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  1. AU="Muneoka, Yusuke"
  2. AU="Griggs, Lisa"
  3. AU="Klauck, Sabine M"
  4. AU="Turton, James A"
  5. AU="Patel, Abhijit A"
  6. AU="Shankowsky, Heather A"
  7. AU="Płóciennik, Przemysław"
  8. AU="Marchesi, Pietro"
  9. AU="Kim Je Hyoung"
  10. AU="Huber, Ingrid"
  11. AU="Hasuko, K."
  12. AU="Yao, Weigen"
  13. AU="Huang, Xiao-Fan"
  14. AU=Zuo Chuantian
  15. AU="Varchetta, Veronica"
  16. AU="Zhang, Lingye"
  17. AU="Venko, Katja"
  18. AU="Kasthuri, Thirupathi"
  19. AU="Pirtskhalava, Tamar"
  20. AU="Saridakis, E N"
  21. AU="Vithana, Eranga N"
  22. AU="Suárez-Lledó, M"
  23. AU="Olivo-Marston, Susan"
  24. AU="Denise P Momesso"
  25. AU="Obrecht-Sturm, Denise"

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  1. Artikel ; Online: Rational Extent of Regional Lymphadenectomy and the Prognostic Impact of the Number of Positive Lymph Nodes for Perihilar Cholangiocarcinoma.

    Sakata, Jun / Takizawa, Kazuyasu / Miura, Kohei / Hirose, Yuki / Muneoka, Yusuke / Tajima, Yosuke / Ichikawa, Hiroshi / Shimada, Yoshifumi / Kobayashi, Takashi / Wakai, Toshifumi

    Annals of surgical oncology

    2023  Band 30, Heft 7, Seite(n) 4306–4317

    Abstract: Background: The definition and classification of regional nodes are not standardized for perihilar cholangiocarcinoma. This study aimed to clarify the rational extent of regional lymphadenectomy and to elucidate the impact of number-based regional nodal ...

    Abstract Background: The definition and classification of regional nodes are not standardized for perihilar cholangiocarcinoma. This study aimed to clarify the rational extent of regional lymphadenectomy and to elucidate the impact of number-based regional nodal classification on survival of patients with this disease.
    Methods: Data of 136 patients with perihilar cholangiocarcinoma who underwent surgery were reviewed. The incidence of metastasis and the survival of patients with metastasis were calculated for each node group.
    Results: The incidence of metastasis for the node groups in the hepatoduodenal ligament (denoted as no. 12) ranged from 3.7% to 25.4%, with 5-year disease-specific survival of 12.9% to 33.3% for patients with metastasis. The incidences of metastasis in the common hepatic artery (no. 8) and posterior superior pancreaticoduodenal (no. 13a) node groups were 14.4% and 11.2%, respectively, with 5-year disease-specific survival rates of 16.7% and 20.0% for the patients with metastasis. When these node groups were defined as regional nodes, the 5-year disease-specific survival rates for the patients with pN0 (n = 80), pN1 (1-3 positive nodes, n = 38), and pN2 (≥ 4 positive nodes, n = 18) were 61.4%, 22.9%, and 17.6%, respectively (p < 0.001). The pN classification was independently associated with disease-specific survival (p < 0.001). When only the no. 12 node groups were regarded as regional nodes, pN classification failed to stratify the patients prognostically.
    Conclusions: No. 8 and no. 13a node groups should be considered regional nodes in addition to no. 12 node groups and should be dissected. The number-based regional nodal classification allows patients with this disease to be stratified prognostically.
    Mesh-Begriff(e) Humans ; Klatskin Tumor/surgery ; Klatskin Tumor/pathology ; Prognosis ; Lymphatic Metastasis/pathology ; Lymph Node Excision ; Bile Duct Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Neoplasm Staging ; Cholangiocarcinoma/pathology
    Sprache Englisch
    Erscheinungsdatum 2023-03-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13361-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: ASO Author Reflections: Adequate Nodal Classification for Perihilar Cholangiocarcinoma.

    Sakata, Jun / Takizawa, Kazuyasu / Miura, Kohei / Hirose, Yuki / Muneoka, Yusuke / Tajima, Yosuke / Ichikawa, Hiroshi / Shimada, Yoshifumi / Kobayashi, Takashi / Wakai, Toshifumi

    Annals of surgical oncology

    2023  Band 30, Heft 7, Seite(n) 4318–4319

    Mesh-Begriff(e) Humans ; Klatskin Tumor/surgery ; Klatskin Tumor/pathology ; Cholangiocarcinoma/pathology ; Bile Duct Neoplasms/pathology ; Bile Ducts, Intrahepatic/pathology
    Sprache Englisch
    Erscheinungsdatum 2023-03-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13418-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Impact of anatomic resection on long-term survival in patients with hepatocellular carcinoma with T1-T2 disease or microscopic vascular invasion.

    Hirose, Yuki / Sakata, Jun / Takizawa, Kazuyasu / Miura, Kohei / Kobayashi, Takashi / Muneoka, Yusuke / Tajima, Yosuke / Ichikawa, Hiroshi / Shimada, Yoshifumi / Wakai, Toshifumi

    Surgical oncology

    2023  Band 49, Seite(n) 101951

    Abstract: Background: This study aimed to clarify potential candidates for anatomic resection (AR) among patients with pathological T1-T2 (pT1-T2) hepatocellular carcinoma (HCC) and to determine whether AR is effective for HCC with microscopic vascular invasion ( ... ...

    Abstract Background: This study aimed to clarify potential candidates for anatomic resection (AR) among patients with pathological T1-T2 (pT1-T2) hepatocellular carcinoma (HCC) and to determine whether AR is effective for HCC with microscopic vascular invasion (MVI).
    Methods: We retrospectively analyzed 288 patients with pT1a (n = 50), pT1b (n = 134) or pT2 (n = 104) HCC who underwent curative-intent resection between 1990 and 2010. Surgical outcomes were compared between patients who underwent AR (n = 189) and those who underwent nonanatomic resection (NAR; n = 99) according to pT category and MVI status.
    Results: Patients who underwent AR were more likely to have good hepatic functional reserve and an aggressive primary tumor than those who underwent NAR. When patients were stratified according to pT category, AR had a more favorable impact on survival than NAR only in patients with pT2 HCC in univariate (5-year survival, 51.5% vs. 34.6%; p = 0.010) and multivariate analysis (hazard ratio 0.505; p = 0.014). However, AR had no impact on survival in patients with pT1a or pT1b HCC. In patients with MVI (n = 57), AR achieved better survival than NAR (5-year survival, 52.0% vs. 16.7%; p = 0.019) and was an independent prognostic factor (hazard ratio 0.335; p = 0.020). In patients without MVI (n = 231), there was no significant difference in survival between the two groups (p = 0.221).
    Conclusion: AR was identified as an independent factor in improved survival in patients with pT2 HCC or HCC with MVI.
    Mesh-Begriff(e) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Retrospective Studies ; Hepatectomy ; Neoplasm Recurrence, Local/surgery ; Prognosis ; Neoplasm Invasiveness
    Sprache Englisch
    Erscheinungsdatum 2023-05-18
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1107810-8
    ISSN 1879-3320 ; 0960-7404
    ISSN (online) 1879-3320
    ISSN 0960-7404
    DOI 10.1016/j.suronc.2023.101951
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [Resectable Pancreatic Cancer Successfully Treated with Neoadjuvant Chemotherapy Regimen Change to Modified FOLFIRINOX-A Case Report].

    Terao, Hikaru / Maruyama, Tomohiro / Aono, Takashi / Suzuki, Susumu / Kaneko, Kazuhiro / Sato, Tomoi / Okada, Takayuki / Muto, Ichiro / Hasegawa, Masaki / Muneoka, Yusuke / Tajima, Yosuke / Ichikawa, Hiroshi / Shimada, Yoshifumi / Sakata, Jun / Wakai, Toshifumi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Band 50, Heft 13, Seite(n) 1569–1571

    Abstract: A 72-year-old woman presented with obstructive jaundice. Computed tomography revealed a 12-mm low-density mass in the head of the pancreas. She was diagnosed as having pancreatic cancer by endoscopic ultrasound-guided fine-needle aspiration. She received ...

    Abstract A 72-year-old woman presented with obstructive jaundice. Computed tomography revealed a 12-mm low-density mass in the head of the pancreas. She was diagnosed as having pancreatic cancer by endoscopic ultrasound-guided fine-needle aspiration. She received gemcitabine plus nab-paclitaxel as preoperative chemotherapy. After 2 courses, hepatoduodenal lymph node metastasis appeared and was accompanied by increased tumor marker levels. The regimen was changed to modified FOLFIRINOX. After 5 courses, the lymph node metastasis was reduced in size and the tumor marker levels were decreased, so subtotal stomach-preserving pancreaticoduodenectomy was performed. Adjuvant chemotherapy was administered postoperatively. The patient was alive and well without recurrence 2 years and 9 months after the surgery, but died of sepsis. Nevertheless, this case highlights that when preoperative chemotherapy for resectable pancreatic cancer appears to be ineffective, a change in regimen may be useful.
    Mesh-Begriff(e) Female ; Humans ; Aged ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoadjuvant Therapy ; Lymphatic Metastasis ; Biomarkers, Tumor ; Irinotecan ; Oxaliplatin ; Leucovorin ; Fluorouracil
    Chemische Substanzen folfirinox ; Biomarkers, Tumor ; Irinotecan (7673326042) ; Oxaliplatin (04ZR38536J) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
    Sprache Japanisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: [Cancer of the Ascending Colon and Left Breast in an Older Adult Complicated by Thoracic Aortic Aneurysm].

    Suemori, Satomi / Nakano, Masato / Shimada, Yoshifumi / Tajima, Yosuke / Nakano, Mae / Tsuchida, Junko / Moro, Kazuki / Muneoka, Yusuke / Hirose, Yuki / Ishikawa, Hirosuke / Kano, Yosuke / Ichikawa, Hiroshi / Takizawa, Kazuyasu / Sakata, Jun / Wakai, Toshifumi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Band 50, Heft 13, Seite(n) 1393–1395

    Abstract: An 87-year-old woman with a gradually enlarging mass in her left breast, diagnosed as having left-sided breast cancer with skin invasion by a local practitioner, was referred to our hospital. Computed tomography revealed ascending colon cancer with ... ...

    Abstract An 87-year-old woman with a gradually enlarging mass in her left breast, diagnosed as having left-sided breast cancer with skin invasion by a local practitioner, was referred to our hospital. Computed tomography revealed ascending colon cancer with abdominal wall invasion and a thoracic aortic aneurysm(Stanford type B), in addition to breast cancer with skin invasion. A thoracic endovascular aortic repair and bypass surgery between the subclavian arteries were both performed for the thoracic aortic aneurysm. After 6 days, a right hemicolectomy and D2 lymphadenectomy were performed for the ascending colon cancer. A postoperative pathological diagnosis of pT3N0M0, pStage Ⅱa, was made. A total left mastectomy with a full-thickness skin graft for left breast cancer was performed after 2 months following the ascending colon cancer surgery. The postoperative pathological diagnosis was pT3N0M0, pStage ⅡB. No evidence of local recurrence or distant metastasis of the ascending colon cancer has been observed at 20 months postoperatively, or of the breast cancer after 18 months following surgery.
    Mesh-Begriff(e) Aged, 80 and over ; Female ; Humans ; Aortic Aneurysm, Thoracic/complications ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis Implantation ; Breast Neoplasms/complications ; Breast Neoplasms/surgery ; Colon, Ascending/surgery ; Colonic Neoplasms/complications ; Colonic Neoplasms/surgery ; Mastectomy ; Stents ; Treatment Outcome
    Sprache Japanisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: [Surgery for Cholangiocarcinoma with Superficial Spread and Lymph Node Metastasis-Report of a Long-Term Survivor Who Had Positive Proximal Ductal Resection Margins with Carcinoma In Situ].

    Ando, Takuya / Sakata, Jun / Kawachi, Yusuke / Abe, Shun / Saito, Seiji / Miura, Yohei / Hirose, Yuki / Ishikawa, Hirosuke / Miura, Kohei / Takizawa, Kazuyasu / Muneoka, Yusuke / Tajima, Yosuke / Ichikawa, Hiroshi / Shimada, Yoshifumi / Wakai, Toshifumi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Band 50, Heft 13, Seite(n) 1753–1755

    Abstract: A 66-year-old man was referred to our hospital with fever and abdominal pain. CT showed a mass in the intrapancreatic bile duct but no wall thickness in the perihilar bile ducts. Neither regional lymphadenopathy nor distant metastasis was observed. ... ...

    Abstract A 66-year-old man was referred to our hospital with fever and abdominal pain. CT showed a mass in the intrapancreatic bile duct but no wall thickness in the perihilar bile ducts. Neither regional lymphadenopathy nor distant metastasis was observed. Biliary cytology showed adenocarcinoma. The diagnosis was distal cholangiocarcinoma, and pancreatoduodenectomy was performed. Intraoperative frozen section examination of the ductal resection margins at the right and left hepatic ducts was positive for carcinoma in situ, and the operation ultimately completed with R1 resection. Histological examination confirmed a diagnosis of cholangiocarcinoma with superficial spread and a single positive lymph node. Adjuvant chemotherapy with S-1 was administered for 1 year. Anastomotic recurrence at the hepaticojejunostomy was found 5 years after resection; biopsy specimens revealed adenocarcinoma. Thereafter, S-1 chemotherapy was resumed, and the patient remains alive and well 9 years and 1 month after resection.
    Mesh-Begriff(e) Male ; Humans ; Aged ; Lymphatic Metastasis ; Margins of Excision ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/surgery ; Cholangiocarcinoma/pathology ; Bile Ducts, Intrahepatic/pathology ; Adenocarcinoma/surgery ; Carcinoma in Situ/surgery ; Hepatectomy ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/pathology ; Survivors
    Sprache Japanisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: [A Case of Intraductal Papillary Mucinous Adenocarcinoma with Hepatic Dysfunction Due to Tumor Perforation into the Bile Duct].

    Ishikawa, Hirosuke / Sakata, Jun / Kawachi, Yusuke / Abe, Shun / Saito, Seiji / Miura, Yohei / Ando, Takuya / Hirose, Yuki / Miura, Kohei / Takizawa, Kazuyasu / Muneoka, Yusuke / Tajima, Yosuke / Ichikawa, Hiroshi / Shimada, Yoshifumi / Wakai, Toshifumi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Band 50, Heft 13, Seite(n) 1872–1874

    Abstract: A 58-year-old woman presented with a complaint of weight loss. Abdominal computed tomography showed dilatation of the biliary and pancreatic ducts and a mural nodule in the pancreatic duct. The diagnosis was intraductal papillary mucinous neoplasm(IPMN). ...

    Abstract A 58-year-old woman presented with a complaint of weight loss. Abdominal computed tomography showed dilatation of the biliary and pancreatic ducts and a mural nodule in the pancreatic duct. The diagnosis was intraductal papillary mucinous neoplasm(IPMN). Endoscopic retrograde cholangiopancreatography(ERCP)and cholangioscopy revealed a fistula between the common bile duct and the IPMN. A sudden increase in hepatobiliary enzymes was noted preoperatively. ERCP showed that the common bile duct was obstructed by mucus. A nasobiliary drainage tube was inserted into the bile duct endoscopically and kept open by daily tube washing, and the liver dysfunction improved. Total pancreatectomy, splenectomy, and regional lymph node dissection were performed. Histological examination confirmed that the primary tumor was mixed invasive intraductal papillary mucinous adenocarcinoma. The patient remains alive and well with no evidence of recurrence 18 months after resection.
    Mesh-Begriff(e) Female ; Humans ; Middle Aged ; Pancreatic Intraductal Neoplasms ; Adenocarcinoma, Papillary/complications ; Adenocarcinoma, Papillary/surgery ; Adenocarcinoma, Papillary/diagnosis ; Bile Ducts/pathology ; Pancreatic Neoplasms/surgery ; Liver Diseases ; Adenocarcinoma, Mucinous/complications ; Adenocarcinoma, Mucinous/surgery ; Adenocarcinoma, Mucinous/diagnosis ; Carcinoma, Pancreatic Ductal/surgery
    Sprache Japanisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: [A Case of Esophageal Carcinoma with Tracheal Invasion after Preoperative Treatment with Docetaxel, Cisplatin, and 5-Fluorouracil in Which Definitive Chemoradiotherapy and Salvage Esophagectomy Prolonged Survival].

    Sakakibara, Kenmo / Ichikawa, Hiroshi / Kano, Yosuke / Muneoka, Yusuke / Usui, Kenji / Moro, Kazuki / Tsuchida, Junko / Yuki, Hirose / Miura, Kohei / Tajima, Yosuke / Nakano, Mae / Takizawa, Kazuyasu / Shimada, Yoshifumi / Sakata, Jun / Waka, Toshifumi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Band 50, Heft 13, Seite(n) 1447–1449

    Abstract: A 57-year-old man was diagnosed as having resectable advanced esophageal carcinoma adjacent to the trachea(Ut, cT3N0M0)and received preoperative docetaxel, cisplatin, and 5-fluorouracil therapy. Due to tracheal tumor invasion and upstaging to cT4bN0M0 ... ...

    Abstract A 57-year-old man was diagnosed as having resectable advanced esophageal carcinoma adjacent to the trachea(Ut, cT3N0M0)and received preoperative docetaxel, cisplatin, and 5-fluorouracil therapy. Due to tracheal tumor invasion and upstaging to cT4bN0M0 after 1 course of chemotherapy, the treatment was converted to definitive chemoradiotherapy (CRT). A remarkable response with no evidence of tracheal invasion was observed on computed tomography following definitive CRT. He underwent successful curative resection with salvage esophagectomy, and the resected tumor was staged as pT1bN0M0. No adjuvant therapy was administered, and the patient was alive with no evidence of disease at the 5-year postoperative follow-up. The response to preoperative treatment should be meticulously assessed and appropriate treatment modalities used to avoid overlooking the potential for cure, even if the response to preoperative treatment with docetaxel, cisplatin, and 5-fluorouracil is poor.
    Mesh-Begriff(e) Male ; Humans ; Middle Aged ; Cisplatin ; Docetaxel/therapeutic use ; Fluorouracil ; Trachea/pathology ; Esophagectomy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Esophageal Neoplasms/drug therapy ; Chemoradiotherapy ; Carcinoma/drug therapy ; Treatment Outcome
    Chemische Substanzen Cisplatin (Q20Q21Q62J) ; Docetaxel (15H5577CQD) ; Fluorouracil (U3P01618RT)
    Sprache Japanisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: [Two Operations for Intrahepatic Recurrence of Biliary Cystadenocarcinoma-A Long-Term Survivor].

    Kawachi, Yusuke / Sakata, Jun / Abe, Shun / Saito, Seiji / Miura, Yohei / Ando, Takuya / Hirose, Yuki / Ishikawa, Hirosuke / Miura, Kohei / Takizawa, Kazuyasu / Muneoka, Yusuke / Tajima, Yosuke / Ichikawa, Hiroshi / Shimada, Yoshifumi / Wakai, Toshifumi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Band 50, Heft 13, Seite(n) 1953–1955

    Abstract: We report a case of biliary cystadenocarcinoma in which long-term survival was achieved after 2 operations for intrahepatic recurrence. A 72-year-old man with biliary cystadenocarcinoma located mainly in segment 3 of the liver underwent left hepatectomy, ...

    Abstract We report a case of biliary cystadenocarcinoma in which long-term survival was achieved after 2 operations for intrahepatic recurrence. A 72-year-old man with biliary cystadenocarcinoma located mainly in segment 3 of the liver underwent left hepatectomy, extrahepatic bile duct resection, and lymph node dissection. Seven years and 9 months after the initial resection, he underwent partial liver resection(segment 5)for intrahepatic recurrence detected by computed tomography. Fifteen years and 7 months after the initial resection, he underwent repeat partial resection of the liver(segment 5)for intrahepatic recurrence. Histologically, these tumors were confirmed to be recurrence of biliary cystadenocarcinoma. He remains alive and well with no further recurrence 21 years and 6 months after the initial resection. This case and a literature review suggest that hepatic resection is a useful treatment option for intrahepatic recurrence of biliary cystadenocarcinoma.
    Mesh-Begriff(e) Male ; Humans ; Aged ; Bile Ducts, Intrahepatic/pathology ; Cholangiocarcinoma/surgery ; Liver/pathology ; Hepatectomy/methods ; Cystadenocarcinoma/surgery ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/pathology
    Sprache Japanisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Japan
    Dokumenttyp Review ; Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: [A Case of Appendiceal Carcinoma with BRAF V600E Mutation and Microsatellite Instability-High].

    Inagaki, Tatsuki / Tajima, Yosuke / Shimada, Yoshifumi / Nakano, Mae / Nakano, Masato / Abe, Kaoru / Yamai, Daisuke / Ozeki, Hikaru / Muneoka, Yusuke / Ishikawa, Hirosuke / Kano, Yosuke / Ichikawa, Hiroshi / Takizawa, Kazuyasu / Sakata, Jun / Wakai, Toshifumi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Band 50, Heft 13, Seite(n) 1584–1586

    Abstract: A 75-year-old woman presented to our hospital with abdominal pain and melena. Colonoscopy revealed an ulcer at the appendiceal orifice. Histopathological examination of biopsy specimens revealed adenocarcinoma. Computed tomography showed an appendiceal ... ...

    Abstract A 75-year-old woman presented to our hospital with abdominal pain and melena. Colonoscopy revealed an ulcer at the appendiceal orifice. Histopathological examination of biopsy specimens revealed adenocarcinoma. Computed tomography showed an appendiceal mass of 11.8×6.7 cm in size involving the cecum and terminal ileum without any distant metastatic findings. Ileocecal resection with regional lymph node dissection to the root of the ileocolonic artery was performed. Histopathological examination of the specimen revealed appendiceal adenocarcinoma. Molecular subtype of the tumor was BRAF V600E mutation and microsatellite instability-high(MSI-H). The pathological stage was pT4bpN1bcM0, pStage ⅢC. She received 8 courses of CapeOX as adjuvant chemotherapy and no recurrence was noted 12 months following the surgery. The establishment of standard treatment strategies including surgery, chemotherapy, and immunotherapy for carcinoma of the appendix with BRAF V600E mutation and/or MSI-H is needed.
    Mesh-Begriff(e) Female ; Humans ; Aged ; Proto-Oncogene Proteins B-raf/genetics ; Microsatellite Instability ; Appendiceal Neoplasms/genetics ; Appendiceal Neoplasms/surgery ; Appendiceal Neoplasms/pathology ; Appendix ; Adenocarcinoma ; Carcinoma ; Mutation
    Chemische Substanzen Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1)
    Sprache Japanisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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