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  1. Article: Ethylene facilitates boil‐peeling in fruits

    Murakami, Satoru

    Food Science & Nutrition, 7(9):2836-2841

    2019  

    Abstract: Boil‐peeling is a common method of cooking or processing some horticultural crops. While boil‐peeling is possible in some horticultural crops, a comprehensive list of crops for which boil‐peeling is possible does not exist. According to a previous study, ...

    Abstract Boil‐peeling is a common method of cooking or processing some horticultural crops. While boil‐peeling is possible in some horticultural crops, a comprehensive list of crops for which boil‐peeling is possible does not exist. According to a previous study, ethylene facilitates boil‐peeling of kiwifruits. Thus, we studied the effect of ethylene treatment on boil‐peeling in the kiwifruit variety “Rainbow red.” We found that with increasing ethylene concentration in the fruits, boil‐peeling success of kiwifruits increased. In the no‐ethylene treatment, flesh firmness of the fruits decreased and boil‐peeling could not be carried out successfully. Thus, it was clear that ethylene facilitates boil‐peeling in kiwifruit. Furthermore, boil‐peeling was possible after ethylene treatment in persimmon and Japanese pear, which had proved to be impossible so far. Kiwifruits, persimmon, and Japanese pear were classified as climacteric fruits that react with high ethylene sensitivity. Thus, ethylene may facilitate boil‐peeling in climacteric fruits. This finding can possibly suggest new application for ethylene during fruit processing or in processed fruits.
    Keywords climacteric fruits ; ethylene ; heat treatment ; polygalacturonase ; peeling
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article: Will perioperative pembrolizumab treatment change perioperative treatment strategies for resectable non-small cell lung cancer?

    Murakami, Shuji

    Translational lung cancer research

    2024  Volume 13, Issue 1, Page(s) 205–209

    Language English
    Publishing date 2024-01-11
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Biology of Cognitive Aging: Model Systems, Technologies and Beyond

    Murakami, Shin

    2017  

    Abstract: Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of ... ...

    Abstract Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer's disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents.-

    Aging specifically reduces the ability to learn new information but leaves "old" memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D.Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind.-

    A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer's disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves "old" memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD.-
    Keywords Genetics ; Science (General)
    Size 1 electronic resource (145 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020095066
    ISBN 9782889451449 ; 2889451445
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Neoadjuvant PD-1 Blockade in Non-Small Cell Lung Cancer: Current perspectives and Moving Forward.

    Shinada, Kanako / Murakami, Shuji

    OncoTargets and therapy

    2023  Volume 16, Page(s) 99–108

    Abstract: Perioperative therapy for non-small cell lung cancer has been studied extensively in a bid to improve overall survival, as approximately half of the patients with surgically resectable tumors at the time of diagnosis relapse. In recent years, immune ... ...

    Abstract Perioperative therapy for non-small cell lung cancer has been studied extensively in a bid to improve overall survival, as approximately half of the patients with surgically resectable tumors at the time of diagnosis relapse. In recent years, immune checkpoint inhibitor therapies, such as the anti-programmed death 1/programmed death-ligand 1 (PD-1/PD-L1) blockade, have contributed to achieving an improved overall survival of patients with advanced stage lung cancer. Thus, the development of this treatment strategy has considerable potential to precipitate a breakthrough in cancer immunotherapy. PD-1/PD-L1 blockade has several potential immunological benefits when used as a neoadjuvant therapy. However, there are concerns associated with this neoadjuvant therapy. Many studies have reported its efficacy, but there is limited evidence regarding the long-term survival of patients. Similarly, it is unclear whether existing biomarkers are adequate for monitoring the prognosis of patients, or if new biomarkers are required. In this article, we present recent reports on neoadjuvant PD-1/PD-L1 blockade therapy and discuss its future challenges.
    Language English
    Publishing date 2023-02-15
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S399657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Artificial Intelligence-Assisted Meta-Analysis of the Frequency of ACE I/D Polymorphisms in Centenarians and Other Long-Lived Individuals.

    Li, Lingxuan / Murakami, Shin

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Current research on the angiotensin-converting-enzyme ( ...

    Abstract Current research on the angiotensin-converting-enzyme (
    MeSH term(s) Aged, 80 and over ; Humans ; Artificial Intelligence ; Centenarians ; Genotype ; Peptidyl-Dipeptidase A/genetics ; Polymorphism, Genetic
    Chemical Substances ACE protein, human (EC 3.4.15.1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043411
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  6. Article ; Online: Parallel and anti-parallel helical surface states for topological semimetals.

    Zhang, Tiantian / Murakami, Shuichi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9239

    Abstract: Weyl points, carrying a Z-type monopole charge [Formula: see text], have bulk-surface correspondence (BSC) associated with helical surface states (HSSs). When |[Formula: see text]| [Formula: see text], multi-HSSs can appear in a parallel manner. However, ...

    Abstract Weyl points, carrying a Z-type monopole charge [Formula: see text], have bulk-surface correspondence (BSC) associated with helical surface states (HSSs). When |[Formula: see text]| [Formula: see text], multi-HSSs can appear in a parallel manner. However, when a pair of Weyl points carrying [Formula: see text] [Formula: see text] meet, a Dirac point carrying [Formula: see text] = 0 can be obtained and the BSC vanishes. Nonetheless, a recent study in Zhang et al. (Phys Rev Res 4:033170, 2022) shows that a new BSC can survive for Dirac points when the system has time-reversal ([Formula: see text])-glide ([Formula: see text]) symmetry ([Formula: see text]=TG), i.e., anti-parallel double/quad-HSSs associated with a new [Formula: see text]-type monopole charge [Formula: see text] appear. In this paper, we systematically review and discuss both the parallel and anti-parallel multi-HSSs for Weyl and Dirac points, carrying two different kinds of monopole charges. Two material examples are offered to understand the whole configuration of multi-HSSs. One carries the Z-type monopole charge [Formula: see text], showing both local and global topology for three kinds of Weyl points, and it leads to parallel multi-HSSs. The other carries the [Formula: see text]-type monopole charge [Formula: see text], only showing the global topology for [Formula: see text]-invariant Dirac points, and it is accompanied by anti-parallel multi-HSSs.
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36168-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Taurine deficiency associated with dilated cardiomyopathy and aging.

    Ito, Takashi / Murakami, Shigeru

    Journal of pharmacological sciences

    2023  Volume 154, Issue 3, Page(s) 175–181

    Abstract: Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously and abundantly in mammalian tissues. Taurine content in the heart is approximately 20 mM, which is approximately 100 times higher than plasma concentration. The high ... ...

    Abstract Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously and abundantly in mammalian tissues. Taurine content in the heart is approximately 20 mM, which is approximately 100 times higher than plasma concentration. The high intracellular concentration of taurine is maintained by the taurine transporter (TauT; Slc6a6). Taurine plays various roles, including the regulation of intracellular ion dynamics, calcium handling, and acting as an antioxidant in the heart. Some species, such as cats and foxes, have low taurine biosynthetic capacity, and dietary taurine deficiency can lead to disorders such as dilated cardiomyopathy and blindness. In humans, the relationship between dietary taurine deficiency and cardiomyopathy is not yet clear, but a genetic mutation related to the taurine transporter has been reported to be associated with dilated cardiomyopathy. On the other hand, many studies have shown an association between dietary taurine intake and age-related diseases. Notably, it has recently been reported that taurine declines with age and is associated with lifespan in worms and mice, as well as healthspan in mice and monkeys. In this review, we summarize the role of dietary and genetic taurine deficiency in the development of cardiomyopathy and aging.
    MeSH term(s) Humans ; Mice ; Animals ; Cardiomyopathy, Dilated/genetics ; Heart ; Aging/genetics ; Taurine/metabolism ; Mammals/metabolism
    Chemical Substances Taurine (1EQV5MLY3D)
    Language English
    Publishing date 2023-12-28
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1016/j.jphs.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 237: Show issues Location:
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  8. Article ; Online: Matrix Vesicle-Mediated Mineralization and Potential Applications.

    Iwayama, T / Bhongsatiern, P / Takedachi, M / Murakami, S

    Journal of dental research

    2022  Volume 101, Issue 13, Page(s) 1554–1562

    Abstract: Hard tissues, including the bones and teeth, are a fundamental part of the body, and their formation and homeostasis are critically regulated by matrix vesicle-mediated mineralization. Matrix vesicles have been studied for 50 y since they were first ... ...

    Abstract Hard tissues, including the bones and teeth, are a fundamental part of the body, and their formation and homeostasis are critically regulated by matrix vesicle-mediated mineralization. Matrix vesicles have been studied for 50 y since they were first observed using electron microscopy. However, research progress has been hampered by various technical barriers. Recently, there have been great advancements in our understanding of the intracellular biosynthesis of matrix vesicles. Mitochondria and lysosomes are now considered key players in matrix vesicle formation. The involvement of mitophagy, mitochondrial-derived vesicles, and mitochondria-lysosome interaction have been suggested as potential detailed mechanisms of the intracellular pathway of matrix vesicles. Their main secretion pathway may be exocytosis, in addition to the traditionally understood mechanism of budding from the outer plasma membrane. This basic knowledge of matrix vesicles should be strengthened by novel nano-level microscopic technologies, together with basic cell biologies, such as autophagy and interorganelle interactions. In the field of tissue regeneration, extracellular vesicles such as exosomes are gaining interest as promising tools in cell-free bone and periodontal regenerative therapy. Matrix vesicles, which are recognized as a special type of extracellular vesicles, could be another potential alternative. In this review, we outline the recent significant progress in the process of matrix vesicle-mediated mineralization and the potential clinical applications of matrix vesicles for tissue regeneration.
    MeSH term(s) Calcification, Physiologic ; Bone and Bones ; Extracellular Vesicles/metabolism ; Exosomes ; Autophagy ; Extracellular Matrix/metabolism
    Language English
    Publishing date 2022-06-19
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345221103145
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  9. Article: Editorial: Insights in neurocognitive aging and behavior: 2022.

    Nielson, Kristy A / Venneri, Annalena / Murakami, Shin

    Frontiers in aging neuroscience

    2024  Volume 16, Page(s) 1361839

    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2024.1361839
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  10. Article ; Online: Increased pain after palliative radiotherapy: not only due to cancer progression.

    Murakami, Satoshi / Kitani, Akira / Kubota, Toru / Uezono, Yasuhito

    Annals of palliative medicine

    2024  Volume 13, Issue 1, Page(s) 18–21

    MeSH term(s) Humans ; Neoplasms/complications ; Neoplasms/radiotherapy ; Pain/etiology ; Pain/radiotherapy ; Palliative Care ; Analgesics, Opioid ; Cancer Pain/etiology ; Cancer Pain/radiotherapy
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2024-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-23-571
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