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  1. AU="Muhammad Asghar Pasha"
  2. AU="Linda Feketeová"
  3. AU="Aldrich, J Matthew"
  4. AU="Williams, Kristopher"
  5. AU="Calvet, Loreley"
  6. AU="Rui Pinto"
  7. AU="Feret, Geoff"
  8. AU="Sherrill-Mix, Scott"
  9. AU="Eleanor Eaton"
  10. AU="Latour, Corine H M"
  11. AU="Radetic, Mark"
  12. AU="James Jensen"
  13. AU="McFalls, Jeanne"
  14. AU="Sylvain Sebert"

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  1. Artikel ; Online: Current Understanding of Asthma Pathogenesis and Biomarkers

    Nazia Habib / Muhammad Asghar Pasha / Dale D. Tang

    Cells, Vol 11, Iss 2764, p

    2022  Band 2764

    Abstract: Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations) and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have been made to dissect the cellular and molecular mechanisms of asthma. ... ...

    Abstract Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations) and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have been made to dissect the cellular and molecular mechanisms of asthma. Aberrant T helper type 2 (Th2) inflammation is the most important pathological process for asthma, which is mediated by Th2 cytokines, such as interleukin (IL)-5, IL-4, and IL-13. Approximately 50% of mild-to-moderate asthma and a large portion of severe asthma is induced by Th2-dependent inflammation. Th2-low asthma can be mediated by non-Th2 cytokines, including IL-17 and tumor necrosis factor-α. There is emerging evidence to demonstrate that inflammation-independent processes also contribute to asthma pathogenesis. Protein kinases, adapter protein, microRNAs, ORMDL3, and gasdermin B are newly identified molecules that drive asthma progression, independent of inflammation. Eosinophils, IgE, fractional exhaled nitric oxide, and periostin are practical biomarkers for Th2-high asthma. Sputum neutrophils are easily used to diagnose Th2-low asthma. Despite progress, more studies are needed to delineate complex endotypes of asthma and to identify new and practical biomarkers for better diagnosis, classification, and treatment.
    Schlagwörter asthma ; smooth muscle ; cytokine ; inflammation ; biomarker ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Allergic Food Sensitization and Disease Manifestation in the Fetus and Infant

    Russell J. Hopp / Peggy Salazar / Muhammad Asghar Pasha

    Allergies, Vol 1, Iss 9, Pp 115-

    A Perspective

    2021  Band 122

    Abstract: Even though allergic disease is identified in the first year of life, it is often in a less forward fashion, with elements of a wait and see approach. If the infant does not have an anaphylactic food reaction, other less dramatic allergic phenomenon is ... ...

    Abstract Even though allergic disease is identified in the first year of life, it is often in a less forward fashion, with elements of a wait and see approach. If the infant does not have an anaphylactic food reaction, other less dramatic allergic phenomenon is often under-emphasized, waiting for additional concerns. We approached this with a conception to first conduct birthday surveys, attempting to link intrauterine and peri-birth circumstances to affect better allergy recognition in young infants.
    Schlagwörter infants ; fetus ; sensitization ; allergic ; allergic disease ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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