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  1. Article ; Online: Acidic pH modulates

    Morales, L Daniela / Av-Gay, Yossef / Murphy, Michael E P

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0273123

    Abstract: Importance: Burkholderia ... ...

    Abstract Importance: Burkholderia cenocepacia
    MeSH term(s) Humans ; Burkholderia cenocepacia ; Cystic Fibrosis/complications ; Cystic Fibrosis/microbiology ; Burkholderia Infections/drug therapy ; Burkholderia Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Hydrogen-Ion Concentration
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02731-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aldehyde-Based Inhibitors of the Peptidoglycan O-Acetylesterase Ape.

    Voskoboinyk, Dmytro / Mahmoodi, Niusha / Lin, Chang Sheng-Huei / Murphy, Michael E P / Tanner, Martin E

    Chembiochem : a European journal of chemical biology

    2023  Volume 24, Issue 11, Page(s) e202300205

    Abstract: The O-acetylation of the muramic acid residues in peptidoglycan (PG) is a modification that protects the bacteria from lysis due to the action of lysozyme. In Gram-negative bacteria, deacetylation is required to allow lytic transglycosylases to promote ... ...

    Abstract The O-acetylation of the muramic acid residues in peptidoglycan (PG) is a modification that protects the bacteria from lysis due to the action of lysozyme. In Gram-negative bacteria, deacetylation is required to allow lytic transglycosylases to promote PG cleavage during cell growth and division. This deacetylation is catalyzed by O-acetylpeptidoglycan esterase (Ape) which is a serine esterase and employs covalent catalysis via a serine-linked acyl enzyme intermediate. Loss of Ape activity affects the size and shape of bacteria and dramatically reduces virulence. In this work, we report the first rationally designed aldehyde-based inhibitors of Ape from Campylobacter jejuni. The most potent of these acts as a competitive inhibitor with a K
    MeSH term(s) Animals ; Acetylesterase ; Peptidoglycan/chemistry ; Aldehydes/pharmacology ; Esterases/chemistry ; Bacteria/metabolism ; Serine ; Hominidae/metabolism
    Chemical Substances Acetylesterase (EC 3.1.1.6) ; Peptidoglycan ; Aldehydes ; Esterases (EC 3.1.-) ; Serine (452VLY9402)
    Language English
    Publishing date 2023-05-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A new member of the flavodoxin superfamily from Fusobacterium nucleatum that functions in heme trafficking and reduction of anaerobilin.

    McGregor, Alexandra K / Chan, Anson C K / Schroeder, Megan D / Do, Long T M / Saini, Gurpreet / Murphy, Michael E P / Wolthers, Kirsten R

    The Journal of biological chemistry

    2023  Volume 299, Issue 7, Page(s) 104902

    Abstract: Fusobacterium nucleatum is an opportunistic oral pathogen that is associated with various cancers. To fulfill its essential need for iron, this anaerobe will express heme uptake machinery encoded at a single genetic locus. The heme uptake operon includes ...

    Abstract Fusobacterium nucleatum is an opportunistic oral pathogen that is associated with various cancers. To fulfill its essential need for iron, this anaerobe will express heme uptake machinery encoded at a single genetic locus. The heme uptake operon includes HmuW, a class C radical SAM-dependent methyltransferase that degrades heme anaerobically to release Fe
    MeSH term(s) Humans ; Flavin Mononucleotide/metabolism ; Flavodoxin/chemistry ; Flavodoxin/classification ; Flavodoxin/genetics ; Flavodoxin/metabolism ; Fusobacterium nucleatum/chemistry ; Fusobacterium nucleatum/genetics ; Fusobacterium nucleatum/metabolism ; Heme/metabolism ; Iron/metabolism ; Oxidation-Reduction ; Tetrapyrroles/metabolism ; Biological Transport ; Genes, Bacterial ; Bacterial Proteins/chemistry ; Bacterial Proteins/classification ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Protein Domains ; Fusobacterium Infections/microbiology
    Chemical Substances anaerobilin ; Flavin Mononucleotide (7N464URE7E) ; Flavodoxin ; Heme (42VZT0U6YR) ; hydroquinone (XV74C1N1AE) ; Iron (E1UOL152H7) ; Tetrapyrroles ; Bacterial Proteins ; protoporphyrin IX (C2K325S808)
    Language English
    Publishing date 2023-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.104902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.108: Show issues Location:
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  4. Article: Dissecting components of the

    Richardson-Sanchez, Tomas / Chan, Anson C K / Sabatino, Brendil / Lin, Helen / Gaynor, Erin C / Murphy, Michael E P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Campylobacter ... ...

    Abstract Campylobacter jejuni
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.05.547857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dissecting components of the

    Richardson-Sanchez, Tomas / Chan, Anson C K / Sabatino, Brendil / Lin, Helen / Gaynor, Erin C / Murphy, Michael E P

    Microbiology spectrum

    2023  Volume 12, Issue 1, Page(s) e0314823

    Abstract: Importance: Campylobacter ... ...

    Abstract Importance: Campylobacter jejuni
    MeSH term(s) Animals ; Humans ; Campylobacter ; Campylobacter jejuni/genetics ; Chickens/microbiology ; Iron ; Campylobacter Infections/veterinary ; Campylobacter Infections/microbiology ; Poultry ; Poultry Diseases/microbiology ; Ferric Compounds ; Metalloporphyrins
    Chemical Substances Iron (E1UOL152H7) ; 5,10,15,20-tetrakis(2,4,6-trimethyl-3,3-disulfonatophenyl)porphyrinato iron(III) ; Ferric Compounds ; Metalloporphyrins
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03148-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sequence Divergence in the Arginase Domain of Ornithine Decarboxylase/Arginase in Fusobacteriacea Leads to Loss of Function in Oral Associated Species

    Mothersole, Robert G. / Kolesnikov, Maxim / Chan, Anson C. K. / Oduro, Emmanuella / Murphy, Michael E. P. / Wolthers, Kirsten R.

    Biochemistry. 2022 June 22, v. 61, no. 13

    2022  

    Abstract: A number of species within the Fusobacteriaceae family of Gram-negative bacteria uniquely encode for an ornithine decarboxylase/arginase (ODA) that ostensibly channels l-ornithine generated by hydrolysis of l-arginine to putrescine formation. However, ... ...

    Abstract A number of species within the Fusobacteriaceae family of Gram-negative bacteria uniquely encode for an ornithine decarboxylase/arginase (ODA) that ostensibly channels l-ornithine generated by hydrolysis of l-arginine to putrescine formation. However, two aspartate residues required for coordination to a catalytically obligatory manganese cluster of arginases are substituted for a serine and an asparagine. Curiously, these natural substitutions occur only in a clade of Fusobacterium species that inhabit the oral cavity. Herein, we expressed and isolated full-length ODA from the opportunistic oral pathogen Fusobacterium nucleatum along with the individual arginase and ornithine decarboxylase components. The crystal structure of the arginase domain reveals that it adopts the classical α/β arginase-fold, but metal ions are absent in the active site. As expected, the ureohydrolase activity with l-arginine was not detected for wild-type ODA or the isolated arginase domain. However, engineering of the complete metal coordination environment through site-directed mutagenesis restored Mn²⁺ binding capacity and arginase activity, although the catalytic efficiency for l-arginine was low (60–100 M–¹ s–¹). Full-length ODA and the isolated ODC component were able to decarboxylate both l-ornithine and l-arginine to form putrescine and agmatine, respectively, but kcₐₜ/KM of l-ornithine was ∼20-fold higher compared to l-arginine. We discuss environmental conditions that may have led to the natural selection of an inactive arginase in the oral associated species of Fusobacterium.
    Keywords Fusobacterium nucleatum ; active sites ; agmatine ; arginase ; arginine ; asparagine ; aspartic acid ; catalytic activity ; crystal structure ; hydrolysis ; manganese ; mouth ; natural selection ; ornithine decarboxylase ; pathogens ; putrescine ; serine ; site-directed mutagenesis
    Language English
    Dates of publication 2022-0622
    Size p. 1378-1391.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.2c00197
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
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  7. Article ; Online: Severe Bronchoconstriction Caused by Administration of Rocuronium in a 3-Month-Old Infant: Case Report.

    Dyess, Nicolle F / Albertz, Megan L / Murphy, Michael E / Kinsella, John P

    The Journal of pediatrics

    2020  Volume 228, Page(s) 297–300

    Abstract: We present the case of a 3-month-old infant with severe, persistent bronchoconstriction following administration of rocuronium. This observation raises awareness of a rare but potentially life-threatening reaction to neuromuscular blocking agents. ...

    Abstract We present the case of a 3-month-old infant with severe, persistent bronchoconstriction following administration of rocuronium. This observation raises awareness of a rare but potentially life-threatening reaction to neuromuscular blocking agents.
    MeSH term(s) Anaphylaxis/chemically induced ; Anaphylaxis/physiopathology ; Bronchoconstriction/drug effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Infant ; Neuromuscular Nondepolarizing Agents/administration & dosage ; Neuromuscular Nondepolarizing Agents/adverse effects ; Rocuronium/administration & dosage ; Rocuronium/adverse effects ; Severity of Illness Index
    Chemical Substances Neuromuscular Nondepolarizing Agents ; Rocuronium (WRE554RFEZ)
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Case Reports ; Research Support, N.I.H., Extramural
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.08.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.116: Show issues Location:
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  8. Article: MOBILE MENTAL HEALTH RESPONSE.

    Florida, Raymond / Murphy, Michael E

    JEMS : a journal of emergency medical services

    2016  Volume 41, Issue 5, Page(s) 54–56

    MeSH term(s) Delivery of Health Care, Integrated ; Humans ; Mental Disorders/therapy ; Mobile Health Units/organization & administration ; New York ; Organizational Case Studies
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1292428-3
    ISSN 0197-2510
    ISSN 0197-2510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4390: Show issues Location:
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  9. Article ; Online: Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures.

    Brajcich, Michelle R / Palau, Mauricio A / Messer, Ricka D / Murphy, Michael E / Marks, Jill

    Pediatrics

    2021  Volume 147, Issue 2

    Abstract: Serotonergic medications are used for the prevention and treatment of depression during pregnancy. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors (SNRIs) can cause poor neonatal adaptation, which has been ... ...

    Abstract Serotonergic medications are used for the prevention and treatment of depression during pregnancy. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors (SNRIs) can cause poor neonatal adaptation, which has been attributed to withdrawal versus toxicity. Bupropion, a norepinephrine-dopamine reuptake inhibitor, is often used as an adjunctive agent to selective serotonin reuptake inhibitors or SNRIs for refractory depression. Quetiapine, an atypical antipsychotic, may also be used in more complex cases. When combined with serotonergic drugs, bupropion and quetiapine are associated with increased risk of serotonin syndrome in adults. We describe a neonate exposed to venlafaxine (an SNRI), bupropion, and quetiapine in utero who presented nearly immediately after birth with encephalopathy and abnormal movements. The severity and rapidity of symptoms may be attributable to potentiation of venlafaxine's serotonergic effects by bupropion and quetiapine. Neonatal providers should be aware of maternal medications and prepare for possible adverse effects, particularly from common psychotropic exposures.
    MeSH term(s) Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Brain Diseases/chemically induced ; Brain Diseases/congenital ; Brain Diseases/diagnosis ; Bupropion/adverse effects ; Bupropion/therapeutic use ; Drug Therapy, Combination ; Dyskinesia, Drug-Induced/congenital ; Dyskinesia, Drug-Induced/diagnosis ; Dyskinesia, Drug-Induced/etiology ; Female ; Humans ; Infant, Newborn ; Male ; Neurotransmitter Uptake Inhibitors/adverse effects ; Neurotransmitter Uptake Inhibitors/therapeutic use ; Pregnancy ; Pregnancy Complications/drug therapy ; Quetiapine Fumarate/adverse effects ; Quetiapine Fumarate/therapeutic use ; Stress Disorders, Post-Traumatic/drug therapy ; Venlafaxine Hydrochloride/adverse effects ; Venlafaxine Hydrochloride/therapeutic use
    Chemical Substances Antidepressive Agents ; Neurotransmitter Uptake Inhibitors ; Bupropion (01ZG3TPX31) ; Quetiapine Fumarate (2S3PL1B6UJ) ; Venlafaxine Hydrochloride (7D7RX5A8MO)
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2019-2250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.131: Show issues Location:
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    Zs.MO 357: Show issues

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  10. Article ; Online: Sequence Divergence in the Arginase Domain of Ornithine Decarboxylase/Arginase in

    Mothersole, Robert G / Kolesnikov, Maxim / Chan, Anson C K / Oduro, Emmanuella / Murphy, Michael E P / Wolthers, Kirsten R

    Biochemistry

    2022  Volume 61, Issue 13, Page(s) 1378–1391

    Abstract: A number of species within ... ...

    Abstract A number of species within the
    MeSH term(s) Arginase/chemistry ; Arginase/genetics ; Arginase/metabolism ; Arginine/metabolism ; Ornithine ; Ornithine Decarboxylase/metabolism ; Putrescine
    Chemical Substances Arginine (94ZLA3W45F) ; Ornithine (E524N2IXA3) ; Arginase (EC 3.5.3.1) ; Ornithine Decarboxylase (EC 4.1.1.17) ; Putrescine (V10TVZ52E4)
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.2c00197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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