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  1. Article ; Online: Can integrated post-exposure vaccination against SARS-COV2 mitigate severe disease?

    Muller, Claude P

    The Lancet regional health. Europe

    2021  Volume 5, Page(s) 100118

    Language English
    Publishing date 2021-05-17
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2021.100118
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  2. Article ; Online: Do asymptomatic carriers of SARS-COV-2 transmit the virus?

    Muller, Claude P

    The Lancet regional health. Europe

    2021  Volume 4, Page(s) 100082

    Language English
    Publishing date 2021-03-20
    Publishing country England
    Document type Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2021.100082
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  3. Article ; Online: Applying next-generation sequencing to unravel the mutational landscape in viral quasispecies.

    Lu, I-Na / Muller, Claude P / He, Feng Q

    Virus research

    2020  Volume 283, Page(s) 197963

    Abstract: Next-generation sequencing (NGS) has revolutionized the scale and depth of biomedical sciences. Because of its unique ability for the detection of sub-clonal variants within genetically diverse populations, NGS has been successfully applied to analyze ... ...

    Abstract Next-generation sequencing (NGS) has revolutionized the scale and depth of biomedical sciences. Because of its unique ability for the detection of sub-clonal variants within genetically diverse populations, NGS has been successfully applied to analyze and quantify the exceptionally-high diversity within viral quasispecies, and many low-frequency drug- or vaccine-resistant mutations of therapeutic importance have been discovered. Although many works have intensively discussed the latest NGS approaches and applications in general, none of them has focused on applying NGS in viral quasispecies studies, mostly due to the limited ability of current NGS technologies to accurately detect and quantify rare viral variants. Here, we summarize several error-correction strategies that have been developed to enhance the detection accuracy of minority variants. We also discuss critical considerations for preparing a sequencing library from viral RNAs and for analyzing NGS data to unravel the mutational landscape.
    MeSH term(s) Genetic Variation ; Genome, Viral ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Mutation ; Quasispecies/genetics ; RNA, Viral/genetics ; Viruses/genetics
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2020.197963
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    Zs.A 1965: Show issues Location:
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  4. Article ; Online: Human Seasonal Influenza Viruses in Swine Workers in Lagos, Nigeria: Consequences for Animal and Public Health.

    Anjorin, Abdul-Azeez A / Sausy, Aurélie / Muller, Claude P / Hübschen, Judith M / Omilabu, Sunday A / Snoeck, Chantal J

    Viruses

    2023  Volume 15, Issue 6

    Abstract: The influenza A virus has been scarcely investigated in pigs in Africa, with rare detection prior to 2009. The spread of A(H1N1)pdm09 changed the epidemiology due to frequent human-to-swine transmission and the emergence of various new reassortants. This ...

    Abstract The influenza A virus has been scarcely investigated in pigs in Africa, with rare detection prior to 2009. The spread of A(H1N1)pdm09 changed the epidemiology due to frequent human-to-swine transmission and the emergence of various new reassortants. This study therefore aimed at estimating the level of circulation and characterizing influenza A viruses at the interface between swine workers, who are crucial players in the inter-species transmission of influenza A viruses, and their animals in several farms in Nigeria, a hub for pig production in Africa. This cross-sectional study showed that 24.6% (58/236) of the pig serum samples collected in 2013-2014 had anti-influenza A antibodies in the absence of vaccination programs, but none of the pig swabs (
    MeSH term(s) Humans ; Animals ; Swine ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/veterinary ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/genetics ; Public Health ; Nigeria/epidemiology ; Cross-Sectional Studies ; Seasons ; Influenza, Human ; Influenza A virus/genetics ; Swine Diseases
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15061219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Measles and Rubella IgG-Seroprevalence in Luxembourg and Alternative Laboratory Approaches

    Bork, Sonja [Verfasser] / Muller, Claude P. [Akademischer Betreuer]

    2021  

    Author's details Sonja Bork ; Betreuer: Claude P. Muller
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Saarländische Universitäts- und Landesbibliothek
    Publishing place Saarbrücken
    Document type Book ; Online ; Thesis
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  6. Article ; Online: Reply to "May Newly Defined Genotypes XVII and XVIII of Newcastle Disease Virus in Poultry from West and Central Africa Be Considered a Single Genotype (XVII)?".

    Snoeck, Chantal J / Muller, Claude P

    Journal of clinical microbiology

    2016  Volume 54, Issue 9, Page(s) 2400–2401

    MeSH term(s) Africa, Central ; Animals ; Genotype ; Newcastle Disease/virology ; Newcastle disease virus/genetics ; Phylogeny ; Poultry ; Poultry Diseases/virology
    Language English
    Publishing date 2016-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00696-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1188: Show issues Location:
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  7. Article: Applying next-generation sequencing to unravel the mutational landscape in viral quasispecies

    Lu, I-Na / Muller, Claude P / He, Feng Q

    Virus research. 2020 July 02, v. 283

    2020  

    Abstract: Next-generation sequencing (NGS) has revolutionized the scale and depth of biomedical sciences. Because of its unique ability for the detection of sub-clonal variants within genetically diverse populations, NGS has been successfully applied to analyze ... ...

    Abstract Next-generation sequencing (NGS) has revolutionized the scale and depth of biomedical sciences. Because of its unique ability for the detection of sub-clonal variants within genetically diverse populations, NGS has been successfully applied to analyze and quantify the exceptionally-high diversity within viral quasispecies, and many low-frequency drug- or vaccine-resistant mutations of therapeutic importance have been discovered. Although many works have intensively discussed the latest NGS approaches and applications in general, none of them has focused on applying NGS in viral quasispecies studies, mostly due to the limited ability of current NGS technologies to accurately detect and quantify rare viral variants. Here, we summarize several error-correction strategies that have been developed to enhance the detection accuracy of minority variants. We also discuss critical considerations for preparing a sequencing library from viral RNAs and for analyzing NGS data to unravel the mutational landscape.
    Keywords DNA libraries ; RNA ; biomedical research ; drugs ; high-throughput nucleotide sequencing ; mutation ; therapeutics ; covid19
    Language English
    Dates of publication 2020-0702
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2020.197963
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    Zs.A 1965: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Seroprevalence of anti-tetanus antibodies in mothers and cord blood and associated factors in health-care settings in Lao People’s Democratic Republic

    Ounnavong, Phoumsavath / Chanthavilay, Phetsavanh / Khampanisong, Phonepaseuth / Reinharz, Daniel / Muller, Claude P / Black, Antony P

    Vaccine. 2020 Jan. 29, v. 38, no. 5

    2020  

    Abstract: Maternal neonatal tetanus (MNT) was eliminated from Lao People’s Democratic Republic (PDR) in 2014. WHO recommends 80% coverage of 2 or more tetanus vaccinations (TT2+) in pregnancy to maintain MNT control. Vaccination coverage in Lao PDR varies among ... ...

    Abstract Maternal neonatal tetanus (MNT) was eliminated from Lao People’s Democratic Republic (PDR) in 2014. WHO recommends 80% coverage of 2 or more tetanus vaccinations (TT2+) in pregnancy to maintain MNT control. Vaccination coverage in Lao PDR varies among regions although the reasons are not clear.185 pregnant women giving birth in three district hospitals in Savannakhet province, Lao PDR were recruited. A questionnaire was administered to determine factors associated with seroprotection and blood was taken from mother and cord blood to be tested for anti-tetanus antibodies by ELISA.77% of mothers and 79% of newborns had sufficiently protective antibody titres (>0.5 IU/ml) against tetanus. Only 70% of the mothers received one dose of TT vaccination during antenatal care (ANC) consultation and 45% received the recommended two injections. Although most of the vaccination took place during ANC 1 and 2, many were missed at these time-points. Anti-tetanus seroprotection in the mothers was associated with maternal age, number of ANC visits, number of TT vaccinations during and before pregnancy and gestational age.Seroprevalence of anti-tetanus antibodies in mothers and newborns was intermediate but TT2+ coverage was low in healthcare settings in Lao PDR. TT2+ coverage during ANC is likely to be significantly lower in settings with less robust ANC practices. Missed opportunities to vaccinate in ANC 1 and 2 suggest a need to promote vaccine awareness and vaccination at first ANC visit. A booster dose of TT containing vaccine should be considered for children aged between 4 and 7 years old.
    Keywords antibodies ; blood ; children ; hospitals ; mothers ; neonates ; pregnancy ; pregnant women ; prenatal care ; questionnaires ; seroprevalence ; tetanus ; vaccination ; vaccines ; Laos
    Language English
    Dates of publication 2020-0129
    Size p. 1234-1240.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2019.11.007
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    Zs.A 1930: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 458: Show issues

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  9. Book ; Online ; Thesis: Characterization of Immunoglobulin Repertoires after Vaccination in OmniRatTM and Monoclonal CD5+ B Cell Expansion in A20BKOsCYLDBOE Mice using an Ion Torrent PGM High-Throughput Sequencing Platform

    Bürckert, Jean-Philippe [Verfasser] / Muller, Claude P. [Akademischer Betreuer] / Muller, Claude P. [Gutachter] / Meyer, Jobst [Gutachter]

    2019  

    Author's details Jean-Philippe Bürckert ; Gutachter: Claude P. Muller, Jobst Meyer ; Betreuer: Claude P. Muller
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universität Trier
    Publishing place Trier
    Document type Book ; Online ; Thesis
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  10. Book: WIRKUNG DER ZELLDICHTE AUF DIE MEMBRANFLUIDITAET UND DEREN EINFLUSS AUF DIE MODULATION SPEZIFISCHER MEMBRANREZEPTOREN

    Muller, Claude P.

    1979  

    Size VIII, 104 S. : ILL., GRAPH. DARST.
    Document type Book
    Note KOELN, UNIV., DISS., 1981
    HBZ-ID HT002623688
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    82 D 8 order for loan Magazin

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