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Book: Image-guided interventions

Mauro, Matthew A. / Murphy, Kieran P. J. / Thomson, Kenneth R. / Venbrux, Anthony C. / Morgan, Robert A.

(Expert radiology series)

2021

Author's details	Matthew A. Mauro, Kieran P. J. Murphy, Kenneth R. Thompson, Anthony C. Venbrux, Robert A. Morgan
Series title	Expert radiology series
Keywords	Interventionsradiologie
Subject	Interventionelle Radiologie ; Interventionelle minimal-invasive Radiologie
Language	English
Size	xxiii, 964 Seiten, Illustrationen
Edition	Third edition
Publisher	Elsevier
Publishing place	Philadelphia
Publishing country	United States
Document type	Book
Note	Zugang zu Online-Ausgabe über Code, Literaturangaben
HBZ-ID	HT020537420
ISBN	9780323612043 ; 0323612040
Database	Catalogue ZB MED Medicine, Health

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2020 A 1028	available for loan (reading room)	Lesesaal EG
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Article ; Online: Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of Cancer.

Fagbohun, Oladapo F / Gillies, Caroline R / Murphy, Kieran P J / Rupasinghe, H P Vasantha

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Cancer is an escalating global issue, with 19.3 million new cases and 9.9 million deaths in 2020. Therefore, effective approaches to prevent cancer are urgently required. Diet plays a significant role in determining cancer risk. Nutrients and food ... ...

Abstract	Cancer is an escalating global issue, with 19.3 million new cases and 9.9 million deaths in 2020. Therefore, effective approaches to prevent cancer are urgently required. Diet plays a significant role in determining cancer risk. Nutrients and food bioactives influence specific signaling pathways in the body. Recently, there have been significant advances in cancer prevention research through nutrigenomics or with the effects of dietary components on the genome. Google Scholar, PubMed, and Scopus databases were used to search for peer-reviewed articles between 2017 and 2023. Criteria used were vitamins, minerals, tumors, cancer, genes, inflammation, signaling pathways, and nutrigenomics. Among the total of 1857 articles available, the highest relevant 90 articles that specifically discussed signaling pathways and genes on cancer cell lines and human cancer patients were selected and reviewed. Food sources are rich in antioxidant micronutrients, which are effective in activating or regulating signaling pathways involved in pathogenesis and cancer therapy by activating enzymes such as mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and phosphatidylinositol 3-kinase (PI3K). The micronutrients are involved in the regulation of β-catenin (WNT/β-catenin) including mutations in Kras and epidermal growth factor receptor (EGFR) alongside inhibition of the NF-kB pathway. The most common mechanism of cancer prevention by these micronutrients is their antioxidative, anti-inflammation, and anti-apoptosis effects. This review discusses how nutrigenomics is essential and beneficial for developing cancer prevention and treatment approaches.
MeSH term(s)	Humans ; Vitamins/pharmacology ; Vitamins/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Micronutrients/pharmacology ; Micronutrients/therapeutic use ; beta Catenin/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Vitamin A ; Vitamin K ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/prevention & control
Chemical Substances	Vitamins ; Antioxidants ; Micronutrients ; beta Catenin ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Vitamin A (11103-57-4) ; Vitamin K (12001-79-5)
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Shrinking of a Tarlov cyst.

Murphy, Kieran P / Ryan, Susannah

BMJ case reports

2019 Volume 12, Issue 3

Abstract: A 65-year-old patient presenting with left labial and perirectal pain was diagnosed with bilateral Tarlov cysts. Upon treatment of the left Tarlov cyst (the right was asymptomatic) using image-guided aspiration and subsequent injection of the cyst with ... ...

Abstract	A 65-year-old patient presenting with left labial and perirectal pain was diagnosed with bilateral Tarlov cysts. Upon treatment of the left Tarlov cyst (the right was asymptomatic) using image-guided aspiration and subsequent injection of the cyst with fibrin sealant, the cyst reduced in size. To our knowledge, there are currently no other documented cases in which the Tarlov cyst reduced in size following this procedure. This case would seem to suggest that clinicians are poorly informed with regard to Tarlov cysts. These cysts are more common in Caucasian women, many of whom are told their cysts are not responsible for their pain or that they are not treatable. However, there is clear evidence that some Tarlov cysts are symptomatic and minimally invasive procedures have been developed to treat them. As they primarily occur in women, it is possible gender bias may also play a role in the delayed diagnosis of the patient's pain.
MeSH term(s)	Aged ; Female ; Fibrin Tissue Adhesive/administration & dosage ; Humans ; Paracentesis/methods ; Tarlov Cysts/therapy ; Tissue Adhesives/administration & dosage ; Treatment Outcome
Chemical Substances	Fibrin Tissue Adhesive ; Tissue Adhesives
Language	English
Publishing date	2019-03-08
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2018-227256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Dietary Antioxidant Formulation Ameliorates DNA Damage Caused by γ-Irradiation in Normal Human Bronchial Epithelial Cells In Vitro.

Merlin, J P Jose / Mathavarajah, Sabateeshan / Dellaire, Graham / Murphy, Kieran P J / Rupasinghe, H P Vasantha

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 7

Abstract: Antioxidants can be used as radioprotectants to reduce DNA damage due to exposure to radiation that could result in malignancies, including lung cancer. Mortality rates are consistently higher in lung cancer, which is usually diagnosed at later stages of ...

Abstract	Antioxidants can be used as radioprotectants to reduce DNA damage due to exposure to radiation that could result in malignancies, including lung cancer. Mortality rates are consistently higher in lung cancer, which is usually diagnosed at later stages of cancer development and progression. In this preliminary study, we examined the potential of an antioxidant formulation (AOX2) to reduce DNA damage using a cell model of human normal bronchial epithelial cells (BEAS-2B). Cells were exposed to γ-irradiation or smoke-related hydrocarbon 4[(acetoxymethyl)nitrosamino]-1 (3-pyridyl) 1-butanone (NNKOAc) to induce DNA damage. We monitored intracellular reactive oxygen species (ROS) levels and evidence of genotoxic damage including DNA fragmentation ELISA, γ-H2AX immunofluorescence, and comet assays. Pre-incubation of the cells with AOX2 before exposure to γ-irradiation and NNKOAc significantly reduced DNA damage. The dietary antioxidant preparation AOX2 significantly reduced the induction of the tumor suppressor protein p53 and DNA damage-associated γ-H2AX phosphorylation by radiation and the NNKOAc treatment. Thus, AOX2 has the potential to act as a chemoprotectant by lowering ROS levels and DNA damage caused by exposure to radiation or chemical carcinogens.
Language	English
Publishing date	2022-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11071407
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Dietary Antioxidant Formulation Ameliorates DNA Damage Caused by γ-Irradiation in Normal Human Bronchial Epithelial Cells In Vitro

Merlin, J. P. Jose / Mathavarajah, Sabateeshan / Dellaire, Graham / Murphy, Kieran P. J. / Rupasinghe, H. P. Vasantha

Antioxidants. 2022 July 20, v. 11, no. 7

2022

Abstract	Antioxidants can be used as radioprotectants to reduce DNA damage due to exposure to radiation that could result in malignancies, including lung cancer. Mortality rates are consistently higher in lung cancer, which is usually diagnosed at later stages of cancer development and progression. In this preliminary study, we examined the potential of an antioxidant formulation (AOX2) to reduce DNA damage using a cell model of human normal bronchial epithelial cells (BEAS-2B). Cells were exposed to γ-irradiation or smoke-related hydrocarbon 4[(acetoxymethyl)nitrosamino]-1 (3-pyridyl) 1-butanone (NNKOAc) to induce DNA damage. We monitored intracellular reactive oxygen species (ROS) levels and evidence of genotoxic damage including DNA fragmentation ELISA, γ-H2AX immunofluorescence, and comet assays. Pre-incubation of the cells with AOX2 before exposure to γ-irradiation and NNKOAc significantly reduced DNA damage. The dietary antioxidant preparation AOX2 significantly reduced the induction of the tumor suppressor protein p53 and DNA damage-associated γ-H2AX phosphorylation by radiation and the NNKOAc treatment. Thus, AOX2 has the potential to act as a chemoprotectant by lowering ROS levels and DNA damage caused by exposure to radiation or chemical carcinogens.
Keywords	DNA ; DNA damage ; DNA fragmentation ; carcinogenesis ; epithelium ; fluorescent antibody technique ; humans ; lung neoplasms ; models ; mortality ; mutagens ; phosphorylation ; reactive oxygen species ; tumor suppressor protein p53
Language	English
Dates of publication	2022-0720
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11071407
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part I-Anatomy and Physiology.

Klostranec, Jesse M / Vucevic, Diana / Bhatia, Kartik D / Kortman, Hans G J / Krings, Timo / Murphy, Kieran P / terBrugge, Karel G / Mikulis, David J

Radiology

2021 Volume 301, Issue 3, Page(s) 502–514

Abstract: Normal physiologic function of organs requires a circulation of interstitial fluid to deliver nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid in most organs; however, these vessels are absent in the ... ...

Abstract	Normal physiologic function of organs requires a circulation of interstitial fluid to deliver nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid in most organs; however, these vessels are absent in the central nervous system. How the central nervous system maintains tight control of extracellular conditions has been a fundamental question in neuroscience until recent discovery of the glial-lymphatic, or glymphatic, system was made this past decade. Networks of paravascular channels surrounding pial and parenchymal arteries and veins were found that extend into the walls of capillaries to allow fluid transport and exchange between the interstitial and cerebrospinal fluid spaces. The currently understood anatomy and physiology of the glymphatic system is reviewed, with the paravascular space presented as an intrinsic component of healthy pial and parenchymal cerebral blood vessels. Glymphatic system behavior in animal models of health and disease, and its enhanced function during sleep, are discussed. The evolving understanding of glymphatic system characteristics is then used to provide a current interpretation of its physiology that can be helpful for radiologists when interpreting neuroimaging investigations.
MeSH term(s)	Extracellular Fluid/physiology ; Glymphatic System/anatomy & histology ; Glymphatic System/physiology ; Humans ; Neuroimaging/methods
Language	English
Publishing date	2021-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2021202043
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Article ; Online: Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part II-Imaging Techniques and Clinical Applications.

Klostranec, Jesse M / Vucevic, Diana / Bhatia, Kartik D / Kortman, Hans G J / Krings, Timo / Murphy, Kieran P / terBrugge, Karel G / Mikulis, David J

Radiology

2021 Volume 301, Issue 3, Page(s) 516–532

Abstract: The glymphatic system is a recently discovered network unique to the central nervous system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid (CSF). As detailed in part I, ISF and CSF transport along paravascular ... ...

Abstract	The glymphatic system is a recently discovered network unique to the central nervous system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid (CSF). As detailed in part I, ISF and CSF transport along paravascular channels of the penetrating arteries and possibly veins allow essential clearance of neurotoxic solutes from the interstitium to the CSF efflux pathways. Imaging tests to investigate this neurophysiologic function, although challenging, are being developed and are reviewed herein. These include direct visualization of CSF transport using postcontrast imaging techniques following intravenous or intrathecal administration of contrast material and indirect glymphatic assessment with detection of enlarged perivascular spaces. Application of MRI techniques, including intravoxel incoherent motion, diffusion tensor imaging, and chemical exchange saturation transfer, is also discussed, as are methods for imaging dural lymphatic channels involved with CSF efflux. Subsequently, glymphatic function is considered in the context of proteinopathies associated with neurodegenerative diseases and traumatic brain injury, cytotoxic edema following acute ischemic stroke, and chronic hydrocephalus after subarachnoid hemorrhage. These examples highlight the substantial role of the glymphatic system in neurophysiology and the development of certain neuropathologic abnormalities, stressing the importance of its consideration when interpreting neuroimaging investigations. © RSNA, 2021.
MeSH term(s)	Animals ; Extracellular Fluid/diagnostic imaging ; Extracellular Fluid/physiology ; Glymphatic System/diagnostic imaging ; Glymphatic System/physiology ; Humans ; Magnetic Resonance Imaging/methods ; Mice ; Neuroimaging/methods
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2021204088
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Article: Fractures of the proximal femur: correlates of radiological evidence of osteoporosis.

Patel, Salil H / Murphy, Kieran P

Skeletal radiology

2006 Volume 35, Issue 4, Page(s) 202–211

Abstract: Objective: Fractures of the proximal femur are common sequelae of osteoporosis, and are responsible for significant morbidity and mortality in elderly patients worldwide. Plain film radiographic assessment methods to assess for fracture risk may be of ... ...

Abstract	Objective: Fractures of the proximal femur are common sequelae of osteoporosis, and are responsible for significant morbidity and mortality in elderly patients worldwide. Plain film radiographic assessment methods to assess for fracture risk may be of particular value. Design and patients: The authors present the results of biomechanical testing, radiographic imaging, and histologic exam of 20 embalmed human bone specimens, with implications for clinical correlation of radiologic findings. Authors assessed bone architecture using the Singh Index, using a blinded 3-rater system to reduce bias and measure intra-observer reliability. After loading to failure with ultimate tensile strength (UTS), bone specimens were assessed by fracture location type and by trabecular bone volume (TBV). Results: Singh scoring was performed with Inter-Class Correlation of 0.80 (F=0.24, by ICC Portney Model 2). A statistically-significant difference among the UTS distributions was noted for UTS by Fracture Site (F=4.49, p=0.026, by ANOVA). No significant association of Singh Index with TBV, or TBV with UTS, was observed, although a trend toward greater UTS with higher Singh grade was observed. Conclusions: The authors propose that the Singh Index is a valuable and reliable indicator which may reflect structural integrity in trabecular bone. Fracture site along the femur is associated with tensile strength. The authors, in the light of these findings, address the promise and potential impact of prophylactic hip augmentation in populations at risk for femoral neck pathology.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomechanical Phenomena ; Female ; Femoral Neck Fractures/complications ; Femoral Neck Fractures/diagnostic imaging ; Femoral Neck Fractures/pathology ; Femoral Neck Fractures/physiopathology ; Femur Head/diagnostic imaging ; Femur Head/injuries ; Femur Head/pathology ; Femur Head/physiopathology ; Hip Fractures/complications ; Hip Fractures/diagnostic imaging ; Hip Fractures/pathology ; Hip Fractures/physiopathology ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Osteoporosis/complications ; Osteoporosis/diagnostic imaging ; Osteoporosis/pathology ; Osteoporosis/physiopathology ; Radiography
Language	English
Publishing date	2006-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-005-0065-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effectiveness of vertebroplasty: a recent controversy.

Munk, Peter L / Liu, David M / Murphy, Kieran P / Baerlocher, Mark O

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

2009 Volume 60, Issue 4, Page(s) 170–171

MeSH term(s)	Fractures, Compression/therapy ; Humans ; Randomized Controlled Trials as Topic ; Spinal Fractures/therapy ; Treatment Outcome ; Vertebroplasty
Language	English
Publishing date	2009-09-17
Publishing country	United States
Document type	Editorial
ZDB-ID	418190-6
ISSN	0846-5371 ; 0008-2902
ISSN	0846-5371 ; 0008-2902
DOI	10.1016/j.carj.2009.08.001
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Article: Percutaneous CT-guided cementoplasty for stabilization of a femoral neck lesion.

Chang, Stephen W / Murphy, Kieran P J

Journal of vascular and interventional radiology : JVIR

2005 Volume 16, Issue 6, Page(s) 889–890

MeSH term(s)	Amyloidosis/complications ; Bone Cements/therapeutic use ; Hip Joint ; Humans ; Joint Diseases/diagnostic imaging ; Joint Diseases/etiology ; Joint Diseases/therapy ; Kidney Failure, Chronic/complications ; Male ; Middle Aged ; Radiography
Chemical Substances	Bone Cements
Language	English
Publishing date	2005-05-04
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/s1051-0443(07)60698-8
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