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  1. Article ; Online: Innovative surfaces and alloys for dental implants: What about biointerface-safety concerns?

    Kunrath, Marcel F / Muradás, Thaís C / Penha, Nilton / Campos, Maria M

    Dental materials : official publication of the Academy of Dental Materials

    2021  Volume 37, Issue 10, Page(s) 1447–1462

    Abstract: Objectives: The present review article aimed to discuss the recent technologies employed for the development of dental implants, mainly regarding innovative surface treatments and alternative alloys, emphasizing the bio-tribocorrosion processes.: ... ...

    Abstract Objectives: The present review article aimed to discuss the recent technologies employed for the development of dental implants, mainly regarding innovative surface treatments and alternative alloys, emphasizing the bio-tribocorrosion processes.
    Methods: An electronic search applying specific MeSH terms was carried out in PubMed and Google Scholar databases to collect data until August 2021, considering basic, pre-clinical, clinical and review studies. The relevant articles (n=111), focused on innovative surface treatments for dental implants and their potential undesirable biological effects, were selected and explored.
    Results: Novel texturization methodologies for dental implants clearly provided superficial and structural atomic alterations in micro- and nanoscale, promoting different mechanical-chemical interactions when applied in the clinical set. Some particulate metals released from implant surfaces, their degradation products and/or contaminants exhibited local and systemic reactions after implant installation and osseointegration, contributing to unexpected treatment drawbacks and adverse effects. Therefore, there is an urgent need for development of pre-clinical and clinical platforms for screening dental implant devices, to predict the biointerface reactions as early as possible during the development phases.
    Significance: Modern surface treatments and innovative alloys developed for dental implants are not completely understood regarding their integrity during long-term clinical function, especially when considering the bio-tribocorrosion process. From this review, it is possible to assume that degradation and contamination of dental surfaces might be associated within peri-implant inflammation and cumulative long-lasting systemic toxicity. The in-depth comprehension of the biointerface modifications on these novel surface treatments might preclude unnecessary expenses and postoperative complications involving osseointegration failures.
    MeSH term(s) Alloys ; Dental Alloys ; Dental Implants ; Dental Prosthesis Design ; Osseointegration ; Surface Properties ; Titanium
    Chemical Substances Alloys ; Dental Alloys ; Dental Implants ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2021-08-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605995-8
    ISSN 1879-0097 ; 0109-5641
    ISSN (online) 1879-0097
    ISSN 0109-5641
    DOI 10.1016/j.dental.2021.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Targeting FFA1 and FFA4 receptors in cancer-induced cachexia.

    Freitas, Raquel D S / Muradás, Thaís C / Dagnino, Ana Paula A / Rost, Fernanda L / Costa, Kesiane M / Venturin, Gianina T / Greggio, Samuel / da Costa, Jaderson C / Campos, Maria M

    American journal of physiology. Endocrinology and metabolism

    2020  Volume 319, Issue 5, Page(s) E877–E892

    Abstract: Free fatty acid (FFA) receptors FFA1 and FFA4 are omega-3 molecular targets in metabolic diseases; however, their function in cancer cachexia remains unraveled. We assessed the role of FFA1 and FFA4 receptors in the mouse model of cachexia induced by ... ...

    Abstract Free fatty acid (FFA) receptors FFA1 and FFA4 are omega-3 molecular targets in metabolic diseases; however, their function in cancer cachexia remains unraveled. We assessed the role of FFA1 and FFA4 receptors in the mouse model of cachexia induced by Lewis lung carcinoma (LLC) cell implantation. Naturally occurring ligands such as α-linolenic acid (ALA) and docosahexaenoic acid (DHA), the synthetic FFA1/FFA4 agonists GW9508 and TUG891, or the selective FFA1 GW1100 or FFA4 AH7614 antagonists were tested. FFA1 and FFA4 expression and other cachexia-related parameters were evaluated. GW9508 and TUG891 decreased tumor weight in LLC-bearing mice. Regarding cachexia-related end points, ALA, DHA, and the preferential FFA1 agonist GW9508 rescued body weight loss. Skeletal muscle mass was reestablished by ALA treatment, but this was not reflected in the fiber cross-sectional areas (CSA) measurement. Otherwise, TUG891, GW1100, or AH7614 reduced the muscle fiber CSA. Treatments with ALA, GW9508, GW1100, or AH7614 restored white adipose tissue (WAT) depletion. As for inflammatory outcomes, ALA improved anemia, whereas GW9508 reduced splenomegaly. Concerning behavioral impairments, ALA and GW9508 rescued locomotor activity, whereas ALA improved motor coordination. Additionally, DHA improved grip strength. Notably, GW9508 restored abnormal brain glucose metabolism in different brain regions. The GW9508 treatment increased leptin levels, without altering uncoupling protein-1 downregulation in visceral fat. LLC-cachectic mice displayed FFA1 upregulation in subcutaneous fat, but not in visceral fat or gastrocnemius muscle, whereas FFA4 was unaltered. Overall, the present study shed new light on FFA1 and FFA4 receptors' role in metabolic disorders, indicating FFA1 receptor agonism as a promising strategy in mitigating cancer cachexia.
    MeSH term(s) Animals ; Benzoates/pharmacology ; Biphenyl Compounds/pharmacology ; Body Weight/drug effects ; Cachexia/drug therapy ; Cachexia/etiology ; Cachexia/metabolism ; Carcinoma, Lewis Lung/complications ; Carcinoma, Lewis Lung/metabolism ; Disease Models, Animal ; Docosahexaenoic Acids/pharmacology ; Docosahexaenoic Acids/therapeutic use ; Methylamines/pharmacology ; Mice ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Neoplasm Transplantation ; Phenylpropionates/pharmacology ; Propionates/pharmacology ; Pyrimidines/pharmacology ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/metabolism ; Sulfonamides/pharmacology ; Xanthenes/pharmacology ; alpha-Linolenic Acid/pharmacology ; alpha-Linolenic Acid/therapeutic use
    Chemical Substances 3-(4-((4-fluoro-4'-methyl-(1,1'-biphenyl)-2-yl)methoxy)phenyl)propanoic acid ; AH7614 ; Benzoates ; Biphenyl Compounds ; FFAR4 protein, mouse ; Ffar1 protein, mouse ; GW1100 ; GW9508 ; Methylamines ; Phenylpropionates ; Propionates ; Pyrimidines ; Receptors, G-Protein-Coupled ; Sulfonamides ; Xanthenes ; alpha-Linolenic Acid (0RBV727H71) ; Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2020-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00509.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Mechanisms underlying the antiproliferative effects of a series of quinoxaline-derived chalcones.

    Mielcke, Tânia R / Muradás, Thaís C / Filippi-Chiela, Eduardo C / Amaral, Maria Eduarda A / Kist, Luiza W / Bogo, Maurício R / Mascarello, Alessandra / Neuenfeldt, Patrícia D / Nunes, Ricardo J / Campos, Maria M

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 15850

    Abstract: The present study aimed to characterize the effects of quinoxaline-derived chalcones, designed on the basis of the selective PI3Kγ inhibitor AS605240, in oral cancer cells. Three lead compounds, namely N9, N17 and N23, were selected from a series of 20 ... ...

    Abstract The present study aimed to characterize the effects of quinoxaline-derived chalcones, designed on the basis of the selective PI3Kγ inhibitor AS605240, in oral cancer cells. Three lead compounds, namely N9, N17 and N23, were selected from a series of 20 quinoxaline-derived chalcones, based on an initial screening using human and rat squamous cell carcinoma lineages, representing compounds with at least one methoxy radical at the A-ring. The selected chalcones, mainly N9 and N17, displayed marked antiproliferative effects, via apoptosis and autophagy induction, with an increase of sub-G1 population and Akt inhibition. The three chalcones displayed marked in vitro antitumor effects in different protocols with standard chemotherapy drugs, with acceptable toxicity on normal cells. There was no growth retrieval, after exposure to chalcone N9 alone, in a long-term assay to determine the cumulative population doubling (CPD) of human oral cancer cells. A PCR array evaluating 168 genes related to cancer and inflammation, demonstrated striking actions for N9, which altered the expression of 74 genes. Altogether, our results point out quinoxalinic chalcones, mainly N9, as potential strategies for oral cancer treatment.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chalcones/chemistry ; Chalcones/pharmacology ; Class Ib Phosphatidylinositol 3-Kinase/antagonists & inhibitors ; Class Ib Phosphatidylinositol 3-Kinase/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Molecular Structure ; Mouth Neoplasms/drug therapy ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Neoplasm Proteins/genetics ; Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Rats ; Structure-Activity Relationship ; Thiazolidinediones/pharmacology
    Chemical Substances 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione ; Chalcones ; Neoplasm Proteins ; Quinoxalines ; Thiazolidinediones ; Class Ib Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; PIK3CG protein, human (EC 2.7.1.137)
    Language English
    Publishing date 2017-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-16199-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.

    Muradás, Thaís C / Abbadi, Bruno L / Villela, Anne D / Macchi, Fernanda S / Bergo, Pedro F / de Freitas, Talita F / Sperotto, Nathalia D M / Timmers, Luis F S M / Norberto de Souza, Osmar / Picada, Jaqueline N / Fachini, Jean / da Silva, Juliana Bondan / de Albuquerque, Nayara C P / Habenschus, Maísa D / Carrão, Daniel B / Rocha, Bruno A / Barbosa Junior, Fernando / de Oliveira, Anderson R M / Mascarello, Alessandra /
    Neuenfeldf, Patrícia / Nunes, Ricardo J / Morbidoni, Héctor R / Campos, Maria M / Basso, Luiz A / Rodrigues-Junior, Valnês S

    PloS one

    2018  Volume 13, Issue 8, Page(s) e0202568

    Abstract: New effective compounds for tuberculosis treatment are needed. This study evaluated the effects of a series of quinoxaline-derived chalcones against laboratorial strains and clinical isolates of M. tuberculosis. Six molecules, namely N5, N9, N10, N15, ... ...

    Abstract New effective compounds for tuberculosis treatment are needed. This study evaluated the effects of a series of quinoxaline-derived chalcones against laboratorial strains and clinical isolates of M. tuberculosis. Six molecules, namely N5, N9, N10, N15, N16, and N23 inhibited the growth of the M. tuberculosis H37Rv laboratorial strain. The three compounds (N9, N15 and N23) with the lowest MIC values were further tested against clinical isolates and laboratory strains with mutations in katG or inhA genes. From these data, N9 was selected as the lead compound for further investigation. Importantly, this chalcone displayed a synergistic effect when combined with moxifloxacin. Noteworthy, the anti-tubercular effects of N9 did not rely on inhibition of mycolic acids synthesis, circumventing important mechanisms of resistance. Interactions with cytochrome P450 isoforms and toxic effects were assessed in silico and in vitro. The chalcone N9 was not predicted to elicit any mutagenic, genotoxic, irritant, or reproductive effects, according to in silico analysis. Additionally, N9 did not cause mutagenicity or genotoxicity, as revealed by Salmonella/microsome and alkaline comet assays, respectively. Moreover, N9 did not inhibit the cytochrome P450 isoforms CYP3A4/5, CYP2C9, and CYP2C19. N9 can be considered a potential lead molecule for development of a new anti-tubercular therapeutic agent.
    MeSH term(s) Antitubercular Agents/pharmacology ; Bacterial Proteins/genetics ; Catalase/genetics ; Chalcones/pharmacology ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 Enzyme System/genetics ; Humans ; Microbial Sensitivity Tests ; Mutation ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/pathogenicity ; Mycolic Acids/antagonists & inhibitors ; Oxidoreductases/genetics ; Quinoxalines/pharmacology ; Tuberculosis/drug therapy ; Tuberculosis/genetics ; Tuberculosis/microbiology ; Tuberculosis/pathology
    Chemical Substances Antitubercular Agents ; Bacterial Proteins ; Chalcones ; Mycolic Acids ; Quinoxalines ; Cytochrome P-450 Enzyme System (9035-51-2) ; Oxidoreductases (EC 1.-) ; Catalase (EC 1.11.1.6) ; katG protein, Mycobacterium tuberculosis (EC 1.11.1.6) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; InhA protein, Mycobacterium (EC 1.3.1.9)
    Language English
    Publishing date 2018-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0202568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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