbid: 55% vs. 69%, p = 0.008; at discharge: 22% vs. 36%, p = 0.004).
    Conclusions: Tolerability of the treatment with valproic acid was similar in patients with or without diabetes. Diabetes as a relevant comorbidity can signal a potentially increased risk of a poor outcome after status epilepticus.
    Trial registration: The study was registered at the German Clinical Trials Register on 8 April 2022 (DRKS 00,027,836).
    Language English
    Publishing date 2022-10-24
    Publishing country England
    Document type Journal Article
    ISSN 2524-3489
    ISSN (online) 2524-3489
    DOI 10.1186/s42466-022-00212-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Fallstudie: Antibiotika in der Palliativmedizin

    Müller, Annekatrin

    2010  

    Author's details vorgelegt von Annekatrin Müller
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Aachen, 2010
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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  7. Book: Pilates für Kinder

    Müller, Anne-Katrin

    stärkende und harmonisierende Körperübungen für 4- bis 10-Jährige

    2012  

    Author's details Anne-Katrin Müller
    Size 93 Seiten: zahlreiche Illustrationen
    Edition 1. Aufl.
    Publisher Don Bosco; München
    Document type Book
    HBZ-ID HT017102061
    ISBN 978-3-7698-1911-3 ; 3-7698-1911-X
    Database Central Library of Sport Science of the German Sport University Cologne

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  8. Article ; Online: Treatment of established status epilepticus in the elderly - a study protocol for a prospective multicenter double-blind comparative effectiveness trial (ToSEE).

    Müller, Annekatrin / Schmiedeknecht, Anett / Mende, Meinhard / Awissus, Carolin / Rosenow, Felix / Hamer, Hajo / Classen, Joseph

    BMC neurology

    2020  Volume 20, Issue 1, Page(s) 438

    Abstract: Background: Status epilepticus (SE) is a common neurological emergency condition that especially affects the elderly and old population. Older people with SE frequently have non-convulsive SE (NCSE) and are also at special risk of suffering a poor ... ...

    Abstract Background: Status epilepticus (SE) is a common neurological emergency condition that especially affects the elderly and old population. Older people with SE frequently have non-convulsive SE (NCSE) and are also at special risk of suffering a poor outcome. The application of benzodiazepines fails to control SE in about one third of the cases. For benzodiazepine refractory SE (BRSE) in elderly, there is little evidence that would justify the choice of one of the commonly used antiepileptic drugs. The present study aims to generate evidence for the treatment of BRSE in this age group.
    Methods: We will conduct a prospective, randomized, double-blind comparative effectiveness study in more than twenty hospitals in Germany over a four-year period. Four hundred and seventy-seven elderly patients (≥ 65 years old) diagnosed with BRSE will be allocated by 1:1 randomization to receive either levetiracetam or valproate. All types of SE will be considered. For the diagnosis NCSE a verification by EEG is required. Levetiracetam or valproate will be administered in one single infusion. The primary endpoint is the stable cessation of ictal activity 15 min after the start of infusion persisting for the following 45 min of observation. EEG recording is maintained over the whole observation period, clinical examinations are conducted in predefined intervals. In case of treatment success patients and study staff remain blinded until 60 min after the start of the infusion. Adverse events will be recorded until the end of the study. EEG data will be reviewed by two external independent experts. To obtain data about the further treatment of SE, intrahospital complications and the functional outcome in the short term the study participants will be observed until the day of discharge or day 30 whichever is earliest.
    Discussion: ToSEE is the first study which shall deliver evidence for the SE-therapy in the elderly and old population in a controlled prospective comparator study. By design it also shall collect information about therapy regimes and outcome aspects of this disease.
    Trial registration: The trial has been registered at the German Clinical Trials Register on 3 July, 2020 ( DRKS00022308 ,  https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00022308 ).
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Anticonvulsants/therapeutic use ; Double-Blind Method ; Germany ; Levetiracetam/therapeutic use ; Prospective Studies ; Status Epilepticus/drug therapy ; Valproic Acid/therapeutic use ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic
    Chemical Substances Anticonvulsants ; Levetiracetam (44YRR34555) ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2020-12-03
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-020-02001-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis.

    Kunst, Stefan / Rojo, Mikel / Schmidbauer, Moritz L / Pelz, Johann O / Mueller, Annekatrin / Minnerup, Jens / Meyer, Lennart / Madžar, Dominik / Reindl, Caroline / Madlener, Marie / Malter, Michael / Neumann, Bernhard / Dimitriadis, Konstantinos

    Epilepsia

    2023  Volume 64, Issue 6, Page(s) 1482–1492

    Abstract: Objective: Super-refractory status epilepticus (SRSE) is an enduring or recurring SE after 24 h or more of general anesthesia. This study aimed to evaluate the efficacy and safety of phenobarbital (PB) for the treatment of SRSE.: Methods: This ... ...

    Abstract Objective: Super-refractory status epilepticus (SRSE) is an enduring or recurring SE after 24 h or more of general anesthesia. This study aimed to evaluate the efficacy and safety of phenobarbital (PB) for the treatment of SRSE.
    Methods: This retrospective, multicenter study included neurointensive care unit (NICU) patients with SRSE treated with PB between September 2015 and September 2020 from six participating centers of the Initiative of German NeuroIntensive Trial Engagement (IGNITE) to evaluate the efficacy and safety of PB treatment for SRSE. The primary outcome measure was seizure termination. In addition, we evaluated maximum reached serum levels, treatment duration, and clinical complications using a multivariate generalized linear model.
    Results: Ninety-one patients were included (45.1% female). Seizure termination was achieved in 54 patients (59.3%). Increasing serum levels of PB were associated with successful seizure control (per μg/mL: adjusted odds ratio [adj.OR] = 1.1, 95% confidence interval [CI] 1.0-1.2, p < .01). The median length of treatment in the NICU was 33.7 [23.2-56.6] days across groups. Clinical complications occurred in 89% (n = 81) of patients and included ICU-acquired infections, hypotension requiring catecholamine therapy, and anaphylactic shock. There was no association between clinical complications and treatment outcome or in-hospital mortality. The overall average modified Rankin scale (mRS) at discharge from the NICU was 5 ± 1. Six patients (6.6%) reached mRS ≤3, of whom five were successfully treated with PB. In-hospital mortality was significantly higher in patients in whom seizure control could not be achieved.
    Significance: We observed a high rate in attainment of seizure control in patients treated with PB. Success of treatment correlated with higher dosing and serum levels. However, as one would expect in a cohort of critically ill patients with prolonged NICU treatment, the rate of favorable clinical outcome at discharge from the NICU remained extremely low. Further prospective studies evaluating long-term clinical outcome of PB treatment as well as an earlier use of PB at higher doses would be of value.
    MeSH term(s) Humans ; Female ; Male ; Retrospective Studies ; Prospective Studies ; Status Epilepticus/therapy ; Phenobarbital/therapeutic use ; Seizures/drug therapy ; Hospital Mortality
    Chemical Substances Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2023-04-16
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17608
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    Zs.MO 475: Show issues

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  10. Article: Assessing endocrine disruption in freshwater fish species from a “hotspot” for estrogenic activity in sediment

    Müller, Anne-Katrin / Markert, Nele / Leser, Katharina / Kämpfer, David / Crawford, Sarah E / Schäffer, Andreas / Segner, Helmut / Hollert, Henner

    Environmental pollution. 2020 Feb., v. 257

    2020  

    Abstract: Little is known about sediment-bound exposure of fish to endocrine disrupting chemicals (EDC) under field conditions. This study aimed to investigate potential routes of EDC exposure to fish and whether sediment-bound contaminants contribute towards ... ...

    Abstract Little is known about sediment-bound exposure of fish to endocrine disrupting chemicals (EDC) under field conditions. This study aimed to investigate potential routes of EDC exposure to fish and whether sediment-bound contaminants contribute towards exposure in fish. Tench (Tinca tinca) and roach (Rutilus rutilus) as a benthic and pelagic living fish species, respectively, were sampled at the Luppe River, previously described as a “hotspot” for accumulation of EDC in sediment. A field reference site, the Laucha River, additionally to fish from a commercial fish farm as reference were studied. Blackworms, Lumbriculus variegatus, which are a source of prey for fish, were exposed to sediment of the Luppe River and estrogenic activity of worm tissue was investigated using in vitro bioassays. A 153-fold greater estrogenic activity was measured using in vitro bioassays in sediment of the Luppe River compared the Laucha River. Nonylphenol (NP; 22 mg/kg) was previously identified as one of the main drivers of estrogenic activity in Luppe sediment. Estrogenic activity of Luppe exposed worm tissue (14 ng 17β-estradiol equivalents/mg) indicated that food might act as secondary source to EDCs. While there were no differences in concentrations of NP in plasma of tench from the Luppe and Laucha, vitellogenin, a biomarker for exposure to EDCs, was induced in male tench and roach from the Luppe River compared to both the Laucha and cultured fish by a factor of 264 and 90, respectively. However, no histological alterations in testis of these fish were observed. Our findings suggest that sediments substantially contribute to the overall EDC exposure of both benthic and pelagic fish but that the exposure did not impact gonad status of the fish.
    Keywords Lumbriculus variegatus ; Rutilus rutilus ; Tinca tinca ; benthic organisms ; bioassays ; biomarkers ; endocrine-disrupting chemicals ; estradiol ; estrogenic properties ; farmed fish ; fish farms ; freshwater fish ; histology ; males ; nonylphenols ; pelagic fish ; rivers ; sediments ; testes ; vitellogenin
    Language English
    Dates of publication 2020-02
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2019.113636
    Database NAL-Catalogue (AGRICOLA)

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    Z 4136: Show issues

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