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Article ; Online: Enhancing postural stability in a musculoskeletal hopping robot through stretch reflex application on biarticular thigh muscles.

Takahashi, Ryu / Murakami, Yuki / Hosoda, Koh

2023 Volume 10, Page(s) 1293365

Abstract: Postural stabilization during rapid and powerful hopping actions represents a significant challenge for legged robotics. One strategy utilized by humans to negotiate this difficulty is the robust activation of biarticular thigh muscles. Guided by this ... ...

Abstract	Postural stabilization during rapid and powerful hopping actions represents a significant challenge for legged robotics. One strategy utilized by humans to negotiate this difficulty is the robust activation of biarticular thigh muscles. Guided by this physiological principle, this study aims to enhance the postural stability of a hopping robot through the emulation of this human mechanism. A legged robot powered by pneumatic artificial muscles (PAMs) was designed to mimic human anatomical structures. A critical aspect of this development was creating a tension-oriented stretch reflex system engineered to initiate muscle activation in response to perturbations. Our research encompassed three experiments: 1) assessing the trunk pitch angle with and without the integration of stretch reflexes, 2) evaluating the consistency of hops made with and without reflexes, and 3) understanding the correlation between the reflex strength equilibrium in the biarticular thigh muscles and trunk pitch angle. The results indicated that the integration of the stretch reflex minimized perturbations, thereby allowing the robot to perform double the continuous hops. As hypothesized, adjusting the reflex strength equilibrium caused a shift in the angle. This reflex mechanism offers potential application to PAM-driven robots and signifies a promising avenue for enhancing postural stability in diverse forms of locomotion, including walking and running.
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781824-X
ISSN	2296-9144 ; 2296-9144
ISSN (online)	2296-9144
ISSN	2296-9144
DOI	10.3389/frobt.2023.1293365
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Article: Current Value of Perioperative Therapies for Resectable or Borderline Resectable Pancreatic Cancer.

Murakami, Yuki / Sakamoto, Teruhisa / Hanaki, Takehiko / Tokuyasu, Naruo / Fujiwara, Yoshiyuki

Yonago acta medica

2023 Volume 66, Issue 2, Page(s) 202–207

Abstract: Invasive pancreatic ductal carcinoma is a representative refractory malignant tumor, and even with the development of early diagnosis and treatment techniques, the treatment outcome has been remarkably poor. Surgical resection is the curative treatment ... ...

Abstract	Invasive pancreatic ductal carcinoma is a representative refractory malignant tumor, and even with the development of early diagnosis and treatment techniques, the treatment outcome has been remarkably poor. Surgical resection is the curative treatment for resectable pancreatic cancer and borderline resectable pancreatic cancer. However, the survival rate in patients with pancreatic cancer treated by resection alone is low because of the high postoperative recurrence rate. In this review article, we report recent studies on perioperative treatment for pancreatic cancer. Perioperative therapy is the addition of chemotherapy or radiation therapy before or after surgery to improve resectability and curative effects. Because it is difficult to cure redsecttable pancreatic cancer by surgery alone, multidisciplinary treatment combined with perioperative adjuvant chemotherapy is the current standard of care. Although perioperative chemotherapy and chemoradiotherapy have been investigated for borderline resectable pancreatic cancer, the effectiveness of preoperative treatment has not been sufficiently proven. Potentially curative pancreatic cancer is treated by surgery plus perioperative therapy; treatment cannot be either alone. We regard the successful completion of surgery and perioperative care as the key to improving treatment outcomes. Therefore, ongoing randomized controlled trials for the treatment of BR-pancreatic cancer are expected to induce further improvements survival outcomes of patients with BR-pancreatic cancer.
Language	English
Publishing date	2023-05-10
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	840719-8
ISSN	1346-8049 ; 0513-5710
ISSN (online)	1346-8049
ISSN	0513-5710
DOI	10.33160/yam.2023.05.014
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Article ; Online: Rearrangement of Methylenebis(cyclohexane-1,3-dione) Enols Induced by Mn(III)-Catalyzed Aerobic Oxidation.

Murakami, Yûki / Hisano, Kazuki / Nishino, Hiroshi

The Journal of organic chemistry

2022 Volume 87, Issue 13, Page(s) 8782–8787

Abstract: The Mn(III)-catalyzed aerobic oxidation of methylenebis(cyclohexane-1,3-dione) ... ...

Abstract	The Mn(III)-catalyzed aerobic oxidation of methylenebis(cyclohexane-1,3-dione) enols
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c00647
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Article: Rearrangement of Methylenebis(cyclohexane-1,3-dione) Enols Induced by Mn(III)-Catalyzed Aerobic Oxidation

Murakami, Yûki / Hisano, Kazuki / Nishino, Hiroshi

Journal of organic chemistry. 2022 June 21, v. 87, no. 13

2022

Abstract: The Mn(III)-catalyzed aerobic oxidation of methylenebis(cyclohexane-1,3-dione) enols 1 resulted in 6a-hydroxy-2,3,4,6a,7,8,9,10a-octahydro-1H-benzo[c]chromene-1,6,10-triones 3 during the formation of 4,5,8,10,11,12-hexahydro-2H-benzo[b]oxecine-2,6,7,9(3H) ...

Abstract	The Mn(III)-catalyzed aerobic oxidation of methylenebis(cyclohexane-1,3-dione) enols 1 resulted in 6a-hydroxy-2,3,4,6a,7,8,9,10a-octahydro-1H-benzo[c]chromene-1,6,10-triones 3 during the formation of 4,5,8,10,11,12-hexahydro-2H-benzo[b]oxecine-2,6,7,9(3H)-tetraones 2. The mechanism for the formation of 3 was proposed on the basis of the isolation of intermediates 2, which were transformed into 3 under Claisen and retro-Claisen conditions.
Keywords	enols ; organic chemistry ; oxidation
Language	English
Dates of publication	2022-0621
Size	p. 8782-8787.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c00647
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Article: An Intrahepatic Fluorodeoxyglucose (FDG)-PET/CT False-Positive Tumor Secondary to Foreign Body Granuloma Masquerading as Colon Cancer Liver Metastasis: A Case Report.

Hanaki, Takehiko / Honjo, Soichiro / Kishino, Mikiya / Murakami, Yuki / Yamamoto, Manabu / Naruo, Tokuyasu / Sakamoto, Teruhisa / Hasegawa, Toshimichi / Fujiwara, Yoshiyuki

Cureus

2024 Volume 16, Issue 1, Page(s) e52657

Abstract: A suture placed next to a dissected liver section during the initial hepatectomy may become an unlikely intrahepatic foreign body granuloma. In this report, we describe a case where a silk suture in the liver section plane placed during initial ... ...

Abstract	A suture placed next to a dissected liver section during the initial hepatectomy may become an unlikely intrahepatic foreign body granuloma. In this report, we describe a case where a silk suture in the liver section plane placed during initial hepatectomy for synchronous colon cancer metastasis became an intrahepatic foreign body granuloma that exhibited fluorodeoxyglucose (FDG) accumulation on positron emission tomography/computed tomography (PET/CT). The granuloma was resected as the second metachronous liver metastatic lesion. A 73-year-old female was referred for a planned second hepatectomy. She had undergone colectomy and hepatectomy for advanced cancer of the ascending colon and synchronous liver metastasis approximately two years ago. However, two possible liver metastases with FDG accumulation were identified in hepatic segments IV and V after one year and nine months after the initial resection. A second hepatectomy was planned after administering systemic chemotherapy. She underwent a left lobectomy with a middle hepatic vein and partial segment V hepatectomy six months after liver lesion identification. The segment IV lesion was histologically proven to be a liver metastasis adenocarcinoma. The segment V lesion revealed a silk thread on the residual liver side at the initial hepatectomy, which was histologically diagnosed as a foreign body granuloma. The possibility of intrahepatic foreign body granuloma development should be considered in subsequent follow-ups in cases where sutures were applied to the dissected residual liver plane during the initial hepatectomy. Additionally, a thorough second hepatectomy should be considered if recurrence is suspected.
Language	English
Publishing date	2024-01-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52657
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Article ; Online: Endoscopic recanalization with an incision using a needle knife after identifying the oral-side lumen in complete anastomotic stenosis.

Murakami, Yuki / Ando, Katsuyoshi / Fujiya, Mikihiro

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2021 Volume 33, Issue 4, Page(s) e85–e86

MeSH term(s)	Anastomosis, Surgical/adverse effects ; Constriction, Pathologic/etiology ; Constriction, Pathologic/surgery ; Endoscopy ; Humans ; Needles ; Surgical Instruments
Language	English
Publishing date	2021-04-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.13963
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Article ; Online: Record of Cryptosporidium serpentis from Goniurosaurus kuroiwae sengokui (Reptilia, Squamata, Eublepharidae) in Tokashikijima, Okinawa Prefecture, Japan.

Ootawa, Tomoki / Toda, Mitsuhiko / Takahashi, Hiroo / Saruta, Tomohisa / Murakami, Yuki / Iguchi, Yuka / Masatani, Tatsunori

The Journal of veterinary medical science

2023 Volume 85, Issue 10, Page(s) 1142–1145

Abstract: In reptiles, infection with Cryptosporidium parasite can be lethal, especially in species of family Eublepharidae such as Eublepharis macularius and Goniurosaurus splendes species. We investigated the presence of Cryptosporidium spp. in wild reptiles, ... ...

Abstract	In reptiles, infection with Cryptosporidium parasite can be lethal, especially in species of family Eublepharidae such as Eublepharis macularius and Goniurosaurus splendes species. We investigated the presence of Cryptosporidium spp. in wild reptiles, especially Goniurosaurus spp., in five islands of Japan. Nested PCR was performed to detect Cryptosporidium spp. in 38 fecal samples of 9 reptile species from five islands of Japan, and 3 (3/8) positive samples of Goniurosaurus kuroiwae sengokui from Tokashikijima, Okinawa Prefecture were detected. A BLAST search of the detected gene sequences revealed that the all 3 samples were identified as Cryptosporidium serpentis, a reptile-specific Cryptosporidium parasite. This is the first record of Cryptosporidium from a wild Goniurosaurus species in Japan and worldwide.
MeSH term(s)	Animals ; Cryptosporidium/genetics ; Cryptosporidiosis/epidemiology ; Japan/epidemiology ; Lizards ; Polymerase Chain Reaction/veterinary ; Feces/parasitology
Language	English
Publishing date	2023-08-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.23-0186
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Article: Molecular discrimination and phylogeographic patterns of clones of the parthenogenetic gecko Lepidodactylus lugubris in the Japanese Archipelago

Murakami, Yuki / Hayashi, Fumio

Population ecology. 2019 July, v. 61, no. 3

2019

Abstract: Vertebrates usually reproduce sexually in which males and females contribute their offspring genome and produce genetically diverse offspring. However, some of them are asexual without genetic contribution from males. The nocturnal gecko, Lepidodactylus ... ...

Abstract	Vertebrates usually reproduce sexually in which males and females contribute their offspring genome and produce genetically diverse offspring. However, some of them are asexual without genetic contribution from males. The nocturnal gecko, Lepidodactylus lugubris, is all females and reproduces parthenogenetically. This gecko is known to consist of diploid and triploid clones in the tropical and subtropical regions, which can be identified by their dorsal marking patterns, ploidy, and protein polymorphism. This gecko is also distributed in the southern parts of Japan, and several clones have been reported. In this study, we investigated the origins and genetic diversity of Japanese L. lugubris by clonal discrimination using microsatellite and mitochondrial DNA analyses. A total of 748 individuals were collected from 21 islands of five island groups (Ogasawara, Okinawa, Miyako, Yaeyama and Daito Islands) and 17 clones were distinguished genetically. Mitochondrial cyt b sequences of these clones suggested that they were all closely related and differentiated recently. Clonal diversity was much higher (14 clones) in the Daito Islands than in the other island groups in which only one or two clones coexisted. Judging from the dorsal marking patterns and ploidy known so far, six clones were cosmopolitan and may be colonized from the outside of Japan. However, other 11 clones were endemic to the Daito Islands and explained by possible hybridization between the one female diploid clone and one male diploid clone because other 9 clones were triploid and all had the combinations of polymorphic microsatellite alleles of these female and male diploid clones. Although the males have never been recorded in the Daito Islands, males might appear in the past. These findings contribute to understanding of clonal diversity and dynamics of asexually reproducing animals. If diploid parthenogenetic geckos can produce triploid clones by mating with the diploid males, clonal diversity would increase rapidly in a small island, and such newly produced triploid clones would expand widely.
Keywords	Ryukyu Archipelago ; diploidy ; females ; genetic variation ; hybridization ; males ; microsatellite repeats ; mitochondria ; mitochondrial DNA ; parthenogenesis ; phylogeography ; population ecology ; progeny ; triploidy
Language	English
Dates of publication	2019-07
Size	p. 315-324.
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2015635-2
ISSN	1438-390X ; 1438-3896
ISSN (online)	1438-390X
ISSN	1438-3896
DOI	10.1002/1438-390X.1030
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Article: Successful Interventional Radiology for Acute Median Arcuate Ligament Syndrome After Pancreaticoduodenectomy.

Hanaki, Takehiko / Sakamoto, Teruhisa / Yata, Shinsaku / Murakami, Yuki / Fujiwara, Yoshiyuki

Cureus

2021 Volume 13, Issue 2, Page(s) e13540

Abstract: Background: Median arcuate ligament (MAL) syndrome (MALS), also known as celiac artery (CA) compression syndrome and Dunbar syndrome, occurs because of extraluminal compression of the CA root by the MAL, which is part of the diaphragm. In MALS, a ... ...

Abstract	Background: Median arcuate ligament (MAL) syndrome (MALS), also known as celiac artery (CA) compression syndrome and Dunbar syndrome, occurs because of extraluminal compression of the CA root by the MAL, which is part of the diaphragm. In MALS, a malposition of the MAL compresses the CA and causes nonspecific symptoms, including epigastric pain after eating, weight loss, nausea, and vomiting and can sometimes cause visceral aneurysms. Typically, in MALS, various chronic ischemic symptoms and visceral aneurysms due to changes in arterial blood flow are observed; however, in acute-onset MALS, acute organ failure due to ischemic changes may be problematic. Surgical treatment is the recommended treatment for MALS, but the optimal treatment of acute MALS that occurs after laparotomy remains controversial because of its rarity. Here, we present the first case of acute MALS, which occurred after pancreaticoduodenectomy (PD) that was successfully treated with interventional radiology (IVR) without reoperation. Case presentation: A 75-year-old man presented with liver infarction after subtotal stomach-preserving PD using the Child method plus Braun enteroenterostomy. As a result of contrast-enhanced computed tomography for the investigation of elevated hepatic cytolysis-related enzymes on the first postoperative day, he was diagnosed with acute MALS resulting from gastrointestinal reconstruction after PD. The patient underwent IVR to restore blood flow of the CA, and an intraluminal stent was inserted. Despite the development of ischemic gastropathy, splenic infarction, and pancreatic fistula, the patient was eventually discharged on postoperative day 82 without any disability. Conclusion: Many studies have reported open, laparoscopic, and robot-assisted MAL incisions for MALS, but few reports have detailed the treatment for postoperative MALS. Here, we report the first case of acute MALS developed after PD that was successfully treated with endovascular CA stenting. For acute MALS after PD, early endovascular treatment may be more useful than re-laparotomy.
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.13540
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Article: Behavioral Interactions for Food among Two Clones of Parthenogenetic Lepidodactylus lugubris and Sexually Reproducing Hemidactylus frenatus Geckos

Murakami, Yuki / Fumio Hayashi

Current herpetology. 2018 Aug., v. 37, no. 2

2018

Abstract: Lepidodactylus lugubris is an all-female parthenogenetic gecko. This gecko consists of diploid and triploid clones in the tropical and subtropical regions, and Clones A (diploid) and C (triploid) cohabit most islands in Ogasawara, Japan. On some ... ...

Abstract	Lepidodactylus lugubris is an all-female parthenogenetic gecko. This gecko consists of diploid and triploid clones in the tropical and subtropical regions, and Clones A (diploid) and C (triploid) cohabit most islands in Ogasawara, Japan. On some Ogasawara islands, another cosmopolitan, but sexually reproductive, gecko Hemidactylus frenatus coexists with L. lugubris. This situation offers a unique opportunity to examine interactions not only between asexual female clones of L. lugubris but also between L. lugubris and both sexes of H. frenatus. We induced behavioral contests for food in small laboratory enclosures between two individuals of different clone, sex, and species combinations. Clone C interacted with other individuals less frequently and had a lower success in feeding the prey than Clone A and both sexes of H. frenatus. Clone C also showed few aggressive behaviors such as arches, growls, bites, and lunges, and never wrestled with other individuals. This interactive tendency of Clone C helps explain the microdistribution patterns of these sympatric geckos in the field.
Keywords	Hemidactylus ; aggression ; clones ; diploidy ; females ; islands ; parthenogenesis ; subtropics ; sympatry ; triploidy ; Japan
Language	English
Dates of publication	2018-08
Size	p. 124-132.
Publishing place	UniBio Press
Document type	Article
ZDB-ID	2276299-1
ISSN	1881-1019 ; 1345-5834
ISSN (online)	1881-1019
ISSN	1345-5834
DOI	10.5358/hsj.37.124
Database	NAL-Catalogue (AGRICOLA)

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