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  1. Article: Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs.

    Szabo, Iulia / Muntean, Laura / Crisan, Tania / Rednic, Voicu / Sirbe, Claudia / Rednic, Simona

    Biomedicines

    2021  Volume 9, Issue 10

    Abstract: Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without ... ...

    Abstract Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without interfering with the DNA sequence. Epigenetic marks may be reversible and their differential response to external stimuli could explain the protean clinical manifestations of SSc while offering the opportunity of targeted drug development. Small, non-coding RNA sequences (miRNAs) have demonstrated complex interactions between vasculature, immune activation, and extracellular matrices. Distinct miRNA profiles were identified in SSc skin specimens and blood samples containing a wide variety of dysregulated miRNAs. Their target genes are mainly involved in profibrotic pathways, but new lines of evidence also confirm their participation in impaired angiogenesis and aberrant immune responses. Research approaches focusing on earlier stages of the disease and on differential miRNA expression in various tissues could bring novel insights into SSc pathogenesis and validate the clinical utility of miRNAs as biomarkers and therapeutic targets.
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9101471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nutrition in Spondyloarthritis and Related Immune-Mediated Disorders.

    Popa, Stefan Lucian / Dumitrascu, Dinu Iuliu / Brata, Vlad Dumitru / Duse, Traian Adrian / Florea, Maria Delia / Ismaiel, Abdulrahman / Muntean, Laura Mirela / Grad, Simona

    Nutrients

    2022  Volume 14, Issue 6

    Abstract: Recent research on the pathogenesis of spondyloarthritis and related immune-mediated diseases associated with human leukocyte antigen class I molecule B27 (HLA-B27) has led to significant progress in terms of management and prognosis, with multiple ... ...

    Abstract Recent research on the pathogenesis of spondyloarthritis and related immune-mediated diseases associated with human leukocyte antigen class I molecule B27 (HLA-B27) has led to significant progress in terms of management and prognosis, with multiple treatments being constantly evaluated and implemented. Correlations between the genetic background of spondyloarthritis and inflammatory bowel diseases and the inflammatory processes involving gut microbiota have been established. This knowledge has allowed progress in pharmacological therapy. The role of diet in the pathogenesis and treatment of diseases pertaining to the HLA-B27 spectrum is of great significance, considering possible future applications in individualized medicine. Diet impacts the composition of gut microbiota, representing a substrate for the synthesis of metabolites affecting the mucosal immune system. Certain pro-inflammatory mediators, such as emulsifiers and microparticles, induce a more profound cytokine response, promoting inflammation. Numerous diets, including the low-starch diet, the Mediterranean diet, diets with low contents of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (low-FODMAP diets), gluten-free diets and fasting, have been analysed and correlated with patients' symptomatology and dietary adherence. The aim of this review is to provide an extensive perspective on the diets available to patients with spondyloarthritis and related immune-mediated disorders.
    MeSH term(s) Diet, Carbohydrate-Restricted ; Gastrointestinal Microbiome/physiology ; Humans ; Monosaccharides ; Nutritional Status ; Spondylarthritis
    Chemical Substances Monosaccharides
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14061278
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  3. Article: Nutrition in Spondyloarthritis and Related Immune-Mediated Disorders

    Popa, Stefan Lucian / Dumitrascu, Dinu Iuliu / Brata, Vlad Dumitru / Duse, Traian Adrian / Florea, Maria Delia / Ismaiel, Abdulrahman / Muntean, Laura Mirela / Grad, Simona

    Nutrients. 2022 Mar. 17, v. 14, no. 6

    2022  

    Abstract: Recent research on the pathogenesis of spondyloarthritis and related immune-mediated diseases associated with human leukocyte antigen class I molecule B27 (HLA-B27) has led to significant progress in terms of management and prognosis, with multiple ... ...

    Abstract Recent research on the pathogenesis of spondyloarthritis and related immune-mediated diseases associated with human leukocyte antigen class I molecule B27 (HLA-B27) has led to significant progress in terms of management and prognosis, with multiple treatments being constantly evaluated and implemented. Correlations between the genetic background of spondyloarthritis and inflammatory bowel diseases and the inflammatory processes involving gut microbiota have been established. This knowledge has allowed progress in pharmacological therapy. The role of diet in the pathogenesis and treatment of diseases pertaining to the HLA-B27 spectrum is of great significance, considering possible future applications in individualized medicine. Diet impacts the composition of gut microbiota, representing a substrate for the synthesis of metabolites affecting the mucosal immune system. Certain pro-inflammatory mediators, such as emulsifiers and microparticles, induce a more profound cytokine response, promoting inflammation. Numerous diets, including the low-starch diet, the Mediterranean diet, diets with low contents of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (low-FODMAP diets), gluten-free diets and fasting, have been analysed and correlated with patients’ symptomatology and dietary adherence. The aim of this review is to provide an extensive perspective on the diets available to patients with spondyloarthritis and related immune-mediated disorders.
    Keywords FODMAP diet ; HLA antigens ; Mediterranean diet ; cytokines ; fasting ; genetic background ; immune system ; inflammation ; intestinal microorganisms ; metabolites ; mucosal immunity ; pathogenesis ; polyols ; precision medicine ; prognosis
    Language English
    Dates of publication 2022-0317
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14061278
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Contributions Regarding the Optimization of Job Descriptions Elaboration Process in the Knowledge-based Organization

    Muntean Laura / Titu Aurel Mihail / Oprean Constantin

    Lecture Notes in Engineering and Computer Science, Vol 2210, Iss 1, Pp 1088-

    2014  Volume 1093

    Keywords Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher Newswood and International Association of Engineers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Contributions Regarding the Design of a Procedure for the Elaboration of the Job Descriptions

    Muntean Laura / Oprean Constantin / Titu Aurel Mihail

    Lecture Notes in Engineering and Computer Science, Vol 2210, Iss 1, Pp 969-

    2014  Volume 974

    Keywords Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher Newswood and International Association of Engineers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Acroosteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis.

    Siao-Pin, Simon / Damian, Laura-Otilia / Muntean, Laura Mirela / Rednic, Simona

    Experimental and therapeutic medicine

    2016  Volume 12, Issue 5, Page(s) 3459–3463

    Abstract: Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast ... ...

    Abstract Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast activation and pathological bone loss remain to be established. Vascular alterations and reduced capillary density impair tissue oxygenation in systemic sclerosis, and the resulting hypoxia might contribute directly to the disease progression. In this paper we summarize the current evidence for hypoxia as the common pathophysiological denominator of digital vasculopathy and enhanced osteoclastic activity in systemic sclerosis-associated acroosteolysis. The hypoxia-inducible transcription factor HIF-1α and VEGF signaling has a critical role in regulating osteoclastic bone-resorption and angiogenesis, and increased osteoclastogenesis and higher VEGF levels may contribute to acroosteolysis in systemic sclerosis. The cells of the osteoblast lineage also have important roles in angiogenic-osteogenic coupling. The research in this field might help limiting the disability associated with the disease.
    Language English
    Publishing date 2016-10-05
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2016.3782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinical and ultrasound findings in patients with calcium pyrophosphate dihydrate deposition disease.

    Vele, Paulina / Simon, Siao-Pin / Damian, Laura / Felea, Ioana / Muntean, Laura / Filipescu, Ileana / Rednic, Simona

    Medical ultrasonography

    2018  Volume 20, Issue 2, Page(s) 159–163

    Abstract: Aim: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ... ...

    Abstract Aim: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ultrasound (US).
    Material and methods: Thirty consecutive patients fulfilling McCarty diagnostic criteria for CPPD were consecutively enrolled in the study. The data registered using the US included the affected joints, the calcification site, and the pattern of calcification (thin hyperechoic bands, parallel to the surface of the hyaline cartilage, hyperechoic spots, and hyperechoic nodular or oval deposits). The presence of CPP crystals in knees was confirmed by polarized light microscopy examination of the synovial fluid and radiographs of the knees were performed in all patients.
    Results: In 30 patients, 390 joints were scanned, (13 joints in every patient). The mean±standard deviation number of joints with US CPPD evidence per patient was 2.93±1.8 (range 1-9). The knee was the most common joint involved both clinically and using US examination. The second US pattern (with hyperechoic spots) was the most frequent. Fibrocartilage calcifications were more common than hyaline calcification. Using radiography as reference method, the sensitivity and specificity of US for diagnosis CPPD in knees was 79.31%, 95CI(66.65%-88.83%), and 14.29%, 95CI(1.78%-42.81%), respectively.
    Conclusions: The knee is the most frequent joint affected by CPPD. The second ultrasound pattern is the most common. CPPD affects the fibrocartilage to a greater extent than the hyaline cartilage.
    MeSH term(s) Chondrocalcinosis/diagnostic imaging ; Chondrocalcinosis/pathology ; Female ; Humans ; Joints/diagnostic imaging ; Joints/pathology ; Knee Joint/diagnostic imaging ; Knee Joint/pathology ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity ; Synovial Fluid/diagnostic imaging ; Ultrasonography/methods
    Language English
    Publishing date 2018-05-04
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2529623-1
    ISSN 2066-8643 ; 1844-4172
    ISSN (online) 2066-8643
    ISSN 1844-4172
    DOI 10.11152/mu-1193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bone mineral density, carotid artery intima-media thickness, and Klotho gene polymorphism in postmenopausal women

    Muntean Laura / Simon Siao-pin / Popp Radu / Albu Adriana / Fodor Daniela

    Open Medicine, Vol 9, Iss 2, Pp 315-

    2014  Volume 324

    Keywords klotho ; osteoporosis ; atherosclerosis ; genetics ; carotid intima-media thickness ; Medicine ; R
    Language English
    Publishing date 2014-04-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: The relationship between the metabolic syndrome and its components and bone status in postmenopausal women.

    Fodor, D / Vesa, S / Albu, A / Simon, S / Craciun, A / Muntean, Laura

    Acta physiologica Hungarica

    2014  Volume 101, Issue 2, Page(s) 216–227

    Abstract: Unlabelled: The association between metabolic syndrome (MS) and bone status remains controversial. We aimed to study the relationships between MS, bone mineral density (BMD), and bone metabolism in postmenopausal women.: Material and methods: MS was ... ...

    Abstract Unlabelled: The association between metabolic syndrome (MS) and bone status remains controversial. We aimed to study the relationships between MS, bone mineral density (BMD), and bone metabolism in postmenopausal women.
    Material and methods: MS was assessed in 218 white postmenopausal women. BMD (lumbar spine and hip) was measured by dual energy X-ray absorptiometry (DXA). Serum carboxyterminal cross-linked telopeptide of type 1 collagen (CTX), undercarboxylated osteocalcin (uOC), bone alkaline phosphate (BAP) and vitamin D were assayed.
    Results: Postmenopausal women with MS had a significantly higher lumber spine BMD than women without MS (p < 0.05). A progressive increase of the BMD at both sites with the number of MS components was observed. Bone turnover markers and vitamin D levels were not significantly influenced by the presence of MS. BMD at both sites positively correlated with body mass index (BMI), waist circumference (WC) and glucose in unadjusted analysis. In multiple regression analysis, WC was independently associated with BMD at both sites, while hypertension was associated only with lumbar spine BMD.
    Conclusions: In postmenopausal women, MS is associated with increased lumbar spine BMD and this relation is explained mainly by the higher BMI and WC in the MS group.
    MeSH term(s) Absorptiometry, Photon ; Age Factors ; Aged ; Alkaline Phosphatase/blood ; Biomarkers/blood ; Blood Glucose/analysis ; Blood Pressure ; Body Mass Index ; Bone Density ; Bone Remodeling ; Collagen Type I/blood ; Cross-Sectional Studies ; Female ; Femur Neck/diagnostic imaging ; Femur Neck/metabolism ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/metabolism ; Metabolic Syndrome/blood ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/metabolism ; Middle Aged ; Osteocalcin/blood ; Peptides/blood ; Postmenopause/blood ; Postmenopause/metabolism ; Vitamin D/blood ; Waist Circumference
    Chemical Substances Biomarkers ; Blood Glucose ; Collagen Type I ; Peptides ; collagen type I trimeric cross-linked peptide ; Osteocalcin (104982-03-8) ; Vitamin D (1406-16-2) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2014-06
    Publishing country Hungary
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 802801-1
    ISSN 1588-2683 ; 0231-424X ; 0001-6756
    ISSN (online) 1588-2683
    ISSN 0231-424X ; 0001-6756
    DOI 10.1556/APhysiol.101.2014.2.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bone mineral density, vertebral fractures and body mass index in postmenopausal women with abdominal aortic calcification.

    Simon, Siao-pin / Fodor, Daniela / Muntean, Laura / Poanta, Laura / Cristea, Paulina / Rednic, Simona

    Endocrine research

    2014  Volume 39, Issue 1, Page(s) 1–6

    Abstract: Background: Evidence suggest that there are connections between osteoporosis and cardiovascular diseases.: Objectives: The aim of the study was to analyze the relationship between radiological measurements of abdominal aorta calcifications (AAC) and ... ...

    Abstract Background: Evidence suggest that there are connections between osteoporosis and cardiovascular diseases.
    Objectives: The aim of the study was to analyze the relationship between radiological measurements of abdominal aorta calcifications (AAC) and bone mineral density (BMD) in postmenopausal women.
    Methods: In this cross-sectional study were included 125 postmenopausal women 50-84 years of age. BMD of the spine and hip was measured by dual energy X-ray absorptiometry (DXA). AAC were assessed by lateral radiographs of lumbar spine (L1-L4), using the antero-posterior severity score (0-24). Vertebral fractures were evaluated from T4 to L4 using Genant's semiquantitative method.
    Results: Forty-one (32.8%) patients had osteoporosis and 61 (48.8%) had AAC with a mean score of 3.1. Postmenopausal women with AAC were older and had significantly lower femoral neck and trochanteric BMD than subjects without AAC (all p < 0.01). There were no significant differences in the frequency of fractures between subjects with AAC and those without AAC (p > 0.05). In univariate analysis, age, height, weight, femoral and trochanter BMD were significantly associated with the severity of AAC score. In multiple regression analysis, femoral neck BMD, but not lumbar spine, trochanter BMD or age, was an independent predictor of AAC.
    Conclusions: Reduced femoral neck BMD is negatively associated with the presence of AAC in postmenopausal women. The association between BMD and AAC seems to be age-independent, which suggests a common pathogenesis for bone loss and vascular calcifications.
    MeSH term(s) Aged ; Aged, 80 and over ; Aortic Diseases/complications ; Aortic Diseases/physiopathology ; Body Mass Index ; Bone Density/physiology ; Calcinosis/complications ; Calcinosis/physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Postmenopause/physiology ; Spinal Fractures/complications ; Spinal Fractures/physiopathology
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605823-1
    ISSN 1532-4206 ; 0743-5800
    ISSN (online) 1532-4206
    ISSN 0743-5800
    DOI 10.3109/07435800.2013.794425
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