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  1. Article ; Online: Influence of Ambient Temperature and Light-curing Moment on Polymerization Shrinkage and Strength of Resin Composite Cements.

    Rohr, N / Müller, J A / Fischer, J

    Operative dentistry

    2018  Volume 43, Issue 6, Page(s) 619–630

    Abstract: Objective:: The purpose of this study was to establish a clinically appropriate light-curing moment for resin composite cements while achieving the highest indirect tensile strength and lowest polymerization shrinkage.: Methods and materials:: ... ...

    Abstract Objective:: The purpose of this study was to establish a clinically appropriate light-curing moment for resin composite cements while achieving the highest indirect tensile strength and lowest polymerization shrinkage.
    Methods and materials:: Polymerization shrinkage of seven resin composite cements (Multilink Automix, Multilink Speed Cem, RelyX Ultimate, RelyX Unicem 2 Automix, Panavia V5, Panavia SA plus, VITA Adiva F-Cem) was measured at ambient temperatures of 23°C and 37°C. Testing was done for autopolymerized and light-cured specimens after light application at either 1, 5, or 10 minutes after mixing. Indirect tensile strength of all cements was measured after 24 hours of storage at temperatures of 23°C and 37°C, for autopolymerized and light-cured specimens after light application 1, 5, or 10 minutes after mixing. To illustrate filler size and microstructures, SEM images of all cements were captured. Statistical analysis was performed with one-way ANOVA followed by post hoc Fisher LSD test ( α=0.05).
    Results:: Final polymerization shrinkage of the resin composite cements ranged from 3.2% to 7.0%. An increase in temperature from 23°C to 37°C as well as the light-curing moment resulted in material dependent effects on the polymerization shrinkage and indirect tensile strength of the cements. Polymerization shrinkage of the cements did not correlate with the indirect tensile strength of the cement in the respective groups. Highest indirect tensile strengths were observed for the materials containing a homogeneous distribution of fillers with a size of about 1 μm (Multilink Automix, Panavia V5, VITA Adiva F-Cem).
    Conclusion:: The magnitude of the effect of light-curing moment and temperature increase on polymerization shrinkage and indirect tensile strength of resin composite cements is material dependent and cannot be generalized.
    MeSH term(s) Composite Resins/chemistry ; Dental Stress Analysis ; Light-Curing of Dental Adhesives ; Materials Testing ; Polymerization ; Resin Cements ; Temperature ; Tensile Strength
    Chemical Substances Composite Resins ; Rely X Unicem ; Rely-X ; Resin Cements ; multilink adhesive system
    Language English
    Publishing date 2018-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752995-8
    ISSN 1559-2863 ; 0361-7734
    ISSN (online) 1559-2863
    ISSN 0361-7734
    DOI 10.2341/17-085-L
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus.

    Bogert, N V / Furkel, J / Din, S / Braren, I / Eckstein, V / Müller, J A / Uhlmann, L / Katus, H A / Konstandin, M H

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 13740

    Abstract: Lentiviral modification of hematopoietic stem cells (HSCs) paved the way for in vivo experimentation and therapeutic approaches in patients with genetic disease. A disadvantage of this method is the use of a ubiquitous promoter leads not only to genetic ... ...

    Abstract Lentiviral modification of hematopoietic stem cells (HSCs) paved the way for in vivo experimentation and therapeutic approaches in patients with genetic disease. A disadvantage of this method is the use of a ubiquitous promoter leads not only to genetic modification of the leukocyte subset of interest e.g. T-cells, but also all other subsequent leukocyte progeny of the parent HSCs. To overcome this limitation we tested a bicistronic lentivirus, enabling subset specific modifications. Designed novel lentiviral constructs harbor a global promoter (mPGK) regulating mCherry for HSCs selection and a T-cell specific promoter upstream of eGFP. Two T-cell specific promoters were assessed: the distal Lck-(dLck) and the CD3δ-promoter. Transduced HSCs were FACS sorted by mCherry expression and transferred into sublethally irradiated C57/BL6 mice. Successful transplantation and T-cell specific expression of eGFP was monitored by peripheral blood assessment. Furthermore, recruitment response of lentiviral engineered leukocytes to the site of inflammation was tested in a peritonitis model without functional impairment. Our constructed lentivirus enables fast generation of subset specific leukocyte transgenesis as shown in T-cells in vivo and opens new opportunities to modify other HSCs derived subsets in the future.
    MeSH term(s) Animals ; CD3 Complex/genetics ; Cell Line, Tumor ; Gene Transfer Techniques ; Genetic Engineering/methods ; Genetic Vectors/genetics ; Green Fluorescent Proteins/genetics ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells/virology ; Inflammation/genetics ; Inflammation/virology ; Lentivirus/genetics ; Lentivirus Infections/virology ; Leukocytes/physiology ; Leukocytes/virology ; Luminescent Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Promoter Regions, Genetic/genetics ; T-Lymphocyte Subsets/physiology ; T-Lymphocyte Subsets/virology
    Chemical Substances CD3 Complex ; CD3delta antigen ; Luminescent Proteins ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2020-08-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-70793-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Eating disorders: identification and intervention.

    Mueller, J A

    The journal of contemporary dental practice

    2001  Volume 2, Issue 2, Page(s) 98

    Abstract: Society's preoccupation with outward appearance and thinness has increased the incidence of both anorexia nervosa and bulimia nervosa, two potentially threatening diseases. Unfortunately, it is difficult to obtain accurate statistics on these eating ... ...

    Abstract Society's preoccupation with outward appearance and thinness has increased the incidence of both anorexia nervosa and bulimia nervosa, two potentially threatening diseases. Unfortunately, it is difficult to obtain accurate statistics on these eating disorders. Those with an eating disorder are often unwilling to admit they have this disorder and are reluctant to seek help. Subsequently, eating disorders have become a serious concern for medical and dental professionals. Since dental professionals see patients on a regular basis, he/she may be the person to whom the eating disorder patient confides.1 For the same reason, the oral care provider may be the first to notice oral manifestations of disease in the anoretic or bulimic person.2,3 The dental professional can serve as an important link between the person with an eating disorder and professional therapy. Knowledge of the signs and symptoms for these diseases is important because early diagnosis and treatment can result in more successful therapy.
    MeSH term(s) Anorexia Nervosa/complications ; Anorexia Nervosa/diagnosis ; Anorexia Nervosa/psychology ; Anorexia Nervosa/therapy ; Bulimia/complications ; Bulimia/diagnosis ; Bulimia/psychology ; Bulimia/therapy ; Dentist-Patient Relations ; Humans ; Mouth Diseases/etiology ; Oral Hygiene ; Referral and Consultation ; Tooth Erosion/etiology
    Language English
    Publishing date 2001-05-15
    Publishing country India
    Document type Journal Article
    ISSN 1526-3711
    ISSN (online) 1526-3711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Prospects and problems of sludge pre-treatment processes.

    Müller, J A

    Water science and technology : a journal of the International Association on Water Pollution Research

    2001  Volume 44, Issue 10, Page(s) 121–128

    Abstract: Pre-treatment processes have been developed in order to improve subsequent sludge treatment and disposal. Disintegration of sludge solids in the aqueous phase changes the sludge structure and solubilizes organic matter. This paper provides an overview of ...

    Abstract Pre-treatment processes have been developed in order to improve subsequent sludge treatment and disposal. Disintegration of sludge solids in the aqueous phase changes the sludge structure and solubilizes organic matter. This paper provides an overview of the applications of wet disintegration in wastewater and sludge treatment. Applied disintegration techniques such as mechanical, thermal, chemical and biological methods are briefly described. The methods are compared regarding energy consumption, operational reliability and stage of development for application on wastewater treatment plants. Mechanical and thermal methods appear to be most suitable at this stage. The effects of pre-treatment on subsequent sludge treatment processes and the wastewater treatment are described. The performance of various methods is assessed. For the improvement of stabilization, mechanical and ozone treatment as well as thermal treatment perform best. Dewatering can be enhanced by thermal and freeze/thaw treatment. All methods show positive effects in the reduction of the number of pathogens. Pre-treatment leads to secondary effects like the generation of recalcitrant compounds and odor, which is mainly a problem of thermal and ozone treatment. The evaluation of capital and operational costs is difficult, because of the lack of full-scale experience. Especially thermal, freeze/thaw and biological treatments can be realized at low costs if the conditions are appropriate. Nevertheless, the economic efficiency has to be investigated critically for each individual application.
    MeSH term(s) Biodegradation, Environmental ; Costs and Cost Analysis ; Environmental Pollution/prevention & control ; Equipment Design ; Organic Chemicals/analysis ; Oxidants, Photochemical ; Ozone ; Sewage/chemistry ; Solubility ; Temperature ; Waste Disposal, Fluid/economics ; Waste Disposal, Fluid/methods ; Water/chemistry
    Chemical Substances Organic Chemicals ; Oxidants, Photochemical ; Sewage ; Water (059QF0KO0R) ; Ozone (66H7ZZK23N)
    Language English
    Publishing date 2001
    Publishing country England
    Document type Journal Article
    ZDB-ID 764273-8
    ISSN 1996-9732 ; 0273-1223
    ISSN (online) 1996-9732
    ISSN 0273-1223
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    Einzelsignatur: Show issues

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  6. Article: Effect of speech rate on neural tracking of speech

    Müller, Jana Annina / Wendt, Dorothea / Kollmeier, Birger / Debener, Stefan / Brand, Thomas

    Frontiers in Psychology

    2019  

    Abstract: Speech comprehension requires effort in demanding listening situations. Selective attention may be required for focusing on a specific talker in a multi-talker environment, may enhance effort by requiring additional cognitive resources, and is known to ... ...

    Title translation Einfluss der Sprechrate auf die neuronale Reaktion auf Sprache
    Abstract Speech comprehension requires effort in demanding listening situations. Selective attention may be required for focusing on a specific talker in a multi-talker environment, may enhance effort by requiring additional cognitive resources, and is known to enhance the neural representation of the attended talker in the listener's neural response. The aim of the study was to investigate the relation of listening effort, as quantified by subjective effort ratings and pupil dilation, and neural speech tracking during sentence recognition. Task demands were varied using sentences with varying levels of linguistic complexity and using two different speech rates in a picture-matching paradigm with 20 normal-hearing listeners. The participant's task was to match the acoustically presented sentence with a picture presented before the acoustic stimulus. Afterwards they rated their perceived effort on a categorical effort scale. During each trial, pupil dilation (as an indicator of listening effort) and electroencephalogram (as an indicator of neural speech tracking) were recorded. Neither measure was significantly affected by linguistic complexity. However, speech rate showed a strong influence on subjectively rated effort, pupil dilation, and neural tracking. The neural tracking analysis revealed a shorter latency for faster sentences, which may reflect a neural adaptation to the rate of the input. No relation was found between neural tracking and listening effort, even though both measures were clearly influenced by speech rate. This is probably due to factors that influence both measures differently. Consequently, the amount of listening effort is not clearly represented in the neural tracking.
    Keywords Auditive Wahrnehmung ; Auditory Perception ; Electrical Activity ; Electroencephalography ; Elektrische Aktivität ; Elektroenzephalographie ; Energieeinsatz ; Energy Expenditure ; Pupil Dilation ; Pupillenerweiterung ; Recognition (Learning) ; Satzverständnis ; Selective Attention ; Selektive Aufmerksamkeit ; Sentence Comprehension ; Speech Perception ; Speech Rate ; Sprachwahrnehmung ; Sprechtempo ; Stimulus Complexity ; Stimuluskomplexität ; Wiedererkennen (Lernen)
    Language English
    Document type Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2019.00449
    Database PSYNDEX

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  7. Article ; Online: Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD.

    Müller, J A / Zirafi, O / Roan, N R / Lee, S J / Münch, J

    Bone marrow transplantation

    2016  Volume 51, Issue 8, Page(s) 1137–1139

    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/bmt.2016.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Zu: A Hohmann, W Rüssmann, FA Kaszli: Qualität des Sehscreenings im Kindesalter.

    Müller, J A

    Klinische Monatsblatter fur Augenheilkunde

    1997  Volume 211, Issue 6, Page(s) 48

    Title translation Comment on A. Hohmann, W. Rüssmann, F.A. Kaszli: Quality of vision screening in childhood.
    MeSH term(s) Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Quality Assurance, Health Care ; Sensitivity and Specificity ; Vision Screening
    Language German
    Publishing date 1997-12
    Publishing country Germany
    Document type Letter
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
    ISSN (online) 1439-3999
    ISSN 0023-2165 ; 0344-6360 ; 0344-6387
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  9. Article ; Online: Optical analysis of glutamate spread in the neuropil.

    Matthews, E A / Sun, W / McMahon, S M / Doengi, M / Halka, L / Anders, S / Müller, J A / Steinlein, P / Vana, N S / van Dyk, G / Pitsch, J / Becker, A J / Pfeifer, A / Kavalali, E T / Lamprecht, A / Henneberger, C / Stein, V / Schoch, S / Dietrich, D

    Cerebral cortex (New York, N.Y. : 1991)

    2022  Volume 32, Issue 17, Page(s) 3669–3689

    Abstract: Fast synaptic communication uses diffusible transmitters whose spread is limited by uptake mechanisms. However, on the submicron-scale, the distance between two synapses, the extent of glutamate spread has so far remained difficult to measure. Here, we ... ...

    Abstract Fast synaptic communication uses diffusible transmitters whose spread is limited by uptake mechanisms. However, on the submicron-scale, the distance between two synapses, the extent of glutamate spread has so far remained difficult to measure. Here, we show that quantal glutamate release from individual hippocampal synapses activates extracellular iGluSnFr molecules at a distance of >1.5 μm. 2P-glutamate uncaging near spines further showed that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-Rs and N-methyl-D-aspartate (NMDA)-Rs respond to distant uncaging spots at approximately 800 and 2000 nm, respectively, when releasing the amount of glutamate contained in approximately five synaptic vesicles. The uncaging-induced remote activation of AMPA-Rs was facilitated by blocking glutamate transporters but only modestly decreased by elevating the recording temperature. When mimicking release from neighboring synapses by three simultaneous uncaging spots in the microenvironment of a spine, AMPA-R-mediated responses increased supra-additively. Interfering with extracellular glutamate diffusion through a glutamate scavenger system weakly reduced field synaptic responses but not the quantal amplitude. Together, our data suggest that the neuropil is more permissive to short-range spread of transmitter than suggested by theory, that multivesicular release could regularly coactivate nearest neighbor synapses and that on this scale glutamate buffering by transporters primarily limits the spread of transmitter and allows for cooperative glutamate signaling in extracellular microdomains.
    MeSH term(s) Glutamic Acid/pharmacology ; Hippocampus/physiology ; Neuropil/metabolism ; Receptors, AMPA/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/physiology ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
    Chemical Substances Receptors, AMPA ; Receptors, N-Methyl-D-Aspartate ; Glutamic Acid (3KX376GY7L) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0)
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhab440
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    Zs.A 3235: Show issues Location:
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  10. Article ; Online: The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy.

    Debski, K J / Ceglia, N / Ghestem, A / Ivanov, A I / Brancati, G E / Bröer, S / Bot, A M / Müller, J A / Schoch, S / Becker, A / Löscher, W / Guye, M / Sassone-Corsi, P / Lukasiuk, K / Baldi, P / Bernard, C

    Science advances

    2020  Volume 6, Issue 41

    Abstract: Gene and protein expressions display circadian oscillations, which can be disrupted in diseases in most body organs. Whether these oscillations occur in the healthy hippocampus and whether they are altered in epilepsy are not known. We identified more ... ...

    Abstract Gene and protein expressions display circadian oscillations, which can be disrupted in diseases in most body organs. Whether these oscillations occur in the healthy hippocampus and whether they are altered in epilepsy are not known. We identified more than 1200 daily oscillating transcripts in the hippocampus of control mice and 1600 in experimental epilepsy, with only one-fourth oscillating in both conditions. Comparison of gene oscillations in control and epilepsy predicted time-dependent alterations in energy metabolism, which were verified experimentally. Although aerobic glycolysis remained constant from morning to afternoon in controls, it increased in epilepsy. In contrast, oxidative phosphorylation increased in control and decreased in epilepsy. Thus, the control hippocampus shows circadian molecular remapping, which is altered in epilepsy. We suggest that the hippocampus operates in a different functioning mode in epilepsy. These alterations need to be considered when studying epilepsy mechanisms, designing drug treatments, and timing their delivery.
    MeSH term(s) Animals ; Epilepsy ; Epilepsy, Temporal Lobe/genetics ; Epilepsy, Temporal Lobe/metabolism ; Hippocampus/metabolism ; Mice ; Proteome/metabolism ; Transcriptome
    Chemical Substances Proteome
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aat5979
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