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Artikel: Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines.

Li, Ru / Mukherjee, Mousumi Beto / Lin, Jun

2022 Band 14, Heft 5

Abstract: Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that impair immune cell functions and promote tumor progression. Mounting evidence indicates that cytokines and chemokines in the tumor microenvironment alter MDSCs. Various cytokines ... ...

Abstract	Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that impair immune cell functions and promote tumor progression. Mounting evidence indicates that cytokines and chemokines in the tumor microenvironment alter MDSCs. Various cytokines and chemokines are involved in MDSC production, their infiltration into tumors, and their exertion of suppressive functions. Here, we consider those cytokines, chemokines, and MDSCs as an intricately connected, complex system and we focus on how tumors manipulate the MDSCs through various cytokines and chemokines. We also discuss treatment capitalizing on cytokines/chemokine signaling aimed at combating the potent immunosuppressive activities of MDSCs to improve disease outcomes.
Sprache	Englisch
Erscheinungsdatum	2022-02-27
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14051236
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Development of Non-ionic Surfactant and Protein-Coated Ultrasmall Silver Nanoparticles: Increased Viscoelasticity Enables Potency in Biological Applications.

Mukherjee, Mousumi / Gangopadhyay, Kaustav / Das, Rahul / Purkayastha, Pradipta

ACS omega

2020 Band 5, Heft 15, Seite(n) 8999–9006

Abstract: To enhance the interactivity with biological cells, we developed ultrasmall (5 nm in diameter) Ag NPs coated with a mixture of Tween-20 (Tw-20) surfactant and human serum albumin (HSA) or hemoglobin (Hb) proteins. These were tested with cancerous and ... ...

Abstract	To enhance the interactivity with biological cells, we developed ultrasmall (5 nm in diameter) Ag NPs coated with a mixture of Tween-20 (Tw-20) surfactant and human serum albumin (HSA) or hemoglobin (Hb) proteins. These were tested with cancerous and healthy cell lines to investigate the therapeutic applicability. Using the established concept of generation of reactive oxygen species (ROS) and the ROS-induced oxidative stress in carcinogenic cells by Ag NPs, we found that the presently synthesized Ag NPs selectively destroyed the cancerous cells. A mixture of Tw-20 with protein, where the surfactant was in large excess, created a coating over the Ag NPs resulting weaker protein-protein interactions and facilitating interfacial protein-surfactant interactions, which leads to an increase in the film viscoelasticity to enhance the stability of the Ag NPs and cell viability. Moreover, this concept has been applied to drug delivery using a model fluorophore (fluorescein) on Ag NPs to explore the prospects in photodynamic therapy. The results are encouraging and deserve further investigation.
Sprache	Englisch
Erscheinungsdatum	2020-04-10
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.0c00825
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The Potential Effect of General Anesthetics in Cancer Surgery: Meta-Analysis of Postoperative Metastasis and Inflammatory Cytokines.

Li, Ru / Mukherjee, Mousumi Beto / Jin, Zhaosheng / Liu, Hengrui / Lin, Kevin / Liu, Qiuyue / Dilger, James P / Lin, Jun

Cancers

2023 Band 15, Heft 10

Abstract: Metastasis or recurrence following curative surgery is the main indicator of tumor progress and is the main cause of patient death. For more than three decades, the potential for general anesthesia to affect cancer outcomes has been a subject of concern ... ...

Abstract	Metastasis or recurrence following curative surgery is the main indicator of tumor progress and is the main cause of patient death. For more than three decades, the potential for general anesthesia to affect cancer outcomes has been a subject of concern with considerable research interest. Here, we conducted this systematic review and meta-analysis to summarize the effect of inhalational anesthesia (IHNA) vs. propofol-based total intravenous anesthesia (TIVA) on metastasis and recurrence after cancer surgery from clinical and pre-clinical studies. The relative risk for metastasis/recurrence in TIVA is 0.61 (95% confidence interval (95% CI) 0.46 to 0.82,
Sprache	Englisch
Erscheinungsdatum	2023-05-15
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15102759
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Zein-Alginate-Phosphatidylcholine Nanocomplex Efficiently Delivers Lycopene and Lutein over Dietary-Derived Carotenoid Mixed Micelles in Caco-2 Cells.

Shwetha, Hulikere Jagdish / Arathi, Bangalore Prabhashankar / Beto Mukherjee, Mousumi / Ambedkar, Rudrappa / Shivaprasad, Shilpa / Raichur, Ashok M / Lakshminarayana, Rangaswamy

Journal of agricultural and food chemistry

2022

Abstract: This study evaluated the potency of zein-alginate-phosphatidylcholine nanoparticles (NPs) on bioaccessibility/intestinal uptake of encapsulated lycopene (LY) and lutein (LT) versus dietary absorption using simulated digestion and human intestinal Caco-2 ... ...

Abstract	This study evaluated the potency of zein-alginate-phosphatidylcholine nanoparticles (NPs) on bioaccessibility/intestinal uptake of encapsulated lycopene (LY) and lutein (LT) versus dietary absorption using simulated digestion and human intestinal Caco-2 cells. LY-zein-alginate-PC (LYZAP) and LT-zein-alginate-PC (LTZAP) NPs yield desired properties, which exhibit sustained release and are suitable for oral administration. Interestingly, co-treatment of LYZAP + LTZAP showed better release of carotenoids instead of individual treatment at intestinal pH. Bioaccessibility, cellular uptake, and basolateral secretion of LY and LT from NPs were significantly enhanced than micellar carotenoids (dietary mode of absorption). The increased absorption of carotenoids from NPs correlated with triglyceride levels. The intestinal cell uptake of carotenoids by nanoencapsulation may be due to endocytosis, paracellular, and SRB-1 protein-mediated transport. Overall, LYZAP and LTZAP NPs possess superior properties to control the release and cellular uptake of unique or distinct carotenoids. The inclusion of alginate and phosphatidylcholine in zein-based nanoencapsulation could be a promising strategy to improve carotenoid bioavailability.
Sprache	Englisch
Erscheinungsdatum	2022-12-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c05008
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Galactose Functionalized Mesoporous Silica Nanoparticles As Delivery Vehicle in the Treatment of Hepatitis C Infection.

Mukherjee, Mousumi Beto / Mullick, Ranajoy / Reddy, B Uma / Das, Saumitra / Raichur, Ashok M

ACS applied bio materials

2020 Band 3, Heft 11, Seite(n) 7598–7610

Abstract: DNA and RNA based antiviral strategies using nonviral vectors have shown better potential over the viral pathway due to the fewer chances of gene recombination and immunogenicity. In this work a mesoporous silica nanoparticle (MSN) based carrier system ... ...

Abstract	DNA and RNA based antiviral strategies using nonviral vectors have shown better potential over the viral pathway due to the fewer chances of gene recombination and immunogenicity. In this work a mesoporous silica nanoparticle (MSN) based carrier system has been used for targeted delivery of shDNA molecule against the conserved 5'-untranslated region (UTR) in the RNA of a hepatitis C virus to inhibit its replication. The MSNs coated with amine and galactose could specifically target liver cells. Significant reduction (about 94%) of viral RNA level was achieved in HCV-JFH1 infectious cell culture compared to the control RNA levels directed the successful delivery and action of the shDNA. This study showed that Gal-AMSN can be used as a synthetic delivery vector to deliver the shDNA effectively for the treatment of HCV infection.
Sprache	Englisch
Erscheinungsdatum	2020-10-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.0c00814
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Fabrication of chitosan nanoparticles with phosphatidylcholine for improved sustain release, basolateral secretion, and transport of lutein in Caco-2 cells.

Shwetha, Hulikere Jagdish / Shilpa, Shivaprasad / Mukherjee, Mousumi Beto / Ambedkar, Rudrappa / Raichur, Ashok M / Lakshminarayana, Rangaswamy

International journal of biological macromolecules

2020 Band 163, Seite(n) 2224–2235

Abstract: Biopolymers-based nanoparticles delivery emerged alternatively to improve nutraceuticals and drug bioavailability. The intestinal physiology suggested a prerequisite of lipid moiety for carotenoid absorption. This study aimed to fabricate chitosan-based ... ...

Abstract	Biopolymers-based nanoparticles delivery emerged alternatively to improve nutraceuticals and drug bioavailability. The intestinal physiology suggested a prerequisite of lipid moiety for carotenoid absorption. This study aimed to fabricate chitosan-based nanoparticles with phosphatidylcholine (PC) to enhance lutein bioavailability. Lutein encapsulated chitosan nanoparticles with PC (LCNPC) or without PC (LCN) were assessed for bioaccessibility, sustain release, cellular uptake/internalization, and basolateral secretion of lutein in Caco-2 cells. Standard lutein mixed micelles (LMM), and micelles derived through in vitro digestion of green leafy vegetables (GMM) treated as controls. The LCNPC showed reduced particle size, higher colloidal stability, homogeneous dispersion, and suitable for oral administration compared to LCN. The cellular uptake of lutein (20 h) in LCNPC was higher than LCN, LMM, and GMM, respectively. Interestingly, lutein uptake was maximum at 8 h in LMM and gradually decreased against sustain-release response in LCNPC and LCN, whereas considerably low lutein uptake from GMM at all time points. Further, LCNPC significantly increased basolateral secretion of triglyceride (TG) and positively correlated enhanced lutein uptake/internalization process than LCN and micelles. Also, LCNPC demonstrated the upregulation of endocytosis, paracellular, scavenger receptor class B type 1 (SRB-1), and peroxisome proliferator-activated receptor gamma (PPARγ) mediated lutein transport mechanism. These results suggested that fabrication of biopolymer-based nanoparticles with PC could provide greater insight to improve lutein bioavailability at enterocyte levels, to avoid age-related macular degeneration and other chronic diseases.
Mesh-Begriff(e)	Biological Availability ; Biopolymers/chemistry ; Biopolymers/pharmacology ; Caco-2 Cells ; Chitosan/chemistry ; Chitosan/pharmacology ; Humans ; Lutein/chemistry ; Lutein/pharmacology ; Nanoparticles/chemistry ; Phosphatidylcholines/chemistry ; Phosphatidylcholines/pharmacology
Chemische Substanzen	Biopolymers ; Phosphatidylcholines ; Chitosan (9012-76-4) ; Lutein (X72A60C9MT)
Sprache	Englisch
Erscheinungsdatum	2020-09-09
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.09.040
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Fabrication of chitosan nanoparticles with phosphatidylcholine for improved sustain release, basolateral secretion, and transport of lutein in Caco-2 cells

Shwetha, Hulikere Jagdish / Shilpa, Shivaprasad / Mukherjee, Mousumi Beto / Ambedkar, Rudrappa / Raichur, Ashok M / Lakshminarayana, Rangaswamy

International journal of biological macromolecules. 2020 Nov. 15, v. 163

2020

Abstract	Biopolymers-based nanoparticles delivery emerged alternatively to improve nutraceuticals and drug bioavailability. The intestinal physiology suggested a prerequisite of lipid moiety for carotenoid absorption. This study aimed to fabricate chitosan-based nanoparticles with phosphatidylcholine (PC) to enhance lutein bioavailability. Lutein encapsulated chitosan nanoparticles with PC (LCNPC) or without PC (LCN) were assessed for bioaccessibility, sustain release, cellular uptake/internalization, and basolateral secretion of lutein in Caco-2 cells. Standard lutein mixed micelles (LMM), and micelles derived through in vitro digestion of green leafy vegetables (GMM) treated as controls. The LCNPC showed reduced particle size, higher colloidal stability, homogeneous dispersion, and suitable for oral administration compared to LCN. The cellular uptake of lutein (20 h) in LCNPC was higher than LCN, LMM, and GMM, respectively. Interestingly, lutein uptake was maximum at 8 h in LMM and gradually decreased against sustain-release response in LCNPC and LCN, whereas considerably low lutein uptake from GMM at all time points. Further, LCNPC significantly increased basolateral secretion of triglyceride (TG) and positively correlated enhanced lutein uptake/internalization process than LCN and micelles. Also, LCNPC demonstrated the upregulation of endocytosis, paracellular, scavenger receptor class B type 1 (SRB-1), and peroxisome proliferator-activated receptor gamma (PPARγ) mediated lutein transport mechanism. These results suggested that fabrication of biopolymer-based nanoparticles with PC could provide greater insight to improve lutein bioavailability at enterocyte levels, to avoid age-related macular degeneration and other chronic diseases.
Schlagwörter	absorption ; bioavailability ; chitosan ; dietary supplements ; digestion ; drugs ; endocytosis ; intestines ; lutein ; macular degeneration ; micelles ; moieties ; oral administration ; particle size ; peroxisome proliferator-activated receptor gamma ; phosphatidylcholines ; secretion ; triacylglycerols
Sprache	Englisch
Erscheinungsverlauf	2020-1115
Umfang	p. 2224-2235.
Erscheinungsort	Elsevier B.V.
Dokumenttyp	Artikel
Anmerkung	NAL-AP-2-clean
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.09.040
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Au–Ag bimetallic nanoparticles, binary and ternary mixed micelles as active catalysts for the reduction of [Co(NH₃)₅Br](NO₃)₂ by iron(II)

Mukherjee, Mousumi / Mahapatra, Ambikesh

Colloids and surfaces. 2013 Aug. 5, v. 430

2013

Abstract: The kinetics of reduction of [Co(NH₃)₅Br](NO₃)₂ by Mohr's salt has been studied in presence of Au–Ag bimetallic nanoparticle, binary, and ternary mixed micelles. The Au–Ag bimetallic nanoparticles with mole ratio of 0.75:0.25 show higher catalytic ... ...

Abstract	The kinetics of reduction of [Co(NH₃)₅Br](NO₃)₂ by Mohr's salt has been studied in presence of Au–Ag bimetallic nanoparticle, binary, and ternary mixed micelles. The Au–Ag bimetallic nanoparticles with mole ratio of 0.75:0.25 show higher catalytic activity than that of Au nanoparticles of same particle size. The higher catalytic activity of the bimetallic nanoparticles is mainly for electronic charge transfer from adjacent Ag to Au atoms. The effects of binary mixed micellar environments of anionic with non-ionic surfactants (SDS/TX-100, SDS/Tween 80 and SDS/Brij 35) and ternary (SDS/Tween 20/Brij 35) mixed micellar environment on the electron transfer rate have been determined. These effects are attributed to the effect of the coulombic interactions and compared with that of pure ones. Above the CMC of the mixed micellar systems, the effects are explained quantitatively using a kinetic model.
Schlagwörter	catalysts ; catalytic activity ; colloids ; electron transfer ; gold ; iron ; micelles ; models ; nanogold ; nanoparticles ; nonionic surfactants ; particle size ; polysorbates
Sprache	Englisch
Erscheinungsverlauf	2013-0805
Umfang	p. 13-20.
Erscheinungsort	Elsevier B.V.
Dokumenttyp	Artikel
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2013.03.062
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Teaching in the Age of Covid-19

Jandrić, Petar Hayes / David, Truelove / Ian, Levinson / Paul, Mayo / Peter, Ryberg / Thomas, Monzó Lilia D. / Allen, Quaylan / Stewart, Paul Alexander / Carr, Paul R. / Jackson, Liz / Bridges, Susan / Escaño, Carlos / Grauslund, Dennis / Mañero, Julia / Lukoko, Happiness Onesmo / Bryant, Peter / Fuentes-Martinez, Ana / Gibbons, Andrew / Sturm, Sean /

Rose, Jennifer / Chuma, Mohamed Muhibu / Biličić, Eva Pfohl / Sarah, Gustafsson / Ulrika, Arantes / Janine Aldous, Ford / Derek, R. / Kihwele, Jimmy Ezekiel / Mozelius, Peter / Suoranta, Juha / Jurjević, Lucija Jurčević Matija Steketee / Anne, Irwin / Jones, White / E. Jayne, Davidsen / Jacob, Jaldemark / Jimmy, Abegglen / Sandra, Burns / Tom, Sinfield / Sandra, Kirylo / James, D. / Kokić, Ivana Batarelo Stewart / Georgina Tuari, Rikowski / Glenn, Christensen / Line Lisberg, Arndt / Sonja, Pyyhtinen / Olli, Reitz / Charles, Lodahl / Mikkel, Humble / Niklas, Buchanan / Rachel, Forster / Daniella, J. / Kishore, Pallavi / Ozoliņš, Jānis John Sharma / Navreeti, Urvashi / Shreya, Nejad / Harry, G. / Hood, Nina / Tesar, Marek / Wang, Yang / Wright, Jake / Brown, James Benedict / Prinsloo, Paul / Kaur, Kulpreet / Mukherjee, Mousumi / Novak, Rene / Shukla, Richa / Hollings, Stephanie / Konnerup, Ulla / Mallya, Madhav / Olorundare, Anthony / Achieng-Evensen, Charlotte / Philip, Abey P. / Hazzan, Moses Kayode / Stockbridge, Kevin / Komolafe, Blessing Funmi / Bolanle, Ogunyemi Folasade / Hogan, Michael / Redder, Bridgette / Sattarzadeh, Sahar D. / Jopling, Michael / SooHoo, Suzanne / Devine, Nesta / Hayes, Sarah

Postdigital Science and Education

Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #705681
Datenquelle	COVID19

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Artikel ; Online: Teaching in the Age of Covid-19

Jandri?, Petar / Hayes, David / Truelove, Ian / Levinson, Paul / Mayo, Peter / Ryberg, Thomas / Monzó, Lilia D. / Allen, Quaylan / Stewart, Paul Alexander / Carr, Paul R. / Jackson, Liz / Bridges, Susan / Escaño, Carlos / Grauslund, Dennis / Mañero, Julia / Lukoko, Happiness Onesmo / Bryant, Peter / Fuentes-Martinez, Ana / Gibbons, Andrew /

Sturm, Sean / Rose, Jennifer / Chuma, Mohamed Muhibu / Biličić, Eva / Pfohl, Sarah / Gustafsson, Ulrika / Arantes, Janine Aldous / Ford, Derek R. / Kihwele, Jimmy Ezekiel / Mozelius, Peter / Suoranta, Juha / Jurjević, Lucija / Jurčević, Matija / Steketee, Anne / Irwin, Jones / White, E. Jayne / Davidsen, Jacob / Jaldemark, Jimmy / Abegglen, Sandra / Burns, Tom / Sinfield, Sandra / Kirylo, James D. / Kokić, Ivana Batarelo / Stewart, Georgina Tuari / Rikowski, Glenn / Christensen, Line Lisberg / Arndt, Sonja / Pyyhtinen, Olli / Reitz, Charles / Lodahl, Mikkel / Humble, Niklas / Buchanan, Rachel / Forster, Daniella J. / Kishore, Pallavi / Ozoliņš, Jānis John / Sharma, Navreeti / Urvashi, Shreya / Nejad, Harry G. / Hood, Nina / Tesar, Marek / Wang, Yang / Wright, Jake / Brown, James Benedict / Prinsloo, Paul / Kaur, Kulpreet / Mukherjee, Mousumi / Novak, Rene / Shukla, Richa / Hollings, Stephanie / Konnerup, Ulla / Mallya, Madhav / Olorundare, Anthony / Achieng-Evensen, Charlotte / Philip, Abey P / Hazzan, Moses Kayode / Stockbridge, Kevin / Komolafe, Blessing Funmi / Bolanle, Ogunyemi Folasade / Hogan, Michael / Redder, Bridgette / Sattarzadeh, Sahar D. / Jopling, Michael / SooHoo, Suzanne / Devine, Nesta / Hayes, Sarah

2020

Schlagwörter	COVID-19 ; Coronavirus ; covid19
Sprache	Englisch
Erscheinungsdatum	2020-01-01
Erscheinungsland	au
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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