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  1. Article ; Online: COVID-19 and our DNA

    Muhammad Aslamkhan

    The International Journal of Frontier Sciences, Vol 4, Iss

    2020  Volume 2

    Abstract: On December 31st 2019, Chinese Health Authorities in Wuhan city of their Hubei province, diagnosed 29 pneumonia cases of unknown etiology and informed WHO (World Health Organization). The unknown virus resembled SARS (severe acute respiratory syndrome), ... ...

    Abstract On December 31st 2019, Chinese Health Authorities in Wuhan city of their Hubei province, diagnosed 29 pneumonia cases of unknown etiology and informed WHO (World Health Organization). The unknown virus resembled SARS (severe acute respiratory syndrome), that occurred in China in November 2002, caused by a novel corona virus spilling over from an animal reservoir and transmitted by respiratory droplets. More than 8000 cases and 774 deaths were caused by SARS and circa US$20 billion coasted for its control.
    Keywords COVID-19 ; DNA ; Epidemic ; Epidemiology ; Genetic Susceptibility ; Genome ; Medicine ; R ; Microbiology ; QR1-502 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontier Science Associates
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Water

    Muhammad Aslamkhan

    The International Journal of Frontier Sciences, Vol 3, Iss

    The Elixir of Life

    2019  Volume 1

    Abstract: Water is a chemical compound made up of two elements, Hydrogen gas, which is combustible and Oxygen gas, which causes to burn. But the union of two atoms of Hydrogen and one atom of Oxygen results in a colourless and odourless liquid, known as water, ... ...

    Abstract Water is a chemical compound made up of two elements, Hydrogen gas, which is combustible and Oxygen gas, which causes to burn. But the union of two atoms of Hydrogen and one atom of Oxygen results in a colourless and odourless liquid, known as water, which extinguish fire.
    Keywords Water ; Medicine ; R ; Microbiology ; QR1-502
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Frontier Science Associates
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Three Years of TIJFS

    Muhammad Shoaib Akhtar / Muhammad Aslamkhan

    The International Journal of Frontier Sciences, Vol 4, Iss

    Observations, Current Practices and Future Perspective

    2020  Volume 1

    Abstract: The International Journal of Frontier Sciences just completed its three years of publication. Start of a journal is always challenging for editors especially if journal is not an official publication of some institute or professional society. However, ... ...

    Abstract The International Journal of Frontier Sciences just completed its three years of publication. Start of a journal is always challenging for editors especially if journal is not an official publication of some institute or professional society. However, completing three years also has been a very learning experience for editorial team. From the start, TIJFS team is focused to catch indexation in EMBASE, MEDLINE, PubMed, Scopus and Web of Science. However, starting years of the journal are always challenging. Journal editors are continuously improving practices to achieve these milestones at earliest. In scope, journal is transdisciplinary mainly covering life and environmental sciences. Starting from Pakistan, it was very difficult to run an internationally covered journal, however, our international editorial team putting its continuous efforts to do this. In last year, journal started its indexing process and just became a part of WHO’s Index Medicus. Also, editors started to generate digital object identifiers (DOIs) of all manuscripts published. Currently, journal is in process of indexation in prestigious international bodies including Web of Science etc. Journal editors hope to be a part of many international indices during the current volume year. Also, its worth to mention that journal is following ethical guidelines by Consolidated Standards of Reporting Trials, Committee of Publication Ethics, International Committee of Medical Journal Editors and World Association of Medical Editors. Current volume contains original articles, clinical audit and a report covering broad spectrum domains of life sciences especially medical science including topics of clinical chemistry, dentistry, gynaecology, neurosurgery, nutrition, pain medicine, public health, rehabilitation, sleep medicine, surgery and virology.
    Keywords tijfs ; Medicine ; R ; Microbiology ; QR1-502
    Subject code 001
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Frontier Science Associates
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Intronic regions of the human coagulation factor VIII gene harboring transcription factor binding sites with a strong bias towards the short-interspersed elements

    Aliakbar Haddad-Mashadrizeh / Jafar Hemmat / Muhammad Aslamkhan

    Heliyon, Vol 6, Iss 9, Pp e04727- (2020)

    2020  

    Abstract: Increasing data show that intronic derived regulatory elements, such as transcription factor binding sites (TFBs), play key roles in gene regulation, and malfunction. Accordingly, characterizing the sequence context of the intronic regions of the human ... ...

    Abstract Increasing data show that intronic derived regulatory elements, such as transcription factor binding sites (TFBs), play key roles in gene regulation, and malfunction. Accordingly, characterizing the sequence context of the intronic regions of the human coagulation factor VIII (hFVIII) gene can be important. In this study, the intronic regions of the hFVIII gene were scrutinized based on in-silico methods. The results disclosed that these regions harbor a rich array of functional elements such as repetitive elements (REs), splicing sites, and transcription factor binding sites (TFBs). Among these elements, TFBs and REs showed a significant distribution and correlation to each other. This survey indicated that 31% of TFBs are localized in the intronic regions of the gene. Moreover, TFBs indicate a strong bias in the regions far from splice sites of introns with mapping to different REs. Accordingly, TFBs showed highly bias toward Short Interspersed Elements (SINEs), which in turn they covering about 12% of the total of REs. However, the distribution pattern of TFBs-REs showed different bias in the intronic regions, spatially into the Introns 13 and 25. The rich array of SINE-TFBs and CR1-TFBs were situated within 5′UTR of the gene that may be an important driving force for regulatory innovation of the hFVIII gene. Taken together, these data may lead to revealing intronic regions with the capacity to renewing gene regulatory networks of the hFVIII gene. On the other hand, these correlations might provide the novel idea for a new hypothesis of molecular evolution of the FVIII gene, and treatment of Hemophilia A which should be considered in future studies.
    Keywords Developmental biology ; Molecular biology ; Epigenetics ; Developmental genetics ; Health sciences ; Human genetics ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 306
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Dichromacy

    Muhammad Shoaib Akhtar / Muhammad Aslamkhan / Mian Sahib Zar / Asif Hanif / Abdul Rehman Haris

    The International Journal of Frontier Sciences, Vol 3, Iss

    Color Vision Impairment and Consanguinity in Heterogenous Population of Pakistan

    2019  Volume 1

    Abstract: Abstract: Background and Objectives: Dichromacy, an X-linked recessive disorder is identified worldwide, more in males than females. In European Caucasians, its incidence is 8% in males and 0.5% in females. In India, it is 8.73% in males and 1.69% in ... ...

    Abstract Abstract: Background and Objectives: Dichromacy, an X-linked recessive disorder is identified worldwide, more in males than females. In European Caucasians, its incidence is 8% in males and 0.5% in females. In India, it is 8.73% in males and 1.69% in females, and in Iran, it is 8.18% in males and 0.43% in females. Population based epidemiological data about dichromacy in different ethnic groups in Pakistan is not available. The aim of this study was to find out the population prevalence of inherited red-green dichromacy in a heterogenous population of the district of Chiniot, Punjab, Pakistan, and to determine the impact of consanguinity and ethnicity. Methods: In this cross-sectional study, boys and girls of the higher secondary schools were examined in the three tehsils of district Chiniot. Pseudoisochromatic Ishihara Test has been employed for detection of dichromacy in the study population. The sample size was calculated statistically as 260, which was expanded to 705 and divided by population density of the three tehsils. Results: Screening of 359 males and 346 females revealed 19 (5.29%) dichromat males and only 2 (0.58%) females. The study population belonged to 23 castes / isonym groups. The consanguinity found in the district of Chiniot is 84.82% and in the dichromat families, it is 85.71%, of which 52.37% are first cousin. Interpretation & Conclusion: The study has shown that the incidence of dichromacy could be reduced through genetic counseling
    Keywords Punjab ; Protanopia ; Pakistan ; Heterogenous Population ; Ethnicity ; Dichromacy ; Medicine ; R ; Microbiology ; QR1-502
    Subject code 590
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Frontier Science Associates
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients

    Haroon Latif Khan / Shahzad Bhatti / Sana Abbas / Yousaf Latif Khan / Rosa Maria Marquez Gonzalez / Muhammad Aslamkhan / Gerardo Rodriguez Gonzalez / Hikmet Hakan Aydin

    Basic and Clinical Andrology, Vol 28, Iss 1, Pp 1-

    2018  Volume 14

    Abstract: Résumé Contexte Malgré une fréquence élevée partout dans le monde de l’éjaculation prématurée (EP), le caractère obscur de sa description, de son épidémiologie et de sa prise en charge reste provocateur. Il est avéré que la dysfonction masculine ... ...

    Abstract Résumé Contexte Malgré une fréquence élevée partout dans le monde de l’éjaculation prématurée (EP), le caractère obscur de sa description, de son épidémiologie et de sa prise en charge reste provocateur. Il est avéré que la dysfonction masculine représentée par l’EP est un problème croissant en raison de l’occurrence de l’éjaculation spontanée dans de nombreux sujets généraux et cliniques. L’objectif principal de la présente étude était de déterminer les relations entre le nombre de répétions de trinucléotides du récepteur aux androgènes (RA), les stéroïdes sexuels et les hormones hypophysaires d’une part, et la fonction sexuelle d’hommes qui présentent un Diabète de type 2 (DT2) et qui rapportent une EP acquise. Sujets et Méthodes Un total de 150 sujets normaux et de 250 sujets qui présentaient une EP et un DT2 ont été enrôlés dans cette étude. Il a été demandé à chaque sujet de remplir un questionnaire approprié au recueil sélectif d’informations précises concernant l’indice de masse corporelle, la durée de l’EP+ DT2, le temps de latence éjaculatoire intra vaginal (IELT) auto-rapporté, ainsi que les statuts sexuel et mental sur la base de l’outil diagnostic de l’éjaculation prématurée (PEDT) et de l’inventaire de dépression de Beck-II (BDI-II). Les coefficients de corrélation de Pearson ont été utilisés pour évaluer les relations entre les paramètres génétiques, cliniques et démographiques. L’analyse de variance minimale des groupements de Ward et l’analyse en composante principale ont été utilisées pour évaluer la dépendance entre les paramètres génétiques, clinique et démographiques. Résultats Les sujets qui avaient le plus faible nombre (≤21) de répétitions de (CAG)n présentaient des taux sériques plus élevés d’ocytocine (114.2 pg/ml; n = 54, 43.2%) que les témoins (69.18 pg/ml; n = 22, 17.6%) et que les sujets avec le nombre le plus élevé (≥26) de répétitions de (CAG)n (62.9 pg/ml; n = 108, 43.2%). D’un autre côté, les sujets qui présentaient le nombre le plus élevé (≥26) de répétitions de (CAG)n avaient ...
    Keywords Androgen receptor ; Testosterone ; Oxytocin ; Premature ejaculation ; Diabetes mellitus ; Medicine (General) ; R5-920
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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