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Article ; Online: Distinct cell types in the superficial superior colliculus project to the dorsal lateral geniculate and lateral posterior thalamic nuclei.

Gale, Samuel D / Murphy, Gabe J

2018 Volume 120, Issue 3, Page(s) 1286–1292

Abstract: The superficial layers of the superior colliculus (sSC) receive retinal input and project to thalamic regions, the dorsal lateral geniculate (dLGN) and lateral posterior (LP; or pulvinar) nuclei, that convey visual information to cortex. A critical step ... ...

Abstract	The superficial layers of the superior colliculus (sSC) receive retinal input and project to thalamic regions, the dorsal lateral geniculate (dLGN) and lateral posterior (LP; or pulvinar) nuclei, that convey visual information to cortex. A critical step toward understanding the functional impact of sSC neurons on these parallel thalamo-cortical pathways is determining whether different classes of sSC neurons, which are known to respond to different features of visual stimuli, innervate overlapping or distinct thalamic targets. Here, we identified a transgenic mouse line that labels sSC neurons that project to dLGN but not LP. We utilized selective expression of fluorophores and channelrhodopsin in this and previously characterized mouse lines to demonstrate that distinct cell types give rise to sSC projections to dLGN and LP. We further show that the glutamatergic sSC cell type that projects to dLGN also provides input to the sSC cell type that projects to LP. These results clarify the cellular origin of parallel sSC-thalamo-cortical pathways and reveal an interaction between these pathways via local connections within the sSC. NEW & NOTEWORTHY The superficial layers of the superior colliculus (sSC) project to two visual thalamic targets: the dorsal lateral geniculate (dLGN) and lateral posterior (LP) nuclei. We show that distinct excitatory sSC cell types give rise to these projections; stellate cells project to dLGN and wide-field (WF) cells project to LP. Moreover, these pathways interact via a connection within the sSC from stellate to WF cells.
MeSH term(s)	Animals ; Female ; Geniculate Bodies/physiology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Neurological ; Neurons/physiology ; Pulvinar/physiology ; Superior Colliculi/physiology ; Visual Pathways/physiology
Language	English
Publishing date	2018-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00248.2018
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Article ; Online: Active Dendritic Properties and Local Inhibitory Input Enable Selectivity for Object Motion in Mouse Superior Colliculus Neurons.

Gale, Samuel D / Murphy, Gabe J

The Journal of neuroscience : the official journal of the Society for Neuroscience

2016 Volume 36, Issue 35, Page(s) 9111–9123

Abstract: Unlabelled: Neurons respond to specific features of sensory stimuli. In the visual system, for example, some neurons respond to motion of small but not large objects, whereas other neurons prefer motion of the entire visual field. Separate neurons ... ...

Abstract	Unlabelled: Neurons respond to specific features of sensory stimuli. In the visual system, for example, some neurons respond to motion of small but not large objects, whereas other neurons prefer motion of the entire visual field. Separate neurons respond equally to local and global motion but selectively to additional features of visual stimuli. How and where does response selectivity emerge? Here, we show that wide-field (WF) cells in retino-recipient layers of the mouse superior colliculus (SC) respond selectively to small moving objects. Moreover, we identify two mechanisms that contribute to this selectivity. First, we show that input restricted to a small portion of the broad dendritic arbor of WF cells is sufficient to trigger dendritic spikes that reliably propagate to the soma/axon. In vivo whole-cell recordings reveal that nearly every action potential evoked by visual stimuli has characteristics of spikes initiated in dendrites. Second, inhibitory input from a different class of SC neuron, horizontal cells, constrains the range of stimuli to which WF cells respond. Horizontal cells respond preferentially to the sudden appearance or rapid movement of large stimuli. Optogenetic reduction of their activity reduces movement selectivity and broadens size tuning in WF cells by increasing the relative strength of responses to stimuli that appear suddenly or cover a large region of space. Therefore, strongly propagating dendritic spikes enable small stimuli to drive spike output in WF cells and local inhibition helps restrict responses to stimuli that are both small and moving. Significance statement: How do neurons respond selectively to some sensory stimuli but not others? In the visual system, a particularly relevant stimulus feature is object motion, which often reveals other animals. Here, we show how specific cells in the superior colliculus, one synapse downstream of the retina, respond selectively to object motion. These wide-field (WF) cells respond strongly to small objects that move slowly anywhere through a large region of space, but not to stationary objects or full-field motion. Action potential initiation in dendrites enables small stimuli to trigger visual responses and inhibitory input from cells that prefer large, suddenly appearing, or quickly moving stimuli restricts responses of WF cells to objects that are small and moving.
MeSH term(s)	Action Potentials/physiology ; Animals ; Biophysics ; Calcium/metabolism ; Channelrhodopsins ; Dendrites/physiology ; Glutamate Decarboxylase/genetics ; Glutamate Decarboxylase/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; In Vitro Techniques ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motion ; Neurons/classification ; Neurons/cytology ; Neurons/physiology ; Optogenetics ; Patch-Clamp Techniques ; Photic Stimulation ; Receptors, Neurotensin/genetics ; Receptors, Neurotensin/metabolism ; Superior Colliculi/cytology ; Vesicular Inhibitory Amino Acid Transport Proteins/genetics ; Vesicular Inhibitory Amino Acid Transport Proteins/metabolism
Chemical Substances	Channelrhodopsins ; Receptors, Neurotensin ; Vesicular Inhibitory Amino Acid Transport Proteins ; Viaat protein, mouse ; neurotensin type 1 receptor ; Green Fluorescent Proteins (147336-22-9) ; Glutamate Decarboxylase (EC 4.1.1.15) ; glutamate decarboxylase 2 (EC 4.1.1.15) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0645-16.2016
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Article ; Online: Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation.

Hage, Travis A / Bosma-Moody, Alice / Baker, Christopher A / Kratz, Megan B / Campagnola, Luke / Jarsky, Tim / Zeng, Hongkui / Murphy, Gabe J

eLife

2022 Volume 11

Abstract: Understanding cortical microcircuits requires thorough measurement of physiological properties of synaptic connections formed within and between diverse subclasses of neurons. Towards this goal, we combined spatially precise optogenetic stimulation with ... ...

Abstract	Understanding cortical microcircuits requires thorough measurement of physiological properties of synaptic connections formed within and between diverse subclasses of neurons. Towards this goal, we combined spatially precise optogenetic stimulation with multicellular recording to deeply characterize intralaminar and translaminar monosynaptic connections to supragranular (L2/3) neurons in the mouse visual cortex. The reliability and specificity of multiphoton optogenetic stimulation were measured across multiple Cre lines, and measurements of connectivity were verified by comparison to paired recordings and targeted patching of optically identified presynaptic cells. With a focus on translaminar pathways, excitatory and inhibitory synaptic connections from genetically defined presynaptic populations were characterized by their relative abundance, spatial profiles, strength, and short-term dynamics. Consistent with the canonical cortical microcircuit, layer 4 excitatory neurons and interneurons within L2/3 represented the most common sources of input to L2/3 pyramidal cells. More surprisingly, we also observed strong excitatory connections from layer 5 intratelencephalic neurons and potent translaminar inhibition from multiple interneuron subclasses. The hybrid approach revealed convergence to and divergence from excitatory and inhibitory neurons within and across cortical layers. Divergent excitatory connections often spanned hundreds of microns of horizontal space. In contrast, divergent inhibitory connections were more frequently measured from postsynaptic targets near each other.
MeSH term(s)	Action Potentials ; Animals ; Brain/cytology ; Brain/physiology ; Cell Line ; Excitatory Postsynaptic Potentials ; Female ; Male ; Mice ; Optogenetics/methods ; Photons ; Primary Visual Cortex/physiology ; Pyramidal Cells/physiology ; Reproducibility of Results ; Synapses/physiology ; Synaptic Transmission/physiology ; Visual Cortex/cytology ; Visual Cortex/physiology
Language	English
Publishing date	2022-01-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.71103
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Article ; Online: Projection-specific characteristics of retinal input to the brain.

Gauvain, Gregory / Murphy, Gabe J

The Journal of neuroscience : the official journal of the Society for Neuroscience

2015 Volume 35, Issue 16, Page(s) 6575–6583

Abstract: The brain receives information about the direction of object motion from several types of retinal ganglion cells (RGCs). On-Off direction-selective (DS) RGCs respond preferentially to stimuli moving quickly in one of four directions and provide a ... ...

Abstract	The brain receives information about the direction of object motion from several types of retinal ganglion cells (RGCs). On-Off direction-selective (DS) RGCs respond preferentially to stimuli moving quickly in one of four directions and provide a significant (but difficult to quantify) fraction of RGC input to the SC. On DS RGCs, in comparison, respond preferentially to stimuli moving slowly in one of three directions and are thought to only target retinorecipient nuclei comprising the accessory optic system, e.g., the medial terminal nucleus (MTN). To determine the fraction of SC-projecting RGCs that exhibit direction selectivity, and the specificity with which On-Off and On DS RGCs target retinorecipient areas, we performed optical and electrophysiological recordings from RGCs retrogradely labeled from the mouse SC and MTN. We found, surprisingly, that both On-Off and On DS RGCs innervate the SC; collectively they constitute nearly 40% of SC-projecting RGCs. In comparison, only On DS RGCs project to the MTN. Subsequent experiments revealed that individual On DS RGCs innervate either the SC or MTN and exhibit robust projection-specific differences in somatodendritic morphology, cellular excitability, and light-evoked activity; several projection-specific differences in the output of On DS RGCs correspond closely to differences in excitatory synaptic input the cells receive. Our results reveal a robust projection of On DS RGCs to the SC, projection-specific differences in the response properties of On DS RGCs, and biophysical and synaptic mechanisms that underlie these functional differences.
MeSH term(s)	Action Potentials/physiology ; Animals ; Brain Stem/cytology ; Brain Stem/physiology ; Female ; Male ; Mice ; Retina ; Retinal Ganglion Cells/cytology ; Retinal Ganglion Cells/physiology ; Superior Colliculi/cytology ; Superior Colliculi/physiology ; Visual Pathways/cytology ; Visual Pathways/physiology
Language	English
Publishing date	2015-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.4298-14.2015
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Article ; Online: Distinct representation and distribution of visual information by specific cell types in mouse superficial superior colliculus.

Gale, Samuel D / Murphy, Gabe J

The Journal of neuroscience : the official journal of the Society for Neuroscience

2014 Volume 34, Issue 40, Page(s) 13458–13471

Abstract: The superficial superior colliculus (sSC) occupies a critical node in the mammalian visual system; it is one of two major retinorecipient areas, receives visual cortical input, and innervates visual thalamocortical circuits. Nonetheless, the contribution ...

Abstract	The superficial superior colliculus (sSC) occupies a critical node in the mammalian visual system; it is one of two major retinorecipient areas, receives visual cortical input, and innervates visual thalamocortical circuits. Nonetheless, the contribution of sSC neurons to downstream neural activity and visually guided behavior is unknown and frequently neglected. Here we identified the visual stimuli to which specific classes of sSC neurons respond, the downstream regions they target, and transgenic mice enabling class-specific manipulations. One class responds to small, slowly moving stimuli and projects exclusively to lateral posterior thalamus; another, comprising GABAergic neurons, responds to the sudden appearance or rapid movement of large stimuli and projects to multiple areas, including the lateral geniculate nucleus. A third class exhibits direction-selective responses and targets deeper SC layers. Together, our results show how specific sSC neurons represent and distribute diverse information and enable direct tests of their functional role.
MeSH term(s)	Action Potentials/physiology ; Animals ; Channelrhodopsins ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; GABA Antagonists/pharmacology ; Glutamate Decarboxylase/genetics ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Transgenic ; Neurons/classification ; Neurons/physiology ; Pyridazines/pharmacology ; Quinoxalines/pharmacology ; Receptors, Neurotensin/genetics ; Receptors, Neurotensin/metabolism ; Superior Colliculi/cytology ; Valine/analogs & derivatives ; Valine/pharmacology ; Vesicular Inhibitory Amino Acid Transport Proteins/genetics ; Vesicular Inhibitory Amino Acid Transport Proteins/metabolism ; Visual Fields/physiology ; Visual Pathways/physiology
Chemical Substances	Channelrhodopsins ; Excitatory Amino Acid Antagonists ; GABA Antagonists ; Luminescent Proteins ; Pyridazines ; Quinoxalines ; Receptors, Neurotensin ; Vesicular Inhibitory Amino Acid Transport Proteins ; Viaat protein, mouse ; neurotensin type 1 receptor ; 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline (118876-58-7) ; Green Fluorescent Proteins (147336-22-9) ; 2-amino-5-phosphopentanoic acid (76326-31-3) ; gabazine (99460MG420) ; Glutamate Decarboxylase (EC 4.1.1.15) ; glutamate decarboxylase 2 (EC 4.1.1.15) ; Valine (HG18B9YRS7)
Language	English
Publishing date	2014-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2768-14.2014
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Article ; Online: Electrical synaptic input to ganglion cells underlies differences in the output and absolute sensitivity of parallel retinal circuits.

Murphy, Gabe J / Rieke, Fred

The Journal of neuroscience : the official journal of the Society for Neuroscience

2011 Volume 31, Issue 34, Page(s) 12218–12228

Abstract: Parallel circuits throughout the CNS exhibit distinct sensitivities and responses to sensory stimuli. Ambiguities in the source and properties of signals elicited by physiological stimuli, however, frequently obscure the mechanisms underlying these ... ...

Abstract	Parallel circuits throughout the CNS exhibit distinct sensitivities and responses to sensory stimuli. Ambiguities in the source and properties of signals elicited by physiological stimuli, however, frequently obscure the mechanisms underlying these distinctions. We found that differences in the degree to which activity in two classes of Off retinal ganglion cell (RGC) encode information about light stimuli near detection threshold were not due to obvious differences in the cells' intrinsic properties or the chemical synaptic input the cells received; indeed, differences in the cells' light responses were largely insensitive to block of fast ionotropic glutamate receptors. Instead, the distinct responses of the two types of RGCs likely reflect differences in light-evoked electrical synaptic input. These results highlight a surprising strategy by which the retina differentially processes and routes visual information and provide new insight into the circuits that underlie responses to stimuli near detection threshold.
MeSH term(s)	Animals ; Cell Communication/physiology ; Electrical Synapses/physiology ; Mice ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Organ Culture Techniques ; Photic Stimulation/methods ; Receptors, Ionotropic Glutamate/antagonists & inhibitors ; Receptors, Ionotropic Glutamate/physiology ; Retina/cytology ; Retina/physiology ; Retinal Ganglion Cells/physiology ; Retinal Ganglion Cells/ultrastructure ; Sensitivity and Specificity ; Sensory Thresholds/physiology ; Synaptic Transmission/physiology ; Vision, Ocular/physiology ; Visual Pathways/physiology
Chemical Substances	Receptors, Ionotropic Glutamate
Language	English
Publishing date	2011-08-24
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.3241-11.2011
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Article ; Online: Shared and distinct retinal input to the mouse superior colliculus and dorsal lateral geniculate nucleus.

Ellis, Erika M / Gauvain, Gregory / Sivyer, Benjamin / Murphy, Gabe J

Journal of neurophysiology

2016 Volume 116, Issue 2, Page(s) 602–610

Abstract: The mammalian retina conveys the vast majority of information about visual stimuli to two brain regions: the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). The degree to which retinal ganglion cells (RGCs) send similar or ... ...

Abstract	The mammalian retina conveys the vast majority of information about visual stimuli to two brain regions: the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). The degree to which retinal ganglion cells (RGCs) send similar or distinct information to the two areas remains unclear despite the important constraints that different patterns of RGC input place on downstream visual processing. To resolve this ambiguity, we injected a glycoprotein-deficient rabies virus coding for the expression of a fluorescent protein into the dLGN or SC; rabies virus labeled a smaller fraction of RGCs than lipophilic dyes such as DiI but, crucially, did not label RGC axons of passage. Approximately 80% of the RGCs infected by rabies virus injected into the dLGN were colabeled with DiI injected into the SC, suggesting that many dLGN-projecting RGCs also project to the SC. However, functional characterization of RGCs revealed that the SC receives input from several classes of RGCs that largely avoid the dLGN, in particular RGCs in which 1) sustained changes in light intensity elicit transient changes in firing rate and/or 2) a small range of stimulus sizes or temporal fluctuations in light intensity elicit robust activity. Taken together, our results illustrate several unexpected asymmetries in the information that the mouse retina conveys to two major downstream targets and suggest that differences in the output of dLGN and SC neurons reflect, at least in part, differences in the functional properties of RGCs that innervate the SC but not the dLGN.
MeSH term(s)	Action Potentials/physiology ; Animals ; Animals, Newborn ; Female ; Geniculate Bodies/cytology ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Light ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Confocal ; Patch-Clamp Techniques ; Retina/cytology ; Retinal Ganglion Cells/physiology ; Superior Colliculi/cytology ; Vesicular Glutamate Transport Protein 2/genetics ; Vesicular Glutamate Transport Protein 2/metabolism ; Visual Pathways/physiology
Chemical Substances	Luminescent Proteins ; Slc17a6 protein, mouse ; Vesicular Glutamate Transport Protein 2 ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2016-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00227.2016
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Article ; Online: Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice.

Huang, Lawrence / Ledochowitsch, Peter / Knoblich, Ulf / Lecoq, Jérôme / Murphy, Gabe J / Reid, R Clay / de Vries, Saskia Ej / Koch, Christof / Zeng, Hongkui / Buice, Michael A / Waters, Jack / Li, Lu

eLife

2021 Volume 10

Abstract: Fluorescent calcium indicators are often used to investigate neural dynamics, but the relationship between fluorescence and action potentials (APs) remains unclear. Most APs can be detected when the soma almost fills the microscope's field of view, but ... ...

Abstract	Fluorescent calcium indicators are often used to investigate neural dynamics, but the relationship between fluorescence and action potentials (APs) remains unclear. Most APs can be detected when the soma almost fills the microscope's field of view, but calcium indicators are used to image populations of neurons, necessitating a large field of view, generating fewer photons per neuron, and compromising AP detection. Here, we characterized the AP-fluorescence transfer function in vivo for 48 layer 2/3 pyramidal neurons in primary visual cortex, with simultaneous calcium imaging and cell-attached recordings from transgenic mice expressing GCaMP6s or GCaMP6f. While most APs were detected under optimal conditions, under conditions typical of population imaging studies, only a minority of 1 AP and 2 AP events were detected (often <10% and ~20-30%, respectively), emphasizing the limits of AP detection under more realistic imaging conditions.
MeSH term(s)	Action Potentials/physiology ; Animals ; Calcium/analysis ; Calcium/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Female ; Fluorescent Dyes/analysis ; Fluorescent Dyes/metabolism ; Male ; Mice ; Mice, Transgenic ; Microscopy, Fluorescence ; Primary Visual Cortex/cytology ; Primary Visual Cortex/physiology ; Pyramidal Cells/cytology ; Pyramidal Cells/metabolism
Chemical Substances	Calcium-Binding Proteins ; Fluorescent Dyes ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.51675
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Article ; Online: Higher-Order Thalamic Circuits Channel Parallel Streams of Visual Information in Mice.

Bennett, Corbett / Gale, Samuel D / Garrett, Marina E / Newton, Melissa L / Callaway, Edward M / Murphy, Gabe J / Olsen, Shawn R

Neuron

2019 Volume 102, Issue 2, Page(s) 477–492.e5

Abstract: Higher-order thalamic nuclei, such as the visual pulvinar, play essential roles in cortical function by connecting functionally related cortical and subcortical brain regions. A coherent framework describing pulvinar function remains elusive because of ... ...

Abstract	Higher-order thalamic nuclei, such as the visual pulvinar, play essential roles in cortical function by connecting functionally related cortical and subcortical brain regions. A coherent framework describing pulvinar function remains elusive because of its anatomical complexity and involvement in diverse cognitive processes. We combined large-scale anatomical circuit mapping with high-density electrophysiological recordings to dissect a homolog of the pulvinar in mice, the lateral posterior thalamic nucleus (LP). We define three broad LP subregions based on correspondence between connectivity and functional properties. These subregions form corticothalamic loops biased toward ventral or dorsal stream cortical areas and contain separate representations of visual space. Silencing the visual cortex or superior colliculus revealed that they drive visual tuning properties in separate LP subregions. Thus, by specifying the driving input sources, functional properties, and downstream targets of LP circuits, our data provide a roadmap for understanding the mechanisms of higher-order thalamic function in vision.
MeSH term(s)	Animals ; Brain Mapping ; Electroencephalography ; Mice ; Pulvinar/physiology ; Superior Colliculi/physiology ; Thalamus/physiology ; Visual Cortex/physiology ; Visual Pathways/physiology
Language	English
Publishing date	2019-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2019.02.010
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Signals and noise in an inhibitory interneuron diverge to control activity in nearby retinal ganglion cells.

Murphy, Gabe J / Rieke, Fred

Nature neuroscience

2008 Volume 11, Issue 3, Page(s) 318–326

Abstract: Information about sensory stimuli is represented by spatiotemporal patterns of neural activity. The complexity of the central nervous system, however, frequently obscures the origin and properties of signals and noise that underlie these activity ... ...

Abstract	Information about sensory stimuli is represented by spatiotemporal patterns of neural activity. The complexity of the central nervous system, however, frequently obscures the origin and properties of signals and noise that underlie these activity patterns. We minimized this constraint by examining mechanisms governing correlated activity in mouse retinal ganglion cells (RGCs) under conditions in which light-evoked responses traverse a specific circuit, the rod bipolar pathway. Signals and noise in this circuit produced correlated synaptic input to neighboring On and Off RGCs. Temporal modulation of light intensity did not alter the degree to which noise in the input to nearby RGCs was correlated, and action potential generation in individual RGCs was largely insensitive to differences in network noise generated by dynamic and static light stimuli. Together, these features enable noise in shared circuitry to diminish simultaneous action potential generation in neighboring On and Off RGCs under a variety of conditions.
MeSH term(s)	Action Potentials/physiology ; Amacrine Cells/physiology ; Animals ; Artifacts ; Interneurons/physiology ; Light ; Lighting ; Mice ; Mice, Inbred C57BL ; Neural Inhibition/physiology ; Neural Pathways/physiology ; Organ Culture Techniques ; Photic Stimulation ; Reaction Time/physiology ; Retinal Bipolar Cells/physiology ; Retinal Ganglion Cells/physiology ; Retinal Rod Photoreceptor Cells/physiology ; Synaptic Transmission/physiology ; Vision, Ocular/physiology
Language	English
Publishing date	2008-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/nn2045
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito