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  1. Article ; Online: The Hemoglobin Wayne Variant and Association With Falsely Elevated HbA

    Mulpuri, Neha / Bryant, Ananda / Shahin, Daryoush / Soe, Kyaw

    JCEM case reports

    2023  Volume 1, Issue 3, Page(s) luad043

    Abstract: The objective of this work is to explain the effect of the clinically silent hemoglobinopathy hemoglobin Wayne (Hb Wayne) variant on glycated hemoglobin ... ...

    Abstract The objective of this work is to explain the effect of the clinically silent hemoglobinopathy hemoglobin Wayne (Hb Wayne) variant on glycated hemoglobin A
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pediatric Orthopaedic Venous Thromboembolism: A Systematic Review Investigating Incidence, Risk Factors, and Outcome.

    Mulpuri, Neha / Sanborn, Ryan M / Pradhan, Pratik / Miller, Patricia E / Canizares, Maria F / Shore, Benjamin J

    JB & JS open access

    2024  Volume 9, Issue 1

    Abstract: Background: There is growing evidence of increased venous thromboembolism (VTE) incidence in children with trauma or infection. The purpose of this study was to conduct a systematic review of existing literature related to VTE in the pediatric ... ...

    Abstract Background: There is growing evidence of increased venous thromboembolism (VTE) incidence in children with trauma or infection. The purpose of this study was to conduct a systematic review of existing literature related to VTE in the pediatric orthopaedic population, to estimate the overall incidence of VTE and identify risk factors associated with this condition.
    Methods: A systematic review of the available literature was performed to identify articles that described VTE in pediatric orthopaedic surgery or admission. Literature queries were performed to identify articles published from 1980 to 2021 that included patients ≤21 years of age. A stepwise search strategy of 5 electronic databases yielded 1,426 articles, which were filtered by 2 reviewers to identify 30 articles for full-text review. The primary aim was to determine the rate of VTE, and the secondary aim was to identify risk factors for VTE. The pooled incidence of VTE was estimated and reported in cases per 10,000. Studies were stratified by study size, by trauma versus elective surgery, and by orthopaedic subspecialty.
    Results: The 30 articles reported 3,113 VTE events in 2,467,764 pediatric patients (including those with non-orthopaedic conditions), for a pooled VTE incidence of 20 events (95% confidence interval [CI] = 10.8 to 37.2) per 10,000. Four of the studies were excluded for incomplete data or high heterogeneity. The remaining 26 studies had 850,268 orthopaedic patients with 1,108 cases of VTE, for a pooled VTE incidence of 16.6 events (95% CI = 9.1 to 30.5) per 10,000. Studies with <10,000 patients and those involving a diagnosis of trauma had the highest VTE incidence when stratification was performed. The most frequently analyzed risk factors in 15 available studies included age, sex, obesity/body mass index, type of surgery, and use of a central venous catheter.
    Conclusions: This systematic review indicated that the risk of VTE associated with pediatric orthopaedic surgery or admission remains low, at <17 events per 10,000 cases. However, orthopaedic surgeons should be aware of the most common risk factors associated with pediatric orthopaedic VTE and should pay special attention to traumatic etiologies, as these yielded the highest incidence.
    Levels of evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2472-7245
    ISSN (online) 2472-7245
    DOI 10.2106/JBJS.OA.23.00107
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  3. Article ; Online: Internal Carotid Artery Aneurysm Disguised as Pituitary Macroadenoma.

    Mulpuri, Neha / Ghayee, Hans K / Abramowitz, Jessica / Mirfakhraee, Sasan

    JCEM case reports

    2023  Volume 1, Issue 4, Page(s) luad076

    Abstract: Hypopituitarism due to an internal carotid artery (ICA) aneurysm is rare. We present a case of hypopituitarism and hyperprolactinemia due to a giant right ICA aneurysm. A 56-year-old woman with a history of primary hypothyroidism presented with fatigue, ... ...

    Abstract Hypopituitarism due to an internal carotid artery (ICA) aneurysm is rare. We present a case of hypopituitarism and hyperprolactinemia due to a giant right ICA aneurysm. A 56-year-old woman with a history of primary hypothyroidism presented with fatigue, right-sided headache, and blurred vision. Magnetic resonance (MR) of the brain revealed a sellar mass measuring 3.5 × 2.2 cm involving the right cavernous sinus. Initial neurologic examination was unremarkable, and her biochemical evaluation revealed secondary adrenal insufficiency, central hypogonadism, low serum free thyroxine, and mildly elevated serum prolactin, consistent with stalk effect. Hydrocortisone therapy was started for secondary adrenal insufficiency and her levothyroxine dose was adjusted. The patient was referred to neurosurgery for surgical management of her sellar lesion. Preoperative computed tomography angiography (CTA) of the brain revealed a right ICA aneurysm that contacted the optic chiasm and displaced the pituitary gland. The aneurysm was embolized and diverting stents were placed. Repeat laboratory tests showed resolution of the patient's secondary adrenal insufficiency, normalization of serum prolactin, and an increase in serum gonadotropin concentrations to the postmenopausal range. This case highlights that not all sellar lesions are pituitary adenomas, and CTA should be performed in the evaluation of large cavernous sinus lesions to exclude ICA aneurysm.
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad076
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  4. Article ; Online: Mental health factors associated with progression to adolescent metabolic and bariatric surgery.

    Franklin, Elizabeth V / Klement, Jessica / Mulpuri, Neha / Qureshi, Faisal G

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2021  Volume 17, Issue 11, Page(s) 1855–1863

    Abstract: Background: While bariatric surgery has demonstrated significant weight loss for adolescents with severe obesity, only a limited number of adolescents referred to surgery successfully complete the surgical program. Better identification of pre-surgical ... ...

    Abstract Background: While bariatric surgery has demonstrated significant weight loss for adolescents with severe obesity, only a limited number of adolescents referred to surgery successfully complete the surgical program. Better identification of pre-surgical factors, especially mental health factors, associated with completing bariatric surgery may determine successful referrals to surgical programs versus alternative behavioral health interventions.
    Objectives: The primary objective of this article was to investigate the relationship between presurgical mental health factors and whether or not a patient received bariatric surgery within the first six months of entering the program.
    Setting: Pediatric Children's Hospital, Bariatric Surgery Program within Pediatric Surgery Department.
    Methods: A retrospective medical record review of all patients referred from 2016 to 2019 to an adolescent surgical weight loss program was conducted. Patients were determined as completers if they received a laparoscopic sleeve gastrectomy within 6 months of entering the program. Demographic and preoperative mental health factors among completers (n = 30) were compared with surgery noncompleters (n = 44) using enter method logistic regression.
    Results: Regression analyses revealed that younger patients, White patients, patients with lower internalizing symptoms on a standardized measure, and patients with greater self-reported motivation for surgery at their initial surgery visit were more likely to obtain surgery within 6 months of starting the program.
    Conclusion: The findings underscore the importance of assessing patients' motivation early in the bariatric surgery referral process. This study highlights potential treatment implications in how best to mitigate patient barriers, such as internalizing symptoms and low motivation, to pursue bariatric surgery and remain committed to weight loss goals through techniques such as motivational interviewing.
    MeSH term(s) Adolescent ; Bariatric Surgery ; Child ; Gastrectomy ; Humans ; Mental Health ; Obesity, Morbid/surgery ; Retrospective Studies
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2021.06.014
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  5. Article: The Impact of COVID-19 on Multidisciplinary Care Delivery to Children with Cerebral Palsy and Other Neuromuscular Complex Chronic Conditions.

    Nguyen, Hillary Brenda / Mulpuri, Neha / Cook, Danielle / Greenberg, Michael / Shrader, M Wade / Sanborn, Ryan / Mulpuri, Kishore / Shore, Benjamin J

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 9

    Abstract: The COVID-19 pandemic has caused unprecedented challenges in the care of children with cerebral palsy (CP) and other neuromuscular complex chronic conditions (NCCCs). The purpose of this study is to explore the direct impact of the COVID-19 pandemic on ... ...

    Abstract The COVID-19 pandemic has caused unprecedented challenges in the care of children with cerebral palsy (CP) and other neuromuscular complex chronic conditions (NCCCs). The purpose of this study is to explore the direct impact of the COVID-19 pandemic on healthcare delivery. From May to August 2020, medical professionals caring for CP and NCCC patients across multiple countries and disciplines completed a self-administered cross-sectional survey comparing practices before and during the COVID-19 pandemic. Of the 79 healthcare workers from eight countries who participated-predominantly pediatric orthopedic surgeons (32%), pediatricians (30%), and pediatric physiatrists (23%)-most of them felt that caring for NCCC patients during the pandemic presented unique difficulties, and they reported a significant decrease in the in-person NCCC clinic volume (
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10091555
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  6. Article: Clinical Outcomes of Coccygectomy for Coccydynia: A Single Institution Series With Mean 5-Year Follow-Up.

    Mulpuri, Neha / Reddy, Nisha / Larsen, Kylan / Patel, Ankit / Diebo, Bassel G / Passias, Peter / Tappen, Lori / Gill, Kevin / Vira, Shaleen

    International journal of spine surgery

    2022  Volume 16, Issue 1, Page(s) 11–19

    Language English
    Publishing date 2022-02-17
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-4599
    ISSN 2211-4599
    DOI 10.14444/8171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Membrane insertion exacerbates the α-Synuclein-Cu(II) dopamine oxidase activity: Metallothionein-3 targets and silences all α-synuclein-Cu(II) complexes.

    Calvo, Jenifer S / Mulpuri, Neha V / Dao, Alex / Qazi, Nabeeha K / Meloni, Gabriele

    Free radical biology & medicine

    2020  Volume 158, Page(s) 149–161

    Abstract: Copper binding to α-synuclein (α-Syn), the major component of intracellular Lewy body inclusions in substantia nigra dopaminergic neurons, potentiate its toxic redox-reactivity and plays a detrimental role in the etiology of Parkinson disease (PD). ... ...

    Abstract Copper binding to α-synuclein (α-Syn), the major component of intracellular Lewy body inclusions in substantia nigra dopaminergic neurons, potentiate its toxic redox-reactivity and plays a detrimental role in the etiology of Parkinson disease (PD). Soluble α-synuclein-Cu(II) complexes possess dopamine oxidase activity and catalyze ROS production in the presence of biological reducing agents via Cu(II)/Cu(I) redox cycling. These metal-centered redox reactivities harmfully promote the oxidation and oligomerization of α-Syn. While this chemistry has been investigated on recombinantly expressed soluble α-Syn, in vivo, α-Syn is acetylated at its N-terminus and is present in equilibrium between soluble and membrane-bound forms. This post-translational modification and membrane-binding alter the Cu(II) coordination environment and binding modes and are expected to affect the α-Syn-Cu(II) reactivity. In this work, we first investigated the reactivity of acetylated and membrane-bound complexes, and subsequently addressed whether the brain metalloprotein Zn
    MeSH term(s) Dopamine ; Humans ; Metallothionein ; Oxidoreductases ; Parkinson Disease ; alpha-Synuclein/genetics
    Chemical Substances alpha-Synuclein ; Metallothionein (9038-94-2) ; Oxidoreductases (EC 1.-) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2020.07.006
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    Zs.A 2109: Show issues Location:
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  8. Article ; Online: Coccygectomy for refractory coccygodynia: a systematic review and meta-analysis.

    Sagoo, Navraj S / Haider, Ali S / Palmisciano, Paolo / Vannabouathong, Christopher / Gonzalez, Roberto / Chen, Andrew L / Lokesh, Nidhish / Sharma, Neha / Larsen, Kylan / Singh, Ravinderjit / Mulpuri, Neha / Rezzadeh, Kevin / Caldwell, Christie / Tappen, Lori A / Gill, Kevin / Vira, Shaleen

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2021  Volume 31, Issue 1, Page(s) 176–189

    Abstract: Purpose: We sought to systematically assess and summarize the available literature on outcomes following coccygectomy for refractory coccygodynia.: Methods: PubMed, Scopus, and Cochrane Library databases were systematically searched in accordance ... ...

    Abstract Purpose: We sought to systematically assess and summarize the available literature on outcomes following coccygectomy for refractory coccygodynia.
    Methods: PubMed, Scopus, and Cochrane Library databases were systematically searched in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data concerning patient demographics, validated patient reported outcome measures (PROMs) for pain relief, disability outcomes, complications, and reoperation rates were extracted and analyzed.
    Results: A total of 21 studies (18 retrospective and 3 prospective) were included in the quantitative analysis. A total of 826 patients (females = 75%) received coccygectomy (720 total and 106 partial) for refractory coccygodynia. Trauma was reported as the most common etiology of coccygodynia (56%; n = 375), followed by idiopathic causes (33%; n = 221). The pooled mean difference (MD) in pain scores from baseline on a 0-10 scale was 5.03 (95% confidence interval [CI]: 4.35 to 6.86) at a 6-12 month follow-up (FU); 5.02 (95% CI: 3.47 to 6.57) at > 12-36 months FU; and 5.41 (95% CI: 4.33 to 6.48) at > 36 months FU. The MCID threshold for pain relief was surpassed at each follow-up. Oswestry Disability Index scores significantly improved postoperatively, with a pooled MD from baseline of - 23.49 (95% CI: - 31.51 to - 15.46), surpassing the MCID threshold. The pooled incidence of complications following coccygectomy was 8% (95% CI: 5% to 12%), the most frequent of which were surgical site infections and wound dehiscence. The pooled incidence of reoperations was 3% (95% CI: 1% to 5%).
    Conclusion: Coccygectomy represents a viable treatment option in patients with refractory coccygodynia.
    MeSH term(s) Coccyx/surgery ; Female ; Humans ; Low Back Pain/etiology ; Prospective Studies ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-10-25
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-021-07041-6
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    Zs.A 3437: Show issues Location:
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