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  1. Article ; Online: PELUANG TERJADINYA IMMUNIZATION STRESS-RELATED RESPONSE (ISRR) SELAMA PROGRAM VAKSINASI COVID-19

    Hafizzanovian Hafizzanovian / Desi Oktariana / Muhammad Ali Apriansyah / Yuniza Yuniza

    Jurnal Kedokteran dan Kesehatan, Vol 8, Iss 3, Pp 211-

    2021  Volume 222

    Abstract: Coronavirus Disease 2019 (COVID-19) telah menjadi bencana katasropik dalam berbagai bidang, terutama bidang kesehatan. Mengingat mortalitas yang tinggi dan penyebaran yang cepat dari penyakit ini, vaksin menjadi salah satu harapan terbesar untuk dapat ... ...

    Abstract Coronavirus Disease 2019 (COVID-19) telah menjadi bencana katasropik dalam berbagai bidang, terutama bidang kesehatan. Mengingat mortalitas yang tinggi dan penyebaran yang cepat dari penyakit ini, vaksin menjadi salah satu harapan terbesar untuk dapat mengendalikan pandemi ini. Immunization stress-related response (ISRR) merupakan salah satu Kejadian Ikutan Pasca imunisasi (KIPI) yang bermanifestasi sebagai respons stres akut, reaksi vasovagal, atau reaksi gejala neurologis disosiatif (dissociative neurological symptom reactions atau DNSR) yang dapat muncul tepat sebelum, selama, atau segera setelah imunisasi. Fenomena kluster ISSR seringkali disebut juga dengan penyakit psikogenik massal. Adanya stigma negatif terhadap efektifitas dan keamanan vaksin Covid-19 dapat membuka peluang terjadinya kluster ISRR yang dapat membuat masyarakat semakin sungkan untuk menerima imunisasi sehingga menyebabkan gagalnya program imunisasi. Langkah preventif dapat meminimalkan risiko ISRR, dan jika ISRR terjadi, maka identifikasi yang cepat, diagnosis, dan manajemen yang tepat dapat mengurangi dampaknya.
    Keywords isrr ; kipi ; vaksin covid-19 ; Medicine ; R
    Language Indonesian
    Publishing date 2021-08-01T00:00:00Z
    Publisher Universitas Sriwijaya
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: EFEKTIVITAS SUPLEMENTASI VITAMIN D TERHADAP SKOR BECK DEPRESSION INVENTORY PADA PASIEN ACQUIRED IMMUNODEFICIENCY SYNDROME DI POLIKLINIK VCT RSUP DR MOHAMMAD HOESIN PALEMBANG

    Ridzqie Dibyantari / Muhammad Ali Apriansyah / Mediarty Syahrir / Erial Bahar

    Jurnal Kedokteran dan Kesehatan, Vol 8, Iss 2, Pp 105-

    2021  Volume 110

    Abstract: Depresi merupakan gangguan psikosomatik tersering pada pasien terinfeksi HIV dan mengganggu kualitas hidup penderita secara bermakna. Hipovitaminosis D sering terjadi pada pasien AIDS dan kadar vitamin D berkorelasi negatif dengan tingkat depresi. Namun, ...

    Abstract Depresi merupakan gangguan psikosomatik tersering pada pasien terinfeksi HIV dan mengganggu kualitas hidup penderita secara bermakna. Hipovitaminosis D sering terjadi pada pasien AIDS dan kadar vitamin D berkorelasi negatif dengan tingkat depresi. Namun, sampai saat ini belum ada penelitian mengenai efektivitas suplementasi vitamin D terhadap tingkat depresi penderita AIDS. Penelitian ini dilakukan untuk menganalisis pengaruh penambahan vitamin D terhadap perubahan tingkat depresi penderita AIDS. Penelitian uji klinis acak tersamar ganda melibatkan penderita AIDS dengan skor BDI ? 10 di Poliklinik VCT RSMH Palembang sejak April 2019 sampai dengan Februari 2020 menggunakan nonprobability consecutive sampling. Sampel dirandomisasi untuk mendapat vitamin D (calitriol 0,5 mcg per hari) atau plasebo selama 8 minggu. Uji T berpasangan digunakan untuk menilai perubahan tingkat depresi. Dari 37 subjek, terdapat 26 orang laki-laki dan 11 orang perempuan dengan skor BDI awal kelompok perlakuan 19,95±9,88 dan kelompok plasebo 20,44±8,86. Setelah 8 minggu penelitian, didapatkan skor BDI kelompok perlakuan 6,63±6,16 dan kelompok plasebo 11,94±7,14. Uji T berpasangan menunjukkan perbedaan bermaka pada tingkat depresi antara kelompok perlakuan dan plasebo (p=0,000). Suplementasi vitamin D secara bermakna memperbaiki skor BDI pada penderita AIDS.
    Keywords aids ; bdi ; depresi ; vitamin d ; Medicine ; R
    Language Indonesian
    Publishing date 2021-03-01T00:00:00Z
    Publisher Universitas Sriwijaya
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Correlation between Transforming Growth Factor-Beta (TGF- β) Serum Level and Beck Depression Inventory (BDI) Score in Colorectal Cancer Patients at RSMH Palembang

    Muhammad Ali Apriansyah / Mediarty Syahrir / Kemas Ya’cub Rahadiyanto / Kiagus Muhammad Rosyidi / Ahmad Faisyar

    Jurnal Penyakit Dalam Indonesia, Vol 7, Iss 2, Pp 86-

    2020  Volume 94

    Abstract: Introduction.Depression not only increase the mortality rate, but also can interfere the quality of life of colorectal cancer patients during treatment. Low levels of systemic inflammation may contribute to the development of depression. The inflammatory ...

    Abstract Introduction.Depression not only increase the mortality rate, but also can interfere the quality of life of colorectal cancer patients during treatment. Low levels of systemic inflammation may contribute to the development of depression. The inflammatory process can be seen by measuring serum transforming growth factor-β (TGF-β) levels and depressive symptoms using the beck depression inventory (BDI) score. This study aimed to determine the correlation between TGF-β serum levels with depression in colorectal cancer patients. Methods. Analytical observational research with cross sectional design was conducted among colorectal cancer patients who underwent chemotherapy with a BDI score ≥10 (depression)in the RSMH Palembang from June 2018 to June 2019. Serum TGF-β levels were measured by the enzyme-linked immunosorbent assay (ELISA) quantitative method. Spearman analysis was used to assess the correlation of TGF-β levels and BDI score. Results. A total of 40 subjects were included in this study with mean value of TGF-β serum was 108.14pg/mL(SD 39.97pg/mL). Medianbeck depression inventory (BDI) score was14 (range 10-28). There was a moderate positive correlation between serum TGF-β levels and BDI score (r = 0.485; p = 0.002). Conclusion. There was a moderate positive correlation between serum TGF-β levels and BDI scorein colorectal cancer patients at RSMH Palembang.
    Keywords bdi score ; colorectal cancer ; depression ; tgf-β ; Internal medicine ; RC31-1245
    Subject code 616
    Language Indonesian
    Publishing date 2020-06-01T00:00:00Z
    Publisher Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Correlation of Depression Level with Tumor Necrosis Factor-Alpha (TNF-α) Concentration in Uncontrolled Bronchial Asthma Patients

    Muhammad Ali Apriansyah / Rudi Putranto / Eddy Mart Salim / Hamzah Shatri

    Jurnal Penyakit Dalam Indonesia, Vol 3, Iss 2, Pp 74-

    2016  Volume 80

    Abstract: Introduction. Depression occurs at high rates in people with chronic diseases, including bronchial asthma, with the prevalence of depression approaches 50% in tertiary care asthma clinic. Tumor necrosis factor alpha (TNF-α) is known to play a critical ... ...

    Abstract Introduction. Depression occurs at high rates in people with chronic diseases, including bronchial asthma, with the prevalence of depression approaches 50% in tertiary care asthma clinic. Tumor necrosis factor alpha (TNF-α) is known to play a critical role in the pathogenic mechanism of a number of chronic inflammatory disease, including bronchial asthma and depression. There has not been any research data on the subject in Indonesia. The objective of this study was to investigate the correlation between depressive level and TNF-α level in uncontrolled bronchial asthma. Methods. This was a cross sectional study conducted in 40 patients with uncontrolled bronchial asthma at the allergy immunology clinic outpatient of Dr Moh Hoesin Hospital Palembang, during June 2014 until August 2014. Uncontrolled bronchial asthma was assessed using the Asthma Control Test (ACT) questionnaire, whereas depressive symptoms were assessed by Beck Depression Inventory (BDI) questionnaire, and diagnosis was confirmed by the criteria of the Diagnostic and Statistical Manual for Psychiatry-IV Text Revision (DSM-IV TR) / International Code Diagnose 10 (ICD-10). Serum levels of TNF-α was measured by the method of quantitative enzyme-linked immunosorbent assay (ELISA). Results. The median value of the level of depression and serum TNF- α in this study were 16 (10 - 45) and 4.09 (1.29 - 19.57) pg/mL. There was no significant correlation between depressive level and TNF-α level ( r = -0.265 , p = 0.098 ). Conclusions. There was no significant correlation between depressive level and TNF-α level in uncontrolled bronchial asthma
    Keywords depressive level ; TNF-α level ; uncontrolled asthma bronchial ; Internal medicine ; RC31-1245
    Subject code 610
    Language Indonesian
    Publishing date 2016-06-01T00:00:00Z
    Publisher Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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