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Article ; Online: Pacemaker Implantation After Transcatheter Aortic Valve Replacement: Controversial Complications With Prognostic Uncertainties-Clearing the Unknowns.

Muñoz-García, Antonio J / Muñoz-García, Erika

2021 Volume 14, Issue 19, Page(s) 2182–2184

MeSH term(s)	Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Humans ; Pacemaker, Artificial ; Prognosis ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2021.08.061
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Article: Comparison of central corneal thickness measurements obtained by OrbscanIIz

Romero-Trevejo, José L / Sánchez-Pérez, Andrés / Muñoz-García, Erika / Fernández-Romero, Lourdes / Jiménez-Navarro, Manuel F

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

2023 Volume 37, Issue 1, Page(s) 10–14

Abstract: Purpose: The objective of this study was to assess the concordance between the values obtained in measuring central corneal thickness using the OrbscanIIz: Methods: Measurements were taken from 88 eyes of 44 patients using the two instruments. The ... ...

Abstract	Purpose: The objective of this study was to assess the concordance between the values obtained in measuring central corneal thickness using the OrbscanIIz Methods: Measurements were taken from 88 eyes of 44 patients using the two instruments. The data obtained were statistically analyzed using version 22 of the IBM SPSS Results: The mean of central corneal thickness measurements obtained from OrbscanIIz Conclusion: OrbscanIIz
Language	English
Publishing date	2023-03-09
Publishing country	India
Document type	Journal Article
ZDB-ID	2515644-5
ISSN	1319-4534
ISSN	1319-4534
DOI	10.4103/sjopt.Sjopt_82_21
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Article ; Online: Choroidal thickness and granulocyte colony-stimulating factor in tears improve the prediction model for coronary artery disease.

Romero-Trevejo, José Lorenzo / Fernández-Romero, Lourdes / Delgado, Josué / Muñoz-García, Erika / Sánchez-Pérez, Andrés / Murri, Mora / Gutiérrez-Bedmar, Mario / Jiménez-Navarro, Manuel Francisco

Cardiovascular diabetology

2022 Volume 21, Issue 1, Page(s) 103

Abstract: Background: Coronary artery disease (CAD) detection in asymptomatic patients still remains controversial. The aim of our study was to evaluate the usefulness of ophthalmologic findings as predictors of the presence of CAD when added to cardiovascular ... ...

Abstract	Background: Coronary artery disease (CAD) detection in asymptomatic patients still remains controversial. The aim of our study was to evaluate the usefulness of ophthalmologic findings as predictors of the presence of CAD when added to cardiovascular classic risk factors (CRF) in patients with acute coronary cardiopathy suspicion. Methods: After clinical stabilization, 96 patients with acute coronary cardiopathy suspicion were selected and divided in two groups: 69 patients with coronary lesions and 27 patients without coronary lesions. Their 192 eyes were subjected to a complete routine ophthalmologic examination. Samples of tear fluid were also collected to be used in the detection of cytokines and inflammatory mediators. Logistic regression models, receiver operating characteristic curves and their area under the curve (AUC) were analysed. Results: Suggestive predictors were choroidal thickness (CT) (OR: 1.02, 95% CI 1.01-1.03) and tear granulocyte colony-stimulating factor (G-CSF) (OR: 0.97, 95% CI 0.95-0.99). We obtained an AUC of 0.9646 (95% CI 0.928-0.999) when CT and tear G-CSF were added as independent variables to the logistic regression model with cardiovascular CRF: sex, age, diabetes, high blood pressure, hypercholesterolemia, smoking habit and obesity. This AUC was significantly higher (p = 0.003) than the prediction derived from the same logistic regression model without CT and tear G-CSF (AUC = 0.828, 95% CI 0.729-0.927). Conclusions: CT and tear G-CSF improved the predictive model for CAD when added to cardiovascular CRF in our sample of symptomatic patients. Subsequent studies are needed for validation of these findings in asymptomatic patients.
MeSH term(s)	Coronary Angiography/adverse effects ; Coronary Artery Disease/diagnosis ; Granulocyte Colony-Stimulating Factor/chemistry ; Humans ; ROC Curve ; Risk Factors ; Tears/chemistry
Chemical Substances	Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-022-01538-0
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Article ; Online: Late Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention in the Workup Pre-TAVR.

Avvedimento, Marisa / Campelo-Parada, Francisco / Munoz-Garcia, Erika / Nombela-Franco, Luis / Fischer, Quentin / Donaint, Pierre / Serra, Vicenç / Veiga, Gabriela / Gutiérrez, Enrique / Esposito, Giovanni / Vilalta, Victoria / Alperi, Alberto / Regueiro, Ander / Asmarats, Lluis / Ribeiro, Henrique B / Matta, Anthony / Munoz-Garcia, Antonio / Tirado-Conte, Gabriela / Urena, Marina /

Metz, Damien / Rodenas-Alesina, Eduard / de la Torre Hernandez, Jose Maria / Fernandez-Nofrerias, Eduard / Pascual, Isaac / Vidal-Cales, Pablo / Arzamendi, Dabit / Campanha-Borges, Diego Carter / Trinh, Kim Hoang / Côté, Mélanie / Faroux, Laurent / Rodés-Cabau, Josep

JACC. Cardiovascular interventions

2023 Volume 16, Issue 17, Page(s) 2153–2164

Abstract: Background: In patients undergoing percutaneous coronary intervention (PCI) in the work-up pre-transcatheter aortic valve replacement (TAVR), the incidence and clinical impact of late bleeding events (LBEs) remain largely unknown.: Objectives: This ... ...

Abstract	Background: In patients undergoing percutaneous coronary intervention (PCI) in the work-up pre-transcatheter aortic valve replacement (TAVR), the incidence and clinical impact of late bleeding events (LBEs) remain largely unknown. Objectives: This study sought to determine the incidence, clinical characteristics, associated factors, and outcomes of LBEs in patients undergoing PCI in the work-up pre-TAVR. Methods: This was a multicenter study including 1,457 consecutive patients (mean age 81 ± 7 years; 41.5% women) who underwent TAVR and survived beyond 30 days. LBEs (>30 days post-TAVR) were defined according to the Valve Academic Research Consortium-2 criteria. Results: LBEs occurred in 116 (7.9%) patients after a median follow-up of 23 (IQR: 12-40) months. Late bleeding was minor, major, and life-threatening or disabling in 21 (18.1%), 63 (54.3%), and 32 (27.6%) patients, respectively. Periprocedural (<30 days post-TAVR) major bleeding and the combination of antiplatelet and anticoagulation therapy at discharge were independent factors associated with LBEs (P ≤ 0.02 for all). LBEs conveyed an increased mortality risk at 4-year follow-up compared with no bleeding (43.9% vs 36.0; P = 0.034). Also, LBE was identified as an independent predictor of all-cause mortality after TAVR (HR: 1.39; 95% CI: 1.05-1.83; P = 0.020). Conclusions: In TAVR candidates with concomitant significant coronary artery disease requiring percutaneous treatment, LBEs after TAVR were frequent and associated with increased mortality. Combining antiplatelet and anticoagulation regimens and the occurrence of periprocedural bleeding determined an increased risk of LBEs. Preventive strategies should be pursued for preventing late bleeding after TAVR, and further studies are needed to provide more solid evidence on the most safe and effective antithrombotic regimen post-TAVR in this challenging group of patients.
MeSH term(s)	Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Percutaneous Coronary Intervention/adverse effects ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome ; Hemorrhage/chemically induced ; Catheters
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2023.06.037
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Article ; Online: Coronary Obstruction After Transcatheter Aortic Valve Replacement: Insights From the Spanish TAVI Registry.

Ojeda, Soledad / González-Manzanares, Rafael / Jiménez-Quevedo, Pilar / Piñón, Pablo / Asmarats, Lluis / Amat-Santos, Ignacio / Fernández-Nofrerias, Eduard / Valle, Raquel Del / Muñoz-García, Erika / Ferrer-Gracia, Maria-Cruz / María de la Torre, Jose / Ruiz-Quevedo, Valeriano / Regueiro, Ander / Sanmiguel, Dario / García-Blas, Sergio / Elízaga, Jaime / Baz, Jose Antonio / Romaguera, Rafael / Cruz-González, Ignacio /

Moreu, José / Gheorghe, Livia L / Salido, Luisa / Moreno, Raúl / Urbano, Cristóbal / Serra, Vicenc / Pan, Manuel

JACC. Cardiovascular interventions

2023 Volume 16, Issue 10, Page(s) 1208–1217

Abstract: Background: Coronary obstruction (CO) following transcatheter aortic valve replacement (TAVR) is a life-threatening complication, scarcely studied.: Objectives: The authors analyzed the incidence of CO after TAVR, presentation, management, and in- ... ...

Abstract	Background: Coronary obstruction (CO) following transcatheter aortic valve replacement (TAVR) is a life-threatening complication, scarcely studied. Objectives: The authors analyzed the incidence of CO after TAVR, presentation, management, and in-hospital and 1-year clinical outcomes in a large series of patients undergoing TAVR. Methods: Patients from the Spanish TAVI (Transcatheter Aortic Valve Implantation) registry who presented with CO in the procedure, during hospitalization or at follow-up were included. Computed tomography (CT) risk factors were assessed. In-hospital, 30-day, and 1-year all-cause mortality rates were analyzed and compared with patients without CO using logistic regression models in the overall cohort and in a propensity score-matched cohort. Results: Of 13,675 patients undergoing TAVR, 115 (0.80%) presented with a CO, mainly during the procedure (83.5%). The incidence of CO was stable throughout the study period (2009-2021), with a median annual rate of 0.8% (range 0.3%-1.3%). Preimplantation CT scans were available in 105 patients (91.3%). A combination of at least 2 CT-based risk factors was less frequent in native than in valve-in-valve patients (31.7% vs 78.3%; P < 0.01). Percutaneous coronary intervention was the treatment of choice in 100 patients (86.9%), with a technical success of 78.0%. In-hospital, 30-day, and 1-year mortality rates were higher in CO patients than in those without CO (37.4% vs 4.1%, 38.3% vs 4.3%, and 39.1% vs 9.1%, respectively; P < 0.001). Conclusions: In this large, nationwide TAVR registry, CO was a rare, but often fatal, complication that did not decrease over time. The lack of identifiable predisposing factors in a subset of patients and the frequently challenging treatment when established may partly explain these findings.
MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome ; Catheters ; Coronary Occlusion ; Registries
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2023.03.024
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Article ; Online: First-in-Man Evaluation of a Sirolimus-Eluting Stent With Abluminal Fluoropolymeric/Triflusal Coating With Ultrathin Struts by OCT at 9 Months' Follow-Up: The PROMETHEUS Study.

de la Torre Hernandez, Jose M / Otaegui, Imanol / Subinas, Asier / Gomez-Menchero, Antonio / Moreno, Raul / Rondan, Juan / Muñoz-Garcia, Erika / Sainz-Laso, Fermin / Garcia Del Blanco, Bruno / Rumoroso, Jose R / Diaz, Jose F / Berenguer, Alberto / Gomez-Lara, Josep / Zueco, Javier

Cardiovascular revascularization medicine : including molecular interventions

2020 Volume 32, Page(s) 18–24

Abstract: Objectives: We sought to investigate stent healing and neointimal hyperplasia with ihtDEStiny drug-eluting stent (DES) by optical coherence tomography (OCT) examination conducted 9 months after implantation.: Background: The currently used DES ... ...

Abstract	Objectives: We sought to investigate stent healing and neointimal hyperplasia with ihtDEStiny drug-eluting stent (DES) by optical coherence tomography (OCT) examination conducted 9 months after implantation. Background: The currently used DES present certain features that have been linked separately to their better performance in terms of efficacy and safety. Methods: First-in-man, prospective and multicenter study including patients treated with ihtDEStiny stent undergoing OCT examination at 9 months follow up. The ihtDEStiny stent is a sirolimus eluting stent with an oval shape ultrathin struts (68 μm) and an abluminal coating of a fluoropolymer containing the antiplatelet agent triflusal. Primary endpoint was the percentage of obstruction of the in-stent volume by the neointima. Results: In 58 patients (63 lesions) in-stent late lumen loss was 0.11 ± 0.23 mm (95% CI 0.05-0.16) with only in 6% of stents being > 0.5 mm and in-segment binary stenosis was 1.6%. In OCT mean neointima volume obstruction was 10.5 ± 6.9% with a mean neointima thickness of 110.9 ± 89.8 μm. The proportion of uncovered struts was 2.5%, malapposed struts 1.1% and malapposed/uncovered struts 0.7% and no subclinical thrombi detected. Mean incomplete stent apposition area was 0.1 ± 0.1 mm Conclusions: In this study the ihtDEStiny stent has shown a very low degree of neointimal proliferation associated with a low rate of uncovered/malapposed struts and total absence of subclinical thrombi at 9 months follow up.
MeSH term(s)	Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Drug-Eluting Stents ; Humans ; Neointima ; Percutaneous Coronary Intervention/adverse effects ; Prospective Studies ; Salicylates ; Sirolimus/adverse effects ; Stents ; Tomography, Optical Coherence ; Treatment Outcome
Chemical Substances	Salicylates ; triflusal (1Z0YFI05OO) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2020-12-29
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2020.12.025
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Article ; Online: Secondary Femoral Access Hemostasis During Transcatheter Aortic Valve Replacement: Impact of Vascular Closure Devices.

The Journal of invasive cardiology

2021 Volume 33, Issue 8, Page(s) E604–E613

Abstract: Background: Vascular and bleeding complications related to secondary femoral access site are frequent in patients undergoing transcatheter aortic valve replacement (TAVR), and their occurrence is associated to poorer outcomes. We aimed to evaluate the ... ...

Abstract	Background: Vascular and bleeding complications related to secondary femoral access site are frequent in patients undergoing transcatheter aortic valve replacement (TAVR), and their occurrence is associated to poorer outcomes. We aimed to evaluate the clinical impact of vascular closure devices (VCDs) for secondary femoral access hemostasis in TAVR procedures. Methods: This was a multicenter study including 4031 patients who underwent TAVR (mean age, 81 ± 8 years; mean Society of Thoracic Surgeons [STS] score, 4.9 [interquartile range, 3.3-7.6]), and had a secondary femoral access. The 30-day clinical outcomes were analyzed according to femoral access-site hemostasis (manual compression vs VCD), and according to the type of VCD (Perclose [Abbott Cardiovascular] vs Angio-Seal [Terumo Interventional Systems]) using a propensity-matched, multivariable, logistic regression model. Results: Manual compression was used in 941 patients (23.3%) and VCDs were used in 3090 patients (76.7%; Perclose in 1549 patients [38.4%] and Angio-Seal in 1541 patients [38.2%]) for secondary femoral access hemostasis. Vascular complications related to secondary access site occurred in 162 patients (4%), and were more frequent in patients who underwent manual compression (7.2%) compared with VCD hemostasis (3%; adjusted P<.001). In the VCD group, the use of Angio-Seal (vs Perclose) was associated with a higher rate of vascular complications (3.7% vs 2.4%, respectively; adjusted P=.02), femoral artery pseudoaneurysm (1.3% vs 0.4%, respectively; adjusted P<.01), invasive treatment requirement for treating vascular complications (surgery: 0.8% vs 0.3%, respectively [adjusted P=.03]; and thrombin injection: 0.9% vs 0%, respectively [adjusted P<.001]). Conclusion: VCDs represented a safer and more effective alternative compared with manual compression for secondary femoral access-site hemostasis in patients undergoing TAVR procedures, and the Perclose VCD was associated with the lowest risk of vascular complications. Future randomized studies are warranted.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Femoral Artery/surgery ; Hemostasis ; Hemostatic Techniques ; Humans ; Transcatheter Aortic Valve Replacement ; Treatment Outcome ; Vascular Closure Devices
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Article ; Online: Incidence, Clinical Characteristics, and Impact of Absent Echocardiographic Signs in Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation.

Mangner, Norman / Panagides, Vassili / Del Val, David / Abdel-Wahab, Mohamed / Crusius, Lisa / Durand, Eric / Ihlemann, Nikolaj / Urena, Marina / Pellegrini, Costanza / Giannini, Francesco / Gasior, Tomasz / Wojakowski, Wojtek / Landt, Martin / Auffret, Vincent / Sinning, Jan-Malte / Cheema, Asim N / Nombela-Franco, Luis / Chamandi, Chekrallah / Campelo-Parada, Francisco /

Munoz-Garcia, Erika / Herrmann, Howard C / Testa, Luca / Kim, Won-Keun / Eltchaninoff, Helene / Søndergaard, Lars / Himbert, Dominique / Husser, Oliver / Latib, Azeem / Le Breton, Hervé / Servoz, Clement / Gervais, Philippe / Côté, Mélanie / Thiele, Holger / Holzhey, David / Linke, Axel / Rodés-Cabau, Josep

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 76, Issue 6, Page(s) 1003–1012

Abstract: Background: Echocardiography is the primary imaging modality for diagnosis of infective endocarditis (IE) in prosthetic valve endocarditis (PVE) including IE after transcatheter aortic valve implantation (TAVI). This study aimed to evaluate the ... ...

Abstract	Background: Echocardiography is the primary imaging modality for diagnosis of infective endocarditis (IE) in prosthetic valve endocarditis (PVE) including IE after transcatheter aortic valve implantation (TAVI). This study aimed to evaluate the characteristics and clinical outcomes of patients with absent compared with evident echocardiographic signs of TAVI-IE. Methods: Patients with definite TAVI-IE derived from the Infectious Endocarditis after TAVI International Registry were investigated comparing those with absent and evident echocardiographic signs of IE defined as vegetation, abscess, pseudo-aneurysm, intracardiac fistula, or valvular perforation or aneurysm. Results: Among 578 patients, 87 (15.1%) and 491 (84.9%) had absent (IE-neg) and evident (IE-pos) echocardiographic signs of IE, respectively. IE-neg were more often treated via a transfemoral access with a self-expanding device and had higher rates of peri-interventional complications (eg, stroke, major vascular complications) during the TAVI procedure (P < .05 for all). IE-neg had higher rates of IE caused by Staphylococcus aureus (33.7% vs 23.2%; P = .038) and enterococci (37.2% vs 23.8%; P = .009) but lower rates of coagulase-negative staphylococci (4.7% vs 20.0%, P = .001). IE-neg was associated with the same dismal prognosis for in-hospital mortality in a multivariate binary regression analysis (odds ratio: 1.51; 95% confidence interval [CI]: .55-4.12) as well as a for 1-year mortality in Cox regression analysis (hazard ratio: 1.10; 95% CI: .67-1.80). Conclusions: Even with negative echocardiographic imaging, patients who have undergone TAVI and presenting with positive blood cultures and symptoms of infection are a high-risk patient group having a reasonable suspicion of IE and the need for an early treatment initiation.
MeSH term(s)	Humans ; Endocarditis, Bacterial/diagnostic imaging ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/etiology ; Transcatheter Aortic Valve Replacement/adverse effects ; Incidence ; Risk Factors ; Prosthesis-Related Infections/diagnostic imaging ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/etiology ; Heart Valve Prosthesis ; Endocarditis/diagnostic imaging ; Endocarditis/epidemiology ; Echocardiography
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciac872
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Article ; Online: Very early infective endocarditis after transcatheter aortic valve replacement.

Panagides, Vassili / Abdel-Wahab, Mohamed / Mangner, Norman / Durand, Eric / Ihlemann, Nikolaj / Urena, Marina / Pellegrini, Costanza / Giannini, Francesco / Scislo, Piotr / Huczek, Zenon / Landt, Martin / Auffret, Vincent / Sinning, Jan Malte / Cheema, Asim N / Nombela-Franco, Luis / Chamandi, Chekrallah / Campelo-Parada, Francisco / Munoz-Garcia, Erika / Herrmann, Howard C /

Testa, Luca / Kim, Won-Keun / Eltchaninoff, Helene / Søndergaard, Lars / Himbert, Dominique / Husser, Oliver / Latib, Azeem / Le Breton, Hervé / Servoz, Clement / Gervais, Philippe / Del Val, David / Linke, Axel / Crusius, Lisa / Thiele, Holger / Holzhey, David / Rodés-Cabau, Josep

Clinical research in cardiology : official journal of the German Cardiac Society

2022 Volume 111, Issue 10, Page(s) 1087–1097

Abstract: Background: Scarce data exist about early infective endocarditis (IE) after trans-catheter aortic valve replacement (TAVR).: Objective: The objective was to evaluate the characteristics, management, and outcomes of very early (VE) IE (≤ 30 days) ... ...

Abstract	Background: Scarce data exist about early infective endocarditis (IE) after trans-catheter aortic valve replacement (TAVR). Objective: The objective was to evaluate the characteristics, management, and outcomes of very early (VE) IE (≤ 30 days) after TAVR. Methods: This multicenter study included a total of 579 patients from the Infectious Endocarditis after TAVR International Registry who had the diagnosis of definite IE following TAVR. Results: Ninety-one patients (15.7%) had VE-IE. Factors associated with VE-IE (vs. delayed IE (D-IE)) were female gender (p = 0.047), the use of self-expanding valves (p < 0.001), stroke (p = 0.019), and sepsis (p < 0.001) after TAVR. Staphylococcus aureus was the main pathogen among VE-IE patients (35.2% vs. 22.7% in the D-IE group, p = 0.012), and 31.2% of Staphylococcus aureus infections in the VE-IE group were methicillin-resistant (vs. 14.3% in the D-IE group, p = 0.001). The second-most common germ was enterococci (34.1% vs. 24.4% in D-IE cases, p = 0.05). VE-IE was associated with very high in-hospital (44%) and 1-year (54%) mortality rates. Acute renal failure following TAVR (p = 0.001) and the presence of a non-enterococci pathogen (p < 0.001) were associated with an increased risk of death. Conclusion: A significant proportion of IE episodes following TAVR occurs within a few weeks following the procedure and are associated with dismal outcomes. Some baseline and TAVR procedural factors were associated with VE-IE, and Staphylococcus aureus and enterococci were the main causative pathogens. These results may help to select the more appropriate antibiotic prophylaxis in TAVR procedures and guide the initial antibiotic therapy in those cases with a clinical suspicion of IE. Very early infective endocarditis after trans-catheter aortic valve replacement. VE-IE indicates very early infective endocarditis (≤30 days post TAVR). D-IE indicates delayed infective endocarditis.
MeSH term(s)	Anti-Bacterial Agents ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Endocarditis/etiology ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/etiology ; Female ; Heart Valve Prosthesis/adverse effects ; Humans ; Male ; Risk Factors ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/etiology ; Transcatheter Aortic Valve Replacement/adverse effects
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-03-09
Publishing country	Germany
Document type	Journal Article ; Multicenter Study
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-022-01998-0
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Article ; Online: Sex Differences in Infective Endocarditis After Transcatheter Aortic Valve Replacement.

Testa, Luca / Kim, Won-Keun / Eltchaninoff, Helene / Sondergaard, Lars / Himbert, Dominique / Husser, Oliver / Latib, Azeem / le Breton, Hervé / Servoz, Clement / Gervais, Philippe / Del Val, David / Linke, Axel / Crusius, Lisa / Thiele, Holger / Holzhey, David / Rodés-Cabau, Josep

The Canadian journal of cardiology

2022 Volume 38, Issue 9, Page(s) 1418–1425

Abstract: Background: Outcomes after transcatheter aortic valve replacement (TAVR) and infectious diseases may vary according to sex.: Methods: This multicentre study aimed to determine the sex differences in clinical characteristics, management, and outcomes ... ...

Abstract	Background: Outcomes after transcatheter aortic valve replacement (TAVR) and infectious diseases may vary according to sex. Methods: This multicentre study aimed to determine the sex differences in clinical characteristics, management, and outcomes of infective endocarditis (IE) after TAVR. A total of 579 patients (217 women, 37.5%) who had the diagnosis of definite IE following TAVR were included retrospectively from the Infectious Endocarditis After TAVR International Registry. Results: Women were older (80 ± 8 vs 78 ± 8 years; P = 0.001) and exhibited a lower comorbidity burden. Clinical characteristics and microbiological profiles were similar between men and women, but culture-negative IE was more frequent in women (9.9% vs 4.3%; P = 0.009). A high proportion of patients had a clinical indication for surgery (54.4% in both groups; P = 0.99), but a surgical intervention was performed in a minority of patients (women 15.2%, men 20.3%; P = 0.13). The mortality rate at index IE hospitalisation was similar in both groups (women 35.4%, men 31.7%; P = 0.37), but women exhibited a higher mortality rate at 2-year follow-up (63% vs 52.1%; P = 0.021). Female sex remained an independent risk factor for cumulative mortality in the multivariable analysis (adjusted HR 1.28, 95% CI 1.02-1.62; P = 0.035). After adjustment for in-hospital events, surgery was not associated with better outcomes in women. Conclusions: There were no significant sex-related differences in the clinical characteristics and management of IE after TAVR. However, female sex was associated with increased 2-year mortality risk.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/surgery ; Endocarditis/diagnosis ; Endocarditis/epidemiology ; Endocarditis/etiology ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/etiology ; Female ; Humans ; Male ; Retrospective Studies ; Risk Factors ; Sex Characteristics ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2022-07-14
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2022.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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