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  1. Article ; Online: Feeding tube practices and the colonisation of the preterm stomach in the first week of life.

    Munkstrup, Charlotte / Krogfelt, Karen A / Greisen, Gorm / Juhl, Sandra M

    Danish medical journal

    2022  Volume 69, Issue 8

    Abstract: Introduction: We aimed to determine if changing nasogastric feeding tubes more often would impact colonisation of the upper gastrointestinal tract of the premature infant.: Methods: We included 22 neonates born less-than 32 weeks gestation within 48 ... ...

    Abstract Introduction: We aimed to determine if changing nasogastric feeding tubes more often would impact colonisation of the upper gastrointestinal tract of the premature infant.
    Methods: We included 22 neonates born less-than 32 weeks gestation within 48 hours after birth. The neonates were randomised to have their feeding tubes changed on day seven or daily during the first week of life. We determined the bacterial concentration by the culture method in maternal milk samples, gastric aspirates and feeding tube flushes. Bacteria were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF). The primary outcome was the concentration of bacteria in the gastric aspirate from a freshly placed nasogastric tube on day seven of life.
    Results: Data from only 11 neonates were eligible for primary outcome analysis. We found no difference in bacterial concentration between the two groups with a mean colony-forming unit count per ml aspirate of 4.62 log10 (standard deviation (SD): ± 3.43) in the intervention group and 2.76 log10 (SD: ± 3.13) in the control group. Data from 19 neonates were eligible for analysis of secondary outcome measures. We found no statistically significant differences in the composition of the bacterial load between the two groups. Infants with a lower gastric pH had lower gastric bacterial counts.
    Conclusion: Changing the feeding tube daily rather than weekly in the first week of life did not result in reduced bacterial concentration in gastric aspirates. The bacterial load from the feeding tubes was low suggesting that contamination of feeding tubes did not affect early colonisation of the upper gastrointestinal tract.
    Funding: none.
    Trial registration: ClinicalTrials identification number NCT02830503.
    MeSH term(s) Enteral Nutrition/methods ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; Intubation, Gastrointestinal ; Stomach
    Language English
    Publishing date 2022-07-13
    Publishing country Denmark
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2648771-8
    ISSN 2245-1919 ; 2245-1919
    ISSN (online) 2245-1919
    ISSN 2245-1919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early and intense epidemic of respiratory syncytial virus (RSV) in Denmark, August to December 2022.

    Munkstrup, Charlotte / Lomholt, Frederikke Kristensen / Emborg, Hanne-Dorthe / Møller, Karina Lauenborg / Krog, Jesper Schak / Trebbien, Ramona / Vestergaard, Lasse S

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2023  Volume 28, Issue 1

    Abstract: In the autumn of 2022, Denmark witnessed the second out-of-season epidemic of respiratory syncytial virus (RSV) following widespread societal preventive measures implemented against the coronavirus disease (COVID-19) pandemic during 2020 and 2021. ... ...

    Abstract In the autumn of 2022, Denmark witnessed the second out-of-season epidemic of respiratory syncytial virus (RSV) following widespread societal preventive measures implemented against the coronavirus disease (COVID-19) pandemic during 2020 and 2021. Admissions peaked at twice the level of pre-pandemic seasons. Especially infants below 6 months of age were affected, but also adults over 45 years of age. The current epidemic is dominated by RSV subtype B, unlike the major RSV summer epidemic in 2021 dominated by RSV subtype A.
    MeSH term(s) Infant ; Adult ; Humans ; Middle Aged ; Respiratory Syncytial Virus Infections/epidemiology ; COVID-19/epidemiology ; Respiratory Syncytial Virus, Human ; Seasons ; Pandemics ; Denmark/epidemiology
    Language English
    Publishing date 2023-01-24
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2023.28.1.2200937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5066: Show issues Location:
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  3. Article ; Online: Age-dependent influenza infection patterns and subtype circulation in Denmark, in seasons 2015/16 to 2021/22.

    Emborg, Hanne-Dorthe / Bolt Botnen, Amanda / Nielsen, Jens / Vestergaard, Lasse S / Lomholt, Frederikke Kristensen / Munkstrup, Charlotte / Møller, Karina Lauenborg / Kjelsø, Charlotte / Rasmussen, Steen Hulthin / Trebbien, Ramona

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2024  Volume 29, Issue 4

    Abstract: BackgroundInfluenza was almost absent for 2 years following the implementation of strict public health measures to prevent the spread of SARS-CoV-2. The consequence of this on infections in different age groups is not yet known.AimTo describe the age ... ...

    Abstract BackgroundInfluenza was almost absent for 2 years following the implementation of strict public health measures to prevent the spread of SARS-CoV-2. The consequence of this on infections in different age groups is not yet known.AimTo describe the age groups infected with the influenza virus in 2021/22, the first post-pandemic influenza season in Denmark, compared with the previous six seasons, and subtypes circulating therein.MethodsInfection and hospitalisation incidences per season and age group were estimated from data in Danish registries. Influenza virus subtypes and lineages were available from samples sent to the National Influenza Centre at Statens Serum Institut.ResultsTest incidence followed a similar pattern in all seasons, being highest in 0-1-year-olds and individuals over 75 years, and lowest in 7-14-year-olds and young people 15 years to late twenties. When the influenza A virus subtypes A(H3N2) and A(H1N1)pdm09 co-circulated in seasons 2015/16 and 2017/18 to 2019/20, the proportion of A(H1N1)pdm09 was higher in 0-1-year-olds and lower in the over 85-year-olds  compared with the overall proportion of A(H1N1)pdm09 in these seasons. The proportion of A(H3N2) was higher in the over 85 years age group compared with the overall proportion of A(H3N2). The 2016/17 and 2021/22 seasons were dominated by A(H3N2) but differed in age-specific trends, with the over 85 years age group initiating the 2016/17 season, while the 2021/22 season was initiated by the 15-25-year-olds, followed by 7-14-year-olds.ConclusionThe 2021/22 influenza season had a different age distribution compared with pre-COVID-19 pandemic seasons.
    MeSH term(s) Humans ; Adolescent ; Aged, 80 and over ; Influenza, Human/prevention & control ; Seasons ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Pandemics ; Denmark/epidemiology ; Influenza Vaccines
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-01-11
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2024.29.4.2300263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5066: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Resurgence of Respiratory Syncytial Virus in the Summer of 2021 in Denmark-a Large out-of-season Epidemic Affecting Older Children.

    Lomholt, Frederikke Kristensen / Emborg, Hanne-Dorthe / Nørgaard, Sarah Kristine / Nielsen, Jens / Munkstrup, Charlotte / Møller, Karina Lauenborg / Krog, Jesper Schak / Trebbien, Ramona / Vestergaard, Lasse Skafte

    Open forum infectious diseases

    2024  Volume 11, Issue 3, Page(s) ofae069

    Abstract: Background: When coronavirus disease 2019 (COVID-19) restrictions were lifted in Denmark in the spring of 2021, a surge in respiratory syncytial virus (RSV) cases followed, causing a large out-of-season epidemic. This study aims to investigate the ... ...

    Abstract Background: When coronavirus disease 2019 (COVID-19) restrictions were lifted in Denmark in the spring of 2021, a surge in respiratory syncytial virus (RSV) cases followed, causing a large out-of-season epidemic. This study aims to investigate the summer epidemic compared with 3 typical pre-COVID-19 RSV winter seasons using Danish registers to identify RSV cases, RSV-related admissions, and use of intensive care treatment.
    Methods: Incidence rates (IR) per 1000 person-years for RSV cases, RSV-related admissions, and intensive care treatment were calculated with 95% confidence interval (CI) for each season, stratified by age groups and incidence rate ratios (IRR) with 95% CI were calculated to compare the summer epidemic with the winter season for 2019-2020.
    Results: In the summer epidemic, the IR of RSV cases and admissions exceeded previous winter seasons for all age groups. The highest increases in IRs were seen among children aged 2 to 3 years and 4 to 5 years. The IRR of cases were 4.6 (95% CI, 4.1-5.2) and 3.3 (2.6-4.2) and the IRR of admissions were 3.3 (2.7-4.2) and 3.8 (2.3-6.5) in the 2 age groups, respectively, when compared with the winter season 2019-2020.
    Conclusions: Likely because of immunity debt following COVID-19 restrictions, the summer epidemic was significantly larger than previous winter seasons, most markedly among children aged 2 to 3 and 4 to 5 years but had a similar disease severity spectrum.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Invasive group A streptococcal infections in children and adolescents in Denmark during 2022-23 compared with 2016-17 to 2021-22: a nationwide, multicentre, population-based cohort study.

    Nygaard, Ulrikka / Hartling, Ulla Birgitte / Munkstrup, Charlotte / Nielsen, Allan Bybeck / Dungu, Kia Hee Schultz / Schmidt, Lisbeth Samsø / Glenthøj, Jonathan / Matthesen, Astrid Thaarup / Rytter, Maren Johanne Heilskov / Holm, Mette

    The Lancet. Child & adolescent health

    2023  Volume 8, Issue 2, Page(s) 112–121

    Abstract: Background: A historic increase in paediatric invasive group A streptococcal (iGAS) infections was reported globally in 2022. iGAS infections can lead to severe manifestations (eg, pleural empyema, necrotising fasciitis, toxic shock syndrome, ... ...

    Abstract Background: A historic increase in paediatric invasive group A streptococcal (iGAS) infections was reported globally in 2022. iGAS infections can lead to severe manifestations (eg, pleural empyema, necrotising fasciitis, toxic shock syndrome, osteomyelitis, septic arthritis, and meningitis). We aimed to compare the incidence and severity of iGAS infections overall, for distinct clinical phenotypes, and for GAS emm variants in Denmark in 2022-23 with reference to the previous six seasons (ie, 2016-17, 2017-18, 2018-19, 2019-20, 2020-21, and 2021-22).
    Methods: In this nationwide, multicentre, population-based cohort study, we included all children and adolescents in Denmark aged 0-17 years with a positive culture of GAS or GAS confirmed through PCR-based methods from otherwise sterile sites in 2022-23 and the previous six seasons from 2016-17 to 2021-22. For all seven seasons, data were obtained from week 21 to week 20 of the next year. Patients at all 18 paediatric hospital departments in Denmark were identified through the Danish Microbiology Database, in which iGAS isolates from sterile sites are prospectively registered, including emm typing. We obtained electronic medical health records for each patient admitted with a diagnosis of iGAS. We calculated the incidence of iGAS per 1 000 000 inhabitants aged 0-17 years in each season from week 21 to week 20 of the next year and the risk ratios (RRs) for incidence of iGAS, distinct disease manifestations, and emm variants in 2022-23 versus the three pre-COVID-19 seasons in 2016-17, 2017-18, and 2018-19 using Fisher's exact test and Pearson's χ
    Findings: Among the Danish population of 1 152 000 children and adolescents aged 0-17 years, 174 with iGAS disease were included. 76 children and adolescents with iGAS during 2022-23 were identified; 31 (41%) of 76 were female and 45 (59%) were male. 98 children and adolescents with iGAS during 2016-17 to 2021-22 were identified; 41 (42%) of 98 were female and 57 (58%) were male. There was an increase in incidence of iGAS from mean 22·6 (95% CI 14·7-33·1) per 1 000 000 children and adolescents during 2016-17 to 2018-19 to 66·0 (52·0-82·6) per 1 000 000 during 2023-23 (RR 2·9, 95% CI 1·9-4·6; p<0·0001). During the COVID-19 pandemic in 2019-20, 2020-21, and 2021-22, the mean incidence of iGAS was 6·1 (95% CI 2·4-12·5) per 1 000 000 children and adolescents. In 2022-23, there was a 9·5-fold increase in emm-12 (95% CI 2·2-40·8; p=0·0002) and a 2·7-fold increase in emm-1 (1·3-5·5; p=0·0037). The most common clinical manifestations of iGAS in 2022-23 were soft-tissue infections, which increased by 4·5-fold (1·9-10·9; p=0·0003), and complicated pneumonia with parapneumonic effusion, which increased by 4·0-fold (1·4-11·4; p=0·0059), both compared with the three pre-COVID-19 seasons. Overall, there was no increased severity of iGAS in 2022-23 compared with the previous six seasons as measured by median duration of hospital stay (8 days, IQR 4-14 vs 9 days, 5-15; p=0·39), paediatric intensive care unit (PICU) admission (17 [22%] of 76 vs 17 [17%] of 98; p=0·53), duration of stay in PICU (4 days, IQR 2-10 vs 4 days, 2-11; p=0·84), or mortality (three [4%] of 76 vs three [3%] of 98; p=1·00). In 2022-23, there was a 3·6-fold (95% CI 1·8-7·3; p=0·0001) increase in children with a preceding upper respiratory tract infection and a 4·6-fold (1·5-14·1; p=0·0034) increase in children with a preceding varicella-zoster infection, both compared with the three pre-COVID-19 seasons.
    Interpretation: In Denmark, the incidence of paediatric iGAS increased in 2022-23 compared with the three pre-COVID-19 seasons of 2016-17, 2017-18, and 2018-19. However, the course of iGAS disease in children and adolescents in 2022-23 was not more severe than in previous seasons. The high morbidity across all seasons highlights iGAS as a major invasive bacterial infection in children and adolescents.
    Funding: Innovation Fund Denmark.
    MeSH term(s) Child ; Humans ; Male ; Female ; Adolescent ; Cohort Studies ; Pandemics ; Streptococcal Infections/epidemiology ; Streptococcus pyogenes/genetics ; COVID-19/epidemiology ; Denmark/epidemiology
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(23)00295-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent

    Johannesen, Thor Bech / Munkstrup, Charlotte / Edslev, Sofie Marie / Baig, Sharmin / Nielsen, Stine / Funk, Tjede / Kristensen, Dennis Karsten / Jacobsen, Lars Hervig / Ravn, Signe Fischer / Bindslev, Niels / Gubbels, Sophie / Voldstedlund, Marianne / Jokelainen, Pikka / Hallstrøm, Søren / Rasmussen, Astrid / Kristinsson, Karl Gústaf / Fuglsang-Damgaard, David / Dessau, Ram B / Olsén, Agnieszka Barbara /
    Jensen, Christian Salgaard / Skovby, Annette / Ellermann-Eriksen, Svend / Jensen, Thøger Gorm / Dzajic, Esad / Østergaard, Claus / Lomborg Andersen, Steen / Hoffmann, Steen / Andersen, Peter Henrik / Stegger, Marc

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2023  Volume 28, Issue 26

    Abstract: A highly virulent sub-lineage of ... ...

    Abstract A highly virulent sub-lineage of the
    MeSH term(s) Humans ; COVID-19 ; Streptococcus pyogenes/genetics ; Seasons ; Streptococcal Infections/epidemiology ; Denmark/epidemiology
    Language English
    Publishing date 2023-06-28
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2023.28.26.2300291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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