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Article ; Online: Global view of vasomotor symptoms and sleep disturbance in menopause: a systematic review.

Kingsberg, S A / Schulze-Rath, R / Mulligan, C / Moeller, C / Caetano, C / Bitzer, J

Climacteric : the journal of the International Menopause Society

2023 Volume 26, Issue 6, Page(s) 537–549

Abstract: Studies have shown racial/ethnic differences in the prevalence of vasomotor symptoms (VMS), sleep disturbance and VMS treatment in menopause. To assess the reproducibility of these differences, we systematically reviewed observational studies, published ... ...

Abstract	Studies have shown racial/ethnic differences in the prevalence of vasomotor symptoms (VMS), sleep disturbance and VMS treatment in menopause. To assess the reproducibility of these differences, we systematically reviewed observational studies, published in 2000-2021, reporting the prevalence/incidence of VMS, sleep disturbance or treatment use in menopausal women stratified by race/ethnicity. We screened 3799 records from PubMed and Embase and included 27 papers (19 studies). No incidence data were found. Prevalence data varied widely, but some common patterns emerged. In all five studies comparing VMS between Black women and White, Hispanic and/or East Asian women, the prevalence was highest in Black women and lowest in East Asian women. The prevalence of sleep disturbance overall was compared among Black, White and East Asian women in two study populations, and was highest in White women in both papers. Sleep disturbance was more common than VMS in East Asian women. In all four studies comparing hormone therapy use between White women and Black and/or East Asian women, treatment use was more common in White women. These results highlight the need for individualized counseling and treatment, outreach to under-served minorities, and standardized definitions and outcome measures for VMS and sleep disturbance for future studies.
MeSH term(s)	Female ; Humans ; Hot Flashes/epidemiology ; Hot Flashes/etiology ; Reproducibility of Results ; Menopause ; Ethnicity ; Sleep ; Vasomotor System
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1469153-x
ISSN	1473-0804 ; 1369-7137
ISSN (online)	1473-0804
ISSN	1369-7137
DOI	10.1080/13697137.2023.2256658
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Article ; Online: Flipping the switch: dynamic modulation of membrane transporter activity in bacteria.

Elston, Rory / Mulligan, Christopher / Thomas, Gavin H

Microbiology (Reading, England)

2023 Volume 169, Issue 11

Abstract: The controlled entry and expulsion of small molecules across the bacterial cytoplasmic membrane is essential for efficient cell growth and cellular homeostasis. While much is known about the transcriptional regulation of genes encoding transporters, less ...

Abstract	The controlled entry and expulsion of small molecules across the bacterial cytoplasmic membrane is essential for efficient cell growth and cellular homeostasis. While much is known about the transcriptional regulation of genes encoding transporters, less is understood about how transporter activity is modulated once the protein is functional in the membrane, a potentially more rapid and dynamic level of control. In this review, we bring together literature from the bacterial transport community exemplifying the extensive and diverse mechanisms that have evolved to rapidly modulate transporter function, predominantly by switching activity off. This includes small molecule feedback, inhibition by interaction with small peptides, regulation through binding larger signal transduction proteins and, finally, the emerging area of controlled proteolysis. Many of these examples have been discovered in the context of metal transport, which has to finely balance active accumulation of elements that are essential for growth but can also quickly become toxic if intracellular homeostasis is not tightly controlled. Consistent with this, these transporters appear to be regulated at multiple levels. Finally, we find common regulatory themes, most often through the fusion of additional regulatory domains to transporters, which suggest the potential for even more widespread regulation of transporter activity in biology.
MeSH term(s)	Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Bacteria/genetics
Chemical Substances	Membrane Transport Proteins
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180712-x
ISSN	1465-2080 ; 1350-0872
ISSN (online)	1465-2080
ISSN	1350-0872
DOI	10.1099/mic.0.001412
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Article ; Online: Common origin of sterol biosynthesis points to a feeding strategy shift in Neoproterozoic animals.

Brunoir, T / Mulligan, C / Sistiaga, A / Vuu, K M / Shih, P M / O'Reilly, S S / Summons, R E / Gold, D A

Nature communications

2023 Volume 14, Issue 1, Page(s) 7941

Abstract: Steranes preserved in sedimentary rocks serve as molecular fossils, which are thought to record the expansion of eukaryote life through the Neoproterozoic Era ( ~ 1000-541 Ma). Scientists hypothesize that ancient ... ...

Abstract	Steranes preserved in sedimentary rocks serve as molecular fossils, which are thought to record the expansion of eukaryote life through the Neoproterozoic Era ( ~ 1000-541 Ma). Scientists hypothesize that ancient C
MeSH term(s)	Animals ; Sterols ; Biological Evolution ; Phytosterols ; Rhodophyta ; Fossils
Chemical Substances	Sterols ; Phytosterols
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43545-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Qualitative analysis of front-of package labeling policy interactions between stakeholders and Health Canada.

Jawad, Aalaa / Mulligan, Christine / Savona, Natalie / L'Abbé, Mary R

Frontiers in public health

2023 Volume 11, Page(s) 982908

Abstract: Background: Front-of-package labelling regulations proposed by Health Canada in their Healthy Eating Strategy (2016) were finally passed in 2022, but remain unimplemented. This study analyzed interactions that occurred between stakeholders and ... ...

Abstract	Background: Front-of-package labelling regulations proposed by Health Canada in their Healthy Eating Strategy (2016) were finally passed in 2022, but remain unimplemented. This study analyzed interactions that occurred between stakeholders and government related to this policy proposal to identify key themes and policy implications. Methods: A qualitative framework analysis was conducted on publicly available documents for stakeholder correspondences related to front-of-package that occurred between 2016 and 2019 in Health Canada's Meetings and Correspondence on Healthy Eating database. Five sequential steps were applied: familiarization, identifying a thematic framework, indexing, charting, and mapping and interpretation. A complex systems (i.e., a dynamic system with multiple interconnecting components) lens was incorporated in the final step to deepen the analysis. Results: Hundred and seventy-three documents were included, the majority from industry stakeholders ( Conclusion: Interactions with industry stakeholders on health food policy proposals require careful consideration, given it may suit their interests to generate delays and policy discordance. Explicitly setting out the principles of engagement and actively encouraging non-industry stakeholder representation provides a more balanced approach to policy consultation and development.
MeSH term(s)	Canada ; Food Industry ; Nutrition Policy ; Qualitative Research ; Product Labeling/legislation & jurisprudence ; Stakeholder Participation ; Databases, Factual
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.982908
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Article ; Online: Child-appealing packaged food and beverage products in Canada-Prevalence, power, and nutritional quality.

Mulligan, Christine / Vergeer, Laura / Kent, Monique Potvin / L'Abbé, Mary R

PloS one

2023 Volume 18, Issue 5, Page(s) e0284350

Abstract: Background: Children are frequently exposed to marketing on food packaging. This study evaluated the presence, type and power of child-appealing marketing and compared the nutritional quality of child-appealing vs. non-child-appealing Canadian packaged ... ...

Abstract	Background: Children are frequently exposed to marketing on food packaging. This study evaluated the presence, type and power of child-appealing marketing and compared the nutritional quality of child-appealing vs. non-child-appealing Canadian packaged foods and examined the relationship between nutrient composition and marketing power. Methods: Child-relevant packaged foods (n = 5,850) were sampled from the Food Label Information Program 2017 database. The presence and power (# of techniques displayed) of child-appealing marketing were identified. Fisher's Exact test compared the proportion of products exceeding Health Canada's nutrient thresholds for advertising restrictions and Mann Whitney U tests compared nutrient composition between products with child- /non-child-appealing packaging. Pearson's correlation analyzed the relationship between nutrient composition and marketing power. Results: 13% (746/5850) of products displayed child-appealing marketing; the techniques used, and the power of the marketing varied ([Formula: see text] 2.2 techniques; range: 0-11). More products with child-appealing packaging than with non-child appealing packaging exceeded Health Canada's thresholds (98% vs. 94%; p < .001). Products with child-appealing packaging (vs. non-child-appealing) were higher in total sugars (median: 14.7 vs. 9 g/RA; p < .001) and free sugars (11.5 vs. 6.2 g/RA; p < .001), but lower in all other nutrients. There was weak overall correlation between marketing power and nutrient levels. Results varied by nutrient and food category. Conclusions: Unhealthy products with powerful child-appealing marketing displayed on package are prevalent in the food supply. Implementing marketing restrictions that protect children should be a priority.
MeSH term(s)	Humans ; Prevalence ; Canada ; Food ; Beverages ; Nutritive Value ; Marketing/methods ; Sugars
Chemical Substances	Sugars
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0284350
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Article ; Online: Wilson Disease: An Overview and Approach to Management.

Mulligan, Caitlin / Bronstein, Jeff M

Neurologic clinics

2020 Volume 38, Issue 2, Page(s) 417–432

Abstract: Wilson's disease is one of the few preventable movement disorders in which there are therapies that modify disease progression. This disease is caused by copper overload caused by reduced copper excretion secondary to genetic mutations in the ATP7B gene. ...

Abstract	Wilson's disease is one of the few preventable movement disorders in which there are therapies that modify disease progression. This disease is caused by copper overload caused by reduced copper excretion secondary to genetic mutations in the ATP7B gene. Copper overload can lead to a variety of clinical presentations, including neurologic symptoms, liver failure, and/or psychiatric manifestations. There is often a delay in diagnosis of Wilson disease, and awareness of the diagnosis and management is important because of the treatable nature of this condition. This article reviews the clinical presentation, epidemiology, genetics, pathophysiology, diagnosis, and management of Wilson disease.
MeSH term(s)	Hepatolenticular Degeneration/diagnosis ; Hepatolenticular Degeneration/therapy ; Humans
Language	English
Publishing date	2020-02-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1013148-6
ISSN	1557-9875 ; 0733-8619
ISSN (online)	1557-9875
ISSN	0733-8619
DOI	10.1016/j.ncl.2020.01.005
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Article ; Online: The fragility of freedom of movement

Mulligan, Cian

Intereconomics : review of European economic policy Vol. 52, No. 5 , p. 254-255

2017 Volume 52, Issue 5, Page(s) 254–255

Author's details	Cian Mulligan
Language	English
Size	Online-Ressource
Publisher	Springer
Publishing place	Berlin
Document type	Article ; Online
ZDB-ID	2066476-X
ISSN	1613-964X ; 0020-5346
ISSN (online)	1613-964X
ISSN	0020-5346
Database	ECONomics Information System

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Article ; Online: Seasonal source identification and source-specific health risk assessment of pollutants in road dust.

Wang, Jingshu / Huang, Jinhui Jeanne / Mulligan, Catherine

Environmental science and pollution research international

2021 Volume 29, Issue 7, Page(s) 10063–10076

Abstract: Humans who are exposed to metals in road dust may have potential health risks through touching, ingesting, and inhaling the suspended road dust. There were limited studies to link seasonal emission sources to health risks from metals in road dust. In ... ...

Abstract	Humans who are exposed to metals in road dust may have potential health risks through touching, ingesting, and inhaling the suspended road dust. There were limited studies to link seasonal emission sources to health risks from metals in road dust. In this study, metals in road dust from different functional areas were seasonally monitored. The contributions of the pollutant sources in study areas varied with seasons. By combining the source apportionment model (PMF), road dust emission model, and health risk models (HI: hazard index and ILCR: incremental lifetime carcinogenic risk), industrial and construction activity was identified as the crucial source of both the pollutants in road dust (29-47%), and the HI for adults (27-45%) and children (41-50%) in different seasons. The traffic non-exhaust emission dominated in the carcinogenic risks for children in spring (45%) and summer (36%). Factors such as seasons, particle size, metal bioavailability, human exposure time, and exposure area were all taken into consideration to avoid overestimating or underestimating health risks. The carcinogenic risks for children (1.6 E-06) and adults (2.8 E-06) exposed to Cr both exceed the minimum threshold (10
MeSH term(s)	Adult ; Child ; China ; Cities ; Dust/analysis ; Environmental Monitoring ; Environmental Pollutants/analysis ; Humans ; Metals, Heavy/analysis ; Risk Assessment ; Seasons
Chemical Substances	Dust ; Environmental Pollutants ; Metals, Heavy
Language	English
Publishing date	2021-09-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-16326-8
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Article ; Online: Top Sodium Food Sources in the American Diet-Using National Health and Nutrition Examination Survey.

Ahmed, Mavra / Ng, Alena Praneet / Christoforou, Anthea / Mulligan, Christine / L'Abbé, Mary R

Nutrients

2023 Volume 15, Issue 4

Abstract: Reducing population-level sodium intake can reduce hypertension, an important preventative strategy to lower the risk of cardiovascular diseases, the leading cause of death in the United States. Considering that most dietary sodium is derived from ... ...

Abstract	Reducing population-level sodium intake can reduce hypertension, an important preventative strategy to lower the risk of cardiovascular diseases, the leading cause of death in the United States. Considering that most dietary sodium is derived from prepackaged foods, this study quantitatively estimates the proportion contribution and mean sodium intake from key food category contributors to total sodium intake in the US population. Data from the 2017-2018 National Health and Nutrition Examination Survey, which collected interviewer-administered 24 h dietary recalls from Americans (
MeSH term(s)	United States ; Nutrition Surveys ; Sodium ; Energy Intake ; Diet ; Vegetables ; Sodium, Dietary
Chemical Substances	Sodium (9NEZ333N27) ; Sodium, Dietary
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15040831
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Article: The impact of characters like Tony the Tiger and other child-targeted techniques used in food and beverage marketing.

Mulligan, Christine / Remedios, Lauren / Ramsay, Tim / Pauzé, Elise / Bagnato, Mariangela / Potvin Kent, Monique

Frontiers in nutrition

2023 Volume 10, Page(s) 1287473

Abstract: Introduction: Food marketing's impact is a function of exposure and power, both of which contribute to children's poor diet quality and obesity risk. Children's exposure to food marketing is well documented, however, few studies have assessed the impact ...

Abstract	Introduction: Food marketing's impact is a function of exposure and power, both of which contribute to children's poor diet quality and obesity risk. Children's exposure to food marketing is well documented, however, few studies have assessed the impact of specific persuasive marketing techniques or aspects of 'power' on children. Methods: This study administered an online survey to 1,341 Canadian children (9-12 years) aiming to determine the impact of: (1) child-targeted vs. adult-targeted marketing, and (2) licensed characters vs. spokes characters on children's food preferences and behavioral intentions. Participants were randomized to a single condition in each survey part and viewed 3 static food advertisements displaying the features of that condition (e.g., child-targeted advertising or licensed characters), and answered 3 Likert-scale (5-point) questions after each exposure. For each condition within each research question, there were four outcome variables related to the impact of marketing on children: food preference, purchase intent, pester power, and total impact. ANOVA tested the difference in impact (Likert scores) between conditions overall and for each outcome, with Bonferroni Results: A greater average total impact was observed among children exposed to child-targeted ads (mean Likert score 3.36) vs. adult-targeted ads (mean score 2.75; Discussion: Overall, this study showed that child-targeted ads and those using characters - especially spokes characters - have a strong overall impact on children's food preferences, purchase intents, and pester power, and support the implementation of comprehensive marketing restrictions to protect children.
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1287473
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