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Article ; Online: Ultrasonic surface acoustic wave-assisted separation of microscale droplets with varying acoustic impedance

Mushtaq Ali / Jinsoo Park

Ultrasonics Sonochemistry, Vol 93, Iss , Pp 106305- (2023)

2023

Abstract: In droplet-based microfluidic platforms, precise separation of microscale droplets of different chemical composition is increasingly necessary for high-throughput combinatorial chemistry in drug discovery and screening assays. A variety of droplet ... ...

Abstract	In droplet-based microfluidic platforms, precise separation of microscale droplets of different chemical composition is increasingly necessary for high-throughput combinatorial chemistry in drug discovery and screening assays. A variety of droplet sorting methods have been proposed, in which droplets of the same kind are translocated. However, there has been relatively less effort in developing techniques to separate the uniform-sized droplets of different chemical composition. Most of the previous droplet sorting or separation techniques either rely on the droplet size for the separation marker or adopt on-demand application of a force field for the droplet sorting or separation. The existing droplet microfluidic separation techniques based on the in-droplet chemical composition are still in infancy because of the technical difficulties. In this study, we propose an acoustofluidic method to simultaneously separate microscale droplets of the same volume and dissimilar acoustic impedance using ultrasonic surface acoustic wave (SAW)-induced acoustic radiation force (ARF). For extensive investigation on the SAW-induced ARF acting on both cylindrical and spherical droplets, we first performed a set of the droplet sorting experiments under varying conditions of acoustic impedance of the dispersed phase fluid, droplet velocity, and wave amplitude. Moreover, for elucidation of the underlying physics, a new dimensionless number ARD was introduced, which was defined as the ratio of the ARF to the drag force acting on the droplets. The experimental results were comparatively analyzed by using a ray acoustics approach and found to be in good agreement with the theoretical estimation. Based on the findings, we successfully demonstrated the simultaneous separation of uniform-sized droplets of the different acoustic impedance under continuous application of the acoustic field in a label-free and detection-free manner. Insomuch as on-chip, precise separation of multiple kinds of droplets is critical in many droplet ...
Keywords	Ultrasonic surface acoustic wave ; Acoustofluidics ; Droplet separation ; Acoustic radiation force ; Acoustic impedance ; Chemistry ; QD1-999 ; Acoustics. Sound ; QC221-246
Subject code	620
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Seamless Copy–Move Replication in Digital Images

Tanzeela Qazi / Mushtaq Ali / Khizar Hayat / Baptiste Magnier

Journal of Imaging, Vol 8, Iss 69, p

2022 Volume 69

Abstract: The importance and relevance of digital-image forensics has attracted researchers to establish different techniques for creating and detecting forgeries. The core category in passive image forgery is copy–move image forgery that affects the originality ... ...

Abstract	The importance and relevance of digital-image forensics has attracted researchers to establish different techniques for creating and detecting forgeries. The core category in passive image forgery is copy–move image forgery that affects the originality of image by applying a different transformation. In this paper, a frequency-domain image-manipulation method is presented. The method exploits the localized nature of discrete wavelet transform (DWT) to attain the region of the host image to be manipulated. Both patch and host image are subjected to DWT at the same level l to obtain <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>3</mn><mi>l</mi><mo>+</mo><mn>1</mn></mrow></semantics></math> sub-bands, and each sub-band of the patch is pasted to the identified region in the corresponding sub-band of the host image. Resulting manipulated host sub-bands are then subjected to inverse DWT to obtain the final manipulated host image. The proposed method shows good resistance against detection by two frequency-domain forgery detection methods from the literature. The purpose of this research work is to create a forgery and highlight the need to produce forgery detection methods that are robust against malicious copy–move forgery.
Keywords	discrete wavelet transform (DWT) ; copy–move replication ; image manipulation ; image tampering ; image forgery ; frequency domain ; Photography ; TR1-1050 ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: VCC-BPS

Waqar Ishaq / Eliya Buyukkaya / Mushtaq Ali / Zakir Khan

PLoS ONE, Vol 16, Iss 1, p e

Vertical Collaborative Clustering using Bit Plane Slicing.

2021 Volume 0244691

Abstract: The vertical collaborative clustering aims to unravel the hidden structure of data (similarity) among different sites, which will help data owners to make a smart decision without sharing actual data. For example, various hospitals located in different ... ...

Abstract	The vertical collaborative clustering aims to unravel the hidden structure of data (similarity) among different sites, which will help data owners to make a smart decision without sharing actual data. For example, various hospitals located in different regions want to investigate the structure of common disease among people of different populations to identify latent causes without sharing actual data with other hospitals. Similarly, a chain of regional educational institutions wants to evaluate their students' performance belonging to different regions based on common latent constructs. The available methods used for finding hidden structures are complicated and biased to perform collaboration in measuring similarity among multiple sites. This study proposes vertical collaborative clustering using a bit plane slicing approach (VCC-BPS), which is simple and unique with improved accuracy, manages collaboration among various data sites. The VCC-BPS transforms data from input space to code space, capturing maximum similarity locally and collaboratively at a particular bit plane. The findings of this study highlight the significance of those particular bits which fit the model in correctly classifying class labels locally and collaboratively. Thenceforth, the data owner appraises local and collaborative results to reach a better decision. The VCC-BPS is validated by Geyser, Skin and Iris datasets and its results are compared with the composite dataset. It is found that the VCC-BPS outperforms existing solutions with improved accuracy in term of purity and Davies-Boulding index to manage collaboration among different data sites. It also performs data compression by representing a large number of observations with a small number of data symbols.
Keywords	Medicine ; R ; Science ; Q
Subject code	006
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article: Contemporary review on pediatric hypertrophic cardiomyopathy: insights into detection and management.

Shafqat, Areez / Shaik, Abdullah / Koritala, Snygdha / Mushtaq, Ali / Sabbah, Belal Nedal / Nahid Elshaer, Ahmed / Baqal, Omar

Frontiers in cardiovascular medicine

2024 Volume 10, Page(s) 1277041

Abstract: Hypertrophic cardiomyopathy is the most common genetic cardiac disorder and is defined by the presence of left ventricular (LV) hypertrophy in the absence of a condition capable of producing such a magnitude of hypertrophy. Over the past decade, ... ...

Abstract	Hypertrophic cardiomyopathy is the most common genetic cardiac disorder and is defined by the presence of left ventricular (LV) hypertrophy in the absence of a condition capable of producing such a magnitude of hypertrophy. Over the past decade, guidelines on the screening, diagnostic, and management protocols of pediatric primary (i.e., sarcomeric) HCM have undergone significant revisions. Important revisions include changes to the appropriate screening age, the role of cardiac MRI (CMR) in HCM diagnosis, and the introduction of individualized pediatric SCD risk assessment models like HCM Risk-kids and PRIMaCY. This review explores open uncertainties in pediatric HCM that merit further attention, such as the divergent American and European recommendations on CMR use in HCM screening and diagnosis, the need for incorporating key genetic and imaging parameters into HCM-Risk Kids and PRIMaCY, the best method of quantifying myocardial fibrosis and its prognostic utility in SCD prediction for pediatric HCM, devising appropriate genotype- and phenotype-based exercise recommendations, and use of heart failure medications that can reverse cardiac remodeling in pediatric HCM.
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1277041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Unexpected Diagnosis of Second Primary Malignancy in a Breast Cancer Survivor: A Case Report.

Haque, Emaan / Mushtaq, Ali H / Alkhatib, Radwan / Alhusaini, Hamed / Suleman, Kausar

Cureus

2023 Volume 15, Issue 8, Page(s) e42819

Abstract: Background: Breast cancer survival rates are increasing more than ever with the development of better diagnostic and therapeutic techniques. Survivors of breast cancer have an increased risk of developing second primary malignancies, which may be ... ...

Abstract	Background: Breast cancer survival rates are increasing more than ever with the development of better diagnostic and therapeutic techniques. Survivors of breast cancer have an increased risk of developing second primary malignancies, which may be mistaken for breast cancer recurrence and lead to delayed diagnosis and poor prognosis. Case report: We report a case of a 62-year-old female who presented with shortness of breath and bone pain. She had a history of left triple-positive invasive ductal carcinoma (T1N0M0) treated with bilateral skin-sparing mastectomy, adjuvant Taxotere, and trastuzumab-based therapy and then continued on trastuzumab and letrozole. She underwent imaging to explore the source of her symptoms at which new pulmonary nodules were discovered. During workup, she was found to have elevated tumor markers. They were initially suspected to be breast cancer recurrence metastases based on elevated tumor markers; however, further investigations confirmed that the nodules were a second primary lung adenocarcinoma with a different molecular profile. The patient had disease progression despite chemotherapy and eventually succumbed to her disease. Conclusion: This case highlights the importance of considering second primary malignancies in breast cancer survivors and utilizing advanced diagnostic modalities to efficiently diagnose such cases.
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42819
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Article: Age-sex effect on in-hospital complications and mortality in patients with Takotsubo syndrome. Insights from the National Inpatient Sample.

Vriz, Olga / Alzahrani, Talal / Landi, Irene / Mushtaq, Ali Hassan / Shaik, Abdullah / Elshaer, Ahmed Nahid

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2023 Volume 94, Issue 1

Abstract: Age and sex differences in Takotsubo syndrome (TTS) are still a matter of debate. The present study aimed to evaluate the difference in cardiovascular (CV) risk factors, CV disease, in-hospital complications, and death within different sex-age groups. ... ...

Abstract	Age and sex differences in Takotsubo syndrome (TTS) are still a matter of debate. The present study aimed to evaluate the difference in cardiovascular (CV) risk factors, CV disease, in-hospital complications, and death within different sex-age groups. Using the National Inpatient Sample database between 2012 and 2016, 32,474 patients older than 18 years of age hospitalized with the primary diagnosis of TTS were identified. A total of 32,474 patients were enrolled; 27,611 (85.04%) were female. CV risk factors were higher in females, while CV diseases and in-hospital complications were significantly higher in males. The mortality in males was twice as high as that of female patients (9.83% versus 4.58%, p<0.01), and in the logistic regression model after adjustment for confounders, the odds ratio (OR) was 1.79, the confidence interval was 1.60-2.02, and p<0.01. After dividing the group based on age, in-hospital complications were inversely related to age in both sexes, and the length of in-hospital stay was double in the youngest group compared to the oldest one. Mortality increased progressively with age in both groups but was constantly higher in males for each age group. Multiple logistic regression analysis for mortality was performed for the two sexes separately and for the three age groups, considering the youngest one as the reference group. In females, the OR was 1.59 and 2.88, respectively, for groups 2 and 3; for males, the OR was 1.92 and 3.15, all of them statistically significant (p<0.01). In-hospital complications were more common in younger patients with TTS, particularly in males. Mortality was positively correlated with age for both sexes, but mortality was higher in males compared to females in all age groups.
MeSH term(s)	Humans ; Male ; Female ; Inpatients ; Takotsubo Cardiomyopathy/diagnosis ; Length of Stay ; Hospital Mortality ; Hospitals
Language	English
Publishing date	2023-04-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2023.2558
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Article ; Online: Machine learning applications and challenges in graft-versus-host disease: a scoping review.

Mushtaq, Ali Hassan / Shafqat, Areez / Salah, Haneen T / Hashmi, Shahrukh K / Muhsen, Ibrahim N

Current opinion in oncology

2023 Volume 35, Issue 6, Page(s) 594–600

Abstract: Purpose of review: This review delves into the potential of artificial intelligence (AI), particularly machine learning (ML), in enhancing graft-versus-host disease (GVHD) risk assessment, diagnosis, and personalized treatment.: Recent findings: ... ...

Abstract	Purpose of review: This review delves into the potential of artificial intelligence (AI), particularly machine learning (ML), in enhancing graft-versus-host disease (GVHD) risk assessment, diagnosis, and personalized treatment. Recent findings: Recent studies have demonstrated the superiority of ML algorithms over traditional multivariate statistical models in donor selection for allogeneic hematopoietic stem cell transplantation. ML has recently enabled dynamic risk assessment by modeling time-series data, an upgrade from the static, "snapshot" assessment of patients that conventional statistical models and older ML algorithms offer. Regarding diagnosis, a deep learning model, a subset of ML, can accurately identify skin segments affected with chronic GVHD with satisfactory results. ML methods such as Q-learning and deep reinforcement learning have been utilized to develop adaptive treatment strategies (ATS) for the personalized prevention and treatment of acute and chronic GVHD. Summary: To capitalize on these promising advancements, there is a need for large-scale, multicenter collaborations to develop generalizable ML models. Furthermore, addressing pertinent issues such as the implementation of stringent ethical guidelines is crucial before the widespread introduction of AI into GVHD care.
MeSH term(s)	Humans ; Artificial Intelligence ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Graft vs Host Disease/therapy ; Graft vs Host Disease/prevention & control ; Bronchiolitis Obliterans Syndrome ; Machine Learning ; Multicenter Studies as Topic
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000000996
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Article ; Online: Takotsubo Syndrome in Black Americans: Insights From the National Inpatient Sample.

Vriz, Olga / Mushtaq, Ali Hassan / Elshaer, Ahmed Nahid / Shaik, Abdullah / Landi, Irene / Alzahrani, Talal

Texas Heart Institute journal

2023 Volume 50, Issue 5

Abstract: Background: Data on race-related differences in the clinical outcomes of Takotsubo syndrome are limited, particularly for Black patients. This study aimed to assess whether race and sex may have an additional impact on the inpatient mortality of ... ...

Abstract	Background: Data on race-related differences in the clinical outcomes of Takotsubo syndrome are limited, particularly for Black patients. This study aimed to assess whether race and sex may have an additional impact on the inpatient mortality of patients with Takotsubo syndrome. Methods: A total of 4,628 patients from the United States' National Inpatient Sample from 2012 to 2016 were identified; propensity score analysis revealed a similar propensity score between Black patients (n = 2,314) and White patients (n = 2,314), which was used to balance observed covariates. Sex and age distributions were identical between the 2 groups. The groups were also similar in baseline characteristics, including cardiovascular risk factors. White patients were compared with Black patients on in-hospital outcomes and inpatient mortality. A logistic regression analysis was conducted to measure the difference in mortality based on race and sex. Results: Compared with White patients, Black patients had a higher percentage of in-hospital complications, including cerebrovascular accidents (4.9% vs 2.5%, P ≤ .01), acute kidney injury (25% vs 19%, P ≤ .01); longer lengths of stay (8 vs 7 days, P ≤ .01); and higher inpatient mortality (6.1% vs 4.5%, P < .01). When analysis was conducted with race and sex combined, inpatient mortality was higher among Black men than among White women (odds ratio, 2.7 [95% CI, 1.80-3.95]; P ≤ .01). Conclusion: This study showed that Black patients with Takotsubo syndrome have higher in-hospital complications and inpatient mortality rates. When race and sex were combined, inpatient mortality was significantly higher among Black men than among either White men and women or Black women.
MeSH term(s)	Female ; Humans ; Male ; Black or African American/statistics & numerical data ; Hospital Mortality/ethnology ; Retrospective Studies ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/epidemiology ; Takotsubo Cardiomyopathy/ethnology ; Takotsubo Cardiomyopathy/therapy ; United States/epidemiology ; White/statistics & numerical data ; Hospitalization/statistics & numerical data ; Sex Factors ; Race Factors
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	604761-0
ISSN	1526-6702 ; 0730-2347
ISSN (online)	1526-6702
ISSN	0730-2347
DOI	10.14503/THIJ-22-8055
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Article: Renal AL Amyloidosis: Updates on Diagnosis, Staging, and Management.

Shafqat, Areez / Elmaleh, Hassan / Mushtaq, Ali / Firdous, Zaina / Ashruf, Omer / Mukhopadhyay, Debduti / Ahmad, Maheen / Ahmad, Mahnoor / Raza, Shahzad / Anwer, Faiz

Journal of clinical medicine

2024 Volume 13, Issue 6

Abstract: AL amyloidosis is caused by the excessive production of nonfunctional immunoglobulins, leading to the formation of amyloid fibrils that damage vital organs, especially the heart and kidneys. AL amyloidosis presents with non-specific symptoms such as ... ...

Abstract	AL amyloidosis is caused by the excessive production of nonfunctional immunoglobulins, leading to the formation of amyloid fibrils that damage vital organs, especially the heart and kidneys. AL amyloidosis presents with non-specific symptoms such as fatigue, weight loss, numbness, pain, and nephrotic syndrome. Consequently, diagnosis is often delayed, and patients typically present with advanced disease at diagnosis. The Pavia renal staging model stratifies patients based on their likelihood of progressing to dialysis. Treatment with daratumumab plus cyclophosphamide, bortezomib, and dexamethasone (i.e., Dara-CyBorD) was effective in inducing renal response in the landmark phase III ANDROMEDA trial and reducing early mortality. However, determining the most appropriate treatment regimen for relapsed or refractory cases remains a challenge due to various patient- and disease-related factors. Encouragingly, t(11:14) may be a positive indicator of therapy responses to the anti-BCL2 therapy venetoclax. Moreover, it is increasingly possible-for the first time-to clear AL amyloid fibrils from peripheral organs by leveraging novel anti-fibril immunotherapeutic approaches, although these medications are still under investigation in clinical trials. Given these advancements, this review provides a comprehensive overview of the current strategies for diagnosing, staging, treating, and monitoring AL amyloidosis, emphasizing renal involvement.
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061744
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Article ; Online: Corrigendum: Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy.

Shafqat, Areez / Omer, Mohamed H / Ahmed, Eman Nayaz / Mushtaq, Ali / Ijaz, Eman / Ahmed, Zara / Alkattan, Khaled / Yaqinuddin, Ahmed

Frontiers in immunology

2023 Volume 14, Page(s) 1252998

Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1200941.]. ...

Abstract	[This corrects the article DOI: 10.3389/fimmu.2023.1200941.].
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1252998
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