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Article ; Online: Heart transplantation for infective endocarditis: Viable option for a limited few?

Murphy, Katie M / Vikram, Holenarasipur R

Transplant infectious disease : an official journal of the Transplantation Society

2018 Volume 21, Issue 1, Page(s) e13006

Abstract: Active infection in the recipient is considered a relative contraindication for solid organ transplantation. However, heart transplantation (HT) can be curative in patients with ventricular assist device infections. For patients with infective ... ...

Abstract	Active infection in the recipient is considered a relative contraindication for solid organ transplantation. However, heart transplantation (HT) can be curative in patients with ventricular assist device infections. For patients with infective endocarditis (IE), valve replacement is part of the management strategy based on emergent, acute, or elective indications. HT has been utilized as an uncommon and sporadic treatment option for carefully selected patients with refractory or recurrent IE after all other surgical treatment options have been exhausted or are not feasible. Herein, we review 19 published cases of IE in whom HT was undertaken in the setting of ongoing active infection with reported good outcomes. We attempt to propose general criteria for HT in the setting of IE and discuss challenges and hurdles that clinicians might encounter when considering HT for active IE in the absence of robust data or clearly defined criteria.
MeSH term(s)	Endocarditis/etiology ; Endocarditis/surgery ; Heart Transplantation/methods ; Heart-Assist Devices/adverse effects ; Humans ; Patient Selection ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/surgery ; Treatment Outcome
Language	English
Publishing date	2018-10-28
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13006
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Article ; Online: Implementing a community specialist team to support the delivery of integrated diabetes care: experiences in Ireland during the COVID-19 pandemic.

Riordan, Fiona / O'Mahony, Lauren / Sheehan, Cormac / Murphy, Katie / O'Donnell, Maire / Hurley, Lorna / Dinneen, Sean / McHugh, Sheena M

HRB open research

2023 Volume 6, Page(s) 1

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-01-05
Publishing country	Ireland
Document type	Journal Article
ISSN	2515-4826
ISSN (online)	2515-4826
DOI	10.12688/hrbopenres.13635.1
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Article: Progress in the Presence of Failure: Updates in Chronic Systolic Heart Failure Management.

Murphy, Katie M / Rosenthal, Julie L

Current treatment options in cardiovascular medicine

2017 Volume 19, Issue 7, Page(s) 50

Abstract: Opinion statement: The therapeutic heart failure armamentarium has evolved from drugs to transplantation to devices through further understanding of its complex pathophysiology and pathogenesis. Current medications capitalize on our evolving ... ...

Abstract	Opinion statement: The therapeutic heart failure armamentarium has evolved from drugs to transplantation to devices through further understanding of its complex pathophysiology and pathogenesis. Current medications capitalize on our evolving understanding of the sympathetic and renin-angiotensin-aldosterone systems that subsequently promote both beneficial and maladaptive responses that ultimately yield a decrease in cardiac function. Despite these advancements, the prevalence of heart failure continues to rise and carries a significant burden on our patients and health care system. This presents a clinical dilemma on how best to care for a growing, complex, and heterogeneous cohort. Ideal treatments should decrease morbidity and mortality while providing an improvement in quality of life and functional capacity. New interventions will continue to become incorporated into everyday practice, but awareness and prevention should remain the mainstay followed by optimization of guideline-directed therapies. It is equally important to individually tailor our therapeutic approach. While strategies to treat heart failure with reduced ejection fraction continue to advance, our understanding of how best to treat specific etiologies remain in question. This review will focus on current and proposed novel interventions for the management of chronic, systolic heart failure including angiotensin receptor-neprilysin inhibitor, I
Language	English
Publishing date	2017-02-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057337-6
ISSN	1534-3189 ; 1092-8464
ISSN (online)	1534-3189
ISSN	1092-8464
DOI	10.1007/s11936-017-0552-4
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Zs.A 5529: Show issues

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Article ; Online: Implementation research for early childhood development programming in humanitarian contexts.

Murphy, Katie Maeve / Yoshikawa, Hirokazu / Wuermli, Alice J

Annals of the New York Academy of Sciences

2018 Volume 1419, Issue 1, Page(s) 90–101

Abstract: Young children living in conditions of war, disaster, and displacement are at high risk for developmental difficulties that can follow them throughout their lives. While there is robust evidence supporting the need for early childhood development (ECD) ... ...

Abstract	Young children living in conditions of war, disaster, and displacement are at high risk for developmental difficulties that can follow them throughout their lives. While there is robust evidence supporting the need for early childhood development (ECD) in humanitarian settings, implementation of ECD programming remains sparse, largely due to the lack of evidence of how and why these programs can improve outcomes in humanitarian settings. In order to build the evidence base for ECD in humanitarian settings, we review the current state of implementation research for ECD programming (targeting children 0-8) in humanitarian settings, through a literature review and a series of key informant interviews. Drawing from existing frameworks of implementation research and the findings from our analysis, we present a framework for ECD implementation research in humanitarian settings and propose an agenda for future research.
MeSH term(s)	Altruism ; Armed Conflicts ; Child ; Child Development ; Child, Preschool ; Developing Countries ; Early Intervention (Education)/organization & administration ; Humans ; Infant ; Infant, Newborn ; Israel
Language	English
Publishing date	2018-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/nyas.13691
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Article ; Online: Cardiac magnetic resonance imaging in heart transplant recipients with biopsy-negative graft dysfunction.

Anand, Senthil / Alnsasra, Hilmi / LeMond, Lisa M / Shrivastava, Sanskriti / Asleh, Rabea / Rosenbaum, Andrew / Kobrossi, Semaan / Mohananey, Akanksha / Murphy, Katie / Smith, Byron H / Kushwaha, Sudhir / Steidley, David E / Clavell, Alfredo / Young, Phillip / Pereira, Naveen L

ESC heart failure

2024

Abstract: Aims: Graft dysfunction (GD) after heart transplantation (HTx) can develop without evidence of cell- or antibody-mediated rejection. Cardiac magnetic resonance imaging (CMR) has an evolving role in detecting rejection; however, its role in biopsy- ... ...

Abstract	Aims: Graft dysfunction (GD) after heart transplantation (HTx) can develop without evidence of cell- or antibody-mediated rejection. Cardiac magnetic resonance imaging (CMR) has an evolving role in detecting rejection; however, its role in biopsy-negative GD has not been described. This study examines CMR findings, evaluates outcomes based on CMR results, and seeks to identify the possibility of rejection missed through endomyocardial biopsy by using CMR in HTx recipients with biopsy-negative GD. Methods and results: HTx recipients with GD [defined as a decrease in left ventricular ejection fraction (LVEF) by >5% and LVEF < 50%] in the absence of rejection by biopsy or allograft vasculopathy and who underwent CMR were included in the study. The primary outcome was a composite of all-cause mortality, re-transplantation, or persistent LVEF < 50%. Overall, 34 HTx recipients developed biopsy-negative GD and underwent CMR. Left ventricular late gadolinium enhancement (LGE) on CMR was observed in 16 patients with two distinct patterns: diffuse epicardial (n = 13) and patchy (n = 3) patterns. Patients with LGE developed GD later after HTx [4 (1.4-6.8) vs. 0.8 (0.3-1.2) years, P < 0.001], were more often symptomatic (88% vs. 56%, P = 0.06), and had greater haemodynamic derangement (pulmonary capillary wedge pressure: 19 ± 7 vs. 13 ± 3 mmHg, P = 0.002) as compared with those without LGE. No significant difference was observed in the primary composite outcome between patients with LGE and those without LGE (50% vs. 38% of patients with events, P = 0.515). During a median follow-up of 3.8 years, mean LVEF improved similarly in the LGE-negative (37-55%) and LGE-positive groups (32-55%) (P = 0.16). Conclusions: Biopsy-negative GD occurs with and without LGE when assessed by CMR, indicative of possible rejection/inflammation occurring only in a subset of patients. Irrespective of LGE, LVEF improvement occurs in most GD patients, suggesting that other neurohormonal or immunomodulatory mechanisms may also contribute to GD development.
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14681
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adapting Reach Up and Learn in Crisis and Conflict Settings: An Exploratory Multiple Case Study.

Wilton, Katelin Swing / Murphy, Katie Maeve / Mahmud, Ahsan / Azam, Syful / Habib, Anika / Ibrahim, Iman / Della Neve, Eloisa / Pena, Gabriela / Mehrin, Syeda Fardina / Shiraji, Shamima / Hamadani, Jena Derakhshani

Pediatrics

2023 Volume 151, Issue Suppl 2

Abstract: Objectives: In 2019, >71 million children aged <5 had spent their entire lives in conflict-affected settings. Compounding adversities including violence, poverty, and displacement have immediate and long-term effects on early childhood development, ... ...

Abstract	Objectives: In 2019, >71 million children aged <5 had spent their entire lives in conflict-affected settings. Compounding adversities including violence, poverty, and displacement have immediate and long-term effects on early childhood development, health, behavior, and well-being. In response, adaptations of Reach Up have been implemented in conflict and crisis settings. Methods: This article uses exploratory multiple case study methodology, drawing from implementation and qualitative data from 3 interventions: a mobile phone-based intervention promoting nurturing care among Rohingya and crisis-affected host communities in Bangladesh; Reach Up amid acute violence and displacement in Northeast Syria; and Reach Up group sessions and home visits integrated with health services for an indigenous population in Venezuela. Results: In Bangladesh, tailoring interactive voice response messages improved responsiveness to the developmental needs of young children, yet complementary in-person services were identified as a key program enhancement. In Syria, rapid adaptations of Reach Up addressed the needs of families in acute crisis, including social-emotional learning games for school-aged children. In Venezuela, Reach Up, coupled with complementary lactation counseling, yielded high rates of uptake and satisfaction, and children's language development was highlighted as a key area of growth. Conclusions: Recommendations to promote early childhood development in crisis and conflict settings include: (1) cultural adaptation based on a holistic understanding of children and caregivers' needs; (2) the integration of child and family safety and linkages with complementary services on the basis of community needs and priorities, and (3) the importance of designing for scale through blended models and costing analyses.
MeSH term(s)	Child ; Female ; Child, Preschool ; Humans ; Child Development ; Learning ; Caregivers ; Bangladesh ; Syria
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2023-060221K
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Book: The complete guide to preserving your own seeds for your garden

Murphy, Katie A

everything you need to know explained simply

(Back to basics growing)

2011

Author's details	Katie A. Murphy
Series title	Back to basics growing
Keywords	Seeds/Collection and preservation. ; Gardening.
Language	English
Size	288 p. :, ill. ;, 24 cm.
Publisher	Atlantic Pub. Group
Publishing place	Ocala, Fla
Document type	Book
ISBN	9781601383525 ; 1601383525
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Acceptability and feasibility of conducting a pilot trial in Irish primary care: lessons from the IDEAs study.

Riordan, Fiona / Murphy, Katie / Bradley, Colin / Kearney, Patricia M / Smith, Susan M / McHugh, Sheena M

HRB open research

2021 Volume 4, Page(s) 73

Abstract: Introduction Understanding primary care practices' 'readiness' to engage in trials and their experience is important to inform trial procedures and supports. Few studies report on the feasibility of study procedures though this is a central part of pilot ...

Abstract	Introduction Understanding primary care practices' 'readiness' to engage in trials and their experience is important to inform trial procedures and supports. Few studies report on the feasibility of study procedures though this is a central part of pilot trials. We explored the acceptability and feasibility of study procedures of a cluster randomised pilot trial of an intervention in primary care to improve uptake of Ireland's national diabetic retinopathy programme. Methods As part of the embedded mixed-methods process evaluation, quantitative and qualitative data were gathered across four general practices participating in the intervention. Interviews were conducted with a purposive sample of staff. Research logs on time spent on intervention delivery, staff assignment, resources, problems/changes, and reasons for drop-outs, were maintained over the course of intervention rollout, and practice audit data were analysed. Quantitative outcomes included recruitment, retention, completion, and data quality and completeness. Qualitative data on perceptions and experience of the pilot trial procedures were analysed using the Framework Method. Findings Nine staff (3 GPs, 4 nurses, 2 administrators) were interviewed. An interest in the topic area or in research motivated practices to take part in the trial. Reimbursement meant they could '
Language	English
Publishing date	2021-07-14
Publishing country	Ireland
Document type	Journal Article
ISSN	2515-4826
ISSN (online)	2515-4826
DOI	10.12688/hrbopenres.13306.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The current literature regarding the cardiovascular effects of electronic cigarettes.

Nelluri, Bhargava / Murphy, Katie / Mookadam, Farouk / Mookadam, Martina

Future cardiology

2016 Volume 12, Issue 2, Page(s) 167–179

Abstract: Smoking is the leading cause of preventable morbidity and mortality globally. Electronic cigarettes are marketed both as nicotine substitutes and recreational devices. The popularity of electronic cigarettes has superseded other forms of nicotine ... ...

Abstract	Smoking is the leading cause of preventable morbidity and mortality globally. Electronic cigarettes are marketed both as nicotine substitutes and recreational devices. The popularity of electronic cigarettes has superseded other forms of nicotine replacement therapy. They are also popular in 'never smokers'. This review summarizes the available data regarding the cardiovascular effects of electronic cigarettes. The existing literature is limited and short term with a lack of high-quality studies and adequate follow-up. The available literature suggests that electronic cigarettes have sympathomimetic effects related to nicotine exposure, however, electronic cigarettes also contain other chemicals that require further investigation. Sparse data suggest vascular injury may be another concern. Further research is needed before broad recommendations can be made.
MeSH term(s)	Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Electronic Nicotine Delivery Systems/adverse effects ; Humans ; Nicotine/adverse effects ; Smoking/adverse effects ; Smoking/physiopathology
Chemical Substances	Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2016-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca.15.83
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Article: Variations and similarities in clinical management of neonatal abstinence syndrome: Findings of a Canadian survey.

Murphy, Katie / Coo, Helen / Warre, Ruth / Shah, Vibhuti / Dow, Kimberly

Paediatrics & child health

2017 Volume 22, Issue 3, Page(s) 148–152

Abstract: Background: There are no evidence-based national guidelines for managing neonatal abstinence syndrome (NAS) and surveys from other countries have demonstrated considerable variations in practice.: Objective: To describe NAS management practices in ... ...

Abstract	Background: There are no evidence-based national guidelines for managing neonatal abstinence syndrome (NAS) and surveys from other countries have demonstrated considerable variations in practice. Objective: To describe NAS management practices in Canada. Method: The directors of all Level 2 and Level 3 neonatal intensive care units (NICUs) were contacted to request their participation in a structured telephone survey. Frequency distributions were generated and associations between practice variations and unit type (Level 2 or 3) and size were examined. Results: Personnel at 65 of 103 sites (63.1%) participated. Most (92.3%) stated their hospital has a written NAS practice guideline. The majority (89.5%) use a version of Finnegan's scoring system to monitor signs. If pharmacological treatment is required, 89.2% admit infants to the NICU and 93.8% routinely use cardiorespiratory monitors when treatment is initiated. Morphine is the first-line medication at most sites (96.9%). There was greater variability in terms of other practices: 44.6% observe at-risk infants in the NICU, while 52.3% allow them to room-in with their mothers; 65.1% use adjunct medications; 36.9% and 38.9% will discharge infants on the first-line and adjunct medications respectively, and 53.8% reported that breastfeeding is always encouraged, while 44.6% discourage breastfeeding if the mother continues to use illicit drugs and 1.5% make recommendations on an individual basis. Few practice variations were associated with unit type or size. Conclusion: While most NICUs surveyed have an NAS practice guideline, there are some notable differences in how NAS is managed. This underscores the need for research that can be translated into best practices.
Language	English
Publishing date	2017-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2106767-3
ISSN	1918-1485 ; 1205-7088
ISSN (online)	1918-1485
ISSN	1205-7088
DOI	10.1093/pch/pxx054
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