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  1. Book ; Online ; E-Book: Nanoparticles in Angiogenesis and Cancer

    Mukherjee, Sudip / Madamsetty, Vijay Sagar

    (Synthesis Lectures on Biomedical Engineering,)

    2022  

    Abstract: This book highlights recent developments of organic and inorganic nanomedicine that play a major role in anti-angiogenic cancer therapy. In addition, the authors present examples of nanomedicine based anti-angiogenic agents and their applications in ... ...

    Author's details by Sudip Mukherjee, Vijay Sagar Madamsetty
    Series title Synthesis Lectures on Biomedical Engineering,
    Synthesis lectures on biomedical engineering
    Collection Synthesis lectures on biomedical engineering
    Abstract This book highlights recent developments of organic and inorganic nanomedicine that play a major role in anti-angiogenic cancer therapy. In addition, the authors present examples of nanomedicine based anti-angiogenic agents and their applications in cancer therapy. Angiogenesis is a pathophysiological phenomenon that modulates cell proliferation and cell migration and plays important roles in cancer. Anti-angiogenic nanotherapies have gained immense attention in recent times as alternative cost-effective therapies that opened a new dimension in cancer theranostics. Further the challenges of the anti-angiogenic nanotherapies and possible future perspective are detailed.
    Keywords Nanomedicine ; Nanotechnology ; Cancer ; Blood-vessels/Growth ; Nanomedicine and Nanotoxicology ; Impact of Nanotechnology ; Cancer Nanotechnology ; Angiogenesis
    Subject code 612.13
    Language English
    Size 1 online resource (85 pages)
    Edition 1st ed. 2022.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-11284-9 ; 9783031112836 ; 978-3-031-11284-3 ; 3031112830
    DOI 10.1007/978-3-031-11284-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Emerging trends in immunomodulatory nanomaterials toward cancer therapy

    Mukherjee, Anubhab / Madamsetty, Vijay Sagar / Mukherjee, Sudip

    2022  

    Author's details Anubhab Mukherjee, Vijay Sagar Madamsetty and Sudip Mukherjee
    MeSH term(s) Nanostructures/therapeutic use. ; Neoplasms/therapy. ; Immunomodulation.
    Keywords Nanostructured materials/Therapeutic use.
    Subject code 610.28
    Language English
    Size 1 online resource (95 pages)
    Publisher Springer Nature Switzerland AG
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-01669-6 ; 3-031-00048-X ; 3-031-00541-4 ; 978-3-031-01669-1 ; 978-3-031-00048-5 ; 978-3-031-00541-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Noise cross correlations can induce instabilities in coupled driven models.

    Mukherjee, Sudip

    Physical review. E

    2023  Volume 108, Issue 2-1, Page(s) 24219

    Abstract: We study the effects of noise cross correlations on the steady states of driven, nonequilibrium systems, which are described by two stochastically driven dynamical variables, in one dimension. We use a well-known stochastically driven coupled model with ... ...

    Abstract We study the effects of noise cross correlations on the steady states of driven, nonequilibrium systems, which are described by two stochastically driven dynamical variables, in one dimension. We use a well-known stochastically driven coupled model with two dynamical variables, where one of the variables is autonomous, being independent of the other, whereas the second one depends explicitly on the former. Introducing cross correlations of the two noises in the two dynamical equations, we show that depending upon the details of the nonlinear coupling between the dynamical fields, such cross correlations can induce instabilities in the models that are otherwise stable in the absence of any cross correlations. We argue that this is reminiscent of the roughening transition found in the Kardar-Parisi-Zhang equation in dimensions greater than two. Phenomenological implications of our results are discussed.
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.108.024219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; E-Book: Biogenic Nanoparticles for Cancer Theranostics

    Patra, Chittaranjan / Ahmad, Irshad / Ayaz, Muhammad / Khalil, Ali Talha / Mukherjee, Sudip / Ovais, Muhammad

    (Micro and Nano Technologies)

    2021  

    Abstract: Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery ... ...

    Series title Micro and Nano Technologies
    Abstract Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and other biological effects. Additionally, the book explores the mechanism of their penetration in cancerous tissue, its clearance, and its metabolism. Moreover, the in vitro and in vivo toxicological effects of biogenic nanoparticles are discussed. This book is an important reference source for materials scientists and biomedical scientists who are looking to increase their understanding of how biogenic nanoparticles are being used for a range of cancer treatment types.
    Keywords Neoplasms/drug therapy ; Antineoplastic agents
    Subject code 616.994069
    Language English
    Size 1 online resource (286 pages)
    Publisher Elsevier
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-821467-8 ; 978-0-12-821467-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Role of quantum fluctuation in inducing ergodicity in the spin glass phase and its effect in quantum annealing.

    Mukherjee, Sudip

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2022  Volume 381, Issue 2241, Page(s) 20210406

    Abstract: We review the numerical studies on the critical behaviour of the quantum Sherrington-Kirkpatrick (SK) spin glass model, which indicate that a quantum critical behaviour is observed up to a low but non-zero value of temperature. We revisit the numerical ... ...

    Abstract We review the numerical studies on the critical behaviour of the quantum Sherrington-Kirkpatrick (SK) spin glass model, which indicate that a quantum critical behaviour is observed up to a low but non-zero value of temperature. We revisit the numerical investigations on the spin glass order parameter distributions, which identify a low temperature along with high transverse field spin glass phase where the order parameter distribution becomes a delta function in the thermodynamic limit indicating the restoration of replica symmetry and ergodic nature of the system. In the remaining spin glass phase associated with high temperature and low transverse field, the observed distribution is broad akin to the Parisi order parameter distribution. This essentially indicates the non-ergodic behaviour of the system. We further discuss the annealing dynamics studies on the quantum SK model. Such investigations reveal the system size independence of annealing time when the annealing paths go through the ergodic spin glass region. Interestingly, when such dynamics are performed in the non-ergodic spin glass phase the annealing time becomes an increasing function of the system size. Spin autocorrelation shows faster relaxation in the ergodic spin glass region compared with that found in the non-ergodic spin glass region. This article is part of the theme issue 'Quantum annealing and computation: challenges and perspectives'.
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2021.0406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/25: Show issues
    Z PHI 2: Show issues

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  6. Article ; Online: Conserved Kardar-Parisi-Zhang equation: Role of quenched disorder in determining universality.

    Mukherjee, Sudip

    Physical review. E

    2021  Volume 103, Issue 4-1, Page(s) 42102

    Abstract: We study the stochastically driven conserved Kardar-Parisi-Zhang (CKPZ) equation with quenched disorders. Short-ranged quenched disorders are found to be a relevant perturbation on the pure CKPZ equation at one dimension and, as a result, a different ... ...

    Abstract We study the stochastically driven conserved Kardar-Parisi-Zhang (CKPZ) equation with quenched disorders. Short-ranged quenched disorders are found to be a relevant perturbation on the pure CKPZ equation at one dimension and, as a result, a different universality class different from pure CKPZ equation appears to emerge. At higher dimensions, quenched disorder turns out to be ineffective to influence the universal scaling. This results in the asymptotic long wavelength scaling to be given by the linear theory, a scenario identical with the pure CKPZ equation. For sufficiently long-ranged quenched disorders, the universal scaling is impacted by the quenched disorder even at higher dimensions.
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.103.042102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Recent progress toward antiangiogenesis application of nanomedicine in cancer therapy.

    Mukherjee, Sudip

    Future science OA

    2018  Volume 4, Issue 7, Page(s) FSO318

    Language English
    Publishing date 2018-06-28
    Publishing country England
    Document type Editorial
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.4155/fsoa-2018-0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rough or crumpled: Phases in kinetic growth with surface relaxation.

    Mukherjee, Sudip / Basu, Abhik

    Physical review. E

    2022  Volume 106, Issue 2, Page(s) L022102

    Abstract: We show that generic kinetic growth processes with surface relaxations can exhibit a hitherto unexplored crumpled phase with short-range orientational order at dimensions d<4. A sufficiently strong spatially nonlocal part of the chemical potential ... ...

    Abstract We show that generic kinetic growth processes with surface relaxations can exhibit a hitherto unexplored crumpled phase with short-range orientational order at dimensions d<4. A sufficiently strong spatially nonlocal part of the chemical potential associated with the particle current above a threshold in the system can trigger this crumpling. The system can also be in a perturbatively accessible rough phase with long-range orientational order but short-range positional order at d<4 with known scaling exponents. Intriguingly, in d>4 we argue that there is no crumpling transition; instead, there is a roughening transition from a smooth to a rough phase for large enough nonlocal particle chemical potential. Experimental and theoretical implications of these results are discussed.
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.106.L022102
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  9. Article ; Online: Small molecule conjugation reduces macrophage uptake and increases in vivo blood circulation of polystyrene nanoparticles.

    Yenurkar, Devyani / Ruocco, Maria / Pragya, Pragya / Liang, Lily / Mukherjee, Sudip

    Biomedical materials (Bristol, England)

    2024  

    Abstract: Nanomedicine often failed clinically to show therapeutic efficacy due to reduced particle circulation and enhanced capture by the reticuloendothelial system (RES), including the liver. Developing novel immunomodulatory surface coating can prevent ... ...

    Abstract Nanomedicine often failed clinically to show therapeutic efficacy due to reduced particle circulation and enhanced capture by the reticuloendothelial system (RES), including the liver. Developing novel immunomodulatory surface coating can prevent macrophage capture and increase the particle circulation of the nanomedicine, resulting in higher therapeutic efficiency. Herein, we demonstrate the development of immunomodulatory small molecule (RZA15) with triazole functionality using copper-catalyzed click chemistry to conjugate onto spherical polystyrene nanoparticles using amide coupling reactions, achieving higher blood circulation and lesser macrophage uptake of the nanoconjugates. In this work, we evaluated the effectiveness of RZA15 coating for the enhanced circulation of polystyrene nanoparticles of 100 nm size, which is commonly utilized for various drug delivery applications, and compared with poly(ethylene)glycol (PEG) coatings. Several polystyrene nanoconjugate formulations were analyzed in vitro in normal and macrophage cells for cell viability and cellular uptake studies. In vitro studies demonstrated lesser macrophage uptake of the nanoconjugates following RZA15 coating. Finally, in vivo, blood-circulation, pharmacokinetics, and biodistribution studies were performed in the C57BL/6J mouse model that endorsed the substantial role of RZA15 in preventing liver and spleen capture and results in extended circulation. Coating immunomodulatory small molecules to nanoparticles can severely enhance the potential therapeutic effects of nanomedicine at lower doses.
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/ad1df8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6626: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Small molecular adjuvants repurpose antibiotics towards Gram-negative bacterial infections and multispecies bacterial biofilms.

    Dey, Rajib / Mukherjee, Sudip / Mukherjee, Riya / Haldar, Jayanta

    Chemical science

    2023  Volume 15, Issue 1, Page(s) 259–270

    Abstract: Gram-negative bacterial infections pose a significant challenge due to two major resistance elements, including the impermeability of the outer membrane and the overexpression of efflux pumps, which contribute to antibiotic resistance. Additionally, the ... ...

    Abstract Gram-negative bacterial infections pose a significant challenge due to two major resistance elements, including the impermeability of the outer membrane and the overexpression of efflux pumps, which contribute to antibiotic resistance. Additionally, the coexistence of multispecies superbugs in mixed species biofilms further complicates treatment, as these infections are refractory to most antibiotics. To address this issue, combining obsolete antibiotics with non-antibiotic adjuvants that target bacterial membranes has shown promise in combating antibacterial resistance. However, the clinical translation of this cocktail therapy has been hindered by the toxicity associated with these membrane active adjuvants, mainly due to a limited understanding of their structure and mechanism of action. Towards this goal, herein, we have designed a small molecular adjuvant by tuning different structural parameters, such as the balance between hydrophilic and hydrophobic groups, spatial positioning of hydrophobicity and hydrogen bonding interactions, causing moderate membrane perturbation in bacterial cells without any toxicity to mammalian cells. Moderate membrane perturbation not only enhances the internalization of antibiotics, but also increases the intracellular concentration of drugs by hampering the efflux machinery. This revitalises the efficacy of various classes of antibiotics by 32-512 fold, without inducing toxicity. The leading combination not only exhibits potent bactericidal activity against
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc05124b
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