Article ; Online: JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS
Journal of medicinal chemistry
2022 Volume 65, Issue 24, Page(s) 16173–16203
Abstract: Rapid emergence of tumor resistance via RAS pathway reactivation has been reported from clinical studies of covalent ... ...
| Abstract | Rapid emergence of tumor resistance via RAS pathway reactivation has been reported from clinical studies of covalent KRAS |
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| MeSH term(s) | Animals ; Humans ; Mice ; Disease Models, Animal ; Drug Design ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Proto-Oncogene Proteins p21(ras) ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use | ||||||||||
| Chemical Substances | KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Pyrazoles ; JDQ443 | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2022-11-18 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 218133-2 | ||||||||||
| ISSN | 1520-4804 ; 0022-2623 | ||||||||||
| ISSN (online) | 1520-4804 | ||||||||||
| ISSN | 0022-2623 | ||||||||||
| DOI | 10.1021/acs.jmedchem.2c01438 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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