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  1. AU="Mukund, Adi X"
  2. AU="Redmer, Jackie"
  3. AU="Xin Zhou"
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  5. AU="Hughes, Colette M"
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  1. Article ; Online: Teaching transgender cultural competency with standardised patients.

    Mukund, Adi X / Jia, Justin L / Nedelman, Michael / Rydel, Tracy A / Bajra, Rika / Srinivasan, Malathi / Schillinger, Erika / Laniakea, Benjamin H

    Medical education

    2024  Volume 58, Issue 5, Page(s) 648–649

    MeSH term(s) Humans ; Transgender Persons ; Cultural Competency/education ; Curriculum ; Cultural Diversity
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.15325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High-throughput functional characterization of combinations of transcriptional activators and repressors.

    Mukund, Adi X / Tycko, Josh / Allen, Sage J / Robinson, Stephanie A / Andrews, Cecelia / Sinha, Joydeb / Ludwig, Connor H / Spees, Kaitlyn / Bassik, Michael C / Bintu, Lacramioara

    Cell systems

    2023  Volume 14, Issue 9, Page(s) 746–763.e5

    Abstract: Despite growing knowledge of the functions of individual human transcriptional effector domains, much less is understood about how multiple effector domains within the same protein combine to regulate gene expression. Here, we measure transcriptional ... ...

    Abstract Despite growing knowledge of the functions of individual human transcriptional effector domains, much less is understood about how multiple effector domains within the same protein combine to regulate gene expression. Here, we measure transcriptional activity for 8,400 effector domain combinations by recruiting them to reporter genes in human cells. In our assay, weak and moderate activation domains synergize to drive strong gene expression, whereas combining strong activators often results in weaker activation. In contrast, repressors combine linearly and produce full gene silencing, and repressor domains often overpower activation domains. We use this information to build a synthetic transcription factor whose function can be tuned between repression and activation independent of recruitment to target genes by using a small-molecule drug. Altogether, we outline the basic principles of how effector domains combine to regulate gene expression and demonstrate their value in building precise and flexible synthetic biology tools. A record of this paper's transparent peer review process is included in the supplemental information.
    MeSH term(s) Humans ; Transcription, Genetic/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcription Factors/metabolism ; Gene Expression Regulation/genetics ; Genes, Reporter
    Chemical Substances Repressor Proteins ; Transcription Factors
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2854138-8
    ISSN 2405-4720 ; 2405-4712
    ISSN (online) 2405-4720
    ISSN 2405-4712
    DOI 10.1016/j.cels.2023.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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