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  1. Article ; Online: P

    Murphy, Morgan B / Huang, Abel S / Schick, Suzaynn F

    Environmental health perspectives

    2021  Volume 129, Issue 6, Page(s) 67701

    MeSH term(s) Air Pollutants/analysis ; Cannabis ; Environmental Monitoring ; Particulate Matter/analysis
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP8689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: PM₂.₅ Concentrations in the Smoking Lounge of a Cannabis Store

    Huang, Abel S. / Murphy, Morgan B. C. / Jacob, Peyton / Schick, Suzaynn F.

    Environmental science & technology letters. 2022 May 26, v. 9, no. 6

    2022  

    Abstract: To assess the exposure of patrons and workers to secondhand cannabis smoke in the smoking lounge of a cannabis store, we measured airborne PM₂.₅, cannabinoids, and nicotine in a cannabis store and a nearby coffee shop. The PM₂.₅ concentration was ... ...

    Abstract To assess the exposure of patrons and workers to secondhand cannabis smoke in the smoking lounge of a cannabis store, we measured airborne PM₂.₅, cannabinoids, and nicotine in a cannabis store and a nearby coffee shop. The PM₂.₅ concentration was measured with laser photometers. Air samples were collected on filters. Cannabinoids were quantified by liquid chromatography with tandem mass spectroscopy, and nicotine was quantified by gas chromatography. Activity and demographic data were recorded. The average PM₂.₅ concentration over nine experiments conducted between September 2018 and August 2019 was 840 μg/m³ (standard deviation of 674 μg/m³). Concentrations of THC, CBD, and CBN in the particulate matter averaged 79.0 μg/m³, 0.708 ng/m³, and 8.60 ng/m³, respectively. Nicotine concentrations were below the level of quantification. Although a variety of consumption methods were observed, 91% of the observed consumption events were smoking. The business installed a ventilation system halfway through our study. Before the ventilation system was installed, the average PM₂.₅ was 905 μg/m³; afterward, it was 795 μg/m³. This 12.2% decrease was not statistically significant. Our results show that smoking cannabis indoors can create high concentrations of particulate air pollution, which is known to cause adverse health effects.
    Keywords Cannabis ; air ; air pollution ; cannabinoids ; gas chromatography ; liquid chromatography ; nicotine ; particulates ; smoke ; standard deviation ; tandem mass spectrometry ; ventilation systems
    Language English
    Dates of publication 2022-0526
    Size p. 551-556.
    Publishing place American Chemical Society
    Document type Article
    ISSN 2328-8930
    DOI 10.1021/acs.estlett.2c00148
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Impairment of Endothelial Function by Aerosol From Marijuana Leaf Vaporizers.

    Liu, Jiangtao / Nabavizadeh, Pooneh / Rao, Poonam / Derakhshandeh, Ronak / Han, Daniel D / Guo, Raymond / Murphy, Morgan B / Cheng, Jing / Schick, Suzaynn F / Springer, Matthew L

    Journal of the American Heart Association

    2023  Volume 12, Issue 23, Page(s) e032969

    Abstract: Background: Marijuana leaf vaporizers, which heat plant material and sublimate Δ-9-tetrahydrocannabinol without combustion, are popular alternatives to smoking cannabis that are generally perceived to be less harmful. We have shown that smoke from ... ...

    Abstract Background: Marijuana leaf vaporizers, which heat plant material and sublimate Δ-9-tetrahydrocannabinol without combustion, are popular alternatives to smoking cannabis that are generally perceived to be less harmful. We have shown that smoke from tobacco and marijuana, as well as aerosol from e-cigarettes and heated tobacco products, impair vascular endothelial function in rats measured as arterial flow-mediated dilation (FMD).
    Methods and results: We exposed 8 rats per group to aerosol generated by 2 vaporizer systems (Volcano and handheld Yocan) using marijuana with varying Δ-9-tetrahydrocannabinol levels, in a single pulsatile exposure session of 2 s/min over 5 minutes, and measured changes in FMD. To model secondhand exposure, we exposed rats for 1 minute to diluted aerosol approximating release of uninhaled Volcano aerosol into typical residential rooms. Exposure to aerosol from marijuana with and without cannabinoids impaired FMD by ≈50%. FMD was similarly impaired by aerosols from Yocan (237 °C), and from Volcano at both its standard temperature (185 °C) and the minimum sublimation temperature of Δ-9-tetrahydrocannabinol (157 °C), although the low-temperature aerosol condition did not effectively deliver Δ-9-tetrahydrocannabinol to the circulation. Modeled secondhand exposure based on diluted Volcano aerosol also impaired FMD. FMD was not affected in rats exposed to clean air or water vapor passed through the Volcano system.
    Conclusions: Acute direct exposure and modeled secondhand exposure to marijuana leaf vaporizer aerosol, regardless of cannabinoid concentration or aerosol generation temperature, impair endothelial function in rats comparably to marijuana smoke. Our findings indicate that use of leaf vaporizers is unlikely to reduce the vascular risk burden of smoking marijuana.
    MeSH term(s) Animals ; Rats ; Aerosols ; Cannabinoids ; Cannabis ; Dilatation, Pathologic ; Dronabinol ; Electronic Nicotine Delivery Systems ; Marijuana Smoking/adverse effects ; Nebulizers and Vaporizers ; Plant Leaves ; Smoke
    Chemical Substances Aerosols ; Cannabinoids ; Dronabinol (7J8897W37S) ; Smoke
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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