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  1. Article: Das Reiskorn - ein Geschenk der Natur. Das Silberhäutchen als universelle Nahrungsergänzung

    Münch, Jutta

    OM & Ernährung

    2023  Volume 182, Issue -, Page(s) 29

    Language German
    Document type Article
    ZDB-ID 2414995-0
    ISSN 1660-8631
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7189: Show issues Location:
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  2. Book ; Thesis: Änderung der kapillaren Strömungsgeschwindigkeit, der Oxygenierung, des HB Gehaltes und des relativen Blutflusses in der Haut des Menschen in einer Tiefe von -2 und -8 mm unter Hautniveau

    Münch, Johannes

    gemessen vor und nach dem Ganzkörpermoorbad sowie nach einer 30-minütigen Ruhepause, unter Verwendung der O2C-Methode

    2016  

    Institution Westfälische Wilhelms-Universität Münster
    Author's details vorgelegt von Johannes Egbert Volker Walter Münch aus Neustadt in Holstein
    Language German
    Size 86 Blätter, Illustrationen, Diagramme
    Publishing place Münster
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Westfälische Wilhelms-Universität Münster, 2016
    HBZ-ID HT019347708
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2017 E 1177 order for loan Magazin

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  3. Article: [No title information]

    Weil, Tatjana / Münch, Jan

    Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)

    2023  Volume 29, Issue 2, Page(s) 150–152

    Abstract: The SARS-CoV-2 pandemic once again highlighted the constant threat posed by viruses. Specific therapeutics are highly warranted, but their development is time consuming and cost intensive. Broad-spectrum antivirals provide a promising option for fast ... ...

    Title translation Molekulare Pinzetten als Breitbandinhibitor viraler Infektionen.
    Abstract The SARS-CoV-2 pandemic once again highlighted the constant threat posed by viruses. Specific therapeutics are highly warranted, but their development is time consuming and cost intensive. Broad-spectrum antivirals provide a promising option for fast application to treat circulating or newly emerged viruses. Here, we introduce molecular tweezers as broad-spectrum antivirals, which abrogate viral infection by directly targeting the viral membrane. Furthermore, we discuss the current stage of tweezer development to fight SARS-CoV-2 and other respiratory viruses.
    Language German
    Publishing date 2023-04-13
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2203536-9
    ISSN 1868-6249 ; 0947-0867
    ISSN (online) 1868-6249
    ISSN 0947-0867
    DOI 10.1007/s12268-023-1906-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Bedeutung der Nef vermittelten Herabregulierung von CD4 und MHC-Klasse I Proteinen für die Replikation und Pathogenese der Immundefizienzviren

    Münch, Jan

    2002  

    Author's details vorgelegt von Jan Münch
    Language German
    Size 56 S., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2002
    HBZ-ID HT013439171
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  5. Article ; Online: Tubular Diseases and Stones Seen From Pediatric and Adult Nephrology Perspectives.

    Münch, Johannes / Goodyer, Paul R / Wagner, Carsten A

    Seminars in nephrology

    2023  Volume 43, Issue 4, Page(s) 151437

    Abstract: The tubular system of the kidneys is a complex series of morphologic and functional units orchestrating the content of tubular fluid as it flows along the nephron and collecting ducts. Renal tubules maintain body water, regulate electrolytes and acid- ... ...

    Abstract The tubular system of the kidneys is a complex series of morphologic and functional units orchestrating the content of tubular fluid as it flows along the nephron and collecting ducts. Renal tubules maintain body water, regulate electrolytes and acid-base balance, reabsorb precious organic solutes, and eliminate specific metabolites, toxins, and drugs. In addition, decisive mechanisms to adjust blood pressure are governed by the renal tubules. Genetic as well as acquired disorders of these tubular functions may cause serious diseases that manifest both in childhood and adulthood. This article addresses a selection of tubulopathies and the underlying pathomechanisms, while highlighting the important differences in pediatric and adult nephrology care. These range from rare monogenic conditions such as nephrogenic diabetes insipidus, cystinosis, and Bartter syndrome that present in childhood, to the genetic and acquired tubular pathologies causing hypertension or nephrolithiasis that are more prevalent in adults. Both pediatric and adult nephrologists must be aware of these conditions and the age-dependent manifestations that warrant close interaction between the two subspecialties.
    MeSH term(s) Humans ; Child ; Nephrology ; Kidney Tubules/pathology ; Kidney/pathology ; Diabetes Insipidus, Nephrogenic/genetics ; Diabetes Insipidus, Nephrogenic/pathology ; Nephrons
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neutral and Anionic Square Planar Palladium(0) Complexes Stabilized by a Silicon Z-Type Ligand.

    Ansmann, Nils / Münch, Joshua / Schorpp, Marcel / Greb, Lutz

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 50, Page(s) e202313636

    Abstract: Anionic [Pd(0)-X] ...

    Abstract Anionic [Pd(0)-X]
    Language English
    Publishing date 2023-11-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202313636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Conformational States of the CXCR4 Inhibitor Peptide EPI-X4-A Theoretical Analysis.

    Jung, Christoph Karsten / Münch, Jan / Jacob, Timo

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: EPI-X4, an endogenous peptide inhibitor, has exhibited potential as a blocker of CXCR4-a G protein-coupled receptor. This unique inhibitor demonstrates the ability to impede HIV-1 infection and halt CXCR4-dependent processes such as tumor cell migration ... ...

    Abstract EPI-X4, an endogenous peptide inhibitor, has exhibited potential as a blocker of CXCR4-a G protein-coupled receptor. This unique inhibitor demonstrates the ability to impede HIV-1 infection and halt CXCR4-dependent processes such as tumor cell migration and invagination. Despite its promising effects, a comprehensive understanding of the interaction between EPI-X4 and CXCR4 under natural conditions remains elusive due to experimental limitations. To bridge this knowledge gap, a simulation approach was undertaken. Approximately 150,000 secondary structures of EPI-X4 were subjected to simulations to identify thermodynamically stable candidates. This simulation process harnessed a self-developed reactive force field operating within the ReaxFF framework. The application of the Two-Phase Thermodynamic methodology to ReaxFF facilitated the derivation of crucial thermodynamic attributes of the EPI-X4 conformers. To deepen insights, an ab initio density functional theory calculation method was employed to assess the electrostatic potentials of the most relevant (i.e., stable) EPI-X4 structures. This analytical endeavor aimed to enhance comprehension of the inhibitor's structural characteristics. As a result of these investigations, predictions were made regarding how EPI-X4 interacts with CXCR4. Two pivotal requirements emerged. Firstly, the spatial conformation of EPI-X4 must align effectively with the CXCR4 receptor protein. Secondly, the functional groups present on the surface of the inhibitor's structure must complement the corresponding features of CXCR4 to induce attraction between the two entities. These predictive outcomes were based on a meticulous analysis of the conformers, conducted in a gaseous environment. Ultimately, this rigorous exploration yielded a suitable EPI-X4 structure that fulfills the spatial and functional prerequisites for interacting with CXCR4, thus potentially shedding light on new avenues for therapeutic development.
    MeSH term(s) Humans ; Peptides/pharmacology ; Peptides/chemistry ; Receptors, CXCR4/metabolism ; HIV Infections ; Molecular Conformation
    Chemical Substances Peptides ; Receptors, CXCR4 ; CXCR4 protein, human
    Language English
    Publishing date 2023-11-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Sensing and Responding of Cardiomyocytes to Changes of Tissue Stiffness in the Diseased Heart.

    Münch, Juliane / Abdelilah-Seyfried, Salim

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 642840

    Abstract: Cardiomyocytes are permanently exposed to mechanical stimulation due to cardiac contractility. Passive myocardial stiffness is a crucial factor, which defines the physiological ventricular compliance and volume of diastolic filling with blood. Heart ... ...

    Abstract Cardiomyocytes are permanently exposed to mechanical stimulation due to cardiac contractility. Passive myocardial stiffness is a crucial factor, which defines the physiological ventricular compliance and volume of diastolic filling with blood. Heart diseases often present with increased myocardial stiffness, for instance when fibrotic changes modify the composition of the cardiac extracellular matrix (ECM). Consequently, the ventricle loses its compliance, and the diastolic blood volume is reduced. Recent advances in the field of cardiac mechanobiology revealed that disease-related environmental stiffness changes cause severe alterations in cardiomyocyte cellular behavior and function. Here, we review the molecular mechanotransduction pathways that enable cardiomyocytes to sense stiffness changes and translate those into an altered gene expression. We will also summarize current knowledge about when myocardial stiffness increases in the diseased heart. Sophisticated
    Language English
    Publishing date 2021-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.642840
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  9. Article ; Online: Semen enhances transmitted/founder HIV-1 infection and only marginally reduces antiviral activity of broadly neutralizing antibodies.

    von Maltitz, Pascal / Wettstein, Lukas / Weil, Tatjana / Schommers, Philipp / Klein, Florian / Münch, Jan

    Journal of virology

    2024  Volume 98, Issue 4, Page(s) e0119023

    Abstract: Topically applied microbicides may play a critical role in preventing sexual transmission of human immunodeficiency virus type 1 (HIV-1); however, their efficacy can be compromised by amyloid fibrils present in semen, which significantly increase HIV-1 ... ...

    Abstract Topically applied microbicides may play a critical role in preventing sexual transmission of human immunodeficiency virus type 1 (HIV-1); however, their efficacy can be compromised by amyloid fibrils present in semen, which significantly increase HIV-1 infectivity. This phenomenon may have contributed to the failure of most microbicide candidates in clinical settings. Understanding the impact of semen on microbicide effectiveness is thus crucial. In our study, we evaluated the influence of semen on the neutralizing activity of broadly neutralizing antibodies (bNAbs), including PG16, PGT121, 10-1074, 3BNC117, and VRC01, which are potential microbicide candidates. We found that semen enhances infection of HIV-1 transmitted/founder viruses but only marginally affects the neutralizing activity of tested antibodies, suggesting their potential for microbicide application. Our findings underscore the need to consider semen-mediated enhancement when evaluating and developing microbicides and highlight the potential of incorporating HIV-1 bNAbs in formulations to enhance efficacy and mitigate HIV-1 transmission during sexual encounters.IMPORTANCEThis study examined the impact of semen on the development of microbicides, substances used to prevent the transmission of HIV-1 during sexual activity. Semen contains certain components that can render the virus more infectious, posing a challenge to microbicide effectiveness. Researchers specifically investigated the effect of semen on a group of powerful antibodies called broadly neutralizing antibodies, which can neutralize a large spectrum of different HIV-1 variants. The results revealed that semen only had a minimal effect on the antibodies' ability to neutralize the virus. This is promising because it suggests that these antibodies could still be effective in microbicides, even in the presence of semen. Understanding this interaction is crucial for developing better strategies to prevent HIV-1 transmission. By incorporating the knowledge gained from this study, scientists can now focus on creating microbicides that consider the impact of semen, bringing us closer to more effective prevention methods.
    MeSH term(s) Humans ; Anti-Infective Agents/pharmacology ; Antibodies, Neutralizing ; Antiviral Agents/pharmacology ; Broadly Neutralizing Antibodies/pharmacology ; HIV Antibodies ; HIV Infections/transmission ; HIV-1/physiology ; Semen/chemistry ; Semen/virology
    Chemical Substances Anti-Infective Agents ; Antibodies, Neutralizing ; Antiviral Agents ; Broadly Neutralizing Antibodies ; HIV Antibodies
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01190-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Secretion and directed evolution of unspecific peroxygenases in S. cerevisiae.

    Dietz, Niklas / Wan, Li / Münch, Judith / Weissenborn, Martin J

    Methods in enzymology

    2023  Volume 693, Page(s) 267–306

    Abstract: Yeast-based secretion systems are advantageous for engineering highly interesting enzymes that are not or barely producible in E. coli. The herein-presented production setup facilitates high-throughput screening as no cell lysis is required. All ... ...

    Abstract Yeast-based secretion systems are advantageous for engineering highly interesting enzymes that are not or barely producible in E. coli. The herein-presented production setup facilitates high-throughput screening as no cell lysis is required. All techniques are described in detail, with access to freely available online tools and all vectors have been made available on the non-profit plasmid repository AddGene. We describe the method for UPOs as a model enzyme, showcasing their secretion, detection, and evolution using S. cerevisiae. Additional material to transfer this to P. pastoris has been published by our group previously (Püllmann & Weissenborn, 2021).
    MeSH term(s) Saccharomyces cerevisiae/genetics ; Escherichia coli ; Mixed Function Oxygenases/genetics ; Plasmids/genetics
    Chemical Substances peroxygenase (EC 1.14.-) ; Mixed Function Oxygenases (EC 1.-)
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2023.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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