Article ; Online: Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy.
2020 Volume 144, Page(s) 109984
Abstract: In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and ... ...
Abstract | In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen. |
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MeSH term(s) | Aminoglycosides/pharmacology ; Aminoglycosides/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/immunology ; Codon, Nonsense/drug effects ; Defensins/biosynthesis ; Defensins/genetics ; Defensins/physiology ; Drug Repositioning ; Humans ; Immunity, Innate/drug effects ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Macrolides/therapeutic use ; Models, Genetic ; Pandemics ; SARS-CoV-2/physiology ; Transcription, Genetic/drug effects ; Virus Internalization |
Chemical Substances | Aminoglycosides ; Antiviral Agents ; Codon, Nonsense ; Defensins ; Immunologic Factors ; Macrolides ; theta-defensin |
Keywords | covid19 |
Language | English |
Publishing date | 2020-06-10 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 193145-3 |
ISSN | 1532-2777 ; 0306-9877 |
ISSN (online) | 1532-2777 |
ISSN | 0306-9877 |
DOI | 10.1016/j.mehy.2020.109984 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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