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  1. Article: Are your cash-flow tools recession ready?

    Mullins, John

    Business horizons

    2020  Volume 63, Issue 6, Page(s) 693–704

    Abstract: In good times like those most businesses have enjoyed for the past decade, business owners have typically watched their income statements with pleasure, as year-to-year performance gains have fattened their dividend payouts and increased the valuation of ...

    Abstract In good times like those most businesses have enjoyed for the past decade, business owners have typically watched their income statements with pleasure, as year-to-year performance gains have fattened their dividend payouts and increased the valuation of the companies they own and run. All too often in such times, scant attention is paid to what's between the top line and the bottom line of the income statement. Worse, most business owners, in my experience, give little more than a cursory nod to the balance sheet. Why does this matter? When a recession lands on their doorstep with a sudden thud, as it apparently just has, many of these same people will find themselves having sailed too close to the wind, with cash running out and a dearth of tools to help them weather the storm and understand what has gone wrong. But it need not be so, for there are four simple tools to help any business owner answer these four important questions: (1) Where is cash going in my business, and where is it coming from? (2) To what extent are my profit margins improving or declining, and why? (3) To what extent am I effectively managing the cash-flow relationships with my customers and my suppliers? (4) What, if anything, can I do to better manage the cash that flows into and out of my business? If your business is threatened by the COVID-19 pandemic, here are some tools to help it survive.
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article
    ISSN 0007-6813
    ISSN 0007-6813
    DOI 10.1016/j.bushor.2020.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Are your cash-flow tools recession ready?

    Mullins, John

    Business Horizons

    Abstract: In good times like those most businesses have enjoyed for the past decade, business owners have typically watched their income statements with pleasure, as year-to-year performance gains have fattened their dividend payouts and increased the valuation of ...

    Abstract In good times like those most businesses have enjoyed for the past decade, business owners have typically watched their income statements with pleasure, as year-to-year performance gains have fattened their dividend payouts and increased the valuation of the companies they own and run All too often in such times, scant attention is paid to what’s between the top line and the bottom line of the income statement Worse, most business owners, in my experience, give little more than a cursory nod to the balance sheet Why does this matter? When a recession lands on their doorstep with a sudden thud, as it apparently just has, many of these same people will find themselves having sailed too close to the wind, with cash running out and a dearth of tools to help them weather the storm and understand what has gone wrong But it need not be so, for there are four simple tools to help any business owner answer these four important questions: (1) Where is cash going in my business, and where is it coming from? (2) To what extent are my profit margins improving or declining, and why? (3) To what extent am I effectively managing the cash-flow relationships with my customers and my suppliers? (4) What, if anything, can I do to better manage the cash that flows into and out of my business? If your business is threatened by the COVID-19 pandemic, here are some tools to help it survive
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #829032
    Database COVID19

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  3. Article: The counter-conventional mindsets of entrepreneurs

    Mullins, John W

    Business horizons Vol. 60, No. 5 , p. 597-601

    2017  Volume 60, Issue 5, Page(s) 597–601

    Author's details John Mullins
    Keywords Entrepreneurship ; Entrepreneur mindset ; Entrepreneurial ideas ; Fostering innovation ; Innovative behavior
    Language English
    Dates of publication 2017-9999
    Publisher Elsevier
    Publishing place Amsterdam
    Document type Article
    ZDB-ID 222663-7
    ISSN 0007-6813
    Database ECONomics Information System

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  4. Article ; Online: P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats.

    Nespoux, Josselin / Monaghan, Marie-Louise T / Jones, Natalie K / Stewart, Kevin / Denby, Laura / Czopek, Alicja / Mullins, John J / Menzies, Robert I / Baker, Andrew H / Bailey, Matthew A

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9573

    Abstract: P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expression is ... ...

    Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expression is increased in kidney disease and blockade/knockout is renoprotective. We generated a P2X7 knockout rat on F344 background, hypothesising enhanced renal blood flow and protection from angiotensin-II-induced renal injury. CRISPR/Cas9 introduced an early stop codon into exon 2 of P2rx7, abolishing P2X7 protein in kidney and reducing P2rx7 mRNA abundance by ~ 60% in bone-marrow derived macrophages. The M1 polarisation response to lipopolysaccharide was unaffected but P2X7 receptor knockout suppressed ATP-induced IL-1β release. In male knockout rats, acetylcholine-induced dilation of the renal artery ex vivo was diminished but not the response to nitroprusside. Renal function in male and female knockout rats was not different from wild-type. Finally, in male rats infused with angiotensin-II for 6 weeks, P2X7 knockout did not reduce albuminuria, tubular injury, renal macrophage accrual, and renal perivascular fibrosis. Contrary to our hypothesis, global P2X7 knockout had no impact on in vivo renal hemodynamics. Our study does not indicate a major role for P2X7 receptor activation in renal vascular injury.
    MeSH term(s) Animals ; Receptors, Purinergic P2X7/metabolism ; Receptors, Purinergic P2X7/genetics ; Angiotensin II ; Male ; Rats ; Kidney/metabolism ; Kidney/pathology ; Rats, Inbred F344 ; Female ; Gene Knockout Techniques ; Macrophages/metabolism ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/genetics ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/pathology
    Chemical Substances Receptors, Purinergic P2X7 ; Angiotensin II (11128-99-7) ; P2rx7 protein, rat
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59635-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cellular plasticity: A mechanism for homeostasis in the kidney.

    Assmus, Adrienne M / Mullins, John J / Brown, Cara M / Mullins, Linda J

    Acta physiologica (Oxford, England)

    2020  Volume 229, Issue 1, Page(s) e13447

    Abstract: Cellular plasticity is a topical subject with interest spanning a wide range of fields from developmental biology to regenerative medicine. Even the nomenclature is a subject of debate, and the underlying mechanisms are still under investigation. On top ... ...

    Abstract Cellular plasticity is a topical subject with interest spanning a wide range of fields from developmental biology to regenerative medicine. Even the nomenclature is a subject of debate, and the underlying mechanisms are still under investigation. On top of injury repair, cell plasticity is a constant physiological process in adult organisms and tissues, in response to homeostatic challenges. In this review we discuss two examples of plasticity for the maintenance of homeostasis in the renal system-namely the renin-producing juxtaglomerular cells (JG cells) and cortical collecting duct (CCD) cells. JG cells show plasticity through recruitment mechanisms, answering the demand for an increase in renin production. In the CCD, cells appear to have the ability to transdifferentiate between principal and intercalated cells to help maintain the highly regulated solute transport levels of that segment. These two cases highlight the complexity of plasticity processes and the role they can play in the kidney.
    MeSH term(s) Animals ; Cell Plasticity ; Homeostasis ; Humans ; Kidney/cytology ; Kidney/metabolism ; Renin/metabolism
    Chemical Substances Renin (EC 3.4.23.15)
    Language English
    Publishing date 2020-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: The customer-funded business

    Mullins, John Walker

    start, finance, or grow your company with your customers' cash

    2014  

    Author's details John Mullins, Ph.D
    Keywords Customer relations ; Entrepreneurship ; New business enterprises/Finance ; Venture capital ; Unternehmensfinanzierung ; Unternehmensgründung ; Unternehmenswachstum
    Language English
    Size XXII, 282 p
    Publisher John Wiley & Sons, Inc
    Publishing place Hoboken, NJ
    Document type Book
    Note Includes index
    ISBN 9781118878859 ; 9781118879047 ; 9781118879139 ; 111887885X ; 111887904X ; 1118879139
    Database ECONomics Information System

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  7. Article: Mit Geld vom Kunden gründen

    Mullins, John W

    Harvard-Business-Manager : das Wissen der Besten Vol. 36, No. 1 , p. 10-13

    2014  Volume 36, Issue 1, Page(s) 10–13

    Author's details von John Mullins
    Keywords Unternehmensgründung ; Unternehmensfinanzierung ; Geschäftsmodell ; Welt
    Language German
    Publisher Manager-Magazin-Verl.-Ges
    Publishing place Hamburg
    Document type Article
    ZDB-ID 1138095-0
    ISSN 0945-6570
    Database ECONomics Information System

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  8. Article ; Online: Role of Pericytes in the Development of the Renin/Angiotensin System: Induction of Functional Renin in Cultures of Pericytes.

    Stefanska, Ania / Briski, Angela / Khan, Nusrat S / Kenyon, Christopher / Péault, Bruno M / Mullins, John J

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2235, Page(s) 169–180

    Abstract: Renal pericytes have a critical importance for angiogenesis and vascular remodeling, medullary blood flow regulation, and development of fibrosis. An emerging role for kidney pericytes is their ability to induce renin expression and synthesis. Here, we ... ...

    Abstract Renal pericytes have a critical importance for angiogenesis and vascular remodeling, medullary blood flow regulation, and development of fibrosis. An emerging role for kidney pericytes is their ability to induce renin expression and synthesis. Here, we present methods for purification of human renal pericytes, their primary culture, and differentiation into renin-producing cells. Possible applications of these protocols include investigations into (1) renin cell recruitment mechanisms, (2) modulation of renin expression/secretion by small molecules, and (3) renin expression/secretion in nonrenal pericytes. A potential therapeutic application of this work is the identification of new players regulating the renin-angiotensin system.
    MeSH term(s) Angiotensins/metabolism ; Animals ; Cell Culture Techniques/methods ; Cell Differentiation/physiology ; Humans ; Kidney/metabolism ; Pericytes/metabolism ; Primary Cell Culture/methods ; Renin/metabolism ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology
    Chemical Substances Angiotensins ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1056-5_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A quality assurance device for measuring afterloader performance and transit dose for nasobiliary high-dose-rate brachytherapy.

    Deufel, Christopher L / Mullins, John P / Zakhary, Mark J

    Brachytherapy

    2018  Volume 17, Issue 4, Page(s) 726–731

    Abstract: Purpose: Nasobiliary high-dose-rate (HDR) brachytherapy has emerged as an effective tool to boost the radiation dose for patients with unresectable perihilar cholangiocarcinoma. This work describes a quality assurance (QA) tool for measuring the HDR ... ...

    Abstract Purpose: Nasobiliary high-dose-rate (HDR) brachytherapy has emerged as an effective tool to boost the radiation dose for patients with unresectable perihilar cholangiocarcinoma. This work describes a quality assurance (QA) tool for measuring the HDR afterloader's performance, including the transit dose, when the source wire travels through a tortuous nasobiliary catheter path.
    Methods and materials: The nasobiliary QA device was designed to mimic the anatomical path of a nasobiliary catheter, including the nasal, stomach, duodenum, and bile duct loops. Two of these loops, the duodenum and bile duct loops, have adjustable radii of curvature, resulting in the ability to maximize stress on the source wire in transit. The device was used to measure the performance over time for the HDR afterloader and the differences between intraluminal catheter lots. An upper limit on the transit dose was also measured using radiochromic film and compared with a simple theoretical model.
    Results: The QA device was capable of detecting performance variations among nasobiliary catheter lots and following radioactive source replacement. The transit dose from a nasobiliary treatment increased by up to one order of magnitude when the source wire encountered higher than normal friction. Three distinct travel speeds of the source wire were observed: 5.2, 17.4, and 54.7 cm/s. The maximum transit dose was 0.3 Gy at a radial distance of 5 mm from a 40.3 kU
    Conclusions: The source wire encounters substantially greater friction when it navigates through the nasobiliary brachytherapy catheter. A QA tool that mimics the nasal, stomach, duodenum, and bile duct loops may be used to evaluate transit dose and the afterloader's performance over time.
    MeSH term(s) Bile Duct Neoplasms/radiotherapy ; Bile Ducts ; Brachytherapy/instrumentation ; Brachytherapy/standards ; Catheterization/instrumentation ; Catheterization/standards ; Catheters/standards ; Cholangiocarcinoma/radiotherapy ; Equipment Design ; Humans ; Iridium Radioisotopes/therapeutic use ; Nose ; Radiotherapy Dosage
    Chemical Substances Iridium Radioisotopes ; Iridium-192
    Language English
    Publishing date 2018-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2098608-7
    ISSN 1873-1449 ; 1538-4721
    ISSN (online) 1873-1449
    ISSN 1538-4721
    DOI 10.1016/j.brachy.2018.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: The new business road test

    Mullins, John Walker

    what entrepreneurs and executives should do before launching a lean start-up

    2013  

    Author's details John Mullins
    Keywords Marketing research ; New business enterprises/Planning ; Unternehmensgründung ; Unternehmensplanung ; Geschäftsmodell ; Marktforschung
    Language English
    Size XIX, 324 S., graph. Darst.
    Edition 4. ed.
    Publisher Pearson
    Publishing place Harlow, England u.a.
    Document type Book
    Note Includes bibliographical references and index
    ISBN 9781292003740 ; 9781292003764 ; 9781292003771 ; 129200374X ; 1292003766 ; 1292003774
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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