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  1. Article ; Online: Influence of vaccine strains on the evolution of canine distemper virus.

    da Fontoura Budaszewski, Renata / Streck, André Felipe / Nunes Weber, Matheus / Maboni Siqueira, Franciele / Muniz Guedes, Rafael Lucas / Wageck Canal, Cláudio

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2016  Volume 41, Page(s) 262–269

    Abstract: Canine distemper virus (CDV) is a major dog pathogen belonging to the genus Morbillivirus of the family Paramyxoviridae. CDV causes disease and high mortality in dogs and wild carnivores. Although homologous recombination has been demonstrated in many ... ...

    Abstract Canine distemper virus (CDV) is a major dog pathogen belonging to the genus Morbillivirus of the family Paramyxoviridae. CDV causes disease and high mortality in dogs and wild carnivores. Although homologous recombination has been demonstrated in many members of Paramyxoviridae, these events have rarely been reported for CDV. To detect potential recombination events, the complete CDV genomes available in GenBank up to June 2015 were screened using distinct algorithms to detect genetic conversions and incongruent phylogenies. Eight putative recombinant viruses derived from different CDV genotypes and different hosts were detected. The breakpoints of the recombinant strains were primarily located on fusion and hemagglutinin glycoproteins. These results suggest that homologous recombination is a frequent phenomenon in morbillivirus populations under natural replication, and CDV vaccine strains might play an important role in shaping the evolution of this virus.
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2016.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Adaptive processes of Staphylococcus aureus isolates during the progression from acute to chronic bone and joint infections in patients.

    Trouillet-Assant, Sophie / Lelièvre, Lucie / Martins-Simões, Patrícia / Gonzaga, Luiz / Tasse, Jason / Valour, Florent / Rasigade, Jean-Philippe / Vandenesch, François / Muniz Guedes, Rafael Lucas / Ribeiro de Vasconcelos, Ana Tereza / Caillon, Jocelyne / Lustig, Sebastien / Ferry, Tristan / Jacqueline, Cédric / Loss de Morais, Guilherme / Laurent, Frédéric

    Cellular microbiology

    2016  Volume 18, Issue 10, Page(s) 1405–1414

    Abstract: Staphylococcus aureus bone and joint infection (BJI) is associated with significant rates of chronicity and relapse. In this study, we investigated how S. aureus is able to adapt to the human environment by comparing isolates from single patients with ... ...

    Abstract Staphylococcus aureus bone and joint infection (BJI) is associated with significant rates of chronicity and relapse. In this study, we investigated how S. aureus is able to adapt to the human environment by comparing isolates from single patients with persisting or relapsing BJIs that were recovered during the initial and recurrent BJI episodes. In vitro and in vivo assays and whole-genome sequencing analyses revealed that the recurrent isolates induced a reduced inflammatory response, formed more biofilms, persisted longer in the intracellular compartments of host bone cells, were less cytotoxic and induced less mortality in a mouse infection model compared with the initial isolates despite the lack of significant changes at the genomic level. These findings suggest that S. aureus BJI chronicization is associated with an in vivo bacterial phenotypical adaptation that leads to decreased virulence and host immune escape, which is linked to increased intraosteoblastic persistence and biofilm formation.
    MeSH term(s) Adaptation, Physiological ; Adult ; Aged, 80 and over ; Amino Acid Sequence ; Arthritis, Infectious/microbiology ; Biofilms ; Cells, Cultured ; Chronic Disease ; Disease Progression ; Female ; Hemolysin Proteins/metabolism ; Host-Pathogen Interactions ; Humans ; Male ; Osteoblasts/immunology ; Osteoblasts/microbiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/physiology
    Chemical Substances Hemolysin Proteins
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1468320-9
    ISSN 1462-5822 ; 1462-5814
    ISSN (online) 1462-5822
    ISSN 1462-5814
    DOI 10.1111/cmi.12582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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