Article ; Online: Branched-chain amino acid levels are inversely associated with incident and prevalent chronic kidney disease in people with type 2 diabetes.
Diabetes, obesity & metabolism
2024 Volume 26, Issue 5, Page(s) 1706–1713
Abstract: Aim: To investigate the association of plasma metabolites with incident and prevalent chronic kidney disease (CKD) in people with type 2 diabetes and establish whether this association is causal.: Materials and methods: The Hoorn Diabetes Care System ...
| Abstract | Aim: To investigate the association of plasma metabolites with incident and prevalent chronic kidney disease (CKD) in people with type 2 diabetes and establish whether this association is causal. Materials and methods: The Hoorn Diabetes Care System cohort is a large prospective cohort consisting of individuals with type 2 diabetes from the northwest part of the Netherlands. In this cohort we assessed the association of baseline plasma levels of 172 metabolites with incident (N Results: Elevated levels of total and individual branched-chain amino acids (BCAAs)-valine, leucine and isoleucine-were associated with an increased risk of incident CKD, but with reduced odds of prevalent CKD, where BMI was identified as an effect modifier. The observed inverse effects were replicated in the UK Biobank. Mendelian randomization analysis did not provide evidence for a causal relationship between BCAAs and prevalent CKD. Conclusions: Our study shows the intricate relationship between plasma BCAA levels and CKD in individuals with type 2 diabetes. While an association exists, its manifestation varies based on disease status and BMI, with no definitive evidence supporting a causal link between BCAAs and prevalent CKD. |
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| MeSH term(s) | Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Risk Factors ; Prospective Studies ; Amino Acids, Branched-Chain/adverse effects ; Amino Acids, Branched-Chain/metabolism ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/chemically induced | |||||
| Chemical Substances | Amino Acids, Branched-Chain | |||||
| Language | English | |||||
| Publishing date | 2024-02-01 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1454944-x | |||||
| ISSN | 1463-1326 ; 1462-8902 | |||||
| ISSN (online) | 1463-1326 | |||||
| ISSN | 1462-8902 | |||||
| DOI | 10.1111/dom.15475 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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