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Article: Aldose reductase gene polymorphism rs752010122 and retinopathy in type 2 diabetics.

Maqsood, Muntaha / Waheed, Palvasha / Rashid, Amir / Majeed, Asifa / Mukhtar, Ahsan

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 5, Page(s) 978–982

Abstract: Objectives: To investigate the association of polymorphism in rs752010122 in aldose reductase gene with the pathogenesis of diabetic retinopathy, and to determine the association and allelic frequency between the variant and the disease.: Methods: ... ...

Abstract	Objectives: To investigate the association of polymorphism in rs752010122 in aldose reductase gene with the pathogenesis of diabetic retinopathy, and to determine the association and allelic frequency between the variant and the disease. Methods: The cross-sectional study was conducted from June 2021 to March 2022 at Centre for Research in Experimental and Applied Medicine (CREAM) Laboratory, Department of Biochemistry and Molecular Biology, Army Medical College, in collaboration with the Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan, and comprised blood samples from subjects of either gender aged 40-70 years. The samples were divided into group I having diabetic retinopathy patients, group II having diabetics without retinopathy, and group III having healthy controls matched for age and gender. The samples were subjected to molecular analysis. Gene sequence was downloaded from the Human Genome Database and Ensemble. Data was analysed using SPSS 22. Results: Of the 150 subjects, there were 50(33.3%) in each of the 3 groups. Variants of aldose reductase rs752010122 polymorphism were significantly associated with a lower risk of diabetic retinopathy (p<0.05). An odds ratio of 1 was noted for both heterozygous and homozygous genotypes (95% confidence interval: 1). Conclusions: Aldose reductase was associated with lower risk of the disease.
MeSH term(s)	Humans ; Aldehyde Reductase/genetics ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/genetics ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Genetic ; Male ; Female ; Adult ; Middle Aged ; Aged
Chemical Substances	Aldehyde Reductase (EC 1.1.1.21) ; AKR1B1 protein, human (EC 1.1.1.21)
Language	English
Publishing date	2023-05-12
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.6382
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Response from M Maqsood, P Waheed, A Rashid, et al. (J Pak Med Assoc. 2023; 73: 978-982) Aldose Reductase Gene Polymorphism Rs752010122 And Retinopathy In Type 2 Diabetics.

Maqsood, Muntaha / Waheed, Palvasha / Rashid, Amir / Majeed, Asifa / Mukhtar, Ahsan

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 11, Page(s) 2306

MeSH term(s)	Humans ; Aldehyde Reductase/genetics ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Polymorphism, Genetic ; Retinal Diseases
Chemical Substances	Aldehyde Reductase (EC 1.1.1.21)
Language	English
Publishing date	2023-11-16
Publishing country	Pakistan
Document type	Letter
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
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Article: Effect of Phacoemulsification on Sub Foveal Choroidal and Central Macular Thickness as measured by Swept Source Optical Coherence Tomography.

Ahmed, Javeria / Mukhtar, Ahsan / Mehboob, Mohammad Asim / Khan, Asfandyar

Pakistan journal of medical sciences

2023 Volume 39, Issue 4, Page(s) 941–944

Abstract: Objectives: To study the effect of Phacoemulsification on Sub Foveal Choroidal Thickness (SFCT) and Central Macular Thickness (CMT) as measured by Swept Source Optical Coherence Tomography (OCT).: Methods: This experimental study was conducted at ... ...

Abstract	Objectives: To study the effect of Phacoemulsification on Sub Foveal Choroidal Thickness (SFCT) and Central Macular Thickness (CMT) as measured by Swept Source Optical Coherence Tomography (OCT). Methods: This experimental study was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from April 2021 to February 2022. One hundred eyes of 100 patients with age related cataract underwent uneventful phacoemulsification surgery. Pre-operative SFCT and CMT was measured and compared with SFCT and CMT at one week, one month and three months after surgery using swept source OCT. Results: Mean age of study population was 56.76±8.31 years. Out of 100 patients, 46 (46%) were males and 54 (54%) were females. Mean pre-operative CMT, one week, one month and three months post-operative CMT was 233.95±9.46 μm, 232.88±8.59 μm, 230.38±10.62 μm and 230.67±7.55 μm respectively. Mean pre-operative SFCT, one week, one month and three months post-operative SFCT was 337.14±8.41 μm, 339.14±9.63 μm, 339.39±11.96 μm and 351.39±9.19 μm respectively. The difference of mean change in CMT from baseline at one week, one month and three months post-operatively was not statistically significant. The difference of mean change in SFCT from baseline at one week and one month post-operatively was not statistically significant. However, the difference of mean change in SFCT from baseline at three months post-operatively was statistically significant (p<0.05). Conclusion: Uneventful phacoemulsification surgery does not have any effect on central macular thickness, however there is a significant increase in subfoveal choroidal thickness at three months after surgery.
Language	English
Publishing date	2023-08-08
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.39.4.6322
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Article: Efficacy of YAG Laser Embolysis in Retinal Artery Occlusion.

Mehboob, Mohammad Asim / Khan, Asfandyar / Mukhtar, Ahsan

Pakistan journal of medical sciences

2020 Volume 37, Issue 1, Page(s) 71–75

Abstract: Objective: To compare the anatomical and functional success between conventional medical method and Neodymium-Doped Yttrium Aluminum Garnet (Nd:YAG) laser embolysis in retinal artery occlusion.: Methods: This randomized control trial was conducted at ...

Abstract	Objective: To compare the anatomical and functional success between conventional medical method and Neodymium-Doped Yttrium Aluminum Garnet (Nd:YAG) laser embolysis in retinal artery occlusion. Methods: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi from July 2018 to May 2020. A total of 14 eyes of 14 patients were received with fovea involving branch or hemiretinal artery occlusion within 24 hours of onset of symptoms. They were divided randomly in two groups. Initial treatment was given to all cases, and seven eyes received Nd:YAG laser treatment for embolysis. Both groups were analysed for anatomical success (reperfusion) and functional success (defined as improvement in visual acuity to better than 6/60 on Snellen's visual acuity chart from baseline visual acuity). Results: In conventional group, anatomical success was achieved in 2 (28.6%) eyes, while significant visual improvement was seen in 3 (42.8%) eyes. In Nd:YAG laser embolysis group, anatomical success was achieved in 5 (71.4%) eyes, while significant visual improvement was seen in 6 (85.7%) eyes. All eyes which showed functional improvement underwent Nd:YAG laser embolysis within 6 hours of onset of symptoms. Conclusions: Nd: YAG laser embolysis is more effective in management of fovea threatening retinal artery occlusion, as compared to conventional medical treatment, if performed within six hours of onset of symptoms.
Language	English
Publishing date	2020-10-29
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.37.1.3196
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Article ; Online: High Altitude Retinopathy Presenting as Central Retinal Vein Occlusion in a Soldier.

Raja, Waseem / Mukhtar, Ahsan

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2017 Volume 27, Issue 12, Page(s) 780–782

Abstract: A 33-year soldier, deployed at an altitude of 3,350 meters for two years, developed unilateral Central Retinal Vein Occlusion (CRVO) in the left eye. He had no risk factor for thrombosis and all thrombophilia screenings were negative. The patient was ... ...

Abstract	A 33-year soldier, deployed at an altitude of 3,350 meters for two years, developed unilateral Central Retinal Vein Occlusion (CRVO) in the left eye. He had no risk factor for thrombosis and all thrombophilia screenings were negative. The patient was managed with intravitreal injections of anti-VEGF (Bevacizumab) every four weeks. He showed gradual improvement in the visual acuity over the next 3 months. Best corrected visual acuity (BCVA) after three months was 6/7.5; whereas, initially it was limited to hand movements only. This case illustrates that prolonged exposure to high altitude is a risk factor for CRVO, too. Frequent eye examination, including fundus, should be carried out among people living at such altitudes.
MeSH term(s)	Adult ; Altitude ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/administration & dosage ; Bevacizumab/therapeutic use ; Humans ; Intravitreal Injections ; Male ; Military Personnel ; Retinal Vein Occlusion/drug therapy ; Treatment Outcome
Chemical Substances	Angiogenesis Inhibitors ; Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2017-12
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	2773
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Article ; Online: Ocular Features in a Case of Nevus of Ota.

Junejo, Murtaza Sameen / Khan, Muhammad Saim / Mukhtar, Ahsan

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2017 Volume 27, Issue 3, Page(s) S56–S57

Abstract: Oculodermal melanocytosis, also known as Nevus of Ota, is a hamartomatous melanocytic nevus of dermal melanocytes. It presents as a bluish grey patch on the face, which may be congenital or acquired involving the area of distribution of the ophthalmic ... ...

Abstract	Oculodermal melanocytosis, also known as Nevus of Ota, is a hamartomatous melanocytic nevus of dermal melanocytes. It presents as a bluish grey patch on the face, which may be congenital or acquired involving the area of distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The nevus can be unilateral or bilateral, and, in addition to skin, it may involve ocular and oral mucosal surfaces. It is a rare disorder and the ocular complications, such as glaucoma and melanoma, may be vision or life-threatening. Here, we report a 26-year male who presented with decreased vision in his left eye. On detailed examination, he turned out to be a case of nevus of Ota.
Language	English
Publishing date	2017-03
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	255
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Article: Change in central corneal thickness, corneal endothelial cell density, anterior chamber depth and axial length after repair of rhegmatogenous retinal detachment.

Mukhtar, Ahsan / Mehboob, Mohammad Asim / Babar, Zaheer Uddin / Ishaq, Mazhar

Pakistan journal of medical sciences

2018 Volume 33, Issue 6, Page(s) 1412–1417

Abstract: Objective: To compare the effects of Pars Plana Vitrectomy (PPV) and Scleral Buckling (SB) with reference to Central Corneal Thickness (CCT), Corneal Endothelial-Cell Density (CED), Anterior Chamber Depth (ACD) and Axial Length (AL) in repair of ... ...

Abstract	Objective: To compare the effects of Pars Plana Vitrectomy (PPV) and Scleral Buckling (SB) with reference to Central Corneal Thickness (CCT), Corneal Endothelial-Cell Density (CED), Anterior Chamber Depth (ACD) and Axial Length (AL) in repair of Rhegmatogenous Retinal Detachment (RRD). Methods: This comparative cross sectional analytical study was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from July 2013 to July 2015. A total of 69 eyes of 69 patients which underwent repair of RRD by either PPV or SB were analyzed to compare mean change in CCT, CED, ACD and AL between two groups. Results: Mean age of patients was 56.23±5.22 years. Mean pre-operative CCT, CED, ACD and AL in PPV group was 533.06±13.28µm, 2231.67±164.57Cells/mm Conclusion: Rhegmatogenous retinal detachment repair causes ocular changes, with significantly more decrease in corneal endothelial cell density after pars plana vitrectomy, and more increase in anterior chamber depth and axial length after scleral buckling.
Language	English
Publishing date	2018-02-13
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.336.13584
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Article: MACULAR COLOBOMA IN A CHILD WITH USHER SYNDROME.

Ishaq, Mazhar / Mukhtar, Ahsan / Khan, Saim

Journal of Ayub Medical College, Abbottabad : JAMC

2015 Volume 27, Issue 2, Page(s) 470–472

Abstract: Macular coloboma is a rare entity and its concomitance with Usher syndrome is described here. A 14 years male child was studied in detail along with other family members. He underwent two complete ophthalmologic examinations (4-years follow-up), ... ...

Abstract	Macular coloboma is a rare entity and its concomitance with Usher syndrome is described here. A 14 years male child was studied in detail along with other family members. He underwent two complete ophthalmologic examinations (4-years follow-up), including visual assessment, orthoptic evaluation, colour vision test, visual fields, corneal topography, Optical coherence tomography, fluorescein angiography, and electroretinography. Detailed ophthalmic examination was also conducted on other asymptomatic members of the same family. Patient had sensorineural deafness, poor visual acuity, and progressive visual field impairment in both eyes, bilaterally presenting macular coloboma and atypical retinitis pigmentosa pattern. The other investigated relatives did not show any specific and/or significant ocular disorder. This concurrence represents no genetic pattern and is observed in sporadic cases.
MeSH term(s)	Abnormalities, Multiple ; Adolescent ; Coloboma/diagnosis ; Diagnosis, Differential ; Electroretinography ; Humans ; Macula Lutea/abnormalities ; Male ; Tomography, Optical Coherence ; Usher Syndromes/diagnosis ; Vision Tests ; Visual Fields
Language	English
Publishing date	2015-04
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2192473-9
ISSN	1025-9589
ISSN	1025-9589
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Article ; Online: Nd YAG Laser Embolysis in a Young Woman with Hemiretinal Artery Occlusion.

Mukhtar, Ahsan / Malik, Sidra / Khan, Muhammad Saim / Ishaq, Mazhar

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2016 Volume 26, Issue 7, Page(s) 629–630

Abstract: Retinal artery occlusion is an uncommon condition but can lead to grave consequences if not managed in time. Elderly population with other comorbid conditions like hypertension, ischemic heart disease, hyperlipidemia and stroke are commonly affected. ... ...

Abstract	Retinal artery occlusion is an uncommon condition but can lead to grave consequences if not managed in time. Elderly population with other comorbid conditions like hypertension, ischemic heart disease, hyperlipidemia and stroke are commonly affected. However, this condition may affect younger population with entirely different systemic associations. Thromboembolism, which usually takes place secondary to cardiac emboli or hypercoagulable states cause retinal artery occlusion in young population. A24-year lady presented with a short history of unilateral altitudinal visual loss. On examination, she was found to have hemiretinal artery occlusion. Ocular massage, anterior chamber paracentesis was performed initially, followed by Nd YAG laser embolysis, which led to successful restoration of retinal circulation and significant improvement in visual field loss. Detailed evaluation and systemic investigations were carried out to identify the underlying cause, but no systemic association could be found.
MeSH term(s)	Embolization, Therapeutic/methods ; Female ; Humans ; Lasers, Solid-State/therapeutic use ; Paracentesis ; Retinal Artery/physiopathology ; Retinal Artery Occlusion/surgery ; Treatment Outcome ; Visual Acuity ; Young Adult
Language	English
Publishing date	2016-07
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	2386
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Article: Visual outcome of retinal vein occlusion in patients residing at high altitude.

Mukhtar, Ahsan / Khan, Muhammad Saim / Habib, Asad / Ishaq, Mazhar / Farooq, Omer

JPMA. The Journal of the Pakistan Medical Association

2017 Volume 67, Issue 5, Page(s) 735–738

Abstract: Objective: To study visual outcome in patients of high altitude retinopathy presenting with retinal venous occlusion.: Methods: The randomised clinical trial study was conducted at the Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan, ... ...

Abstract	Objective: To study visual outcome in patients of high altitude retinopathy presenting with retinal venous occlusion. Methods: The randomised clinical trial study was conducted at the Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan, from January 2013 to December 2015, and comprised eyes of lowlanders. Patients staying at high altitude (>8,000 feet above sea level) as part of their service duty and presented with retinal venous occlusive disease were included. Patients with history of diabetes, hypertension, glaucoma, any pre-existing retinal disease or age-related conditions responsible for decreased vision were excluded. Detailed ocular as well as systemic examination was carried out to establish the diagnosis of retinal venous occlusion. Patients were divided into two groups. First group was observed over a period of 6 months and labelled as control group, whereas the second group was treated with intravitrealbevacizumab and labelled as intervention group. Complete ocular examination was carried out in all patients at 4 weeks, 3 months and 6 months. SPSS 21 was used for data analysis. Results: A series of 32 eyes of 28 male patients were included. The overall mean age was 31.40±3.40 years. The mean altitude of their temporary stay was 4,120±941 metres above sea level and the mean duration of stay was 6.80±4.13months. Besides, 21(75%) subjects were smokers. Moreover, 26(81.25%) eyes had central retinal vein occlusion while branch retinal vein occlusion was seen in 6(18.75%) eyes. The mean visual acuity in the control group was 0.70±0.56 on Logarithm of the Minimum Angle of Resolution chart at the presentation while it was 0.26±0.87, 0.20±0.32 and 0.15±0.23 after 4 weeks, 3 months and 6 months, respectively. The mean best corrected visual acuity in intervention group was 0.68 ± 0.46 before treatment and 0.15±0.11, 0.12±0.11 and 0.10±0.08 at 4 weeks, 3 months and 6 months, respectively. Significant post-intervention change was observed in best corrected visual acuity at 6 months (p<0.05) in patients who presented with severe visual loss. Conclusions: Treatment with intravitrealbevacizumab may be considered in patients with severe visual loss at presentation.
MeSH term(s)	Adult ; Altitude ; Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Humans ; Intravitreal Injections ; Male ; Military Personnel ; Residence Characteristics ; Retinal Vein Occlusion/drug therapy ; Treatment Outcome ; Visual Acuity
Chemical Substances	Angiogenesis Inhibitors ; Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2017-05-15
Publishing country	Pakistan
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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