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  1. Article ; Online: Reply to: "The UK DCD Risk Score: Still no consensus on futility in DCD liver transplantation".

    Schlegel, A / Muiesan, P

    Journal of hepatology

    2019  Volume 70, Issue 5, Page(s) 1036–1038

    MeSH term(s) Death ; Humans ; Liver Transplantation ; Medical Futility ; Tissue and Organ Procurement ; United Kingdom
    Language English
    Publishing date 2019-02-21
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2019.01.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
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  2. Article ; Online: Reply to: "DCD consensus and futility in liver transplantation".

    Schlegel, A / Kalisvaart, M / Isaac, J / Muiesan, P

    Journal of hepatology

    2018  Volume 69, Issue 1, Page(s) 257–258

    MeSH term(s) Brain Death ; Consensus ; Humans ; Liver Transplantation ; Medical Futility ; Tissue Donors
    Language English
    Publishing date 2018-04-13
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2018.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Can we minimize wait-list mortality in young children with Biliary atresia?

    Schlegel, Andrea / Muiesan, Paolo

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2018  Volume 24, Issue 6, Page(s) 731–732

    MeSH term(s) Biliary Atresia ; Child ; Cohort Studies ; Humans ; Liver Transplantation ; Registries ; Waiting Lists
    Language English
    Publishing date 2018-04-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25190
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  4. Article ; Online: Reply to: "Redefining futility in DCD liver transplantation in the era of novel perfusion technologies".

    Schlegel, A / Kalisvaart, M / Isaac, J / Dutkowski, P / Muiesan, P

    Journal of hepatology

    2018  Volume 68, Issue 6, Page(s) 1328–1330

    MeSH term(s) Liver Transplantation ; Medical Futility ; Organ Preservation ; Perfusion
    Language English
    Publishing date 2018-03-15
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2018.03.003
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  5. Article ; Online: Impact of Machine Perfusion on the Immune Response After Liver Transplantation - A Primary Treatment or Just a Delivery Tool.

    Panconesi, Rebecca / Flores Carvalho, Mauricio / Dondossola, Daniele / Muiesan, Paolo / Dutkowski, Philipp / Schlegel, Andrea

    Frontiers in immunology

    2022  Volume 13, Page(s) 855263

    Abstract: The frequent use of marginal livers forces transplant centres to explore novel technologies to improve organ quality and outcomes after implantation. Organ perfusion techniques are therefore frequently discussed with an ever-increasing number of ... ...

    Abstract The frequent use of marginal livers forces transplant centres to explore novel technologies to improve organ quality and outcomes after implantation. Organ perfusion techniques are therefore frequently discussed with an ever-increasing number of experimental and clinical studies. Two main approaches, hypothermic and normothermic perfusion, are the leading strategies to be introduced in clinical practice in many western countries today. Despite this success, the number of studies, which provide robust data on the underlying mechanisms of protection conveyed through this technology remains scarce, particularly in context of different stages of ischemia-reperfusion-injury (IRI). Prior to a successful clinical implementation of machine perfusion, the concept of IRI and potential key molecules, which should be addressed to reduce IRI-associated inflammation, requires a better exploration. During ischemia, Krebs cycle metabolites, including succinate play a crucial role with their direct impact on the production of reactive oxygen species (ROS) at mitochondrial complex I upon reperfusion. Such features are even more pronounced under normothermic conditions and lead to even higher levels of downstream inflammation. The direct consequence appears with an activation of the innate immune system. The number of articles, which focus on the impact of machine perfusion with and without the use of specific perfusate additives to modulate the inflammatory cascade after transplantation is very small. This review describes first, the subcellular processes found in mitochondria, which instigate the IRI cascade together with proinflammatory downstream effects and their link to the innate immune system. Next, the impact of currently established machine perfusion strategies is described with a focus on protective mechanisms known for the different perfusion approaches. Finally, the role of such dynamic preservation techniques to deliver specific agents, which appear currently of interest to modulate this posttransplant inflammation, is discussed together with future aspects in this field.
    MeSH term(s) Humans ; Immunity ; Inflammation ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Organ Preservation/methods ; Perfusion/adverse effects ; Perfusion/methods
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.855263
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  6. Article: Epidemiology and Surgical Management of Foreign Bodies in the Liver in the Pediatric Population: A Systematic Review of the Literature.

    Gigola, Francesca / Grimaldi, Chiara / Bici, Kejd / Ghionzoli, Marco / Spinelli, Claudio / Muiesan, Paolo / Morabito, Antonino

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 2

    Abstract: Retention of foreign bodies (FB) in the liver parenchyma is a rare event in children but it can bring a heavy burden in terms of immediate and long-term complications. Multiple materials can migrate inside the liver. Clinical manifestations may vary, ... ...

    Abstract Retention of foreign bodies (FB) in the liver parenchyma is a rare event in children but it can bring a heavy burden in terms of immediate and long-term complications. Multiple materials can migrate inside the liver. Clinical manifestations may vary, depending on the nature of the foreign body, its route of penetration and timing after the initial event. Moreover, the location of the FB inside the liver parenchyma may pose specific issues related to the possible complications of a challenging surgical extraction. Different clinical settings and the need for highly specialized surgical skills may influence the overall management of these children. Given the rarity of this event, a systematic review of the literature on this topic was conducted and confirmed the pivotal role of surgery in the pediatric population.
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9020120
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  7. Article ; Online: Liver perfusion strategies: what is best and do ischemia times still matter?

    Panconesi, Rebecca / Carvalho, Mauricio Flores / Muiesan, Paolo / Dutkowski, Philipp / Schlegel, Andrea

    Current opinion in organ transplantation

    2022  Volume 27, Issue 4, Page(s) 285–299

    Abstract: Purpose of review: This review describes recent developments in the field of liver perfusion techniques.: Recent findings: Dynamic preservation techniques are increasingly tested due to the urgent need to improve the overall poor donor utilization. ... ...

    Abstract Purpose of review: This review describes recent developments in the field of liver perfusion techniques.
    Recent findings: Dynamic preservation techniques are increasingly tested due to the urgent need to improve the overall poor donor utilization. With their exposure to warm ischemia, livers from donors after circulatory death (DCD) transmit additional risk for severe complications after transplantation. Although the superiority of dynamic approaches compared to static-cold-storage is widely accepted, the number of good quality studies remains limited. Most risk factors, particularly donor warm ischemia, and accepted thresholds are inconsistently reported, leading to difficulties to assess the impact of new preservation technologies. Normothermic regional perfusion (NRP) leads to good outcomes after DCD liver transplantation, with however short ischemia times. While randomized controlled trials (RCT) with NRP are lacking, results from the first RCTs with ex-situ perfusion were reported. Hypothermic oxygenated perfusion was shown to protect DCD liver recipients from ischemic cholangiopathy. In contrast, endischemic normothermic perfusion seems to not impact on the development of biliary complications, although this evidence is only available from retrospective studies.
    Summary: Dynamic perfusion strategies impact posttransplant outcomes and are increasingly commissioned in various countries along with more evidence from RCTs. Transparent reporting of risk and utilization with uniform definitions is required to compare the role of different preservation strategies in DCD livers with prolonged ischemia times.
    MeSH term(s) Humans ; Organ Preservation/adverse effects ; Organ Preservation/methods ; Graft Survival ; Perfusion/adverse effects ; Perfusion/methods ; Warm Ischemia/adverse effects ; Tissue Donors ; Liver/surgery ; Ischemia/prevention & control ; Ischemia/etiology
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5609: Show issues Location:
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  8. Article ; Online: Normothermic regional perfusion - What is the benefit?

    Schlegel, Andrea / Muiesan, Paolo / Dutkowski, Philipp

    Journal of hepatology

    2019  Volume 71, Issue 2, Page(s) 441–443

    MeSH term(s) Death ; Humans ; Liver Transplantation ; Organ Preservation ; Perfusion
    Language English
    Publishing date 2019-05-23
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2019.03.019
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  9. Article: Hepatic vein reconstruction during hepatectomy: A feasible and underused technique.

    Ahuja, Manish / Joshi, Kunal / Coldham, Chris / Muiesan, Paulo / Dasari, Bobby / Abradelo, Manuel / Marudanayagam, Ravi / Mirza, Darius / Isaac, John / Bartlett, David / Chatzizacharias, Nikolaos A / Sutcliffe, Robert P / Roberts, Keith J

    Hepatobiliary & pancreatic diseases international : HBPD INT

    2024  

    Language English
    Publishing date 2024-01-15
    Publishing country Singapore
    Document type Letter
    ZDB-ID 2241386-8
    ISSN 1499-3872
    ISSN 1499-3872
    DOI 10.1016/j.hbpd.2024.01.002
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  10. Article ; Online: The UK-DCD-Risk-Score - practical and new guidance for allocation of a specific organ to a recipient?

    Kalisvaart, Marit / Muiesan, Paolo / Schlegel, Andrea

    Expert review of gastroenterology & hepatology

    2019  Volume 13, Issue 8, Page(s) 771–783

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Death ; Health Status Indicators ; Humans ; Liver Diseases/surgery ; Liver Transplantation ; Models, Biological ; Risk Assessment/methods ; Risk Factors ; Tissue Donors ; Tissue and Organ Procurement
    Language English
    Publishing date 2019-06-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2019.1629286
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