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  1. AU="Murray, Anne M"
  2. AU="Suaña Calsín, Milciades Conrado"
  3. AU="Bai, Yao" AU="Bai, Yao"
  4. AU="Strandberg, Erik"
  5. AU="Dar Dowlatshahi"
  6. AU="Capote, Ailem Rabasa"
  7. AU="Richier, Q"
  8. AU="Jamla, Monica"
  9. AU="Shimomura, Taizou"
  10. AU="Tampakakis, Emmanouil"
  11. AU="Tabares, Jeffrey V"

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  1. Artikel ; Online: Kidney Disease and Brain Health: Current Knowledge and Next Steps.

    Murray, Anne M / Vemuri, Prashanthi

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2022  Band 81, Heft 3, Seite(n) 253–255

    Mesh-Begriff(e) Humans ; Brain ; Kidney Diseases
    Sprache Englisch
    Erscheinungsdatum 2022-11-22
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.09.007
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  2. Artikel ; Online: Cognitive deficits associate with cerebral hypoxia during hemodialysis.

    Wolfgram, Dawn F / Richerson, Wesley T / Murray, Anne M / Schmit, Brian D

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfae101
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  3. Artikel ; Online: Vitamin D: an intervention for cognitive impairment in hemodialysis patients that could make sense.

    Murray, Anne M

    Clinical journal of the American Society of Nephrology : CJASN

    2013  Band 8, Heft 6, Seite(n) 896–897

    Mesh-Begriff(e) Cognition ; Cognition Disorders/epidemiology ; Female ; Humans ; Male ; Renal Dialysis/adverse effects ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/epidemiology
    Chemische Substanzen Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Sprache Englisch
    Erscheinungsdatum 2013-06
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.03980413
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  4. Artikel ; Online: Cognitive impairment, perceived medication adherence, and high-risk medication use in patients with reduced kidney function: A cross-sectional analysis.

    Sheets, Kerry M / Davey, Cynthia S / St Peter, Wendy L / Reule, Scott A / Murray, Anne M

    Health science reports

    2022  Band 5, Heft 4, Seite(n) e697

    Abstract: Background and aims: Reduced estimated glomerular filtration rate (eGFR < 60 ml/min/1.73 m: Methods: An observational cohort study of the epidemiology of CI in community-dwelling adults aged 45 years or older with reduced eGFR.: Results: Our ... ...

    Abstract Background and aims: Reduced estimated glomerular filtration rate (eGFR < 60 ml/min/1.73 m
    Methods: An observational cohort study of the epidemiology of CI in community-dwelling adults aged 45 years or older with reduced eGFR.
    Results: Our analytic cohort consisted of 420 participants (202 with CI; mean age: 69.7 years) with reduced eGFR, at least one prescription medication, and nonmissing medication adherence data. Participants with CI had four times greater unadjusted odds of reporting good medication adherence than participants without CI (self-report of missing medications <4 days/month; odds ratio [OR]: 4.04, 95% confidence interval [CI]:​​​​​ 1.62-10.10). This difference persisted following adjustment for demographic factors and comorbidities (OR: 5.50, 95% CI: 1.86-16.28). Participants with CI were no more likely than participants without CI to report forgetfulness as a reason for missing medication doses. Participants with CI were, on average, taking more total (mean: 13.3 vs. 11.5, median: 12 vs. 11) and more high-risk (mean: 5.0 vs. 4.2, median: 5 vs. 4) medications than those without CI; these differences were attenuated and no longer significant following adjustment for demographics and comorbidities.
    Conclusion: Given the well-documented association between CI and medication nonadherence, better self-reported medication adherence among those with CI may represent perceptions of adherence rather than actual adherence. Participants with CI were, on average, taking more total and more high-risk medications than those without CI, suggesting a possible increased risk for adverse drug events. Our results highlight the potential risks of relying on self-reported medication adherence in reduced eGFR patients with CI.
    Sprache Englisch
    Erscheinungsdatum 2022-06-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.697
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  5. Artikel: Post-Stroke Brain Health Monitoring and Optimization: A Narrative Review.

    Stulberg, Eric L / Sachdev, Perminder S / Murray, Anne M / Cramer, Steven C / Sorond, Farzaneh A / Lakshminarayan, Kamakshi / Sabayan, Behnam

    Journal of clinical medicine

    2023  Band 12, Heft 23

    Abstract: Significant advancements have been made in recent years in the acute treatment and secondary prevention of stroke. However, a large proportion of stroke survivors will go on to have enduring physical, cognitive, and psychological disabilities from ... ...

    Abstract Significant advancements have been made in recent years in the acute treatment and secondary prevention of stroke. However, a large proportion of stroke survivors will go on to have enduring physical, cognitive, and psychological disabilities from suboptimal post-stroke brain health. Impaired brain health following stroke thus warrants increased attention from clinicians and researchers alike. In this narrative review based on an open timeframe search of the PubMed, Scopus, and Web of Science databases, we define post-stroke brain health and appraise the body of research focused on modifiable vascular, lifestyle, and psychosocial factors for optimizing post-stroke brain health. In addition, we make clinical recommendations for the monitoring and management of post-stroke brain health at major post-stroke transition points centered on four key intertwined domains: cognition, psychosocial health, physical functioning, and global vascular health. Finally, we discuss potential future work in the field of post-stroke brain health, including the use of remote monitoring and interventions, neuromodulation, multi-morbidity interventions, enriched environments, and the need to address inequities in post-stroke brain health. As post-stroke brain health is a relatively new, rapidly evolving, and broad clinical and research field, this narrative review aims to identify and summarize the evidence base to help clinicians and researchers tailor their own approach to integrating post-stroke brain health into their practices.
    Sprache Englisch
    Erscheinungsdatum 2023-11-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237413
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  6. Artikel ; Online: Intracranial Atherosclerosis Disease Associated With Cognitive Impairment and Dementia: Systematic Review and Meta-Analysis.

    Sabayan, Behnam / Goudarzi, Roham / Ji, Yuekai / Borhani-Haghighi, Afshin / Olson-Bullis, Barbara A / Murray, Anne M / Sedaghat, Sanaz

    Journal of the American Heart Association

    2023  , Seite(n) e032506

    Abstract: Background: Intracranial atherosclerosis disease (ICAD) alters cerebrovascular hemodynamics and brain structural integrity. Multiple studies have evaluated the link between ICAD and cognitive impairment, with mixed results. This study aims to ... ...

    Abstract Background: Intracranial atherosclerosis disease (ICAD) alters cerebrovascular hemodynamics and brain structural integrity. Multiple studies have evaluated the link between ICAD and cognitive impairment, with mixed results. This study aims to systematically review and summarize the current evidence on this link.
    Methods and results: PubMed, EMBASE, PsycInfo, and Web of Science were searched from 2000 to 2023 without language restriction. Cross-sectional and prospective cohort studies as well as postmortem studies were included. Studies containing data on the link between ICAD, defined as at least 50% stenosis in 1 intracranial vessel, and cognitive impairment and dementia were screened by 2 independent reviewers. A total of 22 (17 observational and 5 postmortem) unique studies, comprising 11 184 individuals (average age range, 59.8-87.6 years; 45.7% women; 36.5% Asian race), were included in the systematic review. Seven of 10 cross-sectional studies and 5 of 7 prospective studies showed a significant association between ICAD and cognitive impairment. In the pooled analysis, ICAD was associated with greater cognitive impairment (measure of association, 1.87 [95% CI, 1.49-2.35]). Meta-regression analyses did not show a significant impact of age, sex, and race. All postmortem studies showed that patients with Alzheimer disease and vascular dementia had a higher burden of ICAD compared with controls.
    Conclusions: This study shows that ICAD is associated with cognitive impairment and dementia across age, sex, and race groups. Our findings may underscore the need to develop individualized dementia preventive care plans in patients with ICAD.
    Sprache Englisch
    Erscheinungsdatum 2023-11-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032506
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  7. Artikel ; Online: Test-Retest Reliability and Minimal Detectable Change of Four Cognitive Tests in Community-Dwelling Older Adults.

    Webb, Katherine L / Ryan, Joanne / Wolfe, Rory / Woods, Robyn L / Shah, Raj C / Murray, Anne M / Orchard, Suzanne G / Storey, Elsdon

    Journal of Alzheimer's disease : JAD

    2022  Band 87, Heft 4, Seite(n) 1683–1693

    Abstract: Background: Cognitive test-retest reliability measures can be used to evaluate meaningful changes in scores.: Objective: This analysis aimed to develop a comprehensive set of test-retest reliability values and minimal detectable change (MDC) values ... ...

    Abstract Background: Cognitive test-retest reliability measures can be used to evaluate meaningful changes in scores.
    Objective: This analysis aimed to develop a comprehensive set of test-retest reliability values and minimal detectable change (MDC) values for a cognitive battery for community-dwelling older individuals in Australia and the U.S., for use in clinical practice.
    Methods: Cognitive scores collected at baseline and year 1, in the ASPirin in Reducing Events in the Elderly clinical trial were used to calculate intraclass correlation coefficients (ICC) for four tests: Modified Mini-Mental State examination (3MS), Hopkins Verbal Learning Test-Revised (HVLT-R), single-letter Controlled Oral Word Association Test (COWAT-F), and Symbol Digit Modalities Test (SDMT). 16,956 participants aged 70 years and over (65 years and over for U.S. minorities) were included. ICCs were used to calculate MDC values for eight education and ethno-racial subgroups.
    Results: All four cognitive tests had moderate (ICC > 0.5) to good (ICC > 0.7) test-retest reliability. ICCs ranged from 0.53 to 0.63 (3MS), 0.68 to 0.77 (SDMT), 0.56 to 0.64 (COWAT-F), 0.57 to 0.69 (HVLT-R total recall), and 0.57 to 0.70 (HVLT-R delayed recall) across the subgroups. MDC values ranged from 6.60 to 9.95 (3MS), 12.42 to 15.61 (SDMT), 6.34 to 8.34 (COWAT-F), 8.13 to 10.85 (HVLT-R total recall), and 4.00 to 5.62 (HVLT-R delayed recall).
    Conclusion: This large cohort of older individuals provides test-retest reliability and MDC values for four widely employed tests of cognitive function. These results can aid interpretation of cognitive scores and decline instead of relying on cross-sectional normative data alone.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Cognition ; Cross-Sectional Studies ; Humans ; Independent Living ; Neuropsychological Tests ; Reproducibility of Results
    Sprache Englisch
    Erscheinungsdatum 2022-04-25
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-215564
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  8. Artikel ; Online: Effects of Aspirin in the Healthy Elderly. Reply.

    McNeil, John J / Woods, Robyn L / Murray, Anne M

    The New England journal of medicine

    2019  Band 380, Heft 18, Seite(n) 1776–1777

    Mesh-Begriff(e) Aged ; Aspirin ; Cardiovascular Diseases ; Humans
    Chemische Substanzen Aspirin (R16CO5Y76E)
    Sprache Englisch
    Erscheinungsdatum 2019-04-29
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1901774
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  9. Artikel ; Online: Late-Life Metabolic Dysfunction-Associated Steatotic Liver Disease and its Association With Physical Disability and Dementia.

    Clayton-Chubb, Daniel / Kemp, William W / Majeed, Ammar / Woods, Robyn L / Ryan, Joanne / Murray, Anne M / Chong, Trevor T J / Lubel, John S / Tran, Cammie / Hodge, Alexander D / Schneider, Hans G / McNeil, John J / Roberts, Stuart K

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2024  Band 79, Heft 4

    Abstract: Background: The burden of metabolic dysfunction-associated steatotic liver disease (MASLD) is growing rapidly, including among older adults. The number of older adults is also rising with concomitantly increasing rates of age-related physical and ... ...

    Abstract Background: The burden of metabolic dysfunction-associated steatotic liver disease (MASLD) is growing rapidly, including among older adults. The number of older adults is also rising with concomitantly increasing rates of age-related physical and cognitive dysfunction. However, data on whether MASLD affects physical and cognitive function in older adults is limited. As such, we aimed to identify whether prevalent MASLD influences the risk of incident physical disability or dementia in initially healthy older adults.
    Methods: A post-hoc analysis of participants from the ASPREE-XT cohort study, which recruited community-dwelling older adults without a history of cardiovascular disease, dementia, or independence-limiting functional impairment. The Fatty Liver Index (to identify MASLD) was calculated in those with complete data. Cox proportional-hazards models were used to investigate the outcomes of dementia and persistent physical disability in participants with MASLD vs those without.
    Results: Of the 9 097 individuals included (mean age 75.1 ± 4.2 years; 45.0% men), 341 (3.7%) developed persistent physical disability and 370 (4.1%) developed dementia over a median follow-up of 6.4 years (IQR 5.3-7.5 years). When adjusting for known contributors including age, gender, education, comorbidity, and functional measures, MASLD was associated with an increased risk of persistent physical disability (HR 1.41 [95% CI: 1.07-1.87]) and reduced risk of incident dementia (HR 0.63 [95% CI: 0.48-0.83]).
    Conclusions: Prevalent MASLD is associated with reduced rates of incident dementia but increased risk of persistent physical disability in initially relatively healthy older adults. Understanding the mechanisms underlying these divergent results to allow appropriate risk stratification and counseling is important.
    Mesh-Begriff(e) Male ; Humans ; Aged ; Female ; Cohort Studies ; Health Status ; Cardiovascular Diseases ; Fatty Liver ; Dementia/epidemiology ; Dementia/etiology
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glae011
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  10. Artikel ; Online: The brain and the kidney connection: A model of accelerated vascular cognitive impairment.

    Murray, Anne M

    Neurology

    2009  Band 73, Heft 12, Seite(n) 916–917

    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Aging/pathology ; Atrophy/pathology ; Atrophy/physiopathology ; Brain/blood supply ; Brain/pathology ; Brain/physiopathology ; Cognition Disorders/etiology ; Cognition Disorders/pathology ; Cognition Disorders/physiopathology ; Dementia/etiology ; Dementia/pathology ; Dementia/physiopathology ; Disease Progression ; Glomerular Filtration Rate/physiology ; Humans ; Kidney/blood supply ; Kidney/pathology ; Kidney/physiopathology ; Microcirculation/physiology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2009-08-19
    Erscheinungsland United States
    Dokumenttyp Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0b013e3181b99a2e
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