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  1. Article: Gold Nanorod Substrate for Rat Fetal Neural Stem Cell Differentiation into Oligodendrocytes.

    Sharma, Krishna Deo / Alghazali, Karrer M / Hamzah, Rabab N / Pandanaboina, Sahitya Chetan / Nima Alsudani, Zeid A / Muhi, Malek / Watanabe, Fumiya / Zhou, Guo-Lei / Biris, Alexandru S / Xie, Jennifer Yanhua

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 6

    Abstract: Gold nanorods (AuNRs) have been proposed to promote stem cell differentiation in vitro and in vivo. In this study, we examined a particular type of AuNR in supporting the differentiation of rat fetal neural stem cells (NSCs) into oligodendrocytes (ODCs). ...

    Abstract Gold nanorods (AuNRs) have been proposed to promote stem cell differentiation in vitro and in vivo. In this study, we examined a particular type of AuNR in supporting the differentiation of rat fetal neural stem cells (NSCs) into oligodendrocytes (ODCs). AuNRs were synthesized according to the seed-mediated method resulting in nanorods with an aspect ratio of around 3 (~12 nm diameter, 36 nm length) and plasmon resonance at 520 and 780 nm, as confirmed by transmission electron microscopy (TEM) and UV-vis spectroscopy, respectively. A layer-by-layer approach was used to fabricate the AuNR substrate on the functionalized glass coverslips. NSCs were propagated for 10 days using fibroblast growth factor, platelet-derived growth-factor-supplemented culture media, and differentiated on an AuNR or poly-D-lysine (PDL)-coated surface using differentiation media containing triiodothyronine for three weeks. Results showed that NSCs survived better and differentiated faster on the AuNRs compared to the PDL surface. By week 1, almost all cells had differentiated on the AuNR substrate, whereas only ~60% differentiated on the PDL surface, with similar percentages of ODCs and astrocytes. This study indicates that functionalized AuNR substrate does promote NSC differentiation and could be a viable tool for tissue engineering to support the differentiation of stem cells.
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12060929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of a polymeric biomedical device platform with controlled disassembly and in vivo testing in a swine intestinal model.

    Alghazali, Karrer M / Pedersen, Alisha P / Hamzah, Rabab N / Mulon, Pierre-Yves / Rifkin, Rebecca E / Mhannawee, Anwer / Nima Alsudani, Zeid A / Griffin, Christopher / Muhi, Malek A H / Mullen, Nikki / Donnell, Robert L / Anderson, David E / Biris, Alexandru S

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3208

    Abstract: The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which then breaks apart and is eliminated from the body in a controlled manner. ... ...

    Abstract The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which then breaks apart and is eliminated from the body in a controlled manner. The device contains mixed polymeric structures that give it a controlled rate of disassembly that could meet the requirements of a specific surgical purpose. The intraluminal anastomotic guide was manufactured as a hollow cylinder composed of layers of porous polyurethane/PCL with polyvinylpyrrolidone as the binding agent similar to a "brick-mortar" architecture. This combination of polymeric structures is a promising manufacturing method from which a variety of tunable devices can be fabricated for specific medical procedures and site-specific indications. The guide was designed to rapidly disassemble within the intestinal lumen after use, reliably degrading while maintaining sufficient mechanical rigidity and stability to support manipulation during complex surgical procedures. The nature of the device's disassembly makes it suitable for use in hollow structures that discharge their contents, resulting in their elimination from the body. A swine model of intestinal anastomosis was utilized to validate the use and function of the device.
    MeSH term(s) Anastomosis, Surgical/methods ; Animals ; Digestive System Surgical Procedures/methods ; Intestines/surgery ; Polymers ; Porosity ; Swine
    Chemical Substances Polymers
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06339-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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