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  1. Article ; Online: Ignition sequence start: epithelial allergen sensing and regulation of the allergic inflammatory response.

    Murphy, Ryan C / Altman, Matthew C

    Nature immunology

    2021  Volume 22, Issue 10, Page(s) 1207–1209

    MeSH term(s) Allergens ; Humans ; Hypersensitivity
    Chemical Substances Allergens
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01005-0
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  2. Article ; Online: The Intersection between Autoimmunity, Macrophage Dysfunction, Endotype, and Exacerbations in Severe Asthma.

    Murphy, Ryan C / Morrell, Eric D / Hallstrand, Teal S

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 4, Page(s) 383–385

    MeSH term(s) Humans ; Autoantibodies ; Autoimmunity ; Asthma/physiopathology ; Respiratory System/physiopathology
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202211-2074ED
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  3. Article ; Online: Exploring the origin and regulatory role of mast cells in asthma.

    Murphy, Ryan C / Hallstrand, Teal S

    Current opinion in allergy and clinical immunology

    2020  Volume 21, Issue 1, Page(s) 71–78

    Abstract: Purpose of review: Mast cells have previously been thought to function solely as effector cells in asthma but more recent studies have indicated that mast cells may play a more central role in propagating and regulating lower airway inflammation in ... ...

    Abstract Purpose of review: Mast cells have previously been thought to function solely as effector cells in asthma but more recent studies have indicated that mast cells may play a more central role in propagating and regulating lower airway inflammation in asthma.
    Recent findings: Initial studies have found increased numbers of mast cell progenitors (MCPs) in the peripheral blood of patients with asthma and these cells could contribute to the increased number of progenitors identified in the airways of patients with asthma. There are unique subpopulations of mast cells within the asthmatic airway, which are characterized by their physical location and distinguished by their expression profile of mast cell proteases. Intraepithelial mast cells are tightly associated with type-2 (T2) inflammation but additional studies have suggested a role for anti-mast cell therapies as a treatment for T2-low asthma. Mast cells have recently been shown to closely communicate with the airway epithelium and airway smooth muscle to regulate lower airway inflammation and airway hyperresponsiveness.
    Summary: Recent studies have better illuminated the central role of mast cells in regulating lower airway inflammation and airway hyperresponsiveness.
    MeSH term(s) Asthma/blood ; Asthma/immunology ; Asthma/pathology ; Carboxypeptidases A/metabolism ; Cell Differentiation/immunology ; Chymases/metabolism ; Humans ; Inflammation/blood ; Inflammation/immunology ; Inflammation/pathology ; Mast Cells/immunology ; Mast Cells/metabolism ; Respiratory Mucosa/cytology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/pathology ; Signal Transduction/immunology ; Tryptases/metabolism
    Chemical Substances CPA3 protein, human (EC 3.4.17.1) ; Carboxypeptidases A (EC 3.4.17.1) ; CMA1 protein, human (EC 3.4.21.39) ; Chymases (EC 3.4.21.39) ; Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2020-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000703
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  4. Article ; Online: Selecting the Optimal Therapy for Mild Asthma.

    Murphy, Ryan C / Mak, Garbo / Feemster, Laura C / Hallstrand, Teal S

    Annals of the American Thoracic Society

    2021  Volume 18, Issue 12, Page(s) 1955–1957

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Humans
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202106-697ED
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  5. Article ; Online: Management Strategies to Reduce Exacerbations in non-T2 Asthma.

    Murphy, Ryan C / Pavord, Ian D / Alam, Rafeul / Altman, Matthew C

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 7, Page(s) 2588–2597

    Abstract: There have been considerable advances in our understanding of asthmatic airway inflammation, resulting in a paradigm shift of classifying individuals on the basis of either the presence or the absence of type 2 (T2) inflammatory markers. Several novel ... ...

    Abstract There have been considerable advances in our understanding of asthmatic airway inflammation, resulting in a paradigm shift of classifying individuals on the basis of either the presence or the absence of type 2 (T2) inflammatory markers. Several novel monoclonal antibody therapies targeting T2 cytokines have demonstrated significant clinical effects including reductions in acute exacerbations and improvements in asthma-related quality of life and lung function for individuals with T2-high asthma. However, there have been fewer advancements in developing therapies for those without evidence of T2 airway inflammation (so-called non-T2 asthma). Here, we review the heterogeneity of molecular mechanisms responsible for initiation and regulation of non-T2 inflammation and discuss both current and potential future therapeutic options for individuals with non-T2 asthma.
    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Cytokines ; Humans ; Inflammation ; Quality of Life
    Chemical Substances Anti-Asthmatic Agents ; Cytokines
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.04.033
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  6. Article ; Online: Neutrophilic asthma at an inhibitory checkpoint: A PD-1-targeted approach.

    Samanas, Nyssa B / Murphy, Ryan C / Miralda, Irina / Hallstrand, Teal S / Piliponsky, Adrian M

    The Journal of allergy and clinical immunology

    2022  Volume 151, Issue 2, Page(s) 420–422

    MeSH term(s) Humans ; Programmed Cell Death 1 Receptor ; Asthma/drug therapy ; Lung ; Neutrophils ; Eosinophils ; Inflammation
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.11.014
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  7. Article ; Online: Intravascular Leukocyte Labeling Refines the Distribution of Myeloid Cells in the Lung in Models of Allergen-induced Airway Inflammation.

    Chow, Yu-Hua / Murphy, Ryan C / An, Dowon / Lai, Ying / Altemeier, William A / Manicone, Anne M / Hallstrand, Teal S

    ImmunoHorizons

    2023  Volume 7, Issue 12, Page(s) 853–860

    Abstract: Innate immune cell populations are critical in asthma with different functional characteristics based on tissue location, which has amplified the importance of characterizing the precise number and location of innate immune populations in murine models ... ...

    Abstract Innate immune cell populations are critical in asthma with different functional characteristics based on tissue location, which has amplified the importance of characterizing the precise number and location of innate immune populations in murine models of asthma. In this study, we performed premortem intravascular (IV) labeling of leukocytes in mice in two models of asthma to differentiate innate immune cell populations within the IV compartment versus those residing in the lung tissue or airway lumen. We performed spectral flow cytometry analysis of the blood, suspensions of digested lung tissue, and bronchoalveolar lavage fluid. We discovered that IV labeled leukocytes do not contaminate analysis of bronchoalveolar lavage fluid but represent a significant proportion of cells in digested lung tissue. Exclusion of IV leukocytes significantly improved the accuracy of the assessments of myeloid cells in the lung tissue and provided important insights into ongoing trafficking in both eosinophilic and neutrophilic asthma models.
    MeSH term(s) Animals ; Mice ; Allergens ; Leukocytes ; Myeloid Cells ; Asthma ; Inflammation ; Lung
    Chemical Substances Allergens
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2300059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Intricate Web of Phospholipase A

    Murphy, Ryan C / Altemeier, William A / Lai, Ying / Hallstrand, Teal S

    American journal of respiratory cell and molecular biology

    2020  Volume 63, Issue 4, Page(s) 543–545

    MeSH term(s) Airway Remodeling ; Asthma ; Bronchial Hyperreactivity ; Bronchoconstriction ; Humans ; Leukotrienes ; Phospholipases ; Phospholipases A2
    Chemical Substances Leukotrienes ; Phospholipases (EC 3.1.-) ; Phospholipases A2 (EC 3.1.1.4)
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0131LE
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  9. Article ; Online: Summary for Clinicians: Clinical Practice Guideline for the Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma.

    Murphy, Ryan C / Zhang, Peng / Tejwani, Vickram / Khatri, Sumita B / Hallstrand, Teal S / Ruminjo, Joseph K / Thomson, Carey C

    Annals of the American Thoracic Society

    2022  Volume 19, Issue 10, Page(s) 1627–1630

    MeSH term(s) Asthma/drug therapy ; Asthma/therapy ; Biomarkers ; Breath Tests ; Exhalation ; Fractional Exhaled Nitric Oxide Testing ; Humans ; Nitric Oxide/therapeutic use
    Chemical Substances Biomarkers ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202204-289CME
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  10. Article ; Online: Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma.

    Murphy, Ryan C / Lai, Ying / Liu, Matthew / Al-Shaikhly, Taha / Altman, Matthew C / Altemeier, William A / Frevert, Charles W / Debley, Jason S / Piliponsky, Adrian M / Ziegler, Steven F / Gharib, Sina A / Hallstrand, Teal S

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 12, Page(s) 1565–1575

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Interleukin-18 ; Interleukin-33/genetics ; Asthma ; Respiratory Hypersensitivity ; Epithelial Cells/pathology ; Inflammation ; Immunity, Innate
    Chemical Substances Interleukin-18 ; Interleukin-33
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202209-1707OC
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