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  1. Article ; Online: Genomic analysis of arginine vasopressin gene in riverine buffalo reveals its potential association with silent estrus behavior

    Javed, Maryam / Nadeem, Asif / Hassan, Faiz-ul / Mujahid, Huma / Rehman, Saif-ur-

    Mol Biol Rep. 2022 Oct., v. 49, no. 10 p.9315-9324

    2022  

    Abstract: BACKGROUND: Poor estrus expression behavior causes suboptimal reproductive efficiency through poor conception rate. Various signaling pathways are involved in estrus expression but arginine vasopressin (AVP) gene with oxytocin predominantly regulates ... ...

    Abstract BACKGROUND: Poor estrus expression behavior causes suboptimal reproductive efficiency through poor conception rate. Various signaling pathways are involved in estrus expression but arginine vasopressin (AVP) gene with oxytocin predominantly regulates estrus behavior. This study aimed to perform genomic characterization and evolutionary dynamics of AVP gene through association testing of the novel polymorphic loci and comparative genomic analysis to explore the potential effect of AVP gene on estrus behavior of Nili-Ravi buffaloes. METHODS AND RESULTS: 198 Nili-Ravi buffaloes were screened for the quest of novel polymorphism in the AVP gene. In exon-1, five polymorphic sites were detected including deletion of two (c.47delA and c.57delA) nucleotides that caused drastic variation in subsequent amino acid sequence due to frame shift including functional short peptide of nine residues. The 3-D structure revealed a loss of transmembrane loop between 16 and 31 residues in Nili-Ravi buffalo AVP protein sequence, suggesting that missing loop apparently reduced the gene functionality in Nili-Ravi buffalo by inhibiting cellular reactions and muting the animal estrus cyclicity. Three polymorphisms detected in AVP gene were significantly associated with silent estrus (P < 0.05). The comparative genomic analysis revealed that AVP gene is present on chromosome 14 having one conserved motif (Neurohypophysial) in buffalo. CONCLUSIONS: This study suggested the potential use of polymorphic sites as promising genetic markers for selection of buffaloes with pronounced estrus expression.
    Keywords amino acid sequences ; arginine vasopressin ; buffaloes ; chromosomes ; conception rate ; estrus ; genes ; genomics ; nucleotides ; oxytocin ; periodicity ; reproductive efficiency ; riparian areas
    Language English
    Dates of publication 2022-10
    Size p. 9315-9324.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07776-5
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  2. Article ; Online: Genomic analysis of arginine vasopressin gene in riverine buffalo reveals its potential association with silent estrus behavior.

    Javed, Maryam / Nadeem, Asif / Hassan, Faiz-Ul / Mujahid, Huma / Rehman, Saif Ur

    Molecular biology reports

    2022  Volume 49, Issue 10, Page(s) 9315–9324

    Abstract: Background: Poor estrus expression behavior causes suboptimal reproductive efficiency through poor conception rate. Various signaling pathways are involved in estrus expression but arginine vasopressin (AVP) gene with oxytocin predominantly regulates ... ...

    Abstract Background: Poor estrus expression behavior causes suboptimal reproductive efficiency through poor conception rate. Various signaling pathways are involved in estrus expression but arginine vasopressin (AVP) gene with oxytocin predominantly regulates estrus behavior. This study aimed to perform genomic characterization and evolutionary dynamics of AVP gene through association testing of the novel polymorphic loci and comparative genomic analysis to explore the potential effect of AVP gene on estrus behavior of Nili-Ravi buffaloes.
    Methods and results: 198 Nili-Ravi buffaloes were screened for the quest of novel polymorphism in the AVP gene. In exon-1, five polymorphic sites were detected including deletion of two (c.47delA and c.57delA) nucleotides that caused drastic variation in subsequent amino acid sequence due to frame shift including functional short peptide of nine residues. The 3-D structure revealed a loss of transmembrane loop between 16 and 31 residues in Nili-Ravi buffalo AVP protein sequence, suggesting that missing loop apparently reduced the gene functionality in Nili-Ravi buffalo by inhibiting cellular reactions and muting the animal estrus cyclicity. Three polymorphisms detected in AVP gene were significantly associated with silent estrus (P < 0.05). The comparative genomic analysis revealed that AVP gene is present on chromosome 14 having one conserved motif (Neurohypophysial) in buffalo.
    Conclusions: This study suggested the potential use of polymorphic sites as promising genetic markers for selection of buffaloes with pronounced estrus expression.
    MeSH term(s) Animals ; Arginine Vasopressin/genetics ; Buffaloes/genetics ; Estrus/genetics ; Female ; Genetic Markers ; Genomics ; Nucleotides ; Oxytocin/genetics
    Chemical Substances Genetic Markers ; Nucleotides ; Arginine Vasopressin (113-79-1) ; Oxytocin (50-56-6)
    Language English
    Publishing date 2022-07-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07776-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Antifungal Activity of

    Naqvi, Syeda Itrat Zahra / Kausar, Humera / Afzal, Arooj / Hashim, Mariam / Mujahid, Huma / Javed, Maryam / Hano, Christophe / Anjum, Sumaira

    Journal of functional biomaterials

    2023  Volume 14, Issue 4

    Abstract: Aflatoxins produced by some species ... ...

    Abstract Aflatoxins produced by some species of
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14040221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives.

    Hashim, Mariam / Mujahid, Huma / Hassan, Samina / Bukhari, Shanila / Anjum, Iram / Hano, Christophe / Abbasi, Bilal Haider / Anjum, Sumaira

    Biomolecules

    2022  Volume 12, Issue 10

    Abstract: Liver and kidney diseases are the most frequently encountered problems around the globe. Damage to the liver and kidney may occur as a result of exposure to various drugs, chemicals, toxins, and pathogens, leading to severe disease conditions such as ... ...

    Abstract Liver and kidney diseases are the most frequently encountered problems around the globe. Damage to the liver and kidney may occur as a result of exposure to various drugs, chemicals, toxins, and pathogens, leading to severe disease conditions such as cirrhosis, fibrosis, hepatitis, acute kidney injury, and liver and renal failure. In this regard, the use of nanoparticles (NPs) such as silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), and zinc oxide nanoparticles (ZnONPs) has emerged as a rapidly developing field of study in terms of safe delivery of various medications to target organs with minimal side effects. Due to their physical characteristics, NPs have inherent pharmacological effects, and an accidental buildup can have a significant impact on the structure and function of the liver and kidney. By suppressing the expression of the proinflammatory cytokines iNOS and COX-2, NPs are known to possess anti-inflammatory effects. Additionally, NPs have demonstrated their ability to operate as an antioxidant, squelching the generation of ROS caused by substances that cause oxidative stress. Finally, because of their pro-oxidant properties, they are also known to increase the level of ROS, which causes malignant liver and kidney cells to undergo apoptosis. As a result, NPs can be regarded as a double-edged sword whose inherent therapeutic benefits can be refined as we work to comprehend them in terms of their toxicity.
    MeSH term(s) Humans ; Gold/pharmacology ; Silver/pharmacology ; Metal Nanoparticles/toxicity ; Reactive Oxygen Species/metabolism ; Zinc Oxide/pharmacology ; Antioxidants/pharmacology ; Cyclooxygenase 2/metabolism ; Nanoparticles/chemistry ; Oxidative Stress ; Liver/metabolism ; Cytokines/metabolism ; Kidney Diseases/metabolism ; Anti-Inflammatory Agents/pharmacology
    Chemical Substances Gold (7440-57-5) ; Silver (3M4G523W1G) ; Reactive Oxygen Species ; Zinc Oxide (SOI2LOH54Z) ; Antioxidants ; Cyclooxygenase 2 (EC 1.14.99.1) ; Cytokines ; Anti-Inflammatory Agents
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12101337
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  5. Article ; Online: In Silico Structural and Functional Analyses of NLRP3 Inflammasomes to Provide Insights for Treating Neurodegenerative Diseases.

    Ghazi, Behram Khan / Bangash, Maria Hussain / Razzaq, Anam Abdul / Kiyani, Madiha / Girmay, Shishay / Chaudhary, Waleed Razzaq / Zahid, Usman / Hussain, Uzma / Mujahid, Huma / Parvaiz, Usama / Buzdar, Irfan Ahmed / Nawaz, Shah / Elsadek, Mohamed Farouk

    publication RETRACTED

    BioMed research international

    2023  Volume 2023, Page(s) 9819005

    Abstract: Inflammasomes are cytoplasmic intracellular multiprotein complexes that control the innate immune system's activation of inflammation in response to derived chemicals. Recent advancements increased our molecular knowledge of activation of NLRP3 ... ...

    Abstract Inflammasomes are cytoplasmic intracellular multiprotein complexes that control the innate immune system's activation of inflammation in response to derived chemicals. Recent advancements increased our molecular knowledge of activation of NLRP3 inflammasomes. Although several studies have been done to investigate the role of inflammasomes in innate immunity and other diseases, structural, functional, and evolutionary investigations are needed to further understand the clinical consequences of NLRP3 gene. The purpose of this study is to investigate the structural and functional impact of the NLRP3 protein by using a computational analysis to uncover putative protein sites involved in the stabilization of the protein-ligand complexes with inhibitors. This will allow for a deeper understanding of the molecular mechanism underlying these interactions. It was found that human NLRP3 gene coexpresses with PYCARD, NLRC4, CASP1, MAVS, and CTSB based on observed coexpression of homologs in other species. The NACHT, LRR, and PYD domain-containing protein 3 is a key player in innate immunity and inflammation as the sensor subunit of the NLRP3 inflammasome. The inflammasome polymeric complex, consisting of NLRP3, PYCARD, and CASP1, is formed in response to pathogens and other damage-associated signals (and possibly CASP4 and CASP5). Comprehensive structural and functional analyses of NLRP3 inflammasome components offer a fresh approach to the development of new treatments for a wide variety of human disorders.
    MeSH term(s) Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neurodegenerative Diseases/genetics ; Immunity, Innate ; Inflammation/genetics ; Caspase 1/metabolism
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2023/9819005
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