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  1. Article ; Online: Corrigendum to "Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease" [Cell. Immunol. 327 (2018) 77-82].

    Karpenko, M N / Vasilishina, A A / Gromova, E A / Muruzheva, Z M / Bernadotte, A

    Cellular immunology

    2018  Volume 334, Page(s) 99

    Language English
    Publishing date 2018-09-10
    Publishing country Netherlands
    Document type Journal Article ; Published Erratum
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2018.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson's Disease.

    Karpenko, M N / Ilyicheva, E Yu / Muruzheva, Z M / Milyukhina, I V / Orlov, Yu A / Puchkova, L V

    Bulletin of experimental biology and medicine

    2018  Volume 164, Issue 5, Page(s) 596–600

    Abstract: Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding ... ...

    Abstract Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson's disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson's disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson's disease.
    MeSH term(s) Animals ; Autonomic Nervous System/metabolism ; Autonomic Nervous System/physiology ; Blood Pressure/physiology ; Copper/metabolism ; Heart Rate/physiology ; Humans ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Male ; Parkinson Disease/metabolism ; Parkinson Disease/physiopathology ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism
    Chemical Substances Copper (789U1901C5) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2018-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390407-6
    ISSN 1573-8221 ; 0007-4888 ; 0365-9615
    ISSN (online) 1573-8221
    ISSN 0007-4888 ; 0365-9615
    DOI 10.1007/s10517-018-4039-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease.

    Karpenko, M N / Vasilishina, A A / Gromova, E A / Muruzheva, Z M / Miliukhina, I V / Bernadotte, A

    Cellular immunology

    2018  Volume 327, Page(s) 77–82

    Abstract: Several parameters representing the clinical diversity of Parkinson's disease (PD), including severity, phenotypes, cognitive decline, anxiety and depression were analyzed to examine the link with interleukin-1β (IL-1β), the interleukin-1 receptor ... ...

    Abstract Several parameters representing the clinical diversity of Parkinson's disease (PD), including severity, phenotypes, cognitive decline, anxiety and depression were analyzed to examine the link with interleukin-1β (IL-1β), the interleukin-1 receptor antagonist (IL-1RA), IL-6, IL-10, and tumor necrosis factor-α (TNFα) and also to determine the relationship between levels of these factors in serum and cerebrospinal fluid (CSF). Significantly elevated serum IL-1β and IL-6 and reduced IL-1RA levels were found in the PD group. In CSF and serum, inflammatory factors behaved differently, with increased CSF TNFα indicating rapid PD progression, and increased IL-1β in serum. A low level of IL-6 was associated with a longer duration of PD. Anxiety, depression, non-tremor phenotype and late-onset PD correlated with a high serum level of IL-10. The serum TNFα level was lower in PD patients with mild cognitive impairment compared to controls. Serum IL-1β, IL-6 and IL-10 levels correlated with CSF markers.
    MeSH term(s) Aged ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Female ; Humans ; Interleukin 1 Receptor Antagonist Protein/analysis ; Interleukin 1 Receptor Antagonist Protein/blood ; Interleukin 1 Receptor Antagonist Protein/cerebrospinal fluid ; Interleukin-10/analysis ; Interleukin-10/blood ; Interleukin-10/cerebrospinal fluid ; Interleukin-1beta/analysis ; Interleukin-1beta/blood ; Interleukin-1beta/cerebrospinal fluid ; Interleukin-6/analysis ; Interleukin-6/blood ; Interleukin-6/cerebrospinal fluid ; Male ; Middle Aged ; Parkinson Disease/blood ; Parkinson Disease/cerebrospinal fluid ; Parkinson Disease/metabolism ; Tumor Necrosis Factor-alpha/analysis ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/cerebrospinal fluid
    Chemical Substances Biomarkers ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1beta ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2018-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2018.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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