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  1. Article: Regulation of the microvasculature during small muscle mass exercise in chronic obstructive pulmonary disease vs. chronic heart failure.

    Hartmann, Jacob Peter / Dahl, Rasmus H / Nymand, Stine / Munch, Gregers W / Ryrsø, Camilla K / Pedersen, Bente K / Thaning, Pia / Mortensen, Stefan P / Berg, Ronan M G / Iepsen, Ulrik Winning

    Frontiers in physiology

    2022  Volume 13, Page(s) 979359

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.979359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effect on glycaemic control of low-volume high-intensity interval training versus endurance training in individuals with type 2 diabetes.

    Winding, Kamilla M / Munch, Gregers W / Iepsen, Ulrik W / Van Hall, Gerrit / Pedersen, Bente K / Mortensen, Stefan P

    Diabetes, obesity & metabolism

    2018  Volume 20, Issue 5, Page(s) 1131–1139

    Abstract: Aim: To evaluate whether high-intensity interval training (HIIT) with a lower time commitment can be as effective as endurance training (END) on glycaemic control, physical fitness and body composition in individuals with type 2 diabetes.: Materials ... ...

    Abstract Aim: To evaluate whether high-intensity interval training (HIIT) with a lower time commitment can be as effective as endurance training (END) on glycaemic control, physical fitness and body composition in individuals with type 2 diabetes.
    Materials and methods: A total of 29 individuals with type 2 diabetes were allocated to control (CON; no training), END or HIIT groups. Training groups received 3 training sessions per week consisting of either 40 minutes of cycling at 50% of peak workload (END) or 10 1-minute intervals at 95% of peak workload interspersed with 1 minute of active recovery (HIIT). Glycaemic control (HbA1c, oral glucose tolerance test, 3-hour mixed meal tolerance test with double tracer technique and continuous glucose monitoring [CGM]), lipolysis, VO
    Results: Exercise training increased VO
    Conclusions: Despite a ~45% lower training volume, HIIT resulted in similar or even better improvements in physical fitness, body composition and glycemic control compared to END. HIIT therefore appears to be an important time-efficient treatment for individuals with type 2 diabetes.
    MeSH term(s) Adiposity ; Aged ; Blood Glucose/analysis ; Body Mass Index ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/therapy ; Endurance Training/adverse effects ; Energy Metabolism ; Female ; Glycated Hemoglobin A/analysis ; High-Intensity Interval Training/adverse effects ; Humans ; Hyperglycemia/prevention & control ; Hypoglycemia/prevention & control ; Insulin Resistance ; Male ; Middle Aged ; Monitoring, Ambulatory ; Overweight/complications ; Oxygen Consumption ; Patient Dropouts ; Physical Fitness ; Time Factors
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Language English
    Publishing date 2018-01-31
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.13198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Effect of 6 wk of high-intensity one-legged cycling on functional sympatholysis and ATP signaling in patients with heart failure.

    Munch, Gregers W / Iepsen, Ulrik W / Ryrsø, Camilla K / Rosenmeier, Jaya B / Pedersen, Bente K / Mortensen, Stefan P

    American journal of physiology. Heart and circulatory physiology

    2017  Volume 314, Issue 3, Page(s) H616–H626

    Abstract: Breathlessness during daily activities is the primary symptom in patients with heart failure (HF). Poor correlation between the hemodynamic parameters of left ventricular performance and perceived symptoms suggests that other factors, such as skeletal ... ...

    Abstract Breathlessness during daily activities is the primary symptom in patients with heart failure (HF). Poor correlation between the hemodynamic parameters of left ventricular performance and perceived symptoms suggests that other factors, such as skeletal muscle function, play a role in determining exercise capacity. We investigated the effect of 6 wk of high-intensity, one-legged cycling (HIC; 8 × 4 at 90% one-legged cycling max) on 1) the ability to override sympathetic vasoconstriction (arterial infusion of tyramine) during one-legged knee-extensor exercise (KEE), 2) vascular function (arterial infusion of ACh, sodium nitroprusside, tyramine, and ATP), and 3) exercise capacity in HF patients with reduced ejection fraction ( n = 8) compared with healthy individuals ( n = 6). Arterial tyramine infusion lowered leg blood flow and leg vascular conductance at rest and during KEE before the training intervention in both groups ( P < 0.05) but not during KEE after the training intervention. There was no difference between groups. The peak vasodilatory response to ATP was blunted in HF patients ( P < 0.05), whereas there was no difference in ACh- and sodium nitroprusside-induced vasodilation between HF patients and healthy individuals. ACh-induced vasodilation increased in HF patients after the training intervention ( P < 0.05). HIC improved aerobic capacity in both groups ( P < 0.05), whereas only HF patients made improvements in the 6-min walking distance ( P < 0.05). These results suggest that exercise hyperemia and functional sympatholysis are not altered in HF patients and that functional sympatholysis is improved with HIC in both HF patients and healthy individuals. Moreover, these results suggest that the peak vasodilatory response to ATP is blunted in HF. NEW & NOTEWORTHY The ability to override sympathetic vasoconstrictor activity (by arterial tyramine infusion) during exercise is not different between heart failure patients and healthy individuals and is improved by high-intensity, one-legged cycling training. The peak vasodilatory response to ATP is reduced in heart failure patients.
    MeSH term(s) Adenosine Triphosphate/administration & dosage ; Aged ; Bicycling ; Denmark ; Exercise Therapy/methods ; Exercise Tolerance/drug effects ; Female ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Hyperemia/physiopathology ; Lower Extremity ; Male ; Middle Aged ; Muscle Contraction ; Muscle, Skeletal/blood supply ; Muscle, Skeletal/innervation ; Regional Blood Flow ; Stroke Volume ; Sympathetic Nervous System/drug effects ; Sympathetic Nervous System/physiopathology ; Sympathomimetics/administration & dosage ; Time Factors ; Treatment Outcome ; Vasodilation/drug effects ; Vasodilator Agents/administration & dosage ; Ventricular Function, Left
    Chemical Substances Sympathomimetics ; Vasodilator Agents ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2017-11-22
    Publishing country United States
    Document type Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00379.2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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