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  1. Book: Herbal Medicine: back to the future / Volume 3

    Murad, Ferid

    2019  

    Author's details edited by Ferid Murad, Atta-ur-Rahman & Ka Bian
    Collection Herbal Medicine ; back to the future
    Language English
    Size iii, 287 Seiten, Illustrationen
    Publishing country Singapore
    Document type Book
    HBZ-ID HT020289539
    ISBN 978-981-14-1119-9 ; 9789811411205 ; 981-14-1119-0 ; 9811411204
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 163 available for loan (reading room) Lesesaal EG

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  2. Collection: Herbal Medicine: back to the future

    Murad, Ferid

    2017  

    Author's details edited by Ferid Murad, Atta-ur-Rahman & Ka Bian
    Language English
    Dates of publication 2017-
    Publisher Bentham Science
    Publishing place singapore
    Publishing country Singapore
    Document type Collection (display volumes)
    HBZ-ID HT020289518
    ISSN 2542-9981
    ISSN 2542-9981
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Discovery of Some of the Biological Effects of Nitric Oxide and Its Role in Cell Signaling (Nobel Lecture).

    Murad, Ferid

    Angewandte Chemie (International ed. in English)

    2021  Volume 38, Issue 13-14, Page(s) 1856–1868

    Abstract: A unique simple molecule with an array of signaling functions: NO. The free radical nitric oxide not only mediates a long list of biological effects by activating guanylyl cyclase and increasing cyclic GMP synthesis from GTP, but can also interact with ... ...

    Abstract A unique simple molecule with an array of signaling functions: NO. The free radical nitric oxide not only mediates a long list of biological effects by activating guanylyl cyclase and increasing cyclic GMP synthesis from GTP, but can also interact with transition metals such as iron, thiol groups, other free radicals, oxygen, superoxide anion, unsaturated fatty acids, and other molecules. Furthermore, NO can function as an intracellular messenger, an autacoid, a paracrine substance, a neurotransmitter, or a hormone that can be carried to distant sites for effects.
    Language English
    Publishing date 2021-06-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1856::AID-ANIE1856>3.0.CO;2-D
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Discovery of nitric oxide and cyclic GMP in cell signaling and their role in drug development

    Murad Ferid

    Molecular Neurodegeneration, Vol 7, Iss Suppl 1, p L

    2012  Volume 1

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-02-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Nitric oxide: the coming of the second messenger.

    Murad, Ferid

    Rambam Maimonides medical journal

    2011  Volume 2, Issue 2, Page(s) e0038

    Language English
    Publishing date 2011-04-30
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2573657-7
    ISSN 2076-9172
    ISSN 2076-9172
    DOI 10.5041/RMMJ.10038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Heart of science.

    Murad, Ferid

    Nature

    2011  Volume 478, Issue 7368, Page(s) S10–1

    MeSH term(s) Animals ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/therapy ; Commerce/education ; Creativity ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/prevention & control ; Diabetes Mellitus/therapy ; Drug Industry ; Drug Resistance, Microbial ; Exobiology ; Humans ; Mentors ; Nitric Oxide/metabolism ; Nobel Prize ; Patents as Topic ; Private Sector ; Public Sector ; Religion and Science ; Research Personnel/education
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2011-10-12
    Publishing country England
    Document type Interview
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/478S10a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  7. Article: Soluble Guanylate Cyclase β1 Subunit Represses Human Glioblastoma Growth.

    Xiao, Haijie / Zhu, Haifeng / Bögler, Oliver / Mónica, Fabiola Zakia / Kots, Alexander Y / Murad, Ferid / Bian, Ka

    Cancers

    2023  Volume 15, Issue 5

    Abstract: Malignant glioma is the most common and deadly brain tumor. A marked reduction in the levels of sGC (soluble guanylyl cyclase) transcript in the human glioma specimens has been revealed in our previous studies. In the present study, restoring the ... ...

    Abstract Malignant glioma is the most common and deadly brain tumor. A marked reduction in the levels of sGC (soluble guanylyl cyclase) transcript in the human glioma specimens has been revealed in our previous studies. In the present study, restoring the expression of sGCβ1 alone repressed the aggressive course of glioma. The antitumor effect of sGCβ1 was not associated with enzymatic activity of sGC since overexpression of sGCβ1 alone did not influence the level of cyclic GMP. Additionally, sGCβ1-induced inhibition of the growth of glioma cells was not influenced by treatment with sGC stimulators or inhibitors. The present study is the first to reveal that sGCβ1 migrated into the nucleus and interacted with the promoter of the
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Nitric oxide and cyclic guanosine monophosphate signaling in the eye.

    Murad, Ferid

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2008  Volume 43, Issue 3, Page(s) 291–294

    Abstract: This brief review describes the components and pathways utilized in nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) signaling. Since the discovery of the effects of NO and cGMP on smooth muscle relaxation about 30 years ago, the field has ... ...

    Abstract This brief review describes the components and pathways utilized in nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) signaling. Since the discovery of the effects of NO and cGMP on smooth muscle relaxation about 30 years ago, the field has expanded in many directions such that many, but not all, biochemical and biological effects seem to be regulated by these unique signaling molecules. While many of the effects of NO are due to activation of soluble guanylyl cyclase (sGC) that can be considered the receptor for NO, cGMP, in turn, can activate a cGMP-dependent protein kinase (PKG) to phosphorylate an array of proteins. Some of the effects of cGMP can be independent of PKG and are due to effects on ion channels or cyclic nucleotide phosphodiesterases. Also, some of the effects of NO can be independent of sGC activation. The isoenzymes and macromolecules that participate in these signaling pathways can serve as molecular targets to identify compounds that increase or decrease their activation and thus serve as chemical leads for discovering novel drugs for a variety of diseases. Some examples are given. However, with about 90,000 publications in the field since our first reports in 1977, this brief review can only give the readers a sample of the excitement and opportunities we have found in this cell signaling system.
    MeSH term(s) Animals ; Cyclic GMP/physiology ; Eye/metabolism ; Guanylate Cyclase/metabolism ; Humans ; Nitric Oxide/physiology ; Nitric Oxide Synthase/metabolism ; Signal Transduction/physiology
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Guanylate Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2008-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.3129/i08-044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development.

    Murad, Ferid

    The New England journal of medicine

    2006  Volume 355, Issue 19, Page(s) 2003–2011

    MeSH term(s) Cyclic GMP/metabolism ; Drug Design ; Guanylate Cyclase/chemistry ; Guanylate Cyclase/metabolism ; Humans ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/chemistry ; Nitric Oxide Synthase/metabolism ; Protein Isoforms ; Reactive Oxygen Species/metabolism ; Signal Transduction
    Chemical Substances Protein Isoforms ; Reactive Oxygen Species ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Guanylate Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2006-11-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMsa063904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: sGC-cGMP signaling: target for anticancer therapy.

    Bian, Ka / Murad, Ferid

    Advances in experimental medicine and biology

    2014  Volume 814, Page(s) 5–13

    Abstract: The biologic endogenous production of cGMP was reported in the 1960s and followed by the demonstration of guanylyl cyclase activity and the isoforms of soluble and membrane-bound guanylyl cyclases. During the same period, cGMP specific phosphodiesterases ...

    Abstract The biologic endogenous production of cGMP was reported in the 1960s and followed by the demonstration of guanylyl cyclase activity and the isoforms of soluble and membrane-bound guanylyl cyclases. During the same period, cGMP specific phosphodiesterases also was discovered. Murad's lab established link between the endothelium derived relaxation factor (EDRF) and elevated cGMP concentration in the vascular system. October 12, 1998, the Nobel Assembly awarded the Nobel Prize in Medicine or Physiology to scientists Robert Furchgott, Louis Ignarro, and Ferid Murad for their discoveries concerning nitric oxide (NO) as a signaling molecule in the cardiovascular system. In contrast with the short research history of the enzymatic synthesis of NO, the introduction of nitrate-containing compounds for medicinal purposes marked its 150th anniversary in 1997. Glyceryl trinitrate (nitroglycerin; GTN) is the first compound of this category. Alfred Nobel (the founder of the Nobel Prize) himself had suffered from angina pectoris and was prescribed nitroglycerin for his chest pain while he refused to take due to the induction of headaches. Almost a century after its first chemical use, research in the nitric oxide and 3',5'-cyclic guanosine monophosphate (NO/cGMP) pathway has dramatically expanded and the role of NO/cGMP in physiology and pathology has been extensively studied. Soluble guanylyl cyclase (sGC) is the receptor for NO. The α1β1 heterodimer is the predominant isoform of sGC that is obligatory for catalytic activity. NO binds to the ferrous (Fe(2+)) heme at histidine 105 of the β1 subunit and leads to an increase in sGC activity and cGMP production of at least 200-fold. In this chapter, we reviewed the studies of sGC-cGMP signaling in cell proliferation; introduced our work of targeting sGC-cGMP signaling for cancer therapy; and explored the role of sGC-cGMP signaling in the chromatin-microenvironment.
    MeSH term(s) Animals ; Cyclic GMP/metabolism ; Guanylate Cyclase/metabolism ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Signal Transduction/physiology ; Tumor Microenvironment/physiology
    Chemical Substances Guanylate Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4939-1031-1_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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