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  1. AU="Munir, Atif"
  2. AU="Ou, Ya-Nan"
  3. AU=Brown James E AU=Brown James E
  4. AU="Wang, Zhongmin"
  5. AU="Lemieux, Audrée"
  6. AU="Abdelhameed, Mohamed F"
  7. AU="Schaible, Lonnie M"
  8. AU="Yazie, Taklo Simeneh Yazie"
  9. AU="Jude Orumuah Agbugui"
  10. AU="Kruse, Robert L"
  11. AU="Shyama Nandakumar"
  12. AU="Gelb, M"
  13. AU="Gasparini, L"
  14. AU="Ulvila, J"
  15. AU="Länsimies, Helena"

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  1. Artikel ; Online: Myxedema Coma.

    Munir, Atif

    Journal of Ayub Medical College, Abbottabad : JAMC

    2018  Band 30, Heft 1, Seite(n) 119–120

    Abstract: Myxedema may be the first presentation of patients with undiagnosed hypothyroidism. Definitive management is with thyroid hormone but supportive measures, identification and treatment of precipitating factors in an appropriately safe environment are ... ...

    Abstract Myxedema may be the first presentation of patients with undiagnosed hypothyroidism. Definitive management is with thyroid hormone but supportive measures, identification and treatment of precipitating factors in an appropriately safe environment are vital. There is no consensus about preferred thyroid hormone regimen. Corticosteroid therapy is given until adrenal insufficiency has been excluded. We present here a case of seventy-four years old woman of myxodema coma.
    Mesh-Begriff(e) Aged ; Coma ; Female ; Humans ; Hypothyroidism/complications ; Hypothyroidism/drug therapy ; Myxedema ; Thyroid Hormones/administration & dosage ; Thyroid Hormones/therapeutic use
    Chemische Substanzen Thyroid Hormones
    Sprache Englisch
    Erscheinungsdatum 2018-01
    Erscheinungsland Pakistan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Berardinelli-Seip Congenital Lipodystrophy - A Case Report and Review of Literature.

    Munir, Atif / Haider, Miqdad / Chachar, Aijaz Zeeshan Khan

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2022  Band 32, Heft 6, Seite(n) 817–819

    Abstract: Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an ... ...

    Abstract Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an inability to store fat in adipocytes. It is extremely rare. Most of the cases reported are from Africa and North America. Only a handful of cases have been reported in the world. The aim of this case report is to highlight the significance of this rare metabolic disorder, which should be considered whilst managing young patients with severe insulin resistance. We present a case of a young Asian child with an increasing need for insulin for his diabetes. He was previously managed on the lines of type 1 diabetes mellitus and his insulin requirements kept on increasing. Diagnosis on the basis of genetic studies was not possible due to the non-availability of the test in Pakistan. BSCL is an infrequent condition leading to several cardiometabolic complications. Timely diagnosis can lead to better management and prevention of complications. Keywords: Insulin resistance, Lipodystrophy, Acanthosis nigricans, Hypertriglyceridemia, Genetic disease.
    Mesh-Begriff(e) Acanthosis Nigricans ; Child ; Humans ; Insulin/therapeutic use ; Insulin Resistance ; Lipodystrophy, Congenital Generalized/complications ; Lipodystrophy, Congenital Generalized/diagnosis ; Lipodystrophy, Congenital Generalized/genetics ; Male ; Rare Diseases
    Chemische Substanzen Insulin
    Sprache Englisch
    Erscheinungsdatum 2022-01-04
    Erscheinungsland Pakistan
    Dokumenttyp Case Reports ; Review
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2022.06.817
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Thyrotoxic periodic paralysis: an endocrine cause of paraparesis.

    Munir, Atif

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2014  Band 24 Suppl 2, Seite(n) S99–100

    Abstract: Periodic paralysis is a muscle disorder that belongs to the family of diseases called channelopathies, manifested by episodes of painless muscle weakness. Periodic paralysis is classified as hypokalemic when episodes occur in association with low ... ...

    Abstract Periodic paralysis is a muscle disorder that belongs to the family of diseases called channelopathies, manifested by episodes of painless muscle weakness. Periodic paralysis is classified as hypokalemic when episodes occur in association with low potassium levels. Most cases are hereditary. Acquired cases have been described in association with hyperthyroidism. Diagnosis is made on clinical and biochemical grounds. Patients may be markedly hypokalemic during the episode and respond well to potassium supplementation. Episodes can be prevented by achieving a euthyroid state. This report describes a young gentleman presenting with thyrotoxic hypokalemic paraparesis. The condition needs to be considered in the differential diagnosis of neuromuscular weakness in the context of hypokalemia by the treating physicians.
    Mesh-Begriff(e) Adult ; Antithyroid Agents/therapeutic use ; Graves Disease/complications ; Humans ; Hyperthyroidism/blood ; Hyperthyroidism/diagnosis ; Hyperthyroidism/drug therapy ; Hypokalemic Periodic Paralysis/etiology ; Male ; Muscle Weakness/diagnosis ; Muscle Weakness/etiology ; Paraparesis/diagnosis ; Paraparesis/etiology ; Potassium/blood ; Propranolol/therapeutic use ; Propylthiouracil/therapeutic use ; Thyroid Function Tests ; Thyrotoxicosis/complications ; Treatment Outcome
    Chemische Substanzen Antithyroid Agents ; Propylthiouracil (721M9407IY) ; Propranolol (9Y8NXQ24VQ) ; Potassium (RWP5GA015D)
    Sprache Englisch
    Erscheinungsdatum 2014-05
    Erscheinungsland Pakistan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 05.2014/JCPSP.S99S100
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Acute pancreatitis secondary to hypertriglyceridaemia caused by undiagnosed type 2 diabetes.

    Khaqan, Arous / Munir, Atif / Haider, Miqdad

    The journal of the Royal College of Physicians of Edinburgh

    2021  Band 51, Heft 2, Seite(n) 140–142

    Abstract: In some patients undiagnosed diabetes may present with metabolic complications of diabetes as their initial presentation. Suboptimal glycaemic control in diagnosed and undiagnosed diabetes can cause hypertriglyceridaemia which can cause pancreatitis. In ... ...

    Abstract In some patients undiagnosed diabetes may present with metabolic complications of diabetes as their initial presentation. Suboptimal glycaemic control in diagnosed and undiagnosed diabetes can cause hypertriglyceridaemia which can cause pancreatitis. In patients presenting with pancreatitis where common causes of pancreatitis are excluded hypertriglyceridaemia should be considered as a cause and hence their lipid profile should be evaluated. If hypertriglyceridaemia is confirmed, then such a patient should be screened for diabetes. We present three cases presenting to hospital with pancreatitis secondary to hypertriglyceridaemia. Hypertriglyceridaemia in all three were secondary to undiagnosed and uncontrolled type 2 diabetes. Early treatment of hypertriglyceridaemia can prevent morbidity and mortality. Diagnosing type 2 diabetes in this context can result in optimisation of glycaemic control, and hence improve hypertriglyceridaemia and reduce the risk of recurrent attacks of pancreatitis.
    Mesh-Begriff(e) Acute Disease ; Diabetes Mellitus, Type 2/complications ; Humans ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/diagnosis ; Pancreatitis/diagnosis ; Pancreatitis/etiology
    Sprache Englisch
    Erscheinungsdatum 2021-07-20
    Erscheinungsland Scotland
    Dokumenttyp Case Reports
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.4997/JRCPE.2021.208
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Thyrotoxic Periodic Paralysis.

    Haider, Miqdad / Khan Chachar, Aijaz Zeeshan / Munir, Atif

    Journal of Ayub Medical College, Abbottabad : JAMC

    2020  Band 31, Heft 4, Seite(n) 619–621

    Abstract: Thyrotoxic periodic paralysis is an uncommon disorder characterized by hypokalaemia, thyrotoxicosis and paralysis, most commonly seen in South Asian males. Aim of our case series is to highlight the significance of this reversible cause of patients ... ...

    Abstract Thyrotoxic periodic paralysis is an uncommon disorder characterized by hypokalaemia, thyrotoxicosis and paralysis, most commonly seen in South Asian males. Aim of our case series is to highlight the significance of this reversible cause of patients presenting with neuromuscular paralysis. We present case series of 1 Asian and three Caucasian patients with thyrotoxic periodic paralysis who came with neuromuscular weakness secondary to thyrotoxicosis. All made a swift and uneventful recovery with no recurrence. Thyrotoxic periodic paralysis (TPP) is an infrequent condition having recurrent episodes of muscle weakness as main feature. Hypokalaemia is a common finding seen in these patients. Resolution of the attacks is achieved with correction of hypokalaemia and hyperthyroidism.
    Mesh-Begriff(e) Adult ; Aged, 80 and over ; Female ; Humans ; Hyperthyroidism/complications ; Hypokalemia/complications ; Male ; Muscle Weakness/etiology ; Paralysis/etiology ; Thyrotoxicosis/etiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-01-13
    Erscheinungsland Pakistan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients.

    Daniel, Eleni / Aylwin, Simon / Mustafa, Omar / Ball, Steve / Munir, Atif / Boelaert, Kristien / Chortis, Vasileios / Cuthbertson, Daniel J / Daousi, Christina / Rajeev, Surya P / Davis, Julian / Cheer, Kelly / Drake, William / Gunganah, Kirun / Grossman, Ashley / Gurnell, Mark / Powlson, Andrew S / Karavitaki, Niki / Huguet, Isabel /
    Kearney, Tara / Mohit, Kumar / Meeran, Karim / Hill, Neil / Rees, Aled / Lansdown, Andrew J / Trainer, Peter J / Minder, Anna-Elisabeth H / Newell-Price, John

    The Journal of clinical endocrinology and metabolism

    2015  Band 100, Heft 11, Seite(n) 4146–4154

    Abstract: Background: Cushing's syndrome (CS) is a severe condition with excess mortality and significant morbidity necessitating control of hypercortisolemia. There are few data documenting use of the steroidogenesis inhibitor metyrapone for this purpose.: ... ...

    Abstract Background: Cushing's syndrome (CS) is a severe condition with excess mortality and significant morbidity necessitating control of hypercortisolemia. There are few data documenting use of the steroidogenesis inhibitor metyrapone for this purpose.
    Objective: The objective was to assess the effectiveness of metyrapone in controlling cortisol excess in a contemporary series of patients with CS.
    Design: This was designed as a retrospective, multicenter study.
    Setting: Thirteen University hospitals were studied.
    Patients: We studied a total of 195 patients with proven CS: 115 Cushing's disease, 37 ectopic ACTH syndrome, 43 ACTH-independent disease (adrenocortical carcinoma 10, adrenal adenoma 30, and ACTH-independent adrenal hyperplasia 3).
    Measurements: Measurements included biochemical parameters of activity of CS: mean serum cortisol "day-curve" (CDC) (target 150-300 nmol/L); 9 am serum cortisol; 24-hour urinary free cortisol (UFC).
    Results: A total of 164/195 received metyrapone monotherapy. Mean age was 49.6 ± 15.7 years; mean duration of therapy 8 months (median 3 mo, range 3 d to 11.6 y). There were significant improvements on metyrapone, first evaluation to last review: CDC (91 patients, 722.9 nmol/L [26.2 μg/dL] vs 348.6 nmol/L [12.6 μg/dL]; P < .0001); 9 am cortisol (123 patients, 882.9 nmol/L [32.0 μg/dL] vs 491.1 nmol/L [17.8 μg/dL]; P < .0001); and UFC (37 patients, 1483 nmol/24 h [537 μg/24 h] vs 452.6 nmol/24 h [164 μg/24 h]; P = .003). Overall, control at last review: 55%, 43%, 46%, and 76% of patients who had CDCs, UFCs, 9 am cortisol less than 331 nmol/L (12.0 μg/dL), and 9 am cortisol less than upper limit of normal/600 nmol/L (21.7 μg/dL). Median final dose: Cushing's disease 1375 mg; ectopic ACTH syndrome 1500 mg; benign adrenal disease 750 mg; and adrenocortical carcinoma 1250 mg. Adverse events occurred in 25% of patients, mostly mild gastrointestinal upset and dizziness, usually within 2 weeks of initiation or dose increase, all reversible.
    Conclusions: Metyrapone is effective therapy for short- and long-term control of hypercortisolemia in CS.
    Mesh-Begriff(e) ACTH-Secreting Pituitary Adenoma/drug therapy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Cushing Syndrome/drug therapy ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/adverse effects ; Enzyme Inhibitors/therapeutic use ; Humans ; Hydrocortisone/blood ; Hydrocortisone/urine ; Infant ; Male ; Metyrapone/administration & dosage ; Metyrapone/adverse effects ; Metyrapone/therapeutic use ; Middle Aged ; Pituitary Neoplasms/drug therapy ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Chemische Substanzen Enzyme Inhibitors ; Hydrocortisone (WI4X0X7BPJ) ; Metyrapone (ZS9KD92H6V)
    Sprache Englisch
    Erscheinungsdatum 2015-09-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2015-2616
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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