LIVIVO - Search results -

Search results

Result 1 - 10 of total 228

Search options

Article ; Online: Atherosclerosis: orchestrating cells and biomolecules involved in its activation and inhibition.

Munjal, Ashok / Khandia, Rekha

Advances in protein chemistry and structural biology

2019 Volume 120, Page(s) 85–122

Abstract: The term atherosclerosis refers to the condition of deposition of lipids and other substances in and on the artery walls, called as plaque that restricts the normal blood flow. The plaque may be stable or unstable in nature. Unstable plaque can burst and ...

Abstract	The term atherosclerosis refers to the condition of deposition of lipids and other substances in and on the artery walls, called as plaque that restricts the normal blood flow. The plaque may be stable or unstable in nature. Unstable plaque can burst and trigger clot formation adding further adversities. The process of plaque formation involves various stages including fatty streak, intermediate or fibro-fatty lesion and advanced lesion. The cells participating in the formation of atherosclerotic plaque include endothelial cells, vascular smooth muscle cells (VSMC), monocytes, monocytes derived macrophages, macrophages and dendritic cells and regulatory T cells (T
MeSH term(s)	Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Cytokines/metabolism ; Humans
Chemical Substances	Cytokines
Language	English
Publishing date	2019-12-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2019.11.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Interplay between inflammation and cancer.

Khandia, Rekha / Munjal, Ashok

Advances in protein chemistry and structural biology

2019 Volume 119, Page(s) 199–245

Abstract: During the 19th century, for the first time, the linkage between inflammation and cancer was established. Inflammatory microenvironment is an essential component of the tumor microenvironment. Chronic inflammation due to persistent infection due to the ... ...

Abstract	During the 19th century, for the first time, the linkage between inflammation and cancer was established. Inflammatory microenvironment is an essential component of the tumor microenvironment. Chronic inflammation due to persistent infection due to the microbes, viruses, helminths or constant exposure to non-infectious factors like smoke, silica or asbestos eventually might result in carcinogenesis. In tumor microenvironment, various inflammatory cells such as T lymphocytes (occasionally B cells), dendritic cells, macrophages, monocytes, neutrophils and natural killer (NK) cells are present. As a mediator of immune surveillance and host defense TRAIL cytokines are produced which upon binding with death receptors (DRs) initiate a cascade of apoptotic pathways. Anti-inflammatory drugs such as aspirin, celecoxib, diclofenac, diflunisal and ibuprofen etc. are being used against cancer, indicating the interplay between both the mechanisms. A deeper understanding of common pathways implicated between both the inflammation and cancer may pave the way to fight against both of these deleterious ailments.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Tumor Microenvironment/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents
Language	English
Publishing date	2019-11-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2019.09.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mycobacterium lepromatosis genome exhibits unusually high CpG dinucleotide content and selection is key force in shaping codon usage.

Munjal, Ashok / Khandia, Rekha / Shende, Kishor K / Das, Jayashankar

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2020 Volume 84, Page(s) 104399

Abstract: Mycobacterium lepromatosis was identified as a causative agent for leprosy in the year 2008 in the United States and later more cases were identified in Canada, Singapore, Brazil, and Myanmar. It is known to cause diffuse lepromatosis leprosy among ... ...

Abstract	Mycobacterium lepromatosis was identified as a causative agent for leprosy in the year 2008 in the United States and later more cases were identified in Canada, Singapore, Brazil, and Myanmar. It is known to cause diffuse lepromatosis leprosy among humans. Since it is invasive, the mortality rates are higher in comparison to the M. leprae. At genomic level, there exists 90.9% similarity between M. lepromatosis and M. leprae. Codon usage analysis based on analyses of 228 coding sequences (CDSs) of M. lepromatosis, revealed that the genome is GC rich. Among the total 16 dinucleotides, CpG dinucleotide possesses the highest dinucleotide frequency in M. lepromatosis, that is strikingly an unobvious observation since higher CpG is associated with higher proinflammatory cytokine production and NF-κB activation that eventually leads to high pathogenicity. To evade immune response, CpG content is generally less in pathogens. The unusually high CpG content can be explained by the fact that the nucleotide composition of M. lepromatosis is CG rich. Various forces interplay to shape codon usage pattern of any organism including selection; mutation, nucleotide composition as well as GC biased gene conversion. To understand the interplay between various forces; neutrality, parity, Nc-GC3 (Effective number of codons-GC content at 3rd position of the codon), aromaticity (AROMO) and the general average hydropathicity score (GRAVY) analyses have been carried out. The analyses revealed that selection force is the major contributory force. Along with the selection; mutation, nucleotide composition as well as GC biased gene conversion also play role in shaping codon usage bias in M. lepromatosis. This is the first report on the codon usage in M. lepromatosis.
MeSH term(s)	Codon/genetics ; Codon/metabolism ; CpG Islands/genetics ; Gene Expression Regulation, Bacterial/physiology ; Genome, Bacterial ; Mycobacterium/genetics
Chemical Substances	Codon
Language	English
Publishing date	2020-06-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2020.104399
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5645: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Advances in Developing Prophylactics and Therapeutics to Counter Inflammatory, Allergic and Infectious Diseases.

Munjal, Ashok / Iqbal, Hafiz M N / Dhama, Kuldeep

Recent patents on inflammation & allergy drug discovery

2018 Volume 12, Issue 1, Page(s) 5–6

MeSH term(s)	Diabetes Complications ; Humans ; Hypersensitivity ; Hypoglycemic Agents ; Patents as Topic ; Plants, Medicinal
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2018-06-28
Publishing country	United Arab Emirates
Document type	Editorial ; Comment
ISSN	1872-213X
ISSN	1872-213X
DOI	10.2174/1872213X1201180821095512
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: Cold acclimation conditions constrain plastic responses for resistance to cold and starvation in

Pathak, Ankita / Munjal, Ashok / Parkash, Ravi

Biology open

2018 Volume 7, Issue 6

Abstract: ... In ... ...

Abstract	In montane
Language	English
Publishing date	2018-07-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2632264-X
ISSN	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.034447
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Pyrosequencing-A Pioneer Technique of New Epoch

Khandia, Rekha / Munjal, Ashok

Current trends in biotechnology and pharmacy. 2016 July, v. 10, no. 3

2016

Abstract: Sanger's dideoxy chain termination method was the widely used technology for DNA sequencing since its inception. However, the technique has its own limitations like it is costly, time consuming, labor intensive and faces the problem of clone biasness. ... ...

Abstract	Sanger's dideoxy chain termination method was the widely used technology for DNA sequencing since its inception. However, the technique has its own limitations like it is costly, time consuming, labor intensive and faces the problem of clone biasness. Pyrosequencing has emerged as a novel sequencing technique, which offers potential advantages in terms of accuracy, cost effectiveness, flexibility, parallel processing, high throughput and further it can be easily automated. It can be widely accepted for the detailed characterization of nucleic acids. The technique is advantageous in DNA sequencing, genotyping, single nucleotide polymorphism analysis, allelic discrimination, allelic quantification and whole-genome sequencing. The technique may be broadly used in area of biotechnology, clinical genetics and pharmacogenetics. Due to efficacy and reliability, the technique may be used in the high-throughput analysis of bacterial and viral samples as well as metagenomic studies. Currently, the technique is the basis of next generation sequencing platform, offered by 454 Life Sciences as an array-based pyrosequencing technology.
Keywords	accuracy ; area ; biotechnology ; cost effectiveness ; genotyping ; high-throughput nucleotide sequencing ; labor ; metagenomics ; nucleic acids ; pharmacogenomics ; reliability ; sampling ; single nucleotide polymorphism
Language	English
Dates of publication	2016-07
Size	p. 290-298.
Publishing place	Association of Biotechnology and Pharmacy
Document type	Article
Note	NAL-light
ISSN	2230-7303
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Evaluation of the ameliorative effects of Phyllanthus niruri on the deleterious insecticide imidacloprid in the vital organs of chicken embryos

Khandia, Rekha / Pathe, Chandra Shekhar / Vishwakarma, Pratibha / Dhama, Kuldeep / Munjal, Ashok

Journal of Ayurveda and integrative medicine. 2020 Oct., Dec., v. 11, no. 4

2020

Abstract: Insecticides are widely used in agriculture to curb the loss caused by insects. These insecticides are incorporated into the food chain and accumulate in the human body, as well disturb the various metabolic pathways. Imidacloprid is an insect neurotoxin ...

Abstract	Insecticides are widely used in agriculture to curb the loss caused by insects. These insecticides are incorporated into the food chain and accumulate in the human body, as well disturb the various metabolic pathways. Imidacloprid is an insect neurotoxin commonly used in agriculture to control the insect pests. P. niruri is a traditional medicinal shrub widely used as an anti-inflammatory, antipyretic, and anti-lethality agent.The present study is designed to evaluate the ameliorative effects of Phyllanthus niruri (Bhumi amla) on the deleterious Insecticide imidacloprid in the vital organs of Chicken embryos.The embryonated chicken eggs were divided into the four groups (one control and three treated groups); the chorioallantoic membranes of control received 200 μl phosphate buffer saline, whereas group I and group II received 100 μg imidacloprid and 200 μl aqueous extract of P. niruri (PNE) respectively. Group III received both 100 μg imidacloprid and 200 μl PNE. The serum was collected on the 18th day its development; which was subjected to the biochemical analysis based on colorimetric assay in semi-automated biochemical analyzer using commercial kits.We observed significant in ovo effects of imidacloprid on chicken embryos; the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), were increased in imidacloprid treated group I; histopathology also revealed damage to the liver (necrotic areas and dilated blood sinusoids). Alkaline phosphatase (ALP), amylase, cholesterol, triglycerides protein and albumin levels were also altered significantly (p < 0.05).The serum biochemicals were returned back to the nearly normal levels. PNE has ameliorated and overcome the effects of imidacloprid reasonably with the subsequent treatment among group III. Hence, P. niruri may be used to minimize the effects of an accidental exposure of imidacloprid.
Keywords	Ayurvedic medicine ; Phyllanthus niruri ; agriculture ; alanine transaminase ; albumins ; alkaline phosphatase ; amylases ; aspartate transaminase ; assays ; biochemical pathways ; blood serum ; chick embryos ; chicken eggs ; chickens ; cholesterol ; colorimetry ; food chain ; histopathology ; humans ; imidacloprid ; insect pests ; liver ; neurotoxins ; phosphates ; shrubs ; triacylglycerols
Language	English
Dates of publication	2020-10
Size	p. 495-501.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ISSN	0975-9476
DOI	10.1016/j.jaim.2019.03.003
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Mycobacterium lepromatosis genome exhibits unusually high CpG dinucleotide content and selection is key force in shaping codon usage

Munjal, Ashok / Khandia, Rekha / Shende, Kishor K / Das, Jayashankar

Infection, genetics, and evolution. 2020 Oct., v. 84

2020

Abstract	Mycobacterium lepromatosis was identified as a causative agent for leprosy in the year 2008 in the United States and later more cases were identified in Canada, Singapore, Brazil, and Myanmar. It is known to cause diffuse lepromatosis leprosy among humans. Since it is invasive, the mortality rates are higher in comparison to the M. leprae. At genomic level, there exists 90.9% similarity between M. lepromatosis and M. leprae. Codon usage analysis based on analyses of 228 coding sequences (CDSs) of M. lepromatosis, revealed that the genome is GC rich. Among the total 16 dinucleotides, CpG dinucleotide possesses the highest dinucleotide frequency in M. lepromatosis, that is strikingly an unobvious observation since higher CpG is associated with higher proinflammatory cytokine production and NF-κB activation that eventually leads to high pathogenicity. To evade immune response, CpG content is generally less in pathogens. The unusually high CpG content can be explained by the fact that the nucleotide composition of M. lepromatosis is CG rich. Various forces interplay to shape codon usage pattern of any organism including selection; mutation, nucleotide composition as well as GC biased gene conversion. To understand the interplay between various forces; neutrality, parity, Nc-GC3 (Effective number of codons-GC content at 3rd position of the codon), aromaticity (AROMO) and the general average hydropathicity score (GRAVY) analyses have been carried out. The analyses revealed that selection force is the major contributory force. Along with the selection; mutation, nucleotide composition as well as GC biased gene conversion also play role in shaping codon usage bias in M. lepromatosis. This is the first report on the codon usage in M. lepromatosis.
Keywords	Singapore ; codon usage ; cytokines ; evolution ; gene conversion ; genomics ; immune response ; infection ; leprosy ; mortality ; mutation ; pathogenicity ; Brazil ; Canada ; Myanmar
Language	English
Dates of publication	2020-10
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2020.104399
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 5645: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Evaluation of the ameliorative effects of Phyllanthus niruri on the deleterious insecticide imidacloprid in the vital organs of chicken embryos.

Khandia, Rekha / Pathe, Chandra Shekhar / Vishwakarma, Pratibha / Dhama, Kuldeep / Munjal, Ashok

Journal of Ayurveda and integrative medicine

2019 Volume 11, Issue 4, Page(s) 495–501

Abstract: Background: Insecticides are widely used in agriculture to curb the loss caused by insects. These insecticides are incorporated into the food chain and accumulate in the human body, as well disturb the various metabolic pathways. Imidacloprid is an ... ...

Abstract	Background: Insecticides are widely used in agriculture to curb the loss caused by insects. These insecticides are incorporated into the food chain and accumulate in the human body, as well disturb the various metabolic pathways. Imidacloprid is an insect neurotoxin commonly used in agriculture to control the insect pests. P. niruri is a traditional medicinal shrub widely used as an anti-inflammatory, antipyretic, and anti-lethality agent. Objective: The present study is designed to evaluate the ameliorative effects of Phyllanthus niruri (Bhumi amla) on the deleterious Insecticide imidacloprid in the vital organs of Chicken embryos. Materials and methods: The embryonated chicken eggs were divided into the four groups (one control and three treated groups); the chorioallantoic membranes of control received 200 μl phosphate buffer saline, whereas group I and group II received 100 μg imidacloprid and 200 μl aqueous extract of P. niruri (PNE) respectively. Group III received both 100 μg imidacloprid and 200 μl PNE. The serum was collected on the 18th day its development; which was subjected to the biochemical analysis based on colorimetric assay in semi-automated biochemical analyzer using commercial kits. Results: We observed significant in ovo effects of imidacloprid on chicken embryos; the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), were increased in imidacloprid treated group I; histopathology also revealed damage to the liver (necrotic areas and dilated blood sinusoids). Alkaline phosphatase (ALP), amylase, cholesterol, triglycerides protein and albumin levels were also altered significantly (p < 0.05). Conclusion: The serum biochemicals were returned back to the nearly normal levels. PNE has ameliorated and overcome the effects of imidacloprid reasonably with the subsequent treatment among group III. Hence, P. niruri may be used to minimize the effects of an accidental exposure of imidacloprid.
Language	English
Publishing date	2019-11-19
Publishing country	United States
Document type	Journal Article
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2019.03.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Heat Shock Proteins: Therapeutic Perspectives in Inflammatory Disorders.

Khandia, Rekha / Munjal, Ashok K / Iqbal, Hafiz M N / Dhama, Kuldeep

Recent patents on inflammation & allergy drug discovery

2017 Volume 10, Issue 2, Page(s) 94–104

Abstract: Background: Heat shock proteins (HSPs) are highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by ... ...

Abstract	Background: Heat shock proteins (HSPs) are highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. These are intracellular proteins but can be present in extracellular fluid like serum of the patients suffering from trauma, autoimmune and inflammatory disorders. Virtually in most inflammatory diseases, immune response towards HSPs is developed. Objective: The present review expedites the role of HSPs in inflammatory process and associated disorders, mainly in context to HSP70 and HSP90. Method: Commencing a thorough survey of the literature and patents available on HSPs and their role in the process of inflammation, from the authentic published resources available on Medline, Pubmed, Pubmed Central, Science Direct and other scientific databases; the information retrieved has been compiled and analyzed. Results: HSPs modulate the process of inflammation by producing anti-inflammatory cytokines in chronic inflammatory disease. HSPs mediated expression of IL10 contributes in anti-inflammatory role via TLR2 and TLR4-dependent mechanisms. Necroptosis, a caspase independent programmed apoptosis plays an important role in progression of several inflammatory disorders and its major components MLKL and RIPK-1 are the clients of HSP. Necroptosis is also involved in exposure of several damageassociated molecular patterns (DAMPs) including HSPs in extracellular environment leading to inflammation. Endocytosed or intracellular HSP70, is presented by MHC-II molecules and in absence of proper co stimulation, it lead to expansion of tolerogenic or regulatory T cells (Tregs) responses, which have inflammation suppressive activity by virtue of production of anti-inflammatory cytokines, suppression or killing of effector T cells or bringing the APC into tolerogenic state. HSP induced Tregs play an important role in combating autoimmunity and inflammation. Conclusion: Present review gives an insight towards the cause of inflammation and an account of different HSPs contributing various inflammatory disorders viz. inflammatory bowel disease (IBD), intestinal inflammation, atherosclerosis, rheumatoid arthritis (RA), multiple sclerosis etc. The importance of HSPs in handling inflammatory disorders has been depicted in recent patents also.
Language	English
Publishing date	2017
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1872-213X
ISSN	1872-213X
DOI	10.2174/1872213X10666161213163301
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED