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  1. Article: Germinal Center Cells Turning to the Dark Side: Neoplasms of B Cells, Follicular Helper T Cells, and Follicular Dendritic Cells.

    Munguía-Fuentes, Rosario / Maqueda-Alfaro, Raúl Antonio / Chacón-Salinas, Rommel / Flores-Romo, Leopoldo / Yam-Puc, Juan Carlos

    Frontiers in oncology

    2021  Volume 10, Page(s) 587809

    Abstract: Gaining knowledge of the neoplastic side of the three main cells-B cells, Follicular Helper T (Tfh) cells, and follicular dendritic cells (FDCs) -involved in the germinal center (GC) reaction can shed light toward further understanding the microuniverse ... ...

    Abstract Gaining knowledge of the neoplastic side of the three main cells-B cells, Follicular Helper T (Tfh) cells, and follicular dendritic cells (FDCs) -involved in the germinal center (GC) reaction can shed light toward further understanding the microuniverse that is the GC, opening the possibility of better treatments. This paper gives a review of the more complex underlying mechanisms involved in the malignant transformations that take place in the GC. Whilst our understanding of the biology of the GC-related B cell lymphomas has increased-this is not reviewed in detail here-the dark side involving neoplasms of Tfh cells and FDCs are poorly studied, in great part, due to their low incidence. The aggressive behavior of Tfh lymphomas and the metastatic potential of FDCs sarcomas make them clinically relevant, merit further attention and are the main focus of this review. Tfh cells and FDCs malignancies can often be misdiagnosed. The better understanding of these entities linked to their molecular and genetic characterization will lead to prediction of high-risk patients, better diagnosis, prognosis, and treatments based on molecular profiles.
    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.587809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Langerhans Cells From Mice at Birth Express Endocytic- and Pattern Recognition-Receptors, Migrate to Draining Lymph Nodes Ferrying Antigen and Activate Neonatal T Cells

    Becerril-García, Miguel Angel / Yam-Puc, Juan Carlos / Maqueda-Alfaro, Raúl / Beristain-Covarrubias, Nonantzin / Heras-Chavarría, Monica / Gallegos-Hernández, Isis Amara / Calderón-Amador, Juana / Munguía-Fuentes, Rosario / Donis-Maturano, Luis / Flores-Langarica, Adriana / Flores-Romo, Leopoldo

    Frontiers in immunology

    2020  Volume 11, Page(s) 744

    Abstract: Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An ... ...

    Abstract Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An arsenal of endocytic molecules is available to this end, including lectins and pathogen recognition receptors (PRRs). However, cutaneous LCs are poorly defined in the early neonatal period. We assessed endocytic molecules expression
    MeSH term(s) Animals ; Animals, Newborn ; Cell Movement ; Cell Proliferation ; Epidermal Cells/metabolism ; Female ; Langerhans Cells/immunology ; Langerhans Cells/physiology ; Lymph Nodes ; Mice ; Mice, Inbred BALB C ; Pregnancy ; Receptors, Cell Surface/metabolism ; Skin/immunology ; T-Lymphocytes/metabolism ; Tumor Necrosis Factor Receptor Superfamily, Member 7
    Chemical Substances Receptors, Cell Surface ; Tumor Necrosis Factor Receptor Superfamily, Member 7
    Language English
    Publishing date 2020-04-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: TLR2 Regulates Mast Cell IL-6 and IL-13 Production During

    Soria-Castro, Rodolfo / Alfaro-Doblado, Ángel R / Rodríguez-López, Gloria / Campillo-Navarro, Marcia / Meneses-Preza, Yatsiri G / Galán-Salinas, Adrian / Alvarez-Jimenez, Violeta / Yam-Puc, Juan C / Munguía-Fuentes, Rosario / Domínguez-Flores, Adriana / Estrada-Parra, Sergio / Pérez-Tapia, Sonia M / Chávez-Blanco, Alma D / Chacón-Salinas, Rommel

    Frontiers in immunology

    2021  Volume 12, Page(s) 650779

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    MeSH term(s) Animals ; Cell Degranulation/immunology ; Cell Degranulation/physiology ; Cells, Cultured ; Cytokines/immunology ; Cytokines/metabolism ; Enzyme Activation/immunology ; Host-Pathogen Interactions/immunology ; Interleukin-13/immunology ; Interleukin-13/metabolism ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Listeria monocytogenes/immunology ; Listeria monocytogenes/physiology ; Mast Cells/immunology ; Mast Cells/microbiology ; Mast Cells/physiology ; Mice, Inbred C57BL ; NF-kappa B/immunology ; NF-kappa B/metabolism ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Toll-Like Receptor 2/immunology ; Toll-Like Receptor 2/metabolism ; p38 Mitogen-Activated Protein Kinases/immunology ; p38 Mitogen-Activated Protein Kinases/metabolism ; Mice
    Chemical Substances Cytokines ; Interleukin-13 ; Interleukin-6 ; NF-kappa B ; Reactive Oxygen Species ; Toll-Like Receptor 2 ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.650779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Immunization of Newborn Mice Accelerates the Architectural Maturation of Lymph Nodes, But AID-Dependent IgG Responses Are Still Delayed Compared to the Adult.

    Munguía-Fuentes, Rosario / Yam-Puc, Juan Carlos / Silva-Sánchez, Aarón / Marcial-Juárez, Edith / Gallegos-Hernández, Isis Amara / Calderón-Amador, Juana / Randall, Troy D / Flores-Romo, Leopoldo

    Frontiers in immunology

    2017  Volume 8, Page(s) 13

    Abstract: Lymph nodes (LNs) have evolved to maximize antigen (Ag) collection and presentation as well as lymphocyte proliferation and differentiation-processes that are spatially regulated by stromal cell subsets, including fibroblastic reticular cells (FRCs) and ... ...

    Abstract Lymph nodes (LNs) have evolved to maximize antigen (Ag) collection and presentation as well as lymphocyte proliferation and differentiation-processes that are spatially regulated by stromal cell subsets, including fibroblastic reticular cells (FRCs) and follicular dendritic cells (FDCs). Here, we showed that naïve neonatal mice have poorly organized LNs with few B and T cells and undetectable FDCs, whereas adult LNs have numerous B cells and large FDC networks. Interestingly, immunization on the day of birth accelerated B cell accumulation and T cell recruitment into follicles as well as FDC maturation and FRC organization in neonatal LNs. However, compared to adults, the formation of germinal centers was both delayed and reduced following immunization of neonatal mice. Although immunized neonates poorly expressed activation-induced cytidine deaminase (AID), they were able to produce Ag-specific IgGs, but with lower titers than adults. Interestingly, the Ag-specific IgM response in neonates was similar to that in adults. These results suggest that despite an accelerated structural maturation of LNs in neonates following vaccination, the B cell response is still delayed and reduced in its ability to isotype switch most likely due to poor AID expression. Of note, naïve pups born to Ag-immunized mothers had high titers of Ag-specific IgGs from day 0 (at birth). These transferred antibodies confirm a mother-derived coverage to neonates for Ags to which mothers (and most likely neonates) are exposed, thus protecting the neonates while they produce their own antibodies. Finally, the type of Ag used in this study and the results obtained also indicate that T cell help would be operating at this stage of life. Thus, neonatal immune system might not be intrinsically immature but rather evolutionary adapted to cope with Ags at birth.
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.00013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reduced in vivo cytotoxicity and increased Mycobacterial burden are associated with virulent Mycobacterium tuberculosis strains during lung infection.

    Quintero-Macías, Liz / Silva-Sánchez, Aarón / Valderrabano-Ortíz, Estela / Munguía-Fuentes, Rosario / Aguilar-León, Diana / Hernández-Pando, Rogelio / Flores-Romo, Leopoldo

    Immunological investigations

    2012  Volume 41, Issue 1, Page(s) 51–60

    Abstract: Cytotoxic cellular responses are crucial for clearing intracellular pathogens and generating host resistance. Experimental pulmonary tuberculosis is associated with an early delay in T cell responses and with elevated lung bacterial burden during chronic ...

    Abstract Cytotoxic cellular responses are crucial for clearing intracellular pathogens and generating host resistance. Experimental pulmonary tuberculosis is associated with an early delay in T cell responses and with elevated lung bacterial burden during chronic infection. In this study we quantified the in vivo cytotoxicity and the mycobacterial burden from two pertinent tissues in groups of mice infected each with a mycobacterial strain of different virulence. None of the strains induced cytotoxic responses during early (day 14) infection. Interestingly, at 21 and 60 days post-infection, Mycobacterium canettii (lowest virulence) triggered the strongest in vivo cytotoxicity both in lungs and mediastinal lymph nodes. In contrast, Mycobacterium tuberculosis H37Rv (intermediate virulence) and Beijing strains (highest virulence) induced lower cytotoxic responses, and exhibited high bacterial growth, especially in lungs. These in vivo data suggest that virulence of Mycobacterium strains are somehow associated with subverting cytotoxic responses, thus contributing to early bacterial replication and subsequent persistence in the lungs.
    MeSH term(s) Animals ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Humans ; Lung/immunology ; Lung/microbiology ; Lung/pathology ; Lymph Nodes/immunology ; Lymph Nodes/microbiology ; Lymph Nodes/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mycobacterium tuberculosis/growth & development ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Pneumonia/immunology ; Pneumonia/microbiology ; Species Specificity ; T-Lymphocytes/immunology ; Tuberculosis/immunology ; Tuberculosis/microbiology ; Virulence/immunology
    Language English
    Publishing date 2012
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632565-8
    ISSN 1532-4311 ; 0882-0139
    ISSN (online) 1532-4311
    ISSN 0882-0139
    DOI 10.3109/08820139.2011.580408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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