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Article ; Online: Carrot or stick: what motivates urban water consumption? Evidence from Southern California

Mukherjee, Maitreyee

International Journal of Water Resources Development. 2023 Jan. 02, v. 39, no. 1 p.1-25

2023

Abstract: California has experienced one of the most intense and prolonged droughts in its history in the last decade, prompting the state government to undertake a series of policy responses. This paper compares the impact of the 2015 urban water-use reduction ... ...

Abstract	California has experienced one of the most intense and prolonged droughts in its history in the last decade, prompting the state government to undertake a series of policy responses. This paper compares the impact of the 2015 urban water-use reduction mandate with respect to pre-policy voluntary conservation efforts and post-policy water consumption trends by examining utility-level water demand dynamics of the Metropolitan Water District in Southern California. The findings overall indicate that despite voluntary measures resulting in a gradual decline in urban water-use, the introduction of the regulatory stick achieved swift reduction targets that remained even after removal of the mandatory policy.
Keywords	issues and policy ; state government ; water ; California ; Drought resilience ; urban water consumption ; water-use restriction ; water conservation
Language	English
Dates of publication	2023-0102
Size	p. 1-25.
Publishing place	Routledge
Document type	Article ; Online
ZDB-ID	2016525-0
ISSN	1360-0648 ; 0790-0627
ISSN (online)	1360-0648
ISSN	0790-0627
DOI	10.1080/07900627.2021.1969222
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Scleroderma Tango: Unraveling the Delicate Dance of Diastolic Dysfunction and Interstitial Lung Disease.

Jani, Vivek P / Mukherjee, Monica

The Journal of rheumatology

2024

Abstract: In this issue ... ...

Abstract	In this issue of
Language	English
Publishing date	2024-03-01
Publishing country	Canada
Document type	Editorial
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.2024-0154
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article ; Online: Type 1 fimbrial phase variation in multidrug-resistant asymptomatic uropathogenic Escherichia coli clinical isolates upon adherence to HTB-4 cells.

Ghosh, Arunita / Mukherjee, Mandira

Folia microbiologica

2024

Abstract: The adherence of bladder uroepithelial cells, subsequent expression, and regulation of type 1 fimbrial genes (key mediator of attachment) in clinical multidrug-resistant uropathogenic Escherichia coli (MDR-UPECs) isolated from individuals with ... ...

Abstract	The adherence of bladder uroepithelial cells, subsequent expression, and regulation of type 1 fimbrial genes (key mediator of attachment) in clinical multidrug-resistant uropathogenic Escherichia coli (MDR-UPECs) isolated from individuals with asymptomatic bacteriuria (ABU) remain unexplored till date. Therefore, this study aimed to investigate the underlying molecular mechanisms associated with the adherence of clinical MDR-ABU-UPECs to human a uroepithelial cell line (HTB-4), both in the absence and presence of D-Mannose. These investigations focused on phase variation, expression, and regulation of type 1 fimbriae and were compared to a prototype ABU-strain (E. coli 83972) and symptomatic MDR-UPECs. Discordant to the ABU prototype strain, MDR-ABU-UPECs exhibited remarkable adhesive capacity that was significantly reduced after D-mannose exposure, fairly like the MDR symptomatic UPECs. The type 1 fimbrial phase variation, determined by the fim switch analysis, asserted the statistically significant incidence of "both OFF and ON" orientation among the adherent MDR-ABU-UPECs with a significant reduction in phase-ON colonies post-D-mannose exposure, akin to the symptomatic ones. This was indicative of an operative and alternating type 1 fimbrial phase switch. The q-PCR assay revealed a coordinated action of the regulatory factors; H-NS, IHF, and Lrp on the expression of FimB and FimE recombinases, which further controlled the function of fimH and fimA genes in ABU-UPECs, similar to symptomatic strains. Therefore, this study is the first of its kind to provide an insight into the regulatory crosstalk of different cellular factors guiding the adhesion of ABU-UPECs to the host. Additionally, it also advocated for the need to accurately characterize ABU-UPECs.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-024-01159-y
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Zs.A 845: Show issues

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Article ; Online: Single proton cooled by distant ions.

Mukherjee, Manas

Nature

2021 Volume 596, Issue 7873, Page(s) 490–491

MeSH term(s)	Ions ; Phase Transition ; Physics ; Protons
Chemical Substances	Ions ; Protons
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	News ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-021-02267-2
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Comprehensive analysis of multiple cytokines to stratify uropathogenic Escherichia coli pathogenesis in mouse model of urinary tract infection.

Koley, Snehashis / Mukherjee, Mandira

Cytokine

2024 Volume 178, Page(s) 156577

Abstract: Purpose: Urinary tract infection (UTI) is one of the most common human bacterial infections primarily caused by uropathogenic E. coli (UPEC). Empiric treatment in UTI cause emergence of multidrug resistance and limit treatment options. Understanding UTI ...

Abstract	Purpose: Urinary tract infection (UTI) is one of the most common human bacterial infections primarily caused by uropathogenic E. coli (UPEC). Empiric treatment in UTI cause emergence of multidrug resistance and limit treatment options. Understanding UTI at the molecular level with respect to the causative pathogen as well as subsequent host response pose an absolute necessity towards appropriate clinical management. This study aimed to investigate host cytokine response in mouse UTI model with respect to bacterial colonization and associated virulence gene expression upon infection. Method: Mouse UTI model was established with two clinical UPEC isolates E. coli NP105 and E. coli P025. UPEC colonization in bladder and kidney was evaluated by bacterial culture (CFU/ml). Histopathology of the tissues were examined by hematoxylin and eosin staining. PCR and real time PCR were used to detect the incidence and expression of respective bacterial genes. Cytokine concentrations in tissues and sera were evaluated using ELISA. GraphPad prism version 8.0.2 was used for statistical interpretation. Result: Highest bacterial colonization was observed on 7th and 9th day post infection (p.i). in bladder and kidney of mouse infected with E. coli P025 and E. coli NP105 respectively with a distinct difference in relative expression of fimH and papC adhesin genes in vivo. IL-1β level in tissues and sera of E. coli NP105 and E. coli P025 infected mouse was significantly different but the IL-17A, GCSF, TGF-β levels were comparable. Conclusion: These findings show a role of IL1β to stratify pathogenicity of UPEC in mouse UTI model.
MeSH term(s)	Humans ; Animals ; Mice ; Uropathogenic Escherichia coli ; Cytokines ; Escherichia coli Infections/microbiology ; Urinary Tract Infections/microbiology ; Urinary Bladder/microbiology
Chemical Substances	Cytokines
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2024.156577
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Article ; Online: Investigating the potential of integrated urban greening strategies for reducing outdoor thermal stresses: a case of asymmetrical configuration in the tropical city of Bhopal.

Ojha, Saurabh Kishore / Mukherjee, Mahua

International journal of biometeorology

2024

Abstract: In Indian cities where streets are the only affordable outdoor public space, pedestrians are always exposed to extreme heat related health risk. However, it's a challenge to reduce heat stress in existing streets characterized by asymmetrical urban ... ...

Abstract	In Indian cities where streets are the only affordable outdoor public space, pedestrians are always exposed to extreme heat related health risk. However, it's a challenge to reduce heat stress in existing streets characterized by asymmetrical urban configuration. Integrating vegetation without reconstituting the original orientation and geometry is one of the feasible ways to alleviate stress. Therefore, current study focuses to analyse the heat stress reduction potential of urban greenery strategy in asymmetrical urban configuration from spatiotemporal perspective. It initiates with the selection of commercial streets in extreme hot climate with an on-site measurement of its climatic and morphological attributes. Furthermore, it leads to the classification and prioritizing of street's sections linked to hot-spots determined by varied sky view factor and asymmetrical aspect ratio. Finally, an Envi-Met model with iterated scenarios at the building and street levels is developed, incorporating three strategies (trees, grass, green-walls). The impact of heat related health risk is quantified using a thermal index Universal Thermal Climate Index along with air temperature and mean radiant temperature. The results suggested that due to asymmetricity a fixed strategy would not be applicable across the street. The highest reduction was observed by trees in asymmetrical sections while lowest was recorded by green-wall. However, it would be worthwhile to adopt green-wall along with dense tree's (leaf area density, 0.3) in order to reduce the heat stress in deeper sections. The evidence-based integration of Urban greenery can assist planners and designers in mitigating extreme heat stress in similar complex urban environment.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	280324-0
ISSN	1432-1254 ; 0020-7128
ISSN (online)	1432-1254
ISSN	0020-7128
DOI	10.1007/s00484-024-02680-y
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Zs.A 998: Show issues

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Book ; Article ; Online: India's mass-market clean mobility initiatives and its unique, customized business models for light electric vehicles

Mukherjee, Mohua

2022

Abstract: Around 99 per cent of vehicles running on India's roads are powered by internal combustion engines running on fossil fuels (petrol, diesel, and some CNG). The passenger car is still a largely aspirational product for around one hundred million newly ... ...

Abstract	Around 99 per cent of vehicles running on India's roads are powered by internal combustion engines running on fossil fuels (petrol, diesel, and some CNG). The passenger car is still a largely aspirational product for around one hundred million newly middle-class Indians (20 million families). Given the current, still very low per capita car ownership in India of 22 per 1,000 citizens, compared to 980 in the US and 850 in the UK, it is an opportune time for India to embrace alternative sustainable mobility solutions for a green and prosperous future. This can only succeed if accessible and affordable solutions are available in adequate numbers. Also, given the segmented nature of the market and the different dynamics within each segment, government support could be better targeted. This effort has already started with the proposed interoperable and standardized light-vehicle battery, to promote greater affordability in the battery-swapping segment. Also, government incentives for increased localization of battery assembly, and eventually cell manufacturing, as well as continued public support for R&D to explore alternative battery chemistries, will all help to reduce costs. The real challenge for India lies in E2Ws and E3Ws, used by nearly 1 billion people in the country every day. Converting these vehicles to electric, making them affordable and convenient, and doing what it takes to turn E2Ws and E3Ws into the first preference over ICE vehicles when making a purchase decision, is what India should be supported and measured on. In India, the adoption of e-mobility through the individual purchase of EVs is not likely to happen very fast in the mass segment of the market, (180 million families or 900 million people) even for 2Ws with leased batteries, selling at a price point today of under $1,000. It is likely to require a few more years until battery prices come down to around half of what they are today. The important lesson for EV market players in India is that the cash flow patterns of the mass market ...
Keywords	ddc:330 ; batteries ; battery swapping ; electric mobility ; electricity vehicles ; India ; Transport
Subject code	303
Language	English
Publisher	Oxford: The Oxford Institute for Energy Studies
Publishing country	de
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Management of Unequal Patient Status in Fertility Medicine: Donors' and Intended Parents' Experiences of Participatory and Imposed Enrollment.

Mukherjee, Meghna

Social science & medicine (1982)

2020 Volume 247, Page(s) 112807

Abstract: This paper explores the micro-dynamics of medicalization and unequal patient statuses across donors and intended parents in assisted fertility practices. Based on twelve months of fieldwork in a fertility clinic, including direct observations of 108 ... ...

Abstract	This paper explores the micro-dynamics of medicalization and unequal patient statuses across donors and intended parents in assisted fertility practices. Based on twelve months of fieldwork in a fertility clinic, including direct observations of 108 patient-medical expert consultations and interviews with donors, I develop an "epistemic-orientation (EO) continuum" to examine the emergence and differing consequences of unequal patient status. Patients who experience practices closer to the "participatory" epistemic orientation end of the continuum enjoy joint decision-making, personal and emotional recognition, and incorporation of their personal values in interactions with medical experts in the clinic. Patients whose experiences align more closely to the "imposed" epistemic orientation end of the continuum experience top-down instruction, neglected personhood, and medical objectification. I find that medical experts rely upon their professional authority to enroll intended parents in participatory epistemic orientations, while donors more likely experience imposed epistemic orientations. Blended orientations also occur within each patient group, often based on individuals' prior fertility experiences. The EO continuum approach carries implications for future research to note how patients of various social identities (i.e. race, class, gender) and patient groups are positioned along the continuum, as well as practical interventions into micro-dynamics of social inequalities in healthcare.
Language	English
Publishing date	2020-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2020.112807
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Article ; Online: Cytokine profile in HTB-4 cells with respect to

Koley, Snehashis / Mukherjee, Mandira

Future microbiology

2023 Volume 18, Page(s) 489–503

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Urinary Tract Infections/drug therapy ; Uropathogenic Escherichia coli/genetics ; Anti-Bacterial Agents/therapeutic use ; Virulence Factors/genetics ; Real-Time Polymerase Chain Reaction ; Escherichia coli Infections/drug therapy ; Adhesins, Escherichia coli/genetics ; Fimbriae Proteins/genetics
Chemical Substances	4-trifluoromethylsalicylic acid (328-90-5) ; Anti-Bacterial Agents ; Virulence Factors ; fimH protein, E coli ; Adhesins, Escherichia coli ; Fimbriae Proteins (147680-16-8)
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2022-0240
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Article ; Online: The alternate ligand Jagged enhances the robustness of Notch signaling patterns.

Mukherjee, Mrinmoy / Levine, Herbert

Soft matter

2023 Volume 19, Issue 26, Page(s) 4859–4868

Abstract: The Notch pathway, an example of juxtacrine signaling, is an evolutionary conserved cell-cell communication mechanism. It governs emergent spatiotemporal patterning in tissues during development, wound healing and tumorigenesis. Communication occurs when ...

Abstract	The Notch pathway, an example of juxtacrine signaling, is an evolutionary conserved cell-cell communication mechanism. It governs emergent spatiotemporal patterning in tissues during development, wound healing and tumorigenesis. Communication occurs when Notch receptors of one cell bind to either of its ligands, Delta/Jagged of the neighboring cell. In general, Delta-mediated signaling drives neighboring cells to have an opposite fate (lateral inhibition) whereas Jagged-mediated signaling drives cells to maintain similar fates (lateral induction). Here, by deriving and solving a reduced set of 12 coupled ordinary differential equations for the Notch-Delta-Jagged system on a hexagonal grid of cells, we determine the allowed states across different parameter sets. We also show that Jagged (at low dose) acts synergistically with Delta to enable more robust pattern formation by making the neighboring cell states more distinct from each other, despite its lateral induction property. Our findings extend our understanding of the possible synergistic role of Jagged with Delta which had been previously proposed through experiments and models in the context of chick inner ear development. Finally, we show how Jagged can help to expand the bistable (both uniform and hexagon phases are stable) region, where a local perturbation can spread over time in an ordered manner to create a biologically relevant, perfectly ordered lateral inhibition pattern.
MeSH term(s)	Ligands ; Membrane Proteins/metabolism ; Calcium-Binding Proteins/metabolism ; Signal Transduction ; Cell Communication
Chemical Substances	Ligands ; Membrane Proteins ; Calcium-Binding Proteins
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d2sm01508k
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